| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin D Haustein, Sebastian Kracun, Xiao-Hong Lu, Tiffany Shih, Olan Jackson-Weaver, Xiaoping Tong, Ji Xu, X William Yang, Thomas J O'Dell, Jonathan S Marvin, Mark H Ellisman, Eric A Bushong, Loren L Looger, Baljit S Khak. Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron. vol 82. issue 2. 2014-06-05. PMID:24742463. |
under these settings, astrocyte responses were global, suppressed by neurotransmitter clearance, and mediated by glutamate and gaba. |
2014-06-05 |
2023-08-13 |
Not clear |
| Yijing Guo, Qiong Wei, Yan Huang, Wenqing Xia, Yi Zhou, Shaohua Wan. The effects of astrocytes on differentiation of neural stem cells are influenced by knock-down of the glutamate transporter, GLT-1. Neurochemistry international. vol 63. issue 5. 2014-06-02. PMID:23988842. |
in this study, we determined whether glt-1 mediated the astrocyte regulation of the cell fate of neural stem/progenitor cells (nscs) by glutamate reuptake. |
2014-06-02 |
2023-08-12 |
Not clear |
| Donato Calabrese, Silvia Giatti, Simone Romano, Carla Porretta-Serapiglia, Roberto Bianchi, Marco Milanese, Giambattista Bonanno, Donatella Caruso, Barbara Viviani, Fabrizio Gardoni, Luis Miguel Garcia-Segura, Roberto Cosimo Melcang. Diabetic neuropathic pain: a role for testosterone metabolites. The Journal of endocrinology. vol 221. issue 1. 2014-05-12. PMID:24424289. |
indeed, dht counteracted the effect of diabetes on the mechanical nociceptive threshold, pre- and post-synaptic components, glutamate release, astrocyte immunoreactivity, and expression of interleukin-1β (il1β), while 3α-diol was effective on tactile allodynia threshold, glutamate release, astrocyte immunoreactivity and the expression of substance p, toll-like receptor 4, tumor necrosis factor-α, transforming growth factor β-1, il1β, and translocator protein. |
2014-05-12 |
2023-08-12 |
human |
| Ran Barzilay, Javier Ganz, Ofer Sadan, Tali Ben-Zur, Ziv Bren, Noa Hinden, Michal Taler, Nirit Lev, Irit Gil-Ad, Abraham Weizman, Daniel Offe. Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 9. 2014-05-01. PMID:23116946. |
upon in vitro co-culture of astrocytes and mscs, the mscs, in the presence of pcp, positively regulated astrocyte expression of genes involved in glutamate metabolism and antioxidant defenses. |
2014-05-01 |
2023-08-12 |
mouse |
| Ran Barzilay, Javier Ganz, Ofer Sadan, Tali Ben-Zur, Ziv Bren, Noa Hinden, Michal Taler, Nirit Lev, Irit Gil-Ad, Abraham Weizman, Daniel Offe. Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 9. 2014-05-01. PMID:23116946. |
the mechanism underlying the beneficial behavioral effect may involve modulation of host astrocyte functioning, including glutamate processing and antioxidant capacity. |
2014-05-01 |
2023-08-12 |
mouse |
| Ayodeji A Asuni, Bryony Gray, Joanne Bailey, Paul Skipp, V Hugh Perry, Vincent O'Conno. Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration. The Journal of biological chemistry. vol 289. issue 7. 2014-04-28. PMID:24366862. |
four of the up-regulated proteins (gfap, high affinity glutamate transporter (eaat-2), apo-j (clusterin), and peroxiredoxin-6) are selectively expressed in astrocytes, but astrocyte proliferation does not contribute to their up-regulation. |
2014-04-28 |
2023-08-12 |
Not clear |
| William Lee, Reno C Reyes, Manoj K Gottipati, Karon Lewis, Mathieu Lesort, Vladimir Parpura, Michelle Gra. Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model. Neurobiology of disease. vol 58. 2014-04-23. PMID:23756199. |
we found a biochemical footprint that would lead to increased availability of cytosolic glutamate in bachd astrocytes: i) augmented de novo glutamate synthesis due to an increase in the level of the astrocyte specific mitochondrial enzyme pyruvate carboxylase; and ii) unaltered conversion of glutamate to glutamine, as there were no changes in the expression level of the astrocyte specific enzyme glutamine synthetase. |
2014-04-23 |
2023-08-12 |
mouse |
| Idaira Oliva, Miriam Fernández, Eduardo D Martí. Dopamine release regulation by astrocytes during cerebral ischemia. Neurobiology of disease. vol 58. 2014-04-23. PMID:23800715. |
simultaneous blockade of astrocyte glutamate transporters and dat prevented the massive release of dopamine and reduced the brain tissue damage. |
2014-04-23 |
2023-08-12 |
mouse |
| Amulya Nidhi Shrivastava, Jacob M Kowalewski, Marianne Renner, Luc Bousset, Annette Koulakoff, Ronald Melki, Christian Giaume, Antoine Trille. β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors. Glia. vol 61. issue 10. 2014-03-27. PMID:23922225. |
β-amyloid and atp-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors. |
2014-03-27 |
2023-08-12 |
mouse |
| Valerie L Jacobs, Joyce A De Le. Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model. Journal of neuro-oncology. vol 114. issue 1. 2014-03-05. PMID:23695515. |
while research has focused on understanding glutamate signaling in glioma cells, little is known about the role of glutamate between glioma and astrocyte interactions. |
2014-03-05 |
2023-08-12 |
Not clear |
