| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Finkel, F Laghrissi-Thode, B G Pollock, J Ron. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacology bulletin. vol 32. issue 4. 1997-02-12. PMID:8993087. |
the selective serotonin reuptake inhibitor, paroxetine, has been reported to inhibit cytochrome p450 activity. |
1997-02-12 |
2023-08-12 |
Not clear |
| P J Nathan, T R Norman, G D Burrow. Nocturnal plasma melatonin concentrations in healthy volunteers: effect of single doses of d-fenfluramine, paroxetine, and ipsapirone. Journal of pineal research. vol 21. issue 2. 1997-02-10. PMID:8912230. |
the effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-ht) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-ht1a receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. |
1997-02-10 |
2023-08-12 |
human |
| R J Cosford, A P Vinson, S Kukoyi, J B Justic. Quantitative microdialysis of serotonin and norepinephrine: pharmacological influences on in vivo extraction fraction. Journal of neuroscience methods. vol 68. issue 1. 1997-02-07. PMID:8884611. |
paroxetine administration decreased the ed of 5ht in the nucleus accumbens from 24 +/- 3 to 18 +/- 0.2% (p < 0.05). |
1997-02-07 |
2023-08-12 |
Not clear |
| H G Westenber. Developments in the drug treatment of panic disorder: what is the place of the selective serotonin reuptake inhibitors? Journal of affective disorders. vol 40. issue 1-2. 1997-02-04. PMID:8882918. |
drug treatment options shown by adequate research to be beneficial in this condition include mainly the benzodiazepine alprazolam, the tricyclic antidepressants (tcas) imipramine and clomipramine, the monoamine oxidase inhibitor (maoi) phenelzine, and the newer selective serotonin reuptake inhibitors (ssris) fluvoxamine and paroxetine. |
1997-02-04 |
2023-08-12 |
Not clear |
| S Goto, T Egashira, Y Wada, F Takayama, Y Yamanak. Effect of fluvoxamine on 5-hydroxytryptamine uptake, paroxetine binding sites and ketanserin binding sites in the Japanese monkey brain and platelets, in vivo and in vitro. Japanese journal of pharmacology. vol 71. issue 4. 1997-01-30. PMID:8886926. |
effect of fluvoxamine on 5-hydroxytryptamine uptake, paroxetine binding sites and ketanserin binding sites in the japanese monkey brain and platelets, in vivo and in vitro. |
1997-01-30 |
2023-08-12 |
monkey |
| U Jeppesen, L F Gram, K Vistisen, S Loft, H E Poulsen, K Brøse. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. European journal of clinical pharmacology. vol 51. issue 1. 1997-01-21. PMID:8880055. |
the purpose of this pharmacokinetic study was to investigate the dose-dependent inhibition of model substrates for cyp2d6, cyp2c19 and cyp1a2 by four marketed selective serotonin reuptake inhibitors (ssris): citalopram, fluoxetine, fluvoxamine and paroxetine. |
1997-01-21 |
2023-08-12 |
Not clear |
| D A Sclar, L M Robison, T L Skaer, R S Galin, R F Legg, N L Nemec, T E Hughes, D P Buesching, M Morga. Antidepressant pharmacotherapy: economic evaluation of fluoxetine, paroxetine and sertraline in a health maintenance organization. The Journal of international medical research. vol 23. issue 6. 1997-01-15. PMID:8746607. |
the present study was designed to compare direct health service expenditures, for the treatment of depression, among patients enrolled in a health maintenance organization, and prescribed one of three selective serotonin reuptake inhibitors, fluoxetine, paroxetine or sertraline. |
1997-01-15 |
2023-08-12 |
Not clear |
| J K Staley, Q Ouyang, J Pablo, W L Hearn, D D Flynn, R B Rothman, K C Rice, D C Mas. Pharmacological screen for activities of 12-hydroxyibogamine: a primary metabolite of the indole alkaloid ibogaine. Psychopharmacology. vol 127. issue 1. 1997-01-10. PMID:8880938. |
the same rank order (12-oh ibogamine > ibogaine), but lower potencies were observed for the [3h]paroxetine binding sites on the 5-ht transporter. |
1997-01-10 |
2023-08-12 |
rat |
| P Brust, R Bergmann, B Johannse. High-affinity binding of [3H]paroxetine to caudate nucleus and microvessels from porcine brain. Neuroreport. vol 7. issue 8. 1997-01-07. PMID:8856686. |
using the selective 5-ht uptake inhibitor [3h]paroxetine we demonstrated the presence of a 5-ht transporter-like protein at the bbb. |
1997-01-07 |
2023-08-12 |
Not clear |
| O Christensen, H A Sørensen, T P Almda. [Adverse effects of selective serotonin uptake inhibitors. Hyponatremia caused by Schwartz-Bartter syndrome]. Ugeskrift for laeger. vol 158. issue 48. 1997-01-07. PMID:8984756. |
the cases are most likely caused by treatment/intoxication with three different selective serotonin reuptake inhibitors: fluoxetine, paroxetine and citalopram. |
1997-01-07 |
2023-08-12 |
Not clear |
| W Guo, K Todd, M Bourin, M Hascoet, F Kouadi. Additive effects of glyburide and antidepressants in the forced swimming test: evidence for the involvement of potassium channel blockade. Pharmacology, biochemistry, and behavior. vol 54. issue 4. 1997-01-06. PMID:8853196. |
