| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aven Lee, David V Po. Astrocytes: Glutamate transport and alternate splicing of transporters. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20883814. |
this review considers key aspects of astrocyte biology including glutamate transport, the targeting of eaats to specific membrane domains, and notes the way that activity may potentially drive alternate splicing as well as contributing to the precise anatomical compartmentation of the resultant eaats. |
2011-04-01 |
2023-08-12 |
human |
| Max R Bennett, Les Farnell, William G Gibso. P2X7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes. Journal of theoretical biology. vol 261. issue 1. 2011-02-24. PMID:19643112. |
glutamate released by these bursts is partly removed by transporters on the enveloping astrocyte processes and also excites ampa receptors on these processes, which then release atp. |
2011-02-24 |
2023-08-12 |
Not clear |
| Max R Bennett, Les Farnell, William G Gibso. P2X7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes. Journal of theoretical biology. vol 261. issue 1. 2011-02-24. PMID:19643112. |
the positive feedback of terminal glutamate release, triggering astrocyte atp release and leading to further glutamate release through activation of p2x7 receptors, is then sufficient to allow the normal low-frequency (2hz) action potentials to now elicit postsynaptic action potentials after the insult is removed. |
2011-02-24 |
2023-08-12 |
Not clear |
| Beatriz Pardo, Tiago B Rodrigues, Laura Contreras, Miguel Garzón, Irene Llorente-Folch, Keiko Kobayashi, Takeyori Saheki, Sebastian Cerdan, Jorgina Satrústegu. Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20736955. |
these findings suggest the existence of a neuron-to-astrocyte aspartate transcellular pathway required for astrocyte glutamate synthesis and subsequent glutamine formation. |
2011-02-03 |
2023-08-12 |
Not clear |
| Stefania Corti, Monica Nizzardo, Martina Nardini, Chiara Donadoni, Sabrina Salani, Chiara Simone, Marianna Falcone, Giulietta Riboldi, Alessandra Govoni, Nereo Bresolin, Giacomo P Com. Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis. Human molecular genetics. vol 19. issue 19. 2011-01-04. PMID:20650960. |
neuroprotection was mediated by multiple effects, in particular by the expression of primary astrocyte glutamate transporter glt1 and by the non-mutant genome. |
2011-01-04 |
2023-08-12 |
mouse |
| Anita J Bechtholt-Gompf, Hali V Walther, Martha A Adams, William A Carlezon, Dost Ongür, Bruce M Cohe. Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 10. 2010-12-06. PMID:20531459. |
these findings identify disruption of astrocyte glutamate uptake as one component of the complex circuits that mediate anhedonia and cognitive impairment, both of which are common symptoms of depression. |
2010-12-06 |
2023-08-12 |
rat |
| L Liu, Y Su, W Yang, M Xiao, J Gao, G H. Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20493929. |
these results highlight that disruptions in structural integrity of the neuronal-glial-vascular units and associated functions including glutamate clearance, water transport and astrocyte syncytium contribute to the neurodegeneration induced by long-term ovarian hormone deprivation and systemic d-galactose exposure. |
2010-11-23 |
2023-08-12 |
mouse |
| Chao Huang, Zhuang-Li Hu, Wen-Ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang, Jian-Guo Che. Existence and distinction of acid-evoked currents in rat astrocytes. Glia. vol 58. issue 12. 2010-11-04. PMID:20549751. |
although it is generally accepted that glutamate receptors mediate most astrocyte effects, acid-evoked currents have recently attracted attention for their role in this regard. |
2010-11-04 |
2023-08-12 |
rat |
| Verneri Anttila, Hreinn Stefansson, Mikko Kallela, Unda Todt, Gisela M Terwindt, M Stella Calafato, Dale R Nyholt, Antigone S Dimas, Tobias Freilinger, Bertram Müller-Myhsok, Ville Artto, Michael Inouye, Kirsi Alakurtti, Mari A Kaunisto, Eija Hämäläinen, Boukje de Vries, Anine H Stam, Claudia M Weller, Axel Heinze, Katja Heinze-Kuhn, Ingrid Goebel, Guntram Borck, Hartmut Göbel, Stacy Steinberg, Christiane Wolf, Asgeir Björnsson, Gretar Gudmundsson, Malene Kirchmann, Anne Hauge, Thomas Werge, Jean Schoenen, Johan G Eriksson, Knut Hagen, Lars Stovner, H-Erich Wichmann, Thomas Meitinger, Michael Alexander, Susanne Moebus, Stefan Schreiber, Yurii S Aulchenko, Monique M B Breteler, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Päivi Tikka-Kleemola, Salli Vepsäläinen, Susanne Lucae, Federica Tozzi, Pierandrea Muglia, Jeffrey Barrett, Jaakko Kaprio, Markus Färkkilä, Leena Peltonen, Kari Stefansson, John-Anker Zwart, Michel D Ferrari, Jes Olesen, Mark Daly, Maija Wessman, Arn M J M van den Maagdenberg, Martin Dichgans, Christian Kubisch, Emmanouil T Dermitzakis, Rune R Frants, Aarno Paloti. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature genetics. vol 42. issue 10. 2010-10-28. PMID:20802479. |
