| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gethin J McBea. The transsulfuration pathway: a source of cysteine for glutathione in astrocytes. Amino acids. vol 42. issue 1. 2012-04-27. PMID:21369939. |
astrocyte cells require cysteine as a substrate for glutamate cysteine ligase (γ-glutamylcysteine synthase; ec 6.3.2.2) catalyst of the rate-limiting step of the γ-glutamylcycle leading to formation of glutathione (l: -γ-glutamyl-l: -cysteinyl-glycine; gsh). |
2012-04-27 |
2023-08-12 |
Not clear |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
glucose oxidation, glutamate uptake, and astrocyte number also increased relative to the sedentary group. |
2012-04-02 |
2023-08-12 |
mouse |
| Angelo C Lepore, John O'Donnell, Joseph F Bonner, Courtney Paul, Mark E Miller, Britta Rauck, Robert A Kushner, Jeffrey D Rothstein, Itzhak Fischer, Nicholas J Maragaki. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. Journal of neuroscience research. vol 89. issue 7. 2012-03-29. PMID:21488085. |
spatial and temporal changes in promoter activity of the astrocyte glutamate transporter glt1 following traumatic spinal cord injury. |
2012-03-29 |
2023-08-12 |
mouse |
| Angelo C Lepore, John O'Donnell, Joseph F Bonner, Courtney Paul, Mark E Miller, Britta Rauck, Robert A Kushner, Jeffrey D Rothstein, Itzhak Fischer, Nicholas J Maragaki. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. Journal of neuroscience research. vol 89. issue 7. 2012-03-29. PMID:21488085. |
we examined spatial and temporal changes in gene expression of the major astrocyte glutamate transporter glt1 following moderate thoracic contusion sci using transgenic bac-glt1-egfp promoter reporter mice. |
2012-03-29 |
2023-08-12 |
mouse |
| Ina-Beate Wanne. An in vitro trauma model to study rodent and human astrocyte reactivity. Methods in molecular biology (Clifton, N.J.). vol 814. 2012-03-27. PMID:22144309. |
prototypical astrocyte proteins including gfap, s100, aquaporin4, glutamate transporters, and tenascin are expressed in mouse, rat, and human in vitro matured astrocyte. |
2012-03-27 |
2023-08-12 |
mouse |
| Julien Ratelade, Jeffrey L Bennett, A S Verkma. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22069320. |
however, little or no internalization of nmo-igg, aqp4, or eaat2 was found in primary astrocyte cultures, nor was glutamate uptake affected by nmo-igg exposure. |
2012-02-27 |
2023-08-12 |
mouse |
| Pavel Katsel, William Byne, Panos Roussos, Weilun Tan, Larry Siever, Vahram Haroutunia. Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 6. 2012-02-09. PMID:21270770. |
astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia. |
2012-02-09 |
2023-08-12 |
Not clear |
| Bing-xu Ren, Xiao-ping Gu, Ya-guo Zheng, Cheng-long Liu, Dan Wang, Yu-e Sun, Zheng-liang M. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. vol 116. issue 1. 2012-02-06. PMID:22123524. |
intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. |
2012-02-06 |
2023-08-12 |
mouse |
| Matthew Raymond, Peijun Li, Jean-Marie Mangin, Molly Huntsman, Vittorio Gall. Chronic perinatal hypoxia reduces glutamate-aspartate transporter function in astrocytes through the Janus kinase/signal transducer and activator of transcription pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159101. |
our findings (1) demonstrate specific changes in astrocyte function after perinatal hypoxia, which might contribute to the particular pathogenesis of perinatal white matter injury, (2) provide evidence that at least part of these changes result from a disturbance of the jak/stat pathway by hypoxia, and (3) identify jak/stat signaling as a potential therapeutic target to restore normal glast expression and uptake of glutamate after perinatal brain injury. |
2012-02-02 |
2023-08-12 |
mouse |
| Claire-Marie Vacher, Valérie Grange-Messent, Ronald St-Louis, Danièle Raison, Jean-Marc Lacorte, Hélène Hardin-Pouze. Architecture of the hypothalamo-posthypophyseal complex is controlled by monoamines. Journal of neuroscience research. vol 89. issue 11. 2012-01-20. PMID:21805494. |
astrocytes showed a decrease in glutamate dehydrogenase (gdh) levels, whereas glutamine synthetase (gs) levels remained constant, suggesting a reduction in astrocyte glutamate catabolism. |
2012-01-20 |
2023-08-12 |
mouse |
