| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allison R Peterson, Devin K Binde. Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy. Frontiers in neurology. vol 11. 2020-10-06. PMID:33013665. |
astrocyte glutamate uptake and signaling as novel targets for antiepileptogenic therapy. |
2020-10-06 |
2023-08-13 |
Not clear |
| Aurélie Garnier, Alexandre Vidal, Habib Benal. A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model. Journal of mathematical neuroscience. vol 6. issue 1. 2020-10-01. PMID:28004309. |
the model consists of a mass model for the neural compartment and an astrocyte compartment which controls dynamics of extracellular glutamate and gaba concentrations. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhongfang Shi, Wei Zhang, Yang Lu, Yi Lu, Lixin Xu, Qing Fang, Min Wu, Mei Jia, Yujiao Wang, Liping Dong, Xu Yan, Shaohua Yang, Fang Yua. Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28503134. |
aquaporin 4-mediated glutamate-induced astrocyte swelling is partially mediated through metabotropic glutamate receptor 5 activation. |
2020-10-01 |
2023-08-13 |
rat |
| Zhongfang Shi, Wei Zhang, Yang Lu, Yi Lu, Lixin Xu, Qing Fang, Min Wu, Mei Jia, Yujiao Wang, Liping Dong, Xu Yan, Shaohua Yang, Fang Yua. Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28503134. |
this leads to astrocyte swelling, which we previously demonstrated is related to metabotropic glutamate receptor (mglur) activation. |
2020-10-01 |
2023-08-13 |
rat |
| Zhongfang Shi, Wei Zhang, Yang Lu, Yi Lu, Lixin Xu, Qing Fang, Min Wu, Mei Jia, Yujiao Wang, Liping Dong, Xu Yan, Shaohua Yang, Fang Yua. Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28503134. |
in the present study, we found that 1 mm glutamate induced astrocyte swelling, quantified by the cell perimeter, but it had no effect on astrocyte viability measured by the cell counting kit-8 (cck-8) and lactate dehydrogenase (ldh) assays. |
2020-10-01 |
2023-08-13 |
rat |
| S F Ali, H Jiang, L Rongzhu, D Milatovic, M Aschne. Methamphetamine Dysregulates Redox Status in Primary Rat Astrocyte and Mesencephalic Neuronal Cultures. American journal of neuroprotection and neuroregeneration. vol 1. issue 1. 2020-10-01. PMID:30627316. |
confluent rat primary astrocyte and mesencephalic neuron cultures were treated for 24 hrs with 0, 0.1, 0.5 or 1 mm meth, and the initial rate of glutamate and glutamine uptake was measured over a 5 min period. |
2020-10-01 |
2023-08-13 |
rat |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
the effects of bicuculline on microglia and astrocyte activation, il-1β content, on membrane expression of ampa and nmda glutamate receptors subunits in the hippocampus and on spatial learning and memory as well as anxiety were assessed. |
2020-10-01 |
2023-08-13 |
rat |
| Christine R Rose, Lisa Felix, Andre Zeug, Dirk Dietrich, Andreas Reiner, Christian Henneberge. Astroglial Glutamate Signaling and Uptake in the Hippocampus. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29386994. |
astrocyte glutamate signaling is initiated upon binding of glutamate to ionotropic and/or metabotropic receptors, which can result in calcium signaling, a major form of glial excitability. |
2020-09-30 |
2023-08-13 |
Not clear |
| José J Miguel-Hidalg. Molecular Neuropathology of Astrocytes and Oligodendrocytes in Alcohol Use Disorders. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29615864. |
studies in animal models of alcoholism and postmortem human brains have identified astrocyte markers altered in response to significant exposures to ethanol or during alcohol withdrawal, such as gap-junction proteins, glutamate transporters or enzymes related to glutamate and gamma-aminobutyric acid (gaba) metabolism. |
2020-09-30 |
2023-08-13 |
human |
| Mohammad Afaque Alam, Prasun K Datt. Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31920679. |
excitatory amino acid transporter 2 (eaat2) is the predominant astrocyte glutamate transporter involved in the reuptake of the majority of the synaptic glutamate in the mammalian central nervous system (cns). |
2020-09-30 |
2023-08-13 |
Not clear |
| Vadim V Tarasov, Andrey A Svistunov, Vladimir N Chubarev, Susanna S Sologova, Polina Mukhortova, Dmitrii Levushkin, Siva G Somasundaram, Cecil E Kirkland, Sergey O Bachurin, Gjumrakch Alie. Alterations of Astrocytes in the Context of Schizophrenic Dementia. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32116664. |
decreased expression of astrocyte glutamate transporters was observed in patients with schizophrenia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xianhua Hou, Yuan Li, Yuanyuan Huang, Huan Zhao, Li Gu. Adenosine Receptor A1-A2a Heteromers Regulate EAAT2 Expression and Glutamate Uptake via YY1-Induced Repression of PPAR PPAR research. vol 2020. 2020-09-28. PMID:32206061. |
