| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica M Proulx, Kathleen Borgman. Inositol-requiring enzyme 1 alpha (IRE1α) regulates astrocyte metabolic and inflammatory phenotypes: Implications in (METH)amphetamine use disorder and HIV-associated neurocognitive disorders. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555709. |
manipulation of ire1α using both pharmacological inhibitors and an overexpression plasmid, confirms ire1α modulates astrocyte calcium signaling, metabolic activity, glutamate clearance, and cytokine release. |
2022-05-13 |
2023-08-13 |
human |
| Swati Gupta, Narges Bazargani, James Drew, Jack H Howden, Souvik Modi, Sana Al Awabdh, Hélène Marie, David Attwell, Josef T Kittle. The non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake. iScience. vol 25. issue 4. 2022-04-18. PMID:35434559. |
the non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake. |
2022-04-18 |
2023-08-13 |
Not clear |
| Lorenzo Di Cesare Mannelli, Laura Micheli, Chiara Cervetto, Alessandra Toti, Elena Lucarini, Carmen Parisio, Manuela Marcoli, Carla Ghelardin. Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain. Neurobiology of disease. 2022-04-03. PMID:35367629. |
ex vivo analysis on spinal purified astrocyte processes (gliosomes) and nerve terminals (synaptosomes) revealed the property of il-1α to reduce the endogenous glutamate release induced by oxaliplatin. |
2022-04-03 |
2023-08-13 |
rat |
| Lorenzo Di Cesare Mannelli, Laura Micheli, Chiara Cervetto, Alessandra Toti, Elena Lucarini, Carmen Parisio, Manuela Marcoli, Carla Ghelardin. Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain. Neurobiology of disease. 2022-04-03. PMID:35367629. |
exogenously administered in rats, il-1α prevents neuropathic pain in the presence of spinal glutamate decrease and astrocyte activation. |
2022-04-03 |
2023-08-13 |
rat |
| Stefan Hirschberg, Anton Dvorzhak, Seyed M A Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Lättig-Tünnemann, Christoph Harms, Dietmar Schmitz, Rosemarie Granty. Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia. Frontiers in cellular neuroscience. vol 15. 2022-02-17. PMID:35173582. |
it was found that the presence of a c-terminal-modified eaat2 transgene (i) increased the level of native eaat2 protein in striatal lysates and perisynaptic astrocyte processes, (ii) enhanced the glutamate uptake of transduced astrocytes, (iii) stimulated glutamate clearance at individual corticostriatal synapses, (iv) increased the glutamate uptake of striatal astrocytes and (iv) alleviated the mhtt-related hypokinesia (open field indicators of movement initiation). |
2022-02-17 |
2023-08-13 |
mouse |
| Xiaokang Zeng, Xinhuai Dong, Qiang Xiao, Jie Ya. Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1. ACS chemical neuroscience. 2022-02-11. PMID:35148069. |
astrocyte glutamate transporter 1 (glt-1) is the main transporter responsible for transporting glutamate, and investigations toward the regulation of glt-1 in astrocytes can reveal important insights. |
2022-02-11 |
2023-08-13 |
Not clear |
| Anca R Rǎdulescu, Gabrielle C Todd, Cassandra L Williams, Benjamin A Bennink, Alex A Lemus, Haley E Chesbro, Justin R Bourgeois, Ashley M Kopec, Damian G Zuloaga, Annalisa Scimem. Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes. PLoS computational biology. vol 18. issue 2. 2022-02-04. PMID:35120128. |
our data, obtained from a combination of experimental and modeling approaches, point to the existence of stark differences in the density of expression of glutamate transporters across different sub-cellular compartments, indicating that the extent to which astrocytes limit extrasynaptic glutamate diffusion depends not only on their level of synaptic coverage, but also on the identity of the astrocyte compartment in contact with the synapse. |
2022-02-04 |
2023-08-13 |
mouse |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a nmda-glun2b receptor mechanism. |
2022-01-29 |
2023-08-13 |
rat |
| Xi-Biao He, Yi Wu, Haozhi Huang, Fang Gu. A novel histone deacetylase inhibitor-based approach to eliminate microglia and retain astrocyte properties in glial cell culture. Journal of neurochemistry. 2022-01-29. PMID:35092690. |
however, withdrawal of tsa not only ensures no microglia repopulation, but also restores all the gene expression changes in terms of astrocyte functions, including neurotrophic factors, glutamate and potassium transporters, and reactive astrocyte subtypes. |
2022-01-29 |
2023-08-13 |
Not clear |
| Elidie Beard, Sylvain Lengacher, Sara Dias, Pierre J Magistretti, Charles Finsterwal. Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives. Frontiers in physiology. vol 12. 2022-01-28. PMID:35087428. |
in particular, neuroenergetic coupling is regulated by astrocytes through glutamate uptake that triggers astrocytic aerobic glycolysis and leads to glucose uptake and lactate release, a mechanism known as the astrocyte neuron lactate shuttle. |
