| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jakob D Nissen, Kamilla Pajęcka, Malin H Stridh, Dorte M Skytt, Helle S Waagepeterse. Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes. Glia. vol 63. issue 12. 2016-07-19. PMID:26221781. |
we have investigated the role of gdh in astrocyte glutamate and glucose metabolism employing sirna mediated knock down (kd) of gdh in cultured astrocytes using stable and radioactive isotopes for metabolic mapping. |
2016-07-19 |
2023-08-13 |
Not clear |
| Ben Ellis, Abdul Hye, Stuart G Snowde. Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis. Journal of Alzheimer's disease : JAD. vol 46. issue 2. 2016-07-11. PMID:25835424. |
shifts in glutamate and glutamine and elevation of 4-hydroxy-2-nonenal suggests peroxidation of the astrocyte lipid bilayer resulting in reduced glutamate clearance from the synaptic cleft, suggesting a excitotoxicity component to ad pathology; however, due to inconsistencies in literature reports, reliable interpretation is difficult. |
2016-07-11 |
2023-08-13 |
human |
| Haruki Fujisawa, Yoshihisa Sugimura, Hiroshi Takagi, Hiroyuki Mizoguchi, Hideyuki Takeuchi, Hisakazu Izumida, Kohtaro Nakashima, Hiroshi Ochiai, Seiji Takeuchi, Atsushi Kiyota, Kazuya Fukumoto, Shintaro Iwama, Yoshiko Takagishi, Yoshitaka Hayashi, Hiroshi Arima, Yukio Komatsu, Yoshiharu Murata, Yutaka Ois. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments. Journal of the American Society of Nephrology : JASN. vol 27. issue 3. 2016-07-08. PMID:26376860. |
a sustained low extracellular sodium ion concentration also decreased glutamate uptake by primary astrocyte cultures, suggesting an underlying mechanism of impaired long-term potentiation. |
2016-07-08 |
2023-08-13 |
rat |
| Marta Gómez-Gonzalo, Marta Navarrete, Gertrudis Perea, Ana Covelo, Mario Martín-Fernández, Ryuichi Shigemoto, Rafael Luján, Alfonso Araqu. Endocannabinoids Induce Lateral Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 10. 2016-07-01. PMID:25260706. |
this ltp requires the coordinated activity of the 3 elements of the tripartite synapse: 1) ecb-evoked astrocyte calcium signal that stimulates glutamate release; 2) postsynaptic nitric oxide production; and 3) activation of protein kinase c and presynaptic group i metabotropic glutamate receptors, whose location at presynaptic sites was confirmed by immunoelectron microscopy. |
2016-07-01 |
2023-08-13 |
Not clear |
| Xiao-xiao Li, Sheng-feng Lu, Bing-mei Zhu, Shu-ping F. [Ischemic Stroke, Excitatory Amino Acids Toxicity and the Adjustment of Acupuncture Intervention]. Zhen ci yan jiu = Acupuncture research. vol 41. issue 2. 2016-06-30. PMID:27323449. |
in this paper the authors introduce the research status of antiexcitatory amino acids toxicity effect of acupuncture in ischemic stroke animals by summarizing its effects on subunits of ionotropic glutamate receptor (nmda/ampa) and metabotropic glutamate receptors (mglurs), and on astrocyte activities. |
2016-06-30 |
2023-08-13 |
Not clear |
| Takayuki Kuriu, Yuta Kakimoto, Osamu Arak. Computational simulation: astrocyte-induced depolarization of neighboring neurons mediates synchronous UP states in a neural network. Journal of biological physics. vol 41. issue 4. 2016-05-23. PMID:25940565. |
our results show that astrocytic depolarization may generate synchronous up states for hundreds of milliseconds in neurons even if they do not directly receive glutamate release from the activated astrocyte. |
2016-05-23 |
2023-08-13 |
Not clear |
| Yunlong Zhang, Xiuping Zhang, Shaogang Q. Ceftriaxone Protects Astrocytes from MPP(+) via Suppression of NF-κB/JNK/c-Jun Signaling. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25112679. |
ceftriaxone enhanced glutamate uptake and promoted primary astrocyte viability after mpp(+) exposure. |
2016-05-17 |
2023-08-13 |
Not clear |
| Kee-Chan Ahn, Erin M MacKenzie, Cameron R Learman, Tia C Hall, Charles L Weaver, Gary L Dunbar, Mee-Sook Son. Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes. Neuroreport. vol 26. issue 14. 2016-05-16. PMID:26302161. |
this study shows that p53 is activated in astrocytes during ischemia and that inhibition of the activity of this molecule prevents not only ogd-induced neuronal and astrocytic death but also astrocyte activation and impaired glutamate uptake. |
2016-05-16 |
2023-08-13 |
Not clear |
| Dayun Feng, Baolin Guo, Gaohua Liu, Bao Wang, Wen Wang, Guodong Gao, Huaizhou Qin, Shengxi W. FGF2 alleviates PTSD symptoms in rats by restoring GLAST function in astrocytes via the JAK/STAT pathway. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25979764. |
we further investigated the changes in the astrocytic glutamate transporters glast and glt-1 and in jak/stat3 signaling (which is involved in astrocyte activation and glast/glt-1 function) in single prolonged stress (sps) model rats. |
2016-05-06 |
2023-08-13 |
rat |
