| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles W Leffler, Helena Parfenova, Alexander L Fedinec, Shyamali Basuroy, Dilyara Tcheranov. Contributions of astrocytes and CO to pial arteriolar dilation to glutamate in newborn pigs. American journal of physiology. Heart and circulatory physiology. vol 291. issue 6. 2007-01-16. PMID:16891404. |
the concurrent loss of co production and pial arteriolar dilation to glutamate following astrocyte injury suggests astrocytes may employ co as a gasotransmitter for glutamatergic cerebrovascular dilation. |
2007-01-16 |
2023-08-12 |
Not clear |
| Clare Howarth, David Attwel. Transports of delight. Neuron. vol 52. issue 2. 2007-01-05. PMID:17046685. |
in this issue of neuron reveals a surprising role of astrocyte glutamate transporters in generating these signals. |
2007-01-05 |
2023-08-12 |
Not clear |
| Freimut Schliess, Boris Görg, Dieter Häussinge. Pathogenetic interplay between osmotic and oxidative stress: the hepatic encephalopathy paradigm. Biological chemistry. vol 387. issue 10-11. 2006-12-04. PMID:17081108. |
astrocyte swelling triggered by ammonia in synergism with different precipitating factors, including hyponatremia, tumor necrosis factor (tnf)-alpha, glutamate and ligands of the peripheral benzodiazepine receptor (pbr), is an early pathogenetic event in he. |
2006-12-04 |
2023-08-12 |
Not clear |
| Andrea C Pardo, Victor Wong, Leah M Benson, Margaret Dykes, Kohichi Tanaka, Jeffrey D Rothstein, Nicholas J Maragaki. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16753145. |
loss of the astrocyte glutamate transporter glt1 modifies disease in sod1(g93a) mice. |
2006-11-14 |
2023-08-12 |
mouse |
| Andrea C Pardo, Victor Wong, Leah M Benson, Margaret Dykes, Kohichi Tanaka, Jeffrey D Rothstein, Nicholas J Maragaki. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16753145. |
the astrocyte glutamate transporter glt1 is responsible for a significant portion of glutamate transport from the synaptic cleft; regulating synaptic transmission and preventing glutamate excitotoxicity. |
2006-11-14 |
2023-08-12 |
mouse |
| Andrea C Pardo, Victor Wong, Leah M Benson, Margaret Dykes, Kohichi Tanaka, Jeffrey D Rothstein, Nicholas J Maragaki. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16753145. |
this study suggests that astrocytes, and the astrocyte glutamate transporter glt1, play a role in modifying disease progression and motor neuron loss in this model. |
2006-11-14 |
2023-08-12 |
mouse |
| André Quincozes dos Santos, Patrícia Nardin, Cláudia Funchal, Lucia Maria Vieira de Almeida, Maria Caroline Jacques-Silva, Susana T Wofchuk, Carlos-Alberto Gonçalves, Carmem Gottfrie. Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Archives of biochemistry and biophysics. vol 453. issue 2. 2006-10-26. PMID:16904623. |
here, we investigated, in c6 glioma cells, the effect of resveratrol on some specific parameters of astrocyte activity (glutamate uptake, glutamine synthetase and secretion of s100b, a neurotrophic cytokine) commonly associated with the protective role of these cells. |
2006-10-26 |
2023-08-12 |
Not clear |
| Daniel Kondziella, Eiliv Brenner, Elvar M Eyjolfsson, Katarina Ryden Markinhuhta, Maria L Carlsson, Ursula Sonnewal. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 9. 2006-09-28. PMID:16395297. |
since the synthesis of glutamate and gaba in neurons is closely connected to astrocyte metabolism, the study of astrocytic function is essential in this context. |
2006-09-28 |
2023-08-12 |
rat |
| Vivianne L Tawfik, Michael L Lacroix-Fralish, Kathryn K Bercury, Nancy Nutile-McMenemy, Brent T Harris, Joyce A Dele. Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype. Glia. vol 54. issue 3. 2006-09-28. PMID:16819765. |
induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype. |
2006-09-28 |
2023-08-12 |
Not clear |
| Javier Vaquero, Roger F Butterwort. The brain glutamate system in liver failure. Journal of neurochemistry. vol 98. issue 3. 2006-09-08. PMID:16771837. |
ammonia and the astrocyte play major roles in such alterations, which affect several components of the brain glutamate system, namely its synthesis, intercellular transport (uptake and release), and function. |