2022-01-28 |
2023-08-13 |
Not clear |
| María Paz Guerrero-Molina, Montserrat Morales-Conejo, Aitor Delmiro, María Morán, Cristina Domínguez-González, Elena Arranz-Canales, Ana Ramos-González, Joaquín Arenas, Miguel A Martín, Jesús González de la Alej. Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. Journal of neurology. 2022-01-28. PMID:35088140. |
given the relevance of neuron-astrocyte metabolic coupling and astrocyte function regulating energetic metabolism, we aimed to assess glutamate and glutamine csf levels in melas patients. |
2022-01-28 |
2023-08-13 |
Not clear |
| Aishwarya Raj, Alka Kaushal, Indrani Datt. Impact of monomeric and aggregated wild-type and A30P/A53T double-mutant α-synuclein on antioxidant mechanism and glutamate metabolic profile of cultured astrocytes. Journal of neuroscience research. 2021-12-14. PMID:34904280. |
wild-type and a53t/a30p double-mutant α-synuclein, both in monomeric and aggregated forms, were added extracellularly to media of midbrain rat astrocyte culture, with their survival, oxidative, and nitrative stress, glutathione and glutamate content, expression of enzymes associated with oxidative stress and glutamate metabolism, glutamate and glutathione transporters being assessed along with the association/engulfment of these peptides by astrocytes. |
2021-12-14 |
2023-08-13 |
rat |
| Maria Amalia Di Castro, Andrea Volterr. Astrocyte control of the entorhinal cortex-dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology. Glia. 2021-12-14. PMID:34904753. |
intriguingly, this astrocyte control is circuit-specific, being present only at mpp-gc (not lpp-gc) synapses, which selectively express atypical presynaptic n-methyl-d-aspartate receptors (nmdar) suitable to activation by astrocyte-released glutamate. |
2021-12-14 |
2023-08-13 |
Not clear |
| Maria Amalia Di Castro, Andrea Volterr. Astrocyte control of the entorhinal cortex-dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology. Glia. 2021-12-14. PMID:34904753. |
during inflammation/infection processes, increased levels of tnfα lead to uncontrolled astrocyte glutamate release, altered pp-gc circuit processing and, ultimately, impaired contextual memory performance. |
2021-12-14 |
2023-08-13 |
Not clear |
| Arthur M Butt, Andrea D River. Astrocytes in Bipolar Disorder. Advances in neurobiology. vol 26. 2021-12-10. PMID:34888832. |
dysregulation of astrocyte homeostatic functions are implicated in bd, notably regulation of glutamate, calcium signalling, circadian rhythms and metabolism. |
2021-12-10 |
2023-08-13 |
Not clear |
| Ákos Menyhárt, Rita Frank, Attila E Farkas, Zoltán Süle, Viktória É Varga, Ádám Nyúl-Tóth, Anne Meiller, Orsolya Ivánkovits-Kiss, Coline L Lemale, Írisz Szabó, Réka Tóth, Dániel Zölei-Szénási, Johannes Woitzik, Stephane Marinesco, István A Krizbai, Ferenc Bari, Jens P Dreier, Eszter Farka. Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021-11-29. PMID:34427145. |
malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci. |
2021-11-29 |
2023-08-13 |
Not clear |
| Jennifer Leigh Green, Wagner Ferreira Dos Santos, Andréia Cristina Karklin Fontan. Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development. Biochemical pharmacology. vol 193. 2021-11-23. PMID:34571003. |
impaired astrocyte function that results in glutamate excitotoxicity has been recognized to play a key role in the pathogenesis of epilepsy. |
2021-11-23 |
2023-08-13 |
Not clear |
| Yi-Bing Ouyang, Lijun Xu, Siwei Liu, Rona G Giffar. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs. Advances in neurobiology. vol 11. 2021-10-21. PMID:25236729. |
one of the main mechanisms of astrocyte protection is rapid removal of excess glutamate from synaptic sites by astrocytic plasma membrane glutamate transporters such as glt-1/eaat-2, reducing excitotoxicity. |
2021-10-21 |
2023-08-13 |
Not clear |
| Nathan B Erdmann, Nick P Whitney, Jialin Zhen. Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase. Clinical neuroscience research. vol 6. issue 5. 2021-10-20. PMID:18059978. |
the overstimulation of glutamate receptors, an increased vulnerability of neurons, and disrupted astrocyte support each potentiate excitotoxic damage to neurons. |
2021-10-20 |
2023-08-12 |
Not clear |
| Lilia Y Kucheryavykh, Yuriy V Kucheryavykh, Mikhail Inyushin, Yaroslav M Shuba, Priscila Sanabria, Luis A Cubano, Serguei N Skatchkov, Misty J Eato. Ischemia Increases TREK-2 Channel Expression in Astrocytes: Relevance to Glutamate Clearance. The open neuroscience journal. vol 3. 2021-10-20. PMID:19890471. |
together, these data suggest that up-regulation of trek-2 channels may help rescue astrocyte function and lower extracellular glutamate during ischemia. |
2021-10-20 |
2023-08-12 |
Not clear |