| Vendula Rusnakova, Pavel Honsa, David Dzamba, Anders Ståhlberg, Mikael Kubista, Miroslava Anderov. Heterogeneity of astrocytes: from development to injury - single cell gene expression. PloS one. vol 8. issue 8. 2014-03-05. PMID:23940528. |
following focal cerebral ischemia, reactive astrocytes underwent pronounced changes in the expression of aquaporins, nonspecific cationic and potassium channels, glutamate receptors and reactive astrocyte markers. |
2014-03-05 |
2023-08-12 |
Not clear |
| Daiane Cattani, Paola Bez Goulart, Vera Lúcia de Liz Oliveira Cavalli, Elisa Winkelmann-Duarte, André Quincozes Dos Santos, Paula Pierozan, Daniela Fraga de Souza, Viviane Mara Woehl, Marilda C Fernandes, Fátima Regina Mena Barreto Silva, Carlos Alberto Gonçalves, Regina Pessoa-Pureur, Ariane Zamone. Congenital hypothyroidism alters the oxidative status, enzyme activities and morphological parameters in the hippocampus of developing rats. Molecular and cellular endocrinology. vol 375. issue 1-2. 2014-02-04. PMID:23693027. |
in addition, congenital hypothyroidism is associated with downregulation of astrocyte glutamate transporters (glast and glt-1) leading to decreased glutamate uptake and subsequent influx of ca(2+) through n-methyl-d-aspartate (nmda) receptors. |
2014-02-04 |
2023-08-12 |
rat |
| Prakash Devaraju, Min-Yu Sun, Timothy L Myers, Kelli Lauderdale, Todd A Fiacc. Astrocytic group I mGluR-dependent potentiation of astrocytic glutamate and potassium uptake. Journal of neurophysiology. vol 109. issue 9. 2014-01-09. PMID:23427307. |
surprisingly, the mechanisms by which astrocyte glutamate uptake is acutely modulated remain to be clarified. |
2014-01-09 |
2023-08-12 |
mouse |
| Prakash Devaraju, Min-Yu Sun, Timothy L Myers, Kelli Lauderdale, Todd A Fiacc. Astrocytic group I mGluR-dependent potentiation of astrocytic glutamate and potassium uptake. Journal of neurophysiology. vol 109. issue 9. 2014-01-09. PMID:23427307. |
similar potentiation of stcs was not observed in the presence of group i mglur antagonists or the pkc inhibitor, pkc 19-36, suggesting that hfs-induced potentiation of astrocyte glutamate uptake is astrocytic group i mglur and pkc dependent. |
2014-01-09 |
2023-08-12 |
mouse |
| Shi Di, Ion R Popescu, Jeffrey G Taske. Glial control of endocannabinoid heterosynaptic modulation in hypothalamic magnocellular neuroendocrine cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 46. 2014-01-06. PMID:24227742. |
therefore, depolarization- and glucocorticoid-evoked 2-arachidonoylglycerol release from magnocellular neurons is spatially restricted to glutamate synapses by astrocytes, but spills over onto gaba synapses under conditions of reduced astrocyte buffering; tonic endocannabinoid modulation of gaba release, in contrast, is likely mediated by anandamide and is insensitive to astrocytic buffering. |
2014-01-06 |
2023-08-12 |
rat |
| Yongjie Yang, Haruki Higashimori, Lydie More. Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders. Journal of neurodevelopmental disorders. vol 5. issue 1. 2013-11-12. PMID:23988237. |
in this review, we discuss our perspectives about how astrocyte developmental maturation is regulated, and how disruption of the astrocyte functional maturation process, especially alterations in their ability to regulate glutamate homeostasis, may alter synaptic physiology and contribute to the pathogenesis of neurodevelopmental disorders. |
2013-11-12 |
2023-08-12 |
Not clear |
| Chunxing Liu, Wenjie Wu, Bin Zhang, Jie Xiang, Jian Zo. Temporospatial expression and cellular localization of glutamine synthetase following traumatic spinal cord injury in adult rats. Molecular medicine reports. vol 7. issue 5. 2013-11-05. PMID:23525248. |
glutamine synthetase (gs) is an enzyme involved in an endogenous mechanism of protection against glutamate neurotoxicity and is important in the regulation of astrocyte migration. |
2013-11-05 |
2023-08-12 |
rat |
| Chun-Jung Chen, Yen-Chuan Ou, Cheng-Yi Chang, Hung-Chuan Pan, Su-Lan Liao, Shih-Yun Chen, Shue-Ling Raung, Ching-Yi La. Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death. Glia. vol 60. issue 3. 2013-11-01. PMID:22144112. |
infection with jev was found to elicit the extracellular glutamate accumulation from microglia but not from neuron and astrocyte cultures. |
2013-11-01 |
2023-08-12 |
Not clear |
| Haruki Higashimori, Lydie Morel, James Huth, Lothar Lindemann, Chris Dulla, Amaro Taylor, Mike Freeman, Yongjie Yan. Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse. Human molecular genetics. vol 22. issue 10. 2013-11-01. PMID:23396537. |
using mismatched astrocyte and neuron co-cultures, we demonstrate that the loss of astroglial (but not neuronal) fmrp particularly reduces neuron-dependent glt1 expression and glutamate uptake in co-cultures. |
2013-11-01 |
2023-08-12 |
mouse |
| Thomas Koeglsperger, Shaomin Li, Christian Brenneis, Jessica L Saulnier, Lior Mayo, Yijun Carrier, Dennis J Selkoe, Howard L Weine. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia. vol 61. issue 6. 2013-10-29. PMID:23536313. |
we found that depletion of tgf-β1 in the cns resulted in a loss of the astrocyte glutamate transporter (glut) proteins glt-1 (eaat2) and glast (eaat1) and decreased glutamate uptake in the mouse hippocampus. |
2013-10-29 |
2023-08-12 |
mouse |