| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jillian L Stobart, Christopher M Anderso. Multifunctional role of astrocytes as gatekeepers of neuronal energy supply. Frontiers in cellular neuroscience. vol 7. 2013-04-19. PMID:23596393. |
membrane receptor or transporter-mediated effects of glutamate represent a convergence point of astrocyte influence on neuronal bioenergetics. |
2013-04-19 |
2023-08-12 |
Not clear |
| Henry Sershe. Astrocyte origin of activity-dependent release of ATP and glutamate in hippocampal slices: real-time measurement utilizing microelectrode biosensors. British journal of pharmacology. vol 167. issue 5. 2013-03-20. PMID:22703189. |
astrocyte origin of activity-dependent release of atp and glutamate in hippocampal slices: real-time measurement utilizing microelectrode biosensors. |
2013-03-20 |
2023-08-12 |
Not clear |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Astrocytes modulate a postsynaptic NMDA-GABAA-receptor crosstalk in hypothalamic neurosecretory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 2. 2013-03-04. PMID:23303942. |
we found that activation of nmdars by endogenous glutamate levels controlled by astrocyte glutamate transporters, evokes a transient and reversible potentiation of postsynaptic gaba(a)rs. |
2013-03-04 |
2023-08-12 |
rat |
| Mark A Lovell, Melissa A Bradley, Shuling X Fiste. 4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22766736. |
4-hydroxyhexenal (hhe) impairs glutamate transport in astrocyte cultures. |
2013-02-20 |
2023-08-12 |
human |
| Mark A Lovell, Melissa A Bradley, Shuling X Fiste. 4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22766736. |
to determine if hhe also impairs glutamate uptake, primary rat astrocyte cultures were exposed to hhe for 4 hours and glutamate transport measured. |
2013-02-20 |
2023-08-12 |
human |
| Danielle K Lewis, Kristen T Thomas, Amutha Selvamani, Farida Sohrabj. Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22154819. |
these studies show that the aging astrocyte may directly contribute to infarct severity by inefficient glutamate clearance and enhanced cytokine production and suggest a cellular target for improved stroke therapy among older females. |
2013-01-24 |
2023-08-12 |
rat |
| Alexandra Witthoft, George Em Karniadaki. A bidirectional model for communication in the neurovascular unit. Journal of theoretical biology. vol 311. 2013-01-15. PMID:22828568. |
the communication mechanisms in the model include neural synaptic glutamate and potassium signaling to the astrocytes, potassium signaling from the astrocyte to the microvasculature, and astrocytic mechanosensation of vascular changes. |
2013-01-15 |
2023-08-12 |
Not clear |
| Jun-Feng Feng, Gene G Gurkoff, Ken C Van, Minsoo Song, David A Lowe, Jia Zhou, Bruce G Lyet. NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia. Brain research. vol 1469. 2013-01-14. PMID:22750589. |
traumatic brain injury (tbi) leads to a rapid and excessive glutamate elevation in the extracellular milieu, resulting in neuronal degeneration and astrocyte damage. |
2013-01-14 |
2023-08-12 |
Not clear |
| Yu Deng, Zhaofa Xu, Bin Xu, Donghui Xu, Yawen Tian, Wanyu Fen. The protective effects of riluzole on manganese-induced disruption of glutamate transporters and glutamine synthetase in the cultured astrocytes. Biological trace element research. vol 148. issue 2. 2012-12-31. PMID:22391793. |
to investigate this accumulation, this study focused on the role of astrocyte glutamate transporters (gluts) and glutamine synthetase (gs), which have roles in glu transport and metabolism, respectively. |
2012-12-31 |
2023-08-12 |
Not clear |
| Irma E Cisneros, Anuja Ghorpad. HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS. Current HIV research. vol 10. issue 5. 2012-12-31. PMID:22591363. |
hiv-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-aids. |
2012-12-31 |
2023-08-12 |
human |
| Irma E Cisneros, Anuja Ghorpad. HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS. Current HIV research. vol 10. issue 5. 2012-12-31. PMID:22591363. |
lastly, we discuss recent evidence of various astrocyte and neuron crosstalk mechanisms implicated in glutamate regulation. |
2012-12-31 |
2023-08-12 |
human |
| Devon C Crawford, Xiaoping Jiang, Amanda Taylor, Steven Menneric. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 38. 2012-12-03. PMID:22993427. |
although astrocyte deprivation resulted in postsynaptic glutamate receptor deficits, this effect appeared independent of astrocytes' role in presynaptic muting. |
2012-12-03 |
2023-08-12 |
rat |
| Robert E Featherstone, Yuling Liang, John A Saunders, Valerie M Tatard-Leitman, Richard S Ehrlichman, Steven J Siege. Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22627142. |
analysis of brains from ketamine-treated mice failed to show evidence of neuronal degeneration as determined by nuen immunohistochemistry, but did show increased astrocyte proliferation and decreased expression of the glial specific glutamate transporter, glt-1. |
2012-11-29 |
2023-08-12 |
mouse |
| Bong Geom Jang, Seok Joon Won, Jin Hee Kim, Bo Young Choi, Min Woo Lee, Min Sohn, Hong Ki Song, Sang Won Su. EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 26. issue 2-3. 2012-10-18. PMID:22575539. |
the astrocyte glutamate transporters, glt1 and glast, are the primary mediators of glutamate clearance. |
2012-10-18 |
2023-08-12 |
mouse |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 3. 2012-10-16. PMID:22696576. |
altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. |
2012-10-16 |
2023-08-12 |
rat |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 3. 2012-10-16. PMID:22696576. |
patch-clamp recordings obtained from mncs in brain slices show that pharmacological blockade of astrocyte glutamate transporter 1 (glt1) function [500 μm dihydrokainate (dhk)], resulted in a persistent n-methyl-d-aspartate receptor (nmdar)-mediated inward current (tonic i(nmda)) in sham rats, an effect that was significantly smaller in mncs from hf rats. |
2012-10-16 |
2023-08-12 |
rat |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 3. 2012-10-16. PMID:22696576. |
conversely, astrocyte glast expression was significantly higher in the son of hf rats, while nonselective blockade of glutamate transport activity (100 μm tboa) evoked an enhanced tonic i(nmda) activation in hf rats. |
2012-10-16 |
2023-08-12 |
rat |
| Jai-Yoon Sul, George Orosz, Richard S Givens, Philip G Haydo. Astrocytic connectivity in the hippocampus. Neuron glia biology. vol 1. issue 1. 2012-10-02. PMID:16575432. |
to explore this issue we photo-released glutamate onto a single astrocyte in murine hippocampal slices and imaged calcium responses. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jai-Yoon Sul, George Orosz, Richard S Givens, Philip G Haydo. Astrocytic connectivity in the hippocampus. Neuron glia biology. vol 1. issue 1. 2012-10-02. PMID:16575432. |
photo-release of glutamate causes a metabotropic glutamate receptor (mglur)-dependent increase in internal calcium in the stimulated astrocyte and delayed calcium elevations in neighboring cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| Qing-Song Liu, Qiwu Xu, Jian Kang, Maiken Nedergaar. Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. Neuron glia biology. vol 1. issue 4. 2012-10-02. PMID:16755304. |
astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. |
2012-10-02 |
2023-08-12 |
Not clear |