| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baoman Li, Leif Hertz, Liang Pen. Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes. Neurochemistry international. vol 61. issue 8. 2013-05-24. PMID:23017600. |
the same level of aralar expression was reached in well-differentiated astrocyte cultures, but not until late development, coinciding with the late-maturing brain capability for glutamate formation and degradation. |
2013-05-24 |
2023-08-12 |
mouse |
| Marco Matos, Elisabete Augusto, Nuno J Machado, Alexandre dos Santos-Rodrigues, Rodrigo A Cunha, Paula Agostinh. Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake. Journal of Alzheimer's disease : JAD. vol 31. issue 3. 2013-05-21. PMID:22647260. |
on glutamate transporters and uptake, dependent on a(2a)r function, was also confirmed in an ex vivo astrocyte preparation (gliosomes) from rats intracerebroventricularly (icv) injected with aβ(1-42). . |
2013-05-21 |
2023-08-12 |
mouse |
| E G Lapilover, K Lippmann, S Salar, A Maslarova, J P Dreier, U Heinemann, A Friedma. Peri-infarct blood-brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22782081. |
we hypothesized that bbb opening with consequent alterations of the extracellular electrolyte composition and extravasation of albumin facilitates generation of sds since albumin mediates an astrocyte transcriptional response with consequent disturbance of potassium and glutamate homeostasis. |
2013-04-30 |
2023-08-12 |
rat |
| Jillian L LeMaistre Stobart, Lingling Lu, Hope D I Anderson, Hisashi Mori, Christopher M Anderso. Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 8. 2013-04-26. PMID:23386721. |
mouse cortical slice astrocyte activation by metabotropic glutamate receptors or photolysis of caged ca(2+) produced dilation of penetrating arterioles in a manner attenuated by scavenging d-serine with d-amino acid oxidase, deleting the enzyme responsible for d-serine synthesis (serine racemase) or blocking nmda receptor glycine coagonist sites with 5,7-dichlorokynurenic acid. |
2013-04-26 |
2023-08-12 |
mouse |
| Douglas L Rothman, Henk M De Feyter, Paul K Maciejewski, Kevin L Beha. Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes? Neurochemical research. vol 37. issue 11. 2013-04-23. PMID:23104556. |
however, in the rat brain both the total ammonia fixation rate by glutamate dehydrogenase and the total branched chain amino acid transaminase activity are sufficient to support a branched chain amino acid/branched chain keto acid shuttle, as proposed by hutson and coworkers, which would support the de novo synthesis of glutamine in the astrocyte to replace the ~20 % of neurotransmitter glutamate that is oxidized. |
2013-04-23 |
2023-08-12 |
rat |
| J Yamada, S Jinn. Upregulation of calcium binding protein, S100A6, in activated astrocytes is linked to glutamate toxicity. Neuroscience. vol 226. 2013-04-22. PMID:22982625. |
administration of ceftriaxone, an astrocyte glutamate transporter enhancer, to axotomized mice significantly decreased the immunoreactivity for s100a6. |
2013-04-22 |
2023-08-12 |
mouse |
| Jillian L Stobart, Christopher M Anderso. Multifunctional role of astrocytes as gatekeepers of neuronal energy supply. Frontiers in cellular neuroscience. vol 7. 2013-04-19. PMID:23596393. |
membrane receptor or transporter-mediated effects of glutamate represent a convergence point of astrocyte influence on neuronal bioenergetics. |
2013-04-19 |
2023-08-12 |
Not clear |
| Henry Sershe. Astrocyte origin of activity-dependent release of ATP and glutamate in hippocampal slices: real-time measurement utilizing microelectrode biosensors. British journal of pharmacology. vol 167. issue 5. 2013-03-20. PMID:22703189. |
astrocyte origin of activity-dependent release of atp and glutamate in hippocampal slices: real-time measurement utilizing microelectrode biosensors. |
2013-03-20 |
2023-08-12 |
Not clear |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Astrocytes modulate a postsynaptic NMDA-GABAA-receptor crosstalk in hypothalamic neurosecretory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 2. 2013-03-04. PMID:23303942. |
we found that activation of nmdars by endogenous glutamate levels controlled by astrocyte glutamate transporters, evokes a transient and reversible potentiation of postsynaptic gaba(a)rs. |