2006-09-08 |
2023-08-12 |
Not clear |
| Morris H Baslo. NAAG peptidase as a therapeutic target: Potential for regulating the link between glucose metabolism and cognition. Drug news & perspectives. vol 19. issue 3. 2006-08-22. PMID:16804566. |
these new drugs impact the first step by inhibiting naag peptidase, located on the astrocyte surface, that cleaves glutamate (glu) from the neuropeptide naag after it has docked with the astrocyte surface metabotropic glu receptor 3 (mglur3). |
2006-08-22 |
2023-08-12 |
Not clear |
| Philip G Haydon, Giorgio Carmignot. Astrocyte control of synaptic transmission and neurovascular coupling. Physiological reviews. vol 86. issue 3. 2006-08-07. PMID:16816144. |
now that we appreciate this range of actions of astrocytic signaling, some of the immediate challenges are to determine how the astrocyte regulates neuronal integration and how both excitatory (glutamate) and inhibitory signals (adenosine) provided by the same glial cell act in concert to regulate neuronal function. |
2006-08-07 |
2023-08-12 |
Not clear |
| Diane B Re, Imane Nafia, Christophe Melon, Keiko Shimamoto, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Glia. vol 54. issue 1. 2006-07-27. PMID:16673373. |
glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. |
2006-07-27 |
2023-08-12 |
Not clear |
| Diane B Re, Imane Nafia, Christophe Melon, Keiko Shimamoto, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Glia. vol 54. issue 1. 2006-07-27. PMID:16673373. |
here we demonstrate that astrocyte death, although correlated with glutamate release, is not resulting from high extracellular glutamate-mediated toxicity. |
2006-07-27 |
2023-08-12 |
Not clear |
| Diane B Re, Imane Nafia, Christophe Melon, Keiko Shimamoto, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Glia. vol 54. issue 1. 2006-07-27. PMID:16673373. |
these data strongly suggest that reversed uptake-mediated astrocyte death results from the leakage of glutamate from a compartmentalized intracellular metabolic pool specifically fuelled by eaat, crucial for preserving gsh contents. |
2006-07-27 |
2023-08-12 |
Not clear |
| Shilpa P Rao, S K Sikda. Astrocytes in 17beta-estradiol treated mixed hippocampal cultures show attenuated calcium response to neuronal activity. Glia. vol 53. issue 8. 2006-06-22. PMID:16565986. |
([ca(2+)](i)) rise in astrocytes in response to local application of the metabotropic glutamate receptor (mglur) agonist t-acpd was attenuated in estradiol treated cultures, suggesting functional changes in the astrocyte mglur following 24-h treatment with estradiol. |
2006-06-22 |
2023-08-12 |
Not clear |
| A R Jayakumar, K S Panickar, Ch R K Murthy, M D Norenber. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672650. |
mechanisms mediating key aspects of ammonia-induced astrocyte dysfunction such as cell swelling and inhibition of glutamate uptake are not clear. |
2006-05-31 |
2023-08-12 |
Not clear |
| A R Jayakumar, K S Panickar, Ch R K Murthy, M D Norenber. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672650. |
we now show that treatment with antioxidants significantly prevents ammonia-induced astrocyte swelling as well as glutamate uptake inhibition. |
2006-05-31 |
2023-08-12 |
Not clear |
| A R Jayakumar, K S Panickar, Ch R K Murthy, M D Norenber. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672650. |
although sb239063 and sp600125 significantly reversed glutamate uptake inhibition and ammonia-induced decline in glutamate-aspartate transporter protein levels, uo126 did not, indicating a differential effect of these kinases in ammonia-induced astrocyte swelling and glutamate transport impairment. |
2006-05-31 |
2023-08-12 |
Not clear |
| Andrew Charle. Teaching resources. Glial intercellular waves. Science's STKE : signal transduction knowledge environment. vol 2005. issue 290. 2006-04-21. PMID:15985642. |
released glutamate is cotransported with na+ into neighboring cells; thus, glutamate uptake leads to an increase in astrocyte intracellular sodium concentration ([na+]i) that is also propagated from cell to cell. |
2006-04-21 |
2023-08-12 |
Not clear |