| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirko Santello, Paola Bezzi, Andrea Volterr. TNFα controls glutamatergic gliotransmission in the hippocampal dentate gyrus. Neuron. vol 69. issue 5. 2011-05-11. PMID:21382557. |
with constitutive tnfα present, activation of astrocyte p2y1 receptors induces localized [ca(2+)](i) elevations followed by glutamate release and presynaptic nmda receptor-dependent synaptic potentiation. |
2011-05-11 |
2023-08-12 |
Not clear |
| V Bramanti, D Tomassoni, D Bronzi, S Grasso, M Currò, M Avitabile, G Li Volsi, M Renis, R Ientile, F Amenta, R Avol. Alpha-lipoic acid modulates GFAP, vimentin, nestin, cyclin D1 and MAP-kinase expression in astroglial cell cultures. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:20814740. |
in the present study, we evaluated the expression of some proliferation and differentiation markers in 15 div astrocyte cultures pretreated or not with 0.5 mm glutamate for 24 h and than maintained under chronic or acute treatment with 50 μm r(+)enantiomer or raceme alpha-lipoic acid (ala). |
2011-04-28 |
2023-08-12 |
Not clear |
| Dorte M Skytt, Karsten K Madsen, Kamilla Pajęcka, Arne Schousboe, Helle S Waagepeterse. Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21127969. |
the cultures were characterized by immunostaining for the astrocyte markers glutamine synthetase (gs), glial fibrillary acidic protein, and the glutamate transporters eaat1 and eaat2. |
2011-04-28 |
2023-08-12 |
mouse |
| Hao Zhou, Qing Chen, Dan Li Kong, Jiang Guo, Qian Wang, Shou Yi Y. Effect of resveratrol on gliotransmitter levels and p38 activities in cultured astrocytes. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20842424. |
the extracellular levels of glutamate, d-/l-serine and d-serine were apparently reduced by 100 μm resveratrol in control astrocyte cultures. |
2011-04-18 |
2023-08-12 |
Not clear |
| Angus M Brown, John Skamarauskas, Timothy Lister, Ameneh Madjd, David E Ra. Differential susceptibility of astrocytic and neuronal function to 3-chloropropanediol in the rat inferior colliculus. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21155803. |
to do this, we have developed an in vivo method for monitoring astrocyte function over time by giving hourly 20-min bolus challenge exposures to ammonia via an implanted microdialysis probe and measuring the resulting transient increases in the extracellular glutamine : glutamate ratio. |
2011-04-15 |
2023-08-12 |
rat |
| Dennis A Turner, David Cory Adamso. Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism. Journal of neuropathology and experimental neurology. vol 70. issue 3. 2011-04-11. PMID:21293295. |
astrocyte functions include buffering the extracellular space, providing substrates to neurons, interchanging glutamate and glutamine for synaptic transmission with neurons, and facilitating access to blood vessels. |
2011-04-11 |
2023-08-12 |
Not clear |
| Aven Lee, David V Po. Astrocytes: Glutamate transport and alternate splicing of transporters. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20883814. |
this review considers key aspects of astrocyte biology including glutamate transport, the targeting of eaats to specific membrane domains, and notes the way that activity may potentially drive alternate splicing as well as contributing to the precise anatomical compartmentation of the resultant eaats. |
2011-04-01 |
2023-08-12 |
human |
| Max R Bennett, Les Farnell, William G Gibso. P2X7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes. Journal of theoretical biology. vol 261. issue 1. 2011-02-24. PMID:19643112. |
glutamate released by these bursts is partly removed by transporters on the enveloping astrocyte processes and also excites ampa receptors on these processes, which then release atp. |
2011-02-24 |
2023-08-12 |
Not clear |
| Max R Bennett, Les Farnell, William G Gibso. P2X7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes. Journal of theoretical biology. vol 261. issue 1. 2011-02-24. PMID:19643112. |
the positive feedback of terminal glutamate release, triggering astrocyte atp release and leading to further glutamate release through activation of p2x7 receptors, is then sufficient to allow the normal low-frequency (2hz) action potentials to now elicit postsynaptic action potentials after the insult is removed. |
2011-02-24 |
2023-08-12 |
Not clear |
| Beatriz Pardo, Tiago B Rodrigues, Laura Contreras, Miguel Garzón, Irene Llorente-Folch, Keiko Kobayashi, Takeyori Saheki, Sebastian Cerdan, Jorgina Satrústegu. Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20736955. |
these findings suggest the existence of a neuron-to-astrocyte aspartate transcellular pathway required for astrocyte glutamate synthesis and subsequent glutamine formation. |
2011-02-03 |
2023-08-12 |
Not clear |
| Stefania Corti, Monica Nizzardo, Martina Nardini, Chiara Donadoni, Sabrina Salani, Chiara Simone, Marianna Falcone, Giulietta Riboldi, Alessandra Govoni, Nereo Bresolin, Giacomo P Com. Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis. Human molecular genetics. vol 19. issue 19. 2011-01-04. PMID:20650960. |