herein, we report that expression of the a1ar protein in the astrocyte membrane and the level of intracellular glutamate were decreased, while expression of the a2ar protein was elevated in cells exposed to oxygen-glucose deprivation (ogd) conditions. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xiaojuan Han, Tianying Zhang, Huanhuan Liu, Yajing Mi, Xingchun Go. Astrocyte Senescence and Alzheimer's Disease: A Review. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32581763. |
astrocyte senescence also leads to a number of detrimental effects, including induced glutamate excitotoxicity, impaired synaptic plasticity, neural stem cell loss, and blood-brain barrier (bbb) dysfunction. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hannah Scott, Tom J Phillips, Greer C Stuart, Mark F Rogers, Bruno R Steinkraus, Simon Grant, C Patrick Cas. Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease. Neuronal signaling. vol 2. issue 4. 2020-09-28. PMID:32714596. |
application of culture medium conditioned by preeclamptic placentae to mixed cortical cultures caused changes in neurons and astrocytes that were related to key changes observed in brains of patients with schizophrenia and autism, including effects on dendrite lengths, astrocyte number as well as on levels of glutamate and γ-aminobutyric acid receptors. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ipsit Srivastava, Erika Vazquez-Juarez, Maria Lindsko. Reducing Glutamate Uptake in Rat Hippocampal Slices Enhances Astrocytic Membrane Depolarization While Down-Regulating CA3-CA1 Synaptic Response. Frontiers in synaptic neuroscience. vol 12. 2020-09-28. PMID:32973483. |
however, reduced glutamate uptake affects many different synaptic mechanisms in the astrocyte as well as in the neuron, and the effects are challenging to delineate. |
2020-09-28 |
2023-08-13 |
rat |
| Safiye Çavdar, Yasemin Kuvvet, Ilknur Sur-Erdem, Merve Özgür, Filiz Ona. Relationships between astrocytes and absence epilepsy in rat: An experimental study. Neuroscience letters. vol 712. 2020-09-23. PMID:31560994. |
astrocytes regulate the concentration of glutamate and gaba in the extracellular space in the brain, the difference in the astrocyte population and gfap protein expression in the epileptic strains clearly shows the involvement of astrocytes in the mechanism of absence epilepsy. |
2020-09-23 |
2023-08-13 |
rat |
| Tharine Dal-Cim, Gabriela G Poluceno, Débora Lanznaster, Karen A de Oliveira, Claudia B Nedel, Carla I Tasc. Guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen/glucose deprivation in cortical astrocyte cultures: involvement of A Purinergic signalling. vol 15. issue 4. 2020-09-08. PMID:31520282. |
guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen/glucose deprivation in cortical astrocyte cultures: involvement of a glial cells are involved in multiple cerebral functions that profoundly influence brain tissue viability during ischemia, and astrocytes are the main source of extracellular purines as adenosine and guanosine. |
2020-09-08 |
2023-08-13 |
Not clear |
| Mostafa M H Ibrahim, Hussain N Alhamami, Karen P Brisk. Norepinephrine regulation of ventromedial hypothalamic nucleus metabolic transmitter biomarker and astrocyte enzyme and receptor expression: Impact of 5' AMP-activated protein kinase. Brain research. vol 1711. 2020-08-04. PMID:30629946. |
current research investigated the premise that ne elicits ampk-dependent adjustments in vmn astrocyte glycogen metabolic enzyme [glycogen synthase (gs); glycogen phosphorylase (gp)] and gluco-regulatory neuron biomarker [glutamate decarboxylase |
2020-08-04 |
2023-08-13 |
Not clear |
| Fernando Ezquer, María Elena Quintanilla, Paola Morales, Daniela Santapau, Marcelo Ezquer, Marcelo J Kogan, Edison Salas-Huenuleo, Mario Herrera-Marschitz, Yedy Israe. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30239077. |
(2) intranasally administered exosomes were found in the brain within 24 hours; (3) fully reversed both alcohol-induced hippocampal oxidative-stress, evidenced by a lower ratio of oxidized to reduced glutathione, and neuroinflammation, shown by a reduced astrocyte activation and microglial density; and (4) increased glutamate transporter glt1 expression in nucleus accumbens, counteracting the inhibition of glutamate transporter activity, reportedly depressed under oxidative-stress conditions. |
2020-08-03 |
2023-08-13 |
human |
| Bruna Bellaver, Andréia S Rocha, Débora G Souza, Douglas T Leffa, Marco Antônio De Bastiani, Guilherme Schu, Pâmela C Lukasewicz Ferreira, Gianina T Venturin, Samuel Greggio, Camila T Ribeiro, Jaderson C da Costa, José Cláudio Fonseca Moreira, Daniel P Gelain, Iraci Lucena da S Torres, Fábio Klamt, Eduardo R Zimme. Activated peripheral blood mononuclear cell mediators trigger astrocyte reactivity. Brain, behavior, and immunity. vol 80. 2020-07-20. PMID:31176000. |
ex vivo analyses demonstrated astrocyte reactivity along with reduced glutamate uptake capacity during sepsis. |
2020-07-20 |
2023-08-13 |
rat |