| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Scott Wilke, Robert Thomas, Natalie Allcock, Robert Fer. Mechanism of acute ischemic injury of oligodendroglia in early myelinating white matter: the importance of astrocyte injury and glutamate release. Journal of neuropathology and experimental neurology. vol 63. issue 8. 2004-09-14. PMID:15330341. |
mechanism of acute ischemic injury of oligodendroglia in early myelinating white matter: the importance of astrocyte injury and glutamate release. |
2004-09-14 |
2023-08-12 |
rat |
| Ethan G Hughes, Jamie L Maguire, Melanie T McMinn, Rachael E Scholz, Margaret L Sutherlan. Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain research. Molecular brain research. vol 124. issue 2. 2004-08-26. PMID:15135219. |
analysis of primary cortical astrocyte cultures prepared from gfap null and wild type mice demonstrated that loss of gfap results in an inability to traffic the glial glutamate transporter, eaat2, to the surface of the cell following protein kinase a (pka) stimulation by dibutyryl camp. |
2004-08-26 |
2023-08-12 |
mouse |
| Yanhua H Huang, Saurabh R Sinha, Kohichi Tanaka, Jeffrey D Rothstein, Dwight E Bergle. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140926. |
astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. |
2004-08-13 |
2023-08-12 |
mouse |
| Richard Piet, Dominique A Poulain, Stéphane H R Olie. Contribution of astrocytes to synaptic transmission in the rat supraoptic nucleus. Neurochemistry international. vol 45. issue 2-3. 2004-07-26. PMID:15145540. |
the use of pharmacological inhibitors of glutamate transporters on this model, in which a physiological change in the astrocyte environment occurs, has brought new insights on the contribution of astrocytes to both excitatory and inhibitory neurotransmissions. |
2004-07-26 |
2023-08-12 |
rat |
| Linda Bambrick, Tibor Kristian, Gary Fisku. Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochemical research. vol 29. issue 3. 2004-06-29. PMID:15038607. |
ischemic alterations to astrocyte energy metabolism and the uptake and metabolism of the excitatory amino acid transmitter glutamate may be particularly important. |
2004-06-29 |
2023-08-12 |
Not clear |
| Marcos Emílio dos Santos Frizzo, Leonara Patrícia Dall'Onder, Karina Borges Dalcin, Diogo Onofre Souz. Riluzole enhances glutamate uptake in rat astrocyte cultures. Cellular and molecular neurobiology. vol 24. issue 1. 2004-06-28. PMID:15049516. |
riluzole enhances glutamate uptake in rat astrocyte cultures. |
2004-06-28 |
2023-08-12 |
rat |
| Marcos Emílio dos Santos Frizzo, Leonara Patrícia Dall'Onder, Karina Borges Dalcin, Diogo Onofre Souz. Riluzole enhances glutamate uptake in rat astrocyte cultures. Cellular and molecular neurobiology. vol 24. issue 1. 2004-06-28. PMID:15049516. |
the effect of riluzole on l-[2,3-3h] glutamate uptake was investigated in rat cortical astrocyte cultures. |
2004-06-28 |
2023-08-12 |
rat |
| Cherif Boudaba, David M Linn, Katalin Cs Halmos, Jeffrey G Taske. Increased tonic activation of presynaptic metabotropic glutamate receptors in the rat supraoptic nucleus following chronic dehydration. The Journal of physiology. vol 551. issue Pt 3. 2004-05-27. PMID:12824445. |
increasing ambient glutamate levels by inhibiting astrocyte glutamate uptake resulted in a decrease in mepsc frequency due to increased activation of presynaptic mglurs. |
2004-05-27 |
2023-08-12 |
rat |
| Zhuying Wang, Gusta Trillo-Pazos, Seon-Young Kim, Mario Canki, Susan Morgello, Leroy R Sharer, Harris A Gelbard, Zao-Zhong Su, Dong-Chul Kang, Andrew I Brooks, Paul B Fisher, David J Volsk. Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. Journal of neurovirology. vol 10 Suppl 1. 2004-05-10. PMID:14982736. |
focusing on a specific astrocyte function relevant to neuropathogenesis, the authors showed that exposure of astrocytes to hiv-1 or gp120 in vitro impairs the ability of the cells to transport l-glutamate and the authors related this defect to transcriptional inhibition of the eaat2 glutamate transporter gene. |
2004-05-10 |
2023-08-12 |
human |
| Nicholas J Maragakis, Joerg Dietrich, Victor Wong, Haipeng Xue, Margot Mayer-Proschel, Mahendra S Rao, Jeffrey D Rothstei. Glutamate transporter expression and function in human glial progenitors. Glia. vol 45. issue 2. 2004-04-30. PMID:14730707. |
eaat3 and eaat4 expression is reduced as glial maturation progresses both in astrocyte precursors and early-differentiated astrocytes and is consistent with their role in adult tissues as primarily neuronal glutamate transporters. |
2004-04-30 |
2023-08-12 |
human |
| Santina Bruzzone, Claudia Verderio, Ursula Schenk, Ernesto Fedele, Elena Zocchi, Michela Matteoli, Antonio De Flor. Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones. Journal of neurochemistry. vol 89. issue 1. 2004-04-26. PMID:15030411. |