neuroprotection was mediated by multiple effects, in particular by the expression of primary astrocyte glutamate transporter glt1 and by the non-mutant genome. |
2011-01-04 |
2023-08-12 |
mouse |
| Anita J Bechtholt-Gompf, Hali V Walther, Martha A Adams, William A Carlezon, Dost Ongür, Bruce M Cohe. Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 10. 2010-12-06. PMID:20531459. |
these findings identify disruption of astrocyte glutamate uptake as one component of the complex circuits that mediate anhedonia and cognitive impairment, both of which are common symptoms of depression. |
2010-12-06 |
2023-08-12 |
rat |
| L Liu, Y Su, W Yang, M Xiao, J Gao, G H. Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20493929. |
these results highlight that disruptions in structural integrity of the neuronal-glial-vascular units and associated functions including glutamate clearance, water transport and astrocyte syncytium contribute to the neurodegeneration induced by long-term ovarian hormone deprivation and systemic d-galactose exposure. |
2010-11-23 |
2023-08-12 |
mouse |
| Chao Huang, Zhuang-Li Hu, Wen-Ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang, Jian-Guo Che. Existence and distinction of acid-evoked currents in rat astrocytes. Glia. vol 58. issue 12. 2010-11-04. PMID:20549751. |
although it is generally accepted that glutamate receptors mediate most astrocyte effects, acid-evoked currents have recently attracted attention for their role in this regard. |
2010-11-04 |
2023-08-12 |
rat |
| Verneri Anttila, Hreinn Stefansson, Mikko Kallela, Unda Todt, Gisela M Terwindt, M Stella Calafato, Dale R Nyholt, Antigone S Dimas, Tobias Freilinger, Bertram Müller-Myhsok, Ville Artto, Michael Inouye, Kirsi Alakurtti, Mari A Kaunisto, Eija Hämäläinen, Boukje de Vries, Anine H Stam, Claudia M Weller, Axel Heinze, Katja Heinze-Kuhn, Ingrid Goebel, Guntram Borck, Hartmut Göbel, Stacy Steinberg, Christiane Wolf, Asgeir Björnsson, Gretar Gudmundsson, Malene Kirchmann, Anne Hauge, Thomas Werge, Jean Schoenen, Johan G Eriksson, Knut Hagen, Lars Stovner, H-Erich Wichmann, Thomas Meitinger, Michael Alexander, Susanne Moebus, Stefan Schreiber, Yurii S Aulchenko, Monique M B Breteler, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Päivi Tikka-Kleemola, Salli Vepsäläinen, Susanne Lucae, Federica Tozzi, Pierandrea Muglia, Jeffrey Barrett, Jaakko Kaprio, Markus Färkkilä, Leena Peltonen, Kari Stefansson, John-Anker Zwart, Michel D Ferrari, Jes Olesen, Mark Daly, Maija Wessman, Arn M J M van den Maagdenberg, Martin Dichgans, Christian Kubisch, Emmanouil T Dermitzakis, Rune R Frants, Aarno Paloti. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature genetics. vol 42. issue 10. 2010-10-28. PMID:20802479. |
rs1835740 is located between mtdh (astrocyte elevated gene 1, also known as aeg-1) and pgcp (encoding plasma glutamate carboxypeptidase). |
2010-10-28 |
2023-08-12 |
Not clear |
| Romain Marignier, Adeline Nicolle, Chantal Watrin, Monique Touret, Sylvie Cavagna, Michel Varrin-Doyer, Gaëlle Cavillon, Véronique Rogemond, Christian Confavreux, Jérôme Honnorat, Pascale Giraudo. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury. Brain : a journal of neurology. vol 133. issue 9. 2010-09-20. PMID:20688809. |
the activity of glutamine synthetase, an astrocyte enzyme converting glutamate into glutamine, decreased in parallel, indicating astrocyte dysfunction. |
2010-09-20 |
2023-08-12 |
rat |
| Lijun Xu, John F Emery, Yi-Bing Ouyang, Ludmila A Voloboueva, Rona G Giffar. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia. vol 58. issue 9. 2010-08-26. PMID:20235222. |
this neuroprotection was associated with significantly better preservation of astrocyte glutamate transporter-1 immunoreactivity at 5-h reperfusion and reduced oxidative stress. |
2010-08-26 |
2023-08-12 |
human |
| C William Shuttlewort. Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation. Neurochemistry international. vol 56. issue 3. 2010-06-08. PMID:20036704. |
of particular importance is the question of whether signals are due primarily to changes in neuronal mitochondrial function, and/or whether astrocyte metabolism triggered by glutamate uptake may be a significant contributor to the overshooting nad(p)h fluorescence increases. |
2010-06-08 |
2023-08-12 |
human |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
modulation of astrocyte glutamate transporters decreases seizures in a mouse model of tuberous sclerosis complex. |
2010-06-08 |
2023-08-12 |
mouse |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
in particular, decreased expression and function of astrocyte glutamate transporters have been implicated in causing elevated extracellular glutamate levels, neuronal death, and epilepsy in a mouse model of tsc (tsc1(gfap)cko mice), involving inactivation of the tsc1 gene primarily in astrocytes. |
2010-06-08 |
2023-08-12 |
mouse |