results showed that when combined with gly, ads whose main pharmacological effect is one of 5-ht uptake blockade (imipramine, amitriptyline, citalopram, paroxetine, fluoxetine, and fluvoxamine) were more effective in decreasing the amount of time mice were immobile, than when these drugs were administered alone. |
1997-01-06 |
2023-08-12 |
mouse |
| J E Sprague, M P Johnson, C J Schmidt, D E Nichol. Studies on the mechanism of p-chloroamphetamine neurotoxicity. Biochemical pharmacology. vol 52. issue 8. 1997-01-02. PMID:8937435. |
the monoamine oxidase-b (mao-b) inhibitor l-deprenyl (2 mg/kg) given 4 hr before a nonneurotoxic dose of pca (2 mg/kg) was shown not to alter the amount of [3h]paroxetine bound to serotonin (5-ht) uptake sites 7 days after treatment. |
1997-01-02 |
2023-08-12 |
Not clear |
| J R Lever, U Scheffel, M Stathis, H H Seltzman, C D Wyrick, P Abraham, K Parham, B F Thomas, J W Boja, M J Kuhar, F I Carrol. Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121). Nuclear medicine and biology. vol 23. issue 3. 1996-12-26. PMID:8782237. |
by contrast, binding was not reduced by paroxetine, a serotonin transporter inhibitor, or desipramine, a norepinephrine transporter inhibitor. |
1996-12-26 |
2023-08-12 |
mouse |
| D P Uzunov, T B Cooper, E Costa, A Guidott. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 22. 1996-12-24. PMID:8901628. |
two other serotonin re-uptake inhibitors, paroxetine and imipramine, in doses equipotent to those of fluoxetine in inhibiting brain serotonin uptake, were either significantly less potent than fluoxetine (paroxetine) or failed to increase (imipramine) 3 alpha, 5 alpha-th prog brain content. |
1996-12-24 |
2023-08-12 |
rat |
| M Engelstoft, J B Hanse. Synthesis and 5HT modulating activity of stereoisomers of 3-phenoxymethyl-4-phenylpiperidines. Acta chemica Scandinavica (Copenhagen, Denmark : 1989). vol 50. issue 2. 1996-12-23. PMID:8819850. |
several derivatives, among which is the antidepressant paroxetine, are very potent inhibitors of 5ht reuptake. |
1996-12-23 |
2023-08-12 |
Not clear |
| C A Stockmeier, L A Shapiro, J W Haycock, P A Thompson, M T Low. Quantitative subregional distribution of serotonin1A receptors and serotonin transporters in the human dorsal raphe. Brain research. vol 727. issue 1-2. 1996-12-23. PMID:8842377. |
[3h]8-hydroxy-2-(di-n-propyl)aminotetralin (8-oh-dpat) and [3h]paroxetine were used to label, respectively, serotonin1a receptors and serotonin transporters in the subnuclei of the dr, which were delineated on the basis of tryptophan hydroxylase (trpoh) immunoreactivity. |
1996-12-23 |
2023-08-12 |
human |
| A L Sharpley, D J Williamson, M E Attenburrow, G Pearson, P Sargent, P J Cowe. The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. Psychopharmacology. vol 126. issue 1. 1996-12-23. PMID:8853216. |
we studied the effect of acute (1 day) and subacute (16 days) administration of the new antidepressant, nefazodone (400 mg daily), and the selective serotonin re-uptake inhibitor (ssri), paroxetine (30 mg daily), on the sleep polysomnogram of 37 healthy volunteers using a random allocation, double-blind, placebo-controlled design. |
1996-12-23 |
2023-08-12 |
human |
| N J Paczkowski, H E Vuocolo, L J Bryan-Lluk. Conclusive evidence for distinct transporters for 5-hydroxytryptamine and noradrenaline in pulmonary endothelial cells of the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 4. 1996-12-23. PMID:8935709. |
initial rates of uptake of 5-ht or noradrenaline were measured in lungs perfused with 2 nmol/l 3h-5-ht or 3h-noradrenaline for 2 min, in the absence or presence of at least three concentrations of paroxetine, citalopram, fluoxetine, 7-methyltryptamine, tryptamine, nisoxetine, imipramine, 5-ht, desipramine, (+)-oxaprotiline, cocaine or tyramine. |
1996-12-23 |
2023-08-12 |
rat |
| L Naylor, B Dean, K Opeskin, G Pavey, C Hill, N Keks, D Copolo. Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 6. 1996-12-17. PMID:8836936. |
changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3h]paroxetine. |
1996-12-17 |
2023-08-12 |
human |
| J N Carlson, K E Visker, D M Nielsen, R W Keller, S D Glic. Chronic antidepressant drug treatment reduces turning behavior and increases dopamine levels in the medial prefrontal cortex. Brain research. vol 707. issue 1. 1996-12-13. PMID:8866721. |
the effects of chronic administration of the antidepressant drugs desipramine, nortryptiline and paroxetine (par) (10 mg/kg/day, 21 days) on changes in turning (circling) behavior and on norepinephrine (ne), dopamine (da) and serotonin and their metabolites 3,4-dihydroxyphenylacetic acid and 5-hydroxyindole acetic acid (5-hiaa) in the medial prefrontal cortex (pfc), nucleus accumbens and striatum were evaluated in rats. |
1996-12-13 |
2023-08-12 |
rat |