| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Lund, B Lomholt, J Fabricius, J A Christensen, E Bechgaar. Paroxetine: pharmacokinetics, tolerance and depletion of blood 5-HT in man. Acta pharmacologica et toxicologica. vol 44. issue 4. 1979-06-11. PMID:433623. |
paroxetine: pharmacokinetics, tolerance and depletion of blood 5-ht in man. |
1979-06-11 |
2023-08-11 |
human |
| J Lund, B Lomholt, J Fabricius, J A Christensen, E Bechgaar. Paroxetine: pharmacokinetics, tolerance and depletion of blood 5-HT in man. Acta pharmacologica et toxicologica. vol 44. issue 4. 1979-06-11. PMID:433623. |
the tolerance of paroxetine (fg 7051), as well as its pharmacokinetics and reduction of 5-ht in blood, has been investigated in man. |
1979-06-11 |
2023-08-11 |
human |
| J Lund, B Lomholt, J Fabricius, J A Christensen, E Bechgaar. Paroxetine: pharmacokinetics, tolerance and depletion of blood 5-HT in man. Acta pharmacologica et toxicologica. vol 44. issue 4. 1979-06-11. PMID:433623. |
25 mg paroxetine per day gave a maximal reduction of 5-ht in the blood within 2--3 weeks (to approximately 0.03 microgram/ml). |
1979-06-11 |
2023-08-11 |
human |
| E N Petersen, E Bechgaard, R J Sortwell, L Wetterber. Potent depletion of 5HT from monkey whole blood by a new 5HT uptake inhibitor, paroxetine (FG 7051). European journal of pharmacology. vol 52. issue 1. 1979-02-21. PMID:102515. |
potent depletion of 5ht from monkey whole blood by a new 5ht uptake inhibitor, paroxetine (fg 7051). |
1979-02-21 |
2023-08-11 |
monkey |
| E N Petersen, E Bechgaard, R J Sortwell, L Wetterber. Potent depletion of 5HT from monkey whole blood by a new 5HT uptake inhibitor, paroxetine (FG 7051). European journal of pharmacology. vol 52. issue 1. 1979-02-21. PMID:102515. |
the potent 5-hydroxytryptamine (5ht) uptake inhibitor fg 7051 (paroxetine, inn) was administered to rhesus monkeys in doses of 1.0, 2.5 or 7.5 mg/kg by oral gavage once daily for 13 weeks. |
1979-02-21 |
2023-08-11 |
monkey |
| E N Petersen, E Bechgaard, R J Sortwell, L Wetterber. Potent depletion of 5HT from monkey whole blood by a new 5HT uptake inhibitor, paroxetine (FG 7051). European journal of pharmacology. vol 52. issue 1. 1979-02-21. PMID:102515. |
blood samples for analysis of 5ht in whole blood and paroxetine in plasma were taken prior to and after 1, 4 and 13 weeks of treatment. |
1979-02-21 |
2023-08-11 |
monkey |
| E N Petersen, E Bechgaard, R J Sortwell, L Wetterber. Potent depletion of 5HT from monkey whole blood by a new 5HT uptake inhibitor, paroxetine (FG 7051). European journal of pharmacology. vol 52. issue 1. 1979-02-21. PMID:102515. |
the lowest dose 1 mg/kg caused 30% depletion of 5ht in whole blood with a level of paroxetine in plasma below 2 ng/ml. |
1979-02-21 |
2023-08-11 |
monkey |
| E N Petersen, E Bechgaard, R J Sortwell, L Wetterber. Potent depletion of 5HT from monkey whole blood by a new 5HT uptake inhibitor, paroxetine (FG 7051). European journal of pharmacology. vol 52. issue 1. 1979-02-21. PMID:102515. |
the results showed that paroxetine is a strong depletor of 5ht from whole blood of monkeys conceivably because it inhibits 5ht uptake inhibition. |
1979-02-21 |
2023-08-11 |
monkey |
| J B Lasse. Influence of the new 5-HT-uptake inhibitor paroxetine on hypermotility in rats produced by p-chloroamphetamine (PCA) and 4,alpha-dimethyl-7-tyramine (H 77/77). Psychopharmacology. vol 57. issue 2. 1978-07-24. PMID:418448. |
two different forms of hypermotility produced by the amphetamine derivatives pca and h 77/77, 5 mg/kg of each, was studied in rats treated s.c. with the new 5-ht uptake inhibitor paroxetine. |
1978-07-24 |
2023-08-11 |
rat |