| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esther Fuente-Martín, Cristina García-Cáceres, Pilar Argente-Arizón, Francisca Díaz, Miriam Granado, Alejandra Freire-Regatillo, David Castro-González, María L Ceballos, Laura M Frago, Suzanne L Dickson, Jesús Argente, Julie A Chowe. Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes. Scientific reports. vol 6. 2017-02-17. PMID:27026049. |
our results indicate that acyl-ghrelin may mediate part of its metabolic actions through modulation of hypothalamic astrocytes and that this effect could involve astrocyte mediated changes in local glucose and glutamate metabolism that alter the signals/nutrients reaching neighboring neurons. |
2017-02-17 |
2023-08-13 |
mouse |
| Maurizio De Pittà, Nicolas Brune. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural plasticity. vol 2016. 2016-12-30. PMID:27195153. |
glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. |
2016-12-30 |
2023-08-13 |
Not clear |
| Chiara Cervetto, Laura Vergani, Mario Passalacqua, Milena Ragazzoni, Arianna Venturini, Francesco Cecconi, Nicola Berretta, Nicola Mercuri, Marcello D'Amelio, Guido Maura, Paolo Mariottini, Adriana Voci, Manuela Marcoli, Manuela Cervell. Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. Neuromolecular medicine. vol 18. issue 1. 2016-12-28. PMID:26530396. |
to investigate the mechanisms by which smo overexpression leads to increased susceptibility to kainate excitotoxicity and seizure, in the cerebral cortex of dach-smo and control mice we assessed markers for astrocyte proliferation and neuron loss, and the ability of kainate to evoke glutamate release from nerve terminals and astrocyte processes. |
2016-12-28 |
2023-08-13 |
mouse |
| Chiara Cervetto, Laura Vergani, Mario Passalacqua, Milena Ragazzoni, Arianna Venturini, Francesco Cecconi, Nicola Berretta, Nicola Mercuri, Marcello D'Amelio, Guido Maura, Paolo Mariottini, Adriana Voci, Manuela Marcoli, Manuela Cervell. Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. Neuromolecular medicine. vol 18. issue 1. 2016-12-28. PMID:26530396. |
we conclude that reactive astrocytosis and activation of glutamate release from astrocyte processes might contribute, together with increased reactive oxygen species production, to the vulnerability to kainate excitotoxicity in dach-smo mice. |
2016-12-28 |
2023-08-13 |
mouse |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. |
2016-12-13 |
2023-08-13 |
human |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
additionally, recent studies examining astrocyte glutamate uptake in dcms have reported conflicting results, adding confusion to the field. |
2016-12-13 |
2023-08-13 |
human |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
with this approach, we set out to test the hypothesis that astrocyte membrane properties and glutamate transport were disrupted in this model of dcm. |
2016-12-13 |
2023-08-13 |
human |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
though we found that the developmental maturation of astrocyte membrane resistance was disrupted by fl, glutamate uptake by individual astrocytes was robust throughout fl development. |
2016-12-13 |
2023-08-13 |
human |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
taken together, our results demonstrate that the maturation of astrocyte membrane resistance, local distribution of glutamate transporters, and glutamatergic input to the cortex are altered in the fl model, but that single-cell astrocytic glutamate uptake is robust. |
2016-12-13 |
2023-08-13 |
human |
| Hima Charika S Abeysinghe, Ellie L Phillips, Heung Chin-Cheng, Philip M Beart, Carli L Roulsto. Modulating Astrocyte Transition after Stroke to Promote Brain Rescue and Functional Recovery: Emerging Targets Include Rho Kinase. International journal of molecular sciences. vol 17. issue 3. 2016-11-04. PMID:26927079. |
one of the major changes in the unit involves extensive morphological transition of astrocytes resulting in altered energy metabolism, decreased glutamate reuptake and recycling, and retraction of astrocyte end feed from both blood vessels and neurons. |
2016-11-04 |
2023-08-13 |
Not clear |
| Jessica L Seidel, Carole Escartin, Cenk Ayata, Gilles Bonvento, C William Shuttlewort. Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? Glia. vol 64. issue 1. 2016-10-20. PMID:26301517. |
it is also possible that astrocytes contribute to the pathophysiology of sd, as a consequence of excessive glutamate release, facilitation of nmda receptor activation, brain edema due to astrocyte swelling, or disrupted coupling to appropriate vascular responses after sd. |