2013-03-04 |
2023-08-12 |
rat |
| Mark A Lovell, Melissa A Bradley, Shuling X Fiste. 4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22766736. |
4-hydroxyhexenal (hhe) impairs glutamate transport in astrocyte cultures. |
2013-02-20 |
2023-08-12 |
human |
| Mark A Lovell, Melissa A Bradley, Shuling X Fiste. 4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22766736. |
to determine if hhe also impairs glutamate uptake, primary rat astrocyte cultures were exposed to hhe for 4 hours and glutamate transport measured. |
2013-02-20 |
2023-08-12 |
human |
| Danielle K Lewis, Kristen T Thomas, Amutha Selvamani, Farida Sohrabj. Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22154819. |
these studies show that the aging astrocyte may directly contribute to infarct severity by inefficient glutamate clearance and enhanced cytokine production and suggest a cellular target for improved stroke therapy among older females. |
2013-01-24 |
2023-08-12 |
rat |
| Alexandra Witthoft, George Em Karniadaki. A bidirectional model for communication in the neurovascular unit. Journal of theoretical biology. vol 311. 2013-01-15. PMID:22828568. |
the communication mechanisms in the model include neural synaptic glutamate and potassium signaling to the astrocytes, potassium signaling from the astrocyte to the microvasculature, and astrocytic mechanosensation of vascular changes. |
2013-01-15 |
2023-08-12 |
Not clear |
| Jun-Feng Feng, Gene G Gurkoff, Ken C Van, Minsoo Song, David A Lowe, Jia Zhou, Bruce G Lyet. NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia. Brain research. vol 1469. 2013-01-14. PMID:22750589. |
traumatic brain injury (tbi) leads to a rapid and excessive glutamate elevation in the extracellular milieu, resulting in neuronal degeneration and astrocyte damage. |
2013-01-14 |
2023-08-12 |
Not clear |
| Yu Deng, Zhaofa Xu, Bin Xu, Donghui Xu, Yawen Tian, Wanyu Fen. The protective effects of riluzole on manganese-induced disruption of glutamate transporters and glutamine synthetase in the cultured astrocytes. Biological trace element research. vol 148. issue 2. 2012-12-31. PMID:22391793. |
to investigate this accumulation, this study focused on the role of astrocyte glutamate transporters (gluts) and glutamine synthetase (gs), which have roles in glu transport and metabolism, respectively. |
2012-12-31 |
2023-08-12 |
Not clear |
| Irma E Cisneros, Anuja Ghorpad. HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS. Current HIV research. vol 10. issue 5. 2012-12-31. PMID:22591363. |
hiv-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-aids. |
2012-12-31 |
2023-08-12 |
human |
| Irma E Cisneros, Anuja Ghorpad. HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS. Current HIV research. vol 10. issue 5. 2012-12-31. PMID:22591363. |
lastly, we discuss recent evidence of various astrocyte and neuron crosstalk mechanisms implicated in glutamate regulation. |
2012-12-31 |
2023-08-12 |
human |
| Devon C Crawford, Xiaoping Jiang, Amanda Taylor, Steven Menneric. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 38. 2012-12-03. PMID:22993427. |
although astrocyte deprivation resulted in postsynaptic glutamate receptor deficits, this effect appeared independent of astrocytes' role in presynaptic muting. |
2012-12-03 |
2023-08-12 |
rat |
| Robert E Featherstone, Yuling Liang, John A Saunders, Valerie M Tatard-Leitman, Richard S Ehrlichman, Steven J Siege. Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22627142. |
analysis of brains from ketamine-treated mice failed to show evidence of neuronal degeneration as determined by nuen immunohistochemistry, but did show increased astrocyte proliferation and decreased expression of the glial specific glutamate transporter, glt-1. |
2012-11-29 |
2023-08-12 |
mouse |
| Bong Geom Jang, Seok Joon Won, Jin Hee Kim, Bo Young Choi, Min Woo Lee, Min Sohn, Hong Ki Song, Sang Won Su. EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 26. issue 2-3. 2012-10-18. PMID:22575539. |
the astrocyte glutamate transporters, glt1 and glast, are the primary mediators of glutamate clearance. |
2012-10-18 |
2023-08-12 |
mouse |