| Juan A Orellana, Xavier F Figueroa, Helmuth A Sánchez, Susana Contreras-Duarte, Victoria Velarde, Juan C Sáe. Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions. CNS & neurological disorders drug targets. vol 10. issue 3. 2012-01-11. PMID:21288190. |
however, if the stimulus is deleterious, microglia and the endothelium become overactivated, both releasing bioactive molecules (e.g., glutamate, cytokines, prostaglandins and atp) that increase the activity of astroglial hemichannels, reducing the astrocyte neuroprotective functions, and further reducing neuronal cell viability. |
2012-01-11 |
2023-08-12 |
Not clear |
| Anthony C Vernon, Edward J Smith, Lara Stevanato, Michel Mod. Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells. Neurochemistry international. vol 59. issue 3. 2011-12-19. PMID:21624409. |
selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells. |
2011-12-19 |
2023-08-12 |
human |
| E V Stelmashook, N K Isaev, E R Lozier, E S Goryacheva, L G Khaspeko. Role of glutamine in neuronal survival and death during brain ischemia and hypoglycemia. The International journal of neuroscience. vol 121. issue 8. 2011-11-29. PMID:21574892. |
the analyzed data suggest that the constant maintenance of optimal concentrations and ratio of glutamine to glutamate in nerve tissue is not only critically important for the normal functioning of nervous system, but is also necessary for neuron and astrocyte viability. |
2011-11-29 |
2023-08-12 |
Not clear |
| Joice Stipursky, Luciana Romão, Vanessa Tortelli, Vivaldo Moura Neto, Flávia Carvalho Alcantara Gome. Neuron-glia signaling: Implications for astrocyte differentiation and synapse formation. Life sciences. vol 89. issue 15-16. 2011-11-15. PMID:21569780. |
further, we discuss the role of the excitatory neurotransmitter, glutamate and transforming growth factor beta 1 (tgf-β1) pathway in astrocyte generation and differentiation. |
2011-11-15 |
2023-08-12 |
Not clear |
| Hung-Yun Lin, Faith B Davis, Mary K Luidens, Shaker A Mousa, James H Cao, Min Zhou, Paul J Davi. Molecular basis for certain neuroprotective effects of thyroid hormone. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22016721. |
thyroid hormone non-genomically stimulates astrocyte glutamate uptake, an action that protects both glial cells and neurons. |
2011-11-10 |
2023-08-12 |
Not clear |
| Aude Panatier, Joanne Vallée, Michael Haber, Keith K Murai, Jean-Claude Lacaille, Richard Robitaill. Astrocytes are endogenous regulators of basal transmission at central synapses. Cell. vol 146. issue 5. 2011-10-31. PMID:21855979. |
astrocyte activation occurs at functional compartments found along astrocytic processes and involves metabotropic glutamate subtype 5 receptors. |
2011-10-31 |
2023-08-12 |
Not clear |
| Monique Lavialle, Georg Aumann, Enrico Anlauf, Felicitas Pröls, Monique Arpin, Amin Derouich. Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 31. 2011-10-27. PMID:21753079. |
structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. |
2011-10-27 |
2023-08-12 |
rat |
| Lyle W Ostrow, Thomas M Suchyna, Frederick Sach. Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs). Biochemical and biophysical research communications. vol 410. issue 1. 2011-09-02. PMID:21640709. |
et-1, a potent vasoconstrictor, also inhibits the expression of astrocyte glutamate transporters and is mitogenic for astrocytes, glioma cells, neurons, and brain capillary endothelia. |
2011-09-02 |
2023-08-12 |
rat |
| Ling-Hui Zeng, Nicholas R Rensing, Bo Zhang, David H Gutmann, Michael J Gambello, Michael Won. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Human molecular genetics. vol 20. issue 3. 2011-07-19. PMID:21062901. |
similar to tsc1(gfap1)cko mice, tsc2(gfap1)cko mice exhibited epilepsy, premature death, progressive megencephaly, diffuse glial proliferation, dispersion of hippocampal pyramidal cells and decreased astrocyte glutamate transporter expression. |
2011-07-19 |
2023-08-12 |
mouse |
| Selva Baltan, Sean P Murphy, Camelia A Danilov, Amelia Bachleda, Richard S Morriso. Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 11. 2011-06-15. PMID:21411642. |
this protection correlates with the upregulation of an astrocyte glutamate transporter, delayed and reduced glutamate accumulation during ogd, preservation of axonal mitochondria and oligodendrocytes, and maintenance of atp levels. |
2011-06-15 |
2023-08-12 |
mouse |