2016-10-20 |
2023-08-13 |
human |
| Letizia Mariotti, Gabriele Losi, Michele Sessolo, Iacopo Marcon, Giorgio Carmignot. The inhibitory neurotransmitter GABA evokes long-lasting Ca(2+) oscillations in cortical astrocytes. Glia. vol 64. issue 3. 2016-10-06. PMID:26496414. |
most of the knowledge on this derives, however, from studies monitoring the astrocyte ca(2+) response to glutamate. |
2016-10-06 |
2023-08-13 |
mouse |
| Yu-Liang Chen, Dan Li, Zhong-Zhuang Wang, Wei-Gang Xu, Run-Ping Li, Jun-Dong Zhan. Glutamate metabolism of astrocytes during hyperbaric oxygen exposure and its effects on central nervous system oxygen toxicity. Neuroreport. vol 27. issue 2. 2016-10-06. PMID:26619231. |
the regulation of astrocyte glutamate metabolism is closely related to epilepsy. |
2016-10-06 |
2023-08-13 |
rat |
| R B Kuwar, D S Stokic, A A Leis, F Bai, A M Paul, J D Fratkin, P J S Vi. Does astroglial protein S100B contribute to West Nile neuro-invasive syndrome? Journal of the neurological sciences. vol 358. issue 1-2. 2016-09-15. PMID:26382833. |
further, the in vitro effects of purified s100b protein on neutrophil migration and glutamate uptake were also determined in astroglial cell lines or primary cultures. |
2016-09-15 |
2023-08-13 |
mouse |
| Amin Derouiche, Julia Haseleu, Horst-Werner Kor. Fine Astrocyte Processes Contain Very Small Mitochondria: Glial Oxidative Capability May Fuel Transmitter Metabolism. Neurochemical research. vol 40. issue 12. 2016-09-13. PMID:25894677. |
the peripheral astrocyte process (pap) is the glial compartment largely handling inactivation of transmitter glutamate, and supplying glutamate to the axon terminal. |
2016-09-13 |
2023-08-13 |
Not clear |
| Christina L Wilson, Vaishaali Natarajan, Stephen L Hayward, Oleh Khalimonchuk, Srivatsan Kidamb. Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles. Nanoscale. vol 7. issue 44. 2016-09-07. PMID:26274697. |
we evaluated some events related to astrocyte functions and mitochondrial dysregulation: (1) glutamate uptake; (2) redox signaling mechanisms by measuring ros production; (3) the expression patterns of dynamin-related proteins (drps) and mitofusins 1 and 2, whose expression is central to mitochondrial dynamics; and (4) mitochondrial morphology by mitotracker® red cmxros staining. |
2016-09-07 |
2023-08-13 |
human |
| Christina L Wilson, Vaishaali Natarajan, Stephen L Hayward, Oleh Khalimonchuk, Srivatsan Kidamb. Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles. Nanoscale. vol 7. issue 44. 2016-09-07. PMID:26274697. |
all three tio2 nanoparticles induced a significant loss in glutamate uptake indicative of a loss in vital astrocyte function. |
2016-09-07 |
2023-08-13 |
human |
| Chiara Cervetto, Daniela Frattaroli, Arianna Venturini, Mario Passalacqua, Mario Nobile, Susanna Alloisio, Carlo Tacchetti, Guido Maura, Luigi Francesco Agnati, Manuela Marcol. Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes. Neuropharmacology. vol 99. 2016-08-30. PMID:26260232. |
we found that: 1) the rat cerebellar purified astrocyte processes (gliosomes) expressed astrocytic and bergmann markers and exhibited negligible contamination by nerve terminals, microglia, or oligodendrocytes; 2) activation of ca2+-permeable ampa receptors caused ca2+ signals in the processes, and the release of glutamate from the processes; 3) effectiveness of rose bengal, trypan blue or bafilomycin a1, indicated that activation of the ampa receptors evoked vesicular glutamate release. |
2016-08-30 |
2023-08-13 |
rat |
| Trista L Thorn, Yan He, Nicole A Jackman, Doug Lobner, James A Hewett, Sandra J Hewet. A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death. ASN neuro. vol 7. issue 6. 2016-08-12. PMID:26553727. |
hence, our results are consistent with the weak excitotoxic hypothesis such that a bioenergetic deficiency, which is measureable in our mixed but not astrocyte cultures, allows normally innocuous concentrations of glutamate to become excitotoxic. |
2016-08-12 |
2023-08-13 |
Not clear |
| Trista L Thorn, Yan He, Nicole A Jackman, Doug Lobner, James A Hewett, Sandra J Hewet. A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death. ASN neuro. vol 7. issue 6. 2016-08-12. PMID:26553727. |
adding to the burgeoning literature detailing the contribution of astrocytes to neuronal injury, we conclude that under our experimental paradigm, a cytotoxic, co-operative interaction between energy deprivation and glutamate release from astrocyte system xc(-) mediates aglycemic neuronal cell death. |
2016-08-12 |
2023-08-13 |
Not clear |