rs1835740 is located between mtdh (astrocyte elevated gene 1, also known as aeg-1) and pgcp (encoding plasma glutamate carboxypeptidase). |
2010-10-28 |
2023-08-12 |
Not clear |
| Romain Marignier, Adeline Nicolle, Chantal Watrin, Monique Touret, Sylvie Cavagna, Michel Varrin-Doyer, Gaëlle Cavillon, Véronique Rogemond, Christian Confavreux, Jérôme Honnorat, Pascale Giraudo. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury. Brain : a journal of neurology. vol 133. issue 9. 2010-09-20. PMID:20688809. |
the activity of glutamine synthetase, an astrocyte enzyme converting glutamate into glutamine, decreased in parallel, indicating astrocyte dysfunction. |
2010-09-20 |
2023-08-12 |
rat |
| Lijun Xu, John F Emery, Yi-Bing Ouyang, Ludmila A Voloboueva, Rona G Giffar. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia. vol 58. issue 9. 2010-08-26. PMID:20235222. |
this neuroprotection was associated with significantly better preservation of astrocyte glutamate transporter-1 immunoreactivity at 5-h reperfusion and reduced oxidative stress. |
2010-08-26 |
2023-08-12 |
human |
| C William Shuttlewort. Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation. Neurochemistry international. vol 56. issue 3. 2010-06-08. PMID:20036704. |
of particular importance is the question of whether signals are due primarily to changes in neuronal mitochondrial function, and/or whether astrocyte metabolism triggered by glutamate uptake may be a significant contributor to the overshooting nad(p)h fluorescence increases. |
2010-06-08 |
2023-08-12 |
human |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
modulation of astrocyte glutamate transporters decreases seizures in a mouse model of tuberous sclerosis complex. |
2010-06-08 |
2023-08-12 |
mouse |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
in particular, decreased expression and function of astrocyte glutamate transporters have been implicated in causing elevated extracellular glutamate levels, neuronal death, and epilepsy in a mouse model of tsc (tsc1(gfap)cko mice), involving inactivation of the tsc1 gene primarily in astrocytes. |
2010-06-08 |
2023-08-12 |
mouse |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
here, we tested whether pharmacological induction of astrocyte glutamate transporter expression can prevent the neurological phenotype of tsc1(gfap)cko mice. |
2010-06-08 |
2023-08-12 |
mouse |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
early treatment with ceftriaxone prior to the onset of epilepsy increased expression of astrocyte glutamate transporters, decreased extracellular glutamate levels, neuronal death, and seizure frequency, and improved survival in tsc1(gfap)cko mice. |
2010-06-08 |
2023-08-12 |
mouse |
| Ling-Hui Zeng, Adam W Bero, Bo Zhang, David M Holtzman, Michael Won. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20045054. |
these results indicate that astrocyte glutamate transporters contribute to epileptogenesis in tsc1(gfap)cko mice and suggest novel therapeutic strategies for epilepsy in tsc directed at astrocytes. |
2010-06-08 |
2023-08-12 |
mouse |
| Jian Zou, Yan-Xia Wang, Fang-Fang Dou, He-Zuo Lü, Zheng-Wen Ma, Pei-Hua Lu, Xiao-Ming X. Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons. Neurochemistry international. vol 56. issue 4. 2010-05-25. PMID:20064572. |
glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons. |
2010-05-25 |
2023-08-12 |
Not clear |
| Jian Zou, Yan-Xia Wang, Fang-Fang Dou, He-Zuo Lü, Zheng-Wen Ma, Pei-Hua Lu, Xiao-Ming X. Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons. Neurochemistry international. vol 56. issue 4. 2010-05-25. PMID:20064572. |
although the role of astrocyte glutamate transporters in glutamate clearance is well illustrated, the role of glutamine synthetase (gs) that influences this process remains to be elucidated. |
2010-05-25 |
2023-08-12 |
Not clear |
| Ken-ichiro Hayashida, Renee A Parker, James C Eisenac. Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain research. vol 1317. 2010-05-19. PMID:20059984. |
in the primary astrocyte culture, riluzole enhanced glutamate-induced glutamate release. |
2010-05-19 |
2023-08-12 |
rat |