| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajiv Jalan, Debbie Shawcross, Nathan Davie. The molecular pathogenesis of hepatic encephalopathy. The international journal of biochemistry & cell biology. vol 35. issue 8. 2003-09-30. PMID:12757755. |
in the brain, the astrocyte is the main site for ammonia detoxification, during the conversion of glutamate to glutamine. |
2003-09-30 |
2023-08-12 |
Not clear |
| Bala T S Susarla, Michael B Robinso. Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. Journal of neurochemistry. vol 86. issue 3. 2003-09-11. PMID:12859677. |
in the present study, the effects of pharmacological inhibitors of pkc were studied in primary astrocyte cultures that express the glutamate aspartate transporter (glast) subtype of glutamate transporter. |
2003-09-11 |
2023-08-12 |
Not clear |
| Charles R Buck, Michael J Jurynec, Deepak K Gupta, Alick K T Law, Johannes Bilger, Douglas C Wallace, Robert J McKeo. Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. Experimental neurology. vol 181. issue 2. 2003-08-05. PMID:12781988. |
the reactive astrocyte response is complex; these cells also produce neurotrophic factors and are responsible for removal of extracellular glutamate, the excitatory neurotransmitter that rises to neurotoxic levels in injury and disease. |
2003-08-05 |
2023-08-12 |
mouse |
| T Böttcher, M Goiny, J Bering, S Domhof, R Nau, U Ungersted. Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain. Experimental brain research. vol 150. issue 2. 2003-07-25. PMID:12669169. |
an impaired function of hippocampal astrocyte glutamate uptake mechanisms or a higher functional capacity of the cortical glutamine synthetase may be possible explanations for the differences demonstrated. |
2003-07-25 |
2023-08-12 |
rabbit |
| Diane B Ré, José Boucraut, Denise Samuel, Serge Birman, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate transport alteration triggers differentiation-state selective oxidative death of cultured astrocytes: a mechanism different from excitotoxicity depending on intracellular GSH contents. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753075. |
recent evidence has been provided for astrocyte degeneration in experimental models of neurodegenerative insults associated with glutamate transport alteration. |
2003-07-24 |
2023-08-12 |
rat |
| Diane B Ré, José Boucraut, Denise Samuel, Serge Birman, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate transport alteration triggers differentiation-state selective oxidative death of cultured astrocytes: a mechanism different from excitotoxicity depending on intracellular GSH contents. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753075. |
to determine whether astrocyte death can directly result from altered glutamate transport, we here investigated the effects of l-trans-pyrrolidine-2,4-dicarboxylate (pdc) on undifferentiated or differentiated cultured rat striatal astrocytes. |
2003-07-24 |
2023-08-12 |
rat |
| Diane B Ré, José Boucraut, Denise Samuel, Serge Birman, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate transport alteration triggers differentiation-state selective oxidative death of cultured astrocytes: a mechanism different from excitotoxicity depending on intracellular GSH contents. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753075. |
altogether, these data demonstrate that basal gsh content is a critical factor of astrocyte vulnerability to glutamate transport alteration with possible insights onto concurrent death of astrocytes and gliosis in neurodegenerative insults. |
2003-07-24 |
2023-08-12 |
rat |
| Marcos Emílio dos Santos Frizzo, Félix Alexandre Antunes Soares, Leonara Patrícia Dall'Onder, Diogo Rizzato Lara, Raymond A Swanson, Diogo Onofre Souz. Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake. Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711081. |
extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake. |
2003-07-11 |
2023-08-12 |
Not clear |
| Marcos Emílio dos Santos Frizzo, Félix Alexandre Antunes Soares, Leonara Patrícia Dall'Onder, Diogo Rizzato Lara, Raymond A Swanson, Diogo Onofre Souz. Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake. Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711081. |
guanosine (guo) has been shown to stimulate glutamate uptake in primary astrocyte cultures. |
2003-07-11 |
2023-08-12 |
Not clear |
| Marcos Emílio dos Santos Frizzo, Félix Alexandre Antunes Soares, Leonara Patrícia Dall'Onder, Diogo Rizzato Lara, Raymond A Swanson, Diogo Onofre Souz. Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake. Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711081. |