the causal role of neurone-released glutamate in inducing overexpression of astrocyte cd38 is demonstrated by two observations: first, in the absence of neurones, induction of cd38 in pure astrocyte cultures can be obtained with glutamate and second, it can be prevented in co-cultures by glutamate receptor antagonists. |
2004-04-26 |
2023-08-12 |
Not clear |
| Giovanni Li Volti, Riccardo Ientile, Nader G Abraham, Angelo Vanella, Giuseppe Cannavò, Francesco Mazza, Monica Currò, Giuseppina Raciti, Roberto Avola, Agata Campis. Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate. Biochemical and biophysical research communications. vol 315. issue 2. 2004-04-20. PMID:14766239. |
immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate. |
2004-04-20 |
2023-08-12 |
Not clear |
| M E S Frizzo, C Schwarzbold, L O Porciúncula, K B Dalcin, R B Rosa, C A J Ribeiro, D O Souza, M Wajne. 3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats. Neurochemistry international. vol 44. issue 5. 2004-02-02. PMID:14643752. |
although the exact mechanisms involved in 3-ohga-stimulatory effect on astrocyte glutamate uptake are unknown, the present findings contribute to the understanding of the pathophysiology of ga-i, suggesting that astrocytes may protect neurons against excitotoxic damage caused by 3-ohga by increasing glutamate uptake and therefore reducing the concentration of this excitatory neurotransmitter in the synaptic cleft. |
2004-02-02 |
2023-08-12 |
rat |
| Michael Wong, Kevin C Ess, Erik J Uhlmann, Laura A Jansen, Wen Li, Peter B Crino, Steven Mennerick, Kelvin A Yamada, David H Gutman. Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model. Annals of neurology. vol 54. issue 2. 2004-01-05. PMID:12891680. |
electrophysiological assays demonstrate a functional decrease in glutamate transport currents of tsc1 cko astrocytes in hippocampal slices and astrocyte cultures. |
2004-01-05 |
2023-08-12 |
mouse |
| Rajiv Jalan, Debbie Shawcross, Nathan Davie. The molecular pathogenesis of hepatic encephalopathy. The international journal of biochemistry & cell biology. vol 35. issue 8. 2003-09-30. PMID:12757755. |
in the brain, the astrocyte is the main site for ammonia detoxification, during the conversion of glutamate to glutamine. |
2003-09-30 |
2023-08-12 |
Not clear |
| Bala T S Susarla, Michael B Robinso. Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. Journal of neurochemistry. vol 86. issue 3. 2003-09-11. PMID:12859677. |
in the present study, the effects of pharmacological inhibitors of pkc were studied in primary astrocyte cultures that express the glutamate aspartate transporter (glast) subtype of glutamate transporter. |
2003-09-11 |
2023-08-12 |
Not clear |
| Charles R Buck, Michael J Jurynec, Deepak K Gupta, Alick K T Law, Johannes Bilger, Douglas C Wallace, Robert J McKeo. Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. Experimental neurology. vol 181. issue 2. 2003-08-05. PMID:12781988. |
the reactive astrocyte response is complex; these cells also produce neurotrophic factors and are responsible for removal of extracellular glutamate, the excitatory neurotransmitter that rises to neurotoxic levels in injury and disease. |
2003-08-05 |
2023-08-12 |
mouse |
| T Böttcher, M Goiny, J Bering, S Domhof, R Nau, U Ungersted. Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain. Experimental brain research. vol 150. issue 2. 2003-07-25. PMID:12669169. |
an impaired function of hippocampal astrocyte glutamate uptake mechanisms or a higher functional capacity of the cortical glutamine synthetase may be possible explanations for the differences demonstrated. |
2003-07-25 |
2023-08-12 |
rabbit |
| Diane B Ré, José Boucraut, Denise Samuel, Serge Birman, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate transport alteration triggers differentiation-state selective oxidative death of cultured astrocytes: a mechanism different from excitotoxicity depending on intracellular GSH contents. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753075. |
recent evidence has been provided for astrocyte degeneration in experimental models of neurodegenerative insults associated with glutamate transport alteration. |
2003-07-24 |
2023-08-12 |
rat |
| Diane B Ré, José Boucraut, Denise Samuel, Serge Birman, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate transport alteration triggers differentiation-state selective oxidative death of cultured astrocytes: a mechanism different from excitotoxicity depending on intracellular GSH contents. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753075. |
to determine whether astrocyte death can directly result from altered glutamate transport, we here investigated the effects of l-trans-pyrrolidine-2,4-dicarboxylate (pdc) on undifferentiated or differentiated cultured rat striatal astrocytes. |
2003-07-24 |
2023-08-12 |
rat |