| Carla Álvarez-Ferradas, Juan Carlos Morales, Mario Wellmann, Francisco Nualart, Manuel Roncagliolo, Marco Fuenzalida, Christian Bonansc. Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain. Glia. vol 63. issue 9. 2016-04-13. PMID:25980474. |
moreover, mglur5 blockade eliminates any synaptic effects induced by p2y1r inhibition alone, suggesting that the pr modulation via mglur occurs downstream of p2y1r-mediated ca(2+)-dependent glutamate release from astrocyte. |
2016-04-13 |
2023-08-13 |
rat |
| Jennifer R Ayers-Ringler, Yun-Fang Jia, Yan-Yan Qiu, Doo-Sup Cho. Role of astrocytic glutamate transporter in alcohol use disorder. World journal of psychiatry. vol 6. issue 1. 2016-03-25. PMID:27014596. |
one major function of the astrocyte is protecting neurons from excitotoxicity by removing glutamate from the synapse via excitatory amino acid transporter type 2. |
2016-03-25 |
2023-08-13 |
Not clear |
| Dongdong Li, Karine Hérault, Kathleen Zylbersztejn, Marcel A Lauterbach, Marc Guillon, Martin Oheim, Nicole Roper. Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking. The Journal of physiology. vol 593. issue 13. 2016-03-24. PMID:25864578. |
astrocyte vamp3 vesicles undergo ca2+ -independent cycling and modulate glutamate transporter trafficking. |
2016-03-24 |
2023-08-13 |
mouse |
| Na Wang, Liang-Cai Zhao, Yong-Quan Zheng, Min-Jian Dong, Yongchao Su, Wei-Jian Chen, Zi-Long Hu, Yun-Jun Yang, Hong-Chang Ga. Alteration of interaction between astrocytes and neurons in different stages of diabetes: a nuclear magnetic resonance study using [1-(13)C]glucose and [2-(13)C]acetate. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25048983. |
the increased labeling of glutamine c4 but unchanged labeling of glutamate c4 from [2-(13)c]acetate suggests decreased astrocyte supply to the neurons. |
2016-03-08 |
2023-08-13 |
rat |
| Chunshu Piao, Hantamalala Ralay Ranaivo, Allison Rusie, Nitin Wadhwani, Sookyong Koh, Mark S Wainwrigh. Thrombin decreases expression of the glutamate transporter GLAST and inhibits glutamate uptake in primary cortical astrocytes via the Rho kinase pathway. Experimental neurology. vol 273. 2016-02-18. PMID:26391563. |
astrocyte glutamate transporters glast and glt1 play a key role in regulating neuronal excitation and their levels are altered in patients with epilepsy, and after traumatic brain injury. |
2016-02-18 |
2023-08-13 |
human |
| Chunshu Piao, Hantamalala Ralay Ranaivo, Allison Rusie, Nitin Wadhwani, Sookyong Koh, Mark S Wainwrigh. Thrombin decreases expression of the glutamate transporter GLAST and inhibits glutamate uptake in primary cortical astrocytes via the Rho kinase pathway. Experimental neurology. vol 273. 2016-02-18. PMID:26391563. |
we tested the hypothesis that exposure of astrocytes to high levels of thrombin, as may occur after a compromise of the blood-brain barrier, would reduce astrocyte glutamate transporter levels. |
2016-02-18 |
2023-08-13 |
human |
| Claudia Karus, Miguel A Mondragão, Daniel Ziemens, Christine R Ros. Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity. Glia. vol 63. issue 6. 2016-01-08. PMID:25639699. |
the gliotoxin nafac (sodium-fluoroacetate) resulted in elevation of astrocyte sodium concentration and reduced glial uptake of glutamate and potassium uptake through na(+) /k(+)-atpase. |
2016-01-08 |
2023-08-13 |
mouse |
| C R Robinson, P M Doughert. Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy. Neuroscience. vol 285. 2015-12-31. PMID:25446343. |
spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy. |
2015-12-31 |
2023-08-13 |
rat |
| Elisabeth Hansso. Actin filament reorganization in astrocyte networks is a key functional step in neuroinflammation resulting in persistent pain: novel findings on network restoration. Neurochemical research. vol 40. issue 2. 2015-12-30. PMID:24952067. |
in addition, ca(2+) signaling systems are altered, na(+)- and glutamate transporters are downregulated, and pro-inflammatory cytokines, particularly il-1β, are released in dysfunctional astrocyte networks. |
2015-12-30 |
2023-08-13 |
Not clear |
| Eman Abdou, Alan S Hazel. Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations. Neurochemical research. vol 40. issue 2. 2015-12-30. PMID:25297573. |
the consequences of this include oxidative stress, excitotoxicity, inflammatory responses, decreased neurogenesis, blood-brain barrier disruption, lactic acidosis and a reduction in astrocyte functional integrity involving a loss of glutamate transporters and other astrocyte-specific proteins which together contribute in a major way to the resulting neurodegeneration. |
2015-12-30 |
2023-08-13 |
Not clear |
| Theresa S Rimmele, Jean-Yves Chatto. A novel optical intracellular imaging approach for potassium dynamics in astrocytes. PloS one. vol 9. issue 10. 2015-12-22. PMID:25275375. |
we then found that glutamate superfusion caused a reversible drop of [k+]i that depended on the glutamate concentration with an apparent ec50 of 11.1±1.4 µm, corresponding to the affinity of astrocyte glutamate transporters. |
2015-12-22 |
2023-08-13 |
mouse |