these results point to specificity in the interaction between guo and the astrocyte glutamate uptake system. |
2003-07-11 |
2023-08-12 |
Not clear |
| Norbert Braun, Jean Sévigny, Santosh K Mishra, Simon C Robson, Stephan W Barth, Ruediger Gerstberger, Klaus Hammer, Herbert Zimmerman. Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain. The European journal of neuroscience. vol 17. issue 7. 2003-06-20. PMID:12713638. |
double labelling for the astrocyte intermediate filament protein gfap and the glial glutamate transporter glast identifies the ntpdase2-positive cells as type-b cells. |
2003-06-20 |
2023-08-12 |
rat |
| Zu-Cheng Ye, Megan S Wyeth, Selva Baltan-Tekkok, Bruce R Ranso. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736329. |
our results indicated that astrocyte hemichannels could influence cns levels of extracellular glutamate with implications for normal and pathological brain function. |
2003-06-19 |
2023-08-12 |
Not clear |
| Douglas L Rothman, Kevin L Behar, Fahmeed Hyder, Robert G Shulma. In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annual review of physiology. vol 65. 2003-06-18. PMID:12524459. |
these (13)c mrs studies clearly demonstrate that glutamate released from presynaptic neurons is taken up by the astrocyte for subsequent glutamine synthesis. |
2003-06-18 |
2023-08-12 |
human |
| Caroline Rae, Nathan Hare, William A Bubb, Sally R McEwan, Angelika Bröer, James A McQuillan, Vladimir J Balcar, Arthur D Conigrave, Stefan Bröe. Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. Journal of neurochemistry. vol 85. issue 2. 2003-05-14. PMID:12675927. |
the role of glutamine and alanine transport in the recycling of neurotransmitter glutamate was investigated in guinea pig brain cortical tissue slices and prisms, and in cultured neuroblastoma and astrocyte cell lines. |
2003-05-14 |
2023-08-12 |
Not clear |
| M Mateo Paz Soldán, Arthur E Warrington, Allan J Bieber, Bogoljub Ciric, Virginia Van Keulen, Larry R Pease, Moses Rodrigue. Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair. Molecular and cellular neurosciences. vol 22. issue 1. 2003-04-21. PMID:12595235. |
astrocyte ca2+ signaling is mediated by a phospholipase c-dependent pathway while oligodendrocyte ca2+ signaling is mediated via ampa-sensitive glutamate receptors. |
2003-04-21 |
2023-08-12 |
mouse |
| Kazuho Abe, Miwa Misaw. Amyloid beta protein enhances the clearance of extracellular L-glutamate by cultured rat cortical astrocytes. Neuroscience research. vol 45. issue 1. 2003-04-08. PMID:12507721. |
to explore the impact of alzheimer's disease amyloid beta protein (abeta) on astrocyte functions, we investigated the effect of abeta on glutamate clearance capacity of cultured rat cortical astrocytes. |
2003-04-08 |
2023-08-12 |
rat |
| Micaela Zonta, Giorgio Carmignot. Calcium oscillations encoding neuron-to-astrocyte communication. Journal of physiology, Paris. vol 96. issue 3-4. 2003-04-04. PMID:12445896. |
the observation that the excitatory neurotransmitter glutamate released from presynaptic terminals can activate, beside the post-synaptic neuron, the glial cell astrocyte, stimulated glial cell research like no other event since the recognition in the 1980s that astrocytes can express on their membrane many receptors for classical neurotransmitters. |
2003-04-04 |
2023-08-12 |
Not clear |
| Laurence Had-Aissouni, Diane-Bérangère Ré, André Nieoullon, Lydia Kerkerian-Le Gof. Importance of astrocytic inactivation of synaptically released glutamate for cell survival in the central nervous system--are astrocytes vulnerable to low intracellular glutamate concentrations? Journal of physiology, Paris. vol 96. issue 3-4. 2003-04-04. PMID:12445912. |
inactivation of synaptically released glutamate is not only important for the phasic aspect of glutamatergic transmission but also for astrocyte metabolism, which supply neurons with different metabolic precursors, and for cell survival in the central nervous system. |
2003-04-04 |
2023-08-12 |
Not clear |
| Julian P Meeks, Steven Menneric. Feeding hungry neurons: astrocytes deliver food for thought. Neuron. vol 37. issue 2. 2003-04-04. PMID:12546812. |
provide evidence that astrocyte uptake of synaptic glutamate triggers astrocytic glycolysis and release of lactate, which in turn nourishes neurons and sustains neuronal activity. |
2003-04-04 |
2023-08-12 |
Not clear |
| Shumin Duan, Christopher M Anderson, Edmund C Keung, Yongmei Chen, Yiren Chen, Raymond A Swanso. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 4. 2003-03-24. PMID:12598620. |
astrocyte glutamate release can modulate synaptic activity and participate in brain intercellular signaling. |
2003-03-24 |
2023-08-12 |
Not clear |