| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Tanigaki, K Manno, K Sugihara, N Miki, S Ichida, H Yoshid. [Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 89. issue 4. 1987-08-28. PMID:3038714. |
from the above findings, it can be concluded that paroxetine has only a weak affinity for various neuro-receptors and inhibits specifically 5-ht uptake. |
1987-08-28 |
2023-08-11 |
Not clear |
| C R Lee, A M Galzin, M A Taranger, S Z Lange. Pitfalls in demonstrating an endogenous ligand of imipramine recognition sites. Biochemical pharmacology. vol 36. issue 6. 1987-04-27. PMID:3032200. |
the recognition sites for the 5-hydroxytryptamine (5-ht) uptake inhibitors imipramine and paroxetine may represent receptors for a presently unknown endogenous ligand, whose function would be to modulate 5-ht uptake. |
1987-04-27 |
2023-08-11 |
rat |
| S J Ireland, D W Straughan, M B Tyer. Influence of 5-hydroxytryptamine uptake on the apparent 5-hydroxytryptamine antagonist potency of metoclopramide in the rat isolated superior cervical ganglion. British journal of pharmacology. vol 90. issue 1. 1987-04-17. PMID:3814917. |
ganglionic 5-ht uptake was blocked by desmethylimipramine (ic50 1.4 x 10(-6)m), chlorimipramine (8.7 x 10(-9) m), zimelidine (1.5 x 10(-7) m), paroxetine (4.3 x 10(-8) m) and citalopram (6.2 x 10(-8) m). |
1987-04-17 |
2023-08-11 |
rat |
| S J Ireland, D W Straughan, M B Tyer. Influence of 5-hydroxytryptamine uptake on the apparent 5-hydroxytryptamine antagonist potency of metoclopramide in the rat isolated superior cervical ganglion. British journal of pharmacology. vol 90. issue 1. 1987-04-17. PMID:3814917. |
the 5-ht uptake inhibitor paroxetine, 1 x 10(-6) m, did not modify the apparent 5-ht antagonist potency of metoclopramide on the vn, but raised the pkb obtained against 5-ht on the scg from 5.74 (+/- 0.07) to 6.25 (+/- 0.03). |
1987-04-17 |
2023-08-11 |
rat |
| S Z Langer, A M Galzin, C R Lee, H Schoemake. Antidepressant-binding sites in brain and platelets. Ciba Foundation symposium. vol 123. 1987-04-08. PMID:3816412. |
[3h]imipramine and [3h]paroxetine label with high affinity a site associated with the serotonin transporter in brain and platelets. |
1987-04-08 |
2023-08-11 |
Not clear |
| A Segonzac, H Schoemaker, S Z Lange. Temperature dependence of drug interaction with the platelet 5-hydroxytryptamine transporter: a clue to the imipramine selectivity paradox. Journal of neurochemistry. vol 48. issue 2. 1987-02-19. PMID:2947974. |
as this apparent discrepancy could be related to the assay temperature, we studied the thermodynamics of drug interaction with the 5-ht transporter at assay temperatures between 0 degrees c and 37 degrees c, using as radioligands [3h]imipramine (0 degrees c and 20 degrees c) and [3h]paroxetine (20 degrees c and 37 degrees c), a newly available probe for the 5-ht transporter. |
1987-02-19 |
2023-08-11 |
human |
| A Segonzac, H Schoemaker, S Z Lange. Temperature dependence of drug interaction with the platelet 5-hydroxytryptamine transporter: a clue to the imipramine selectivity paradox. Journal of neurochemistry. vol 48. issue 2. 1987-02-19. PMID:2947974. |
at 20 degrees c, ki values of 14 tricyclic and nontricyclic drugs for inhibition of [3h]imipramine and [3h]paroxetine binding to human platelet membranes were highly significantly correlated (r = 0.98, p less than 0.001), validating the use of these two radioligands to study the 5-ht transporter over a temperature range larger than was previously possible with [3h]imipramine alone. |
1987-02-19 |
2023-08-11 |
human |
| A Segonzac, H Schoemaker, S Z Lange. Temperature dependence of drug interaction with the platelet 5-hydroxytryptamine transporter: a clue to the imipramine selectivity paradox. Journal of neurochemistry. vol 48. issue 2. 1987-02-19. PMID:2947974. |
the affinity of imipramine for the 5-ht transporter is progressively enhanced with decreasing incubation temperature, thus favoring the selectivity of [3h]imipramine for the 5-ht transporter at 0 degrees c. at 37 degrees c, the ki of imipramine for inhibition of [3h]paroxetine binding is 32 nm, and equals its ki value for inhibition of 5-ht uptake into human platelets. |
1987-02-19 |
2023-08-11 |
human |
| E T Mellerup, P Pleng. High affinity binding of 3H-paroxetine and 3H-imipramine to rat neuronal membranes. Psychopharmacology. vol 89. issue 4. 1986-10-01. PMID:2944152. |
paroxetine is the most potent and one of the most specific serotonin uptake inhibitors. |
1986-10-01 |
2023-08-11 |
rat |
| A J Cross, P Slater, G P Reynold. Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease. Neuroscience letters. vol 67. issue 2. 1986-08-15. PMID:2873534. |
in contrast, the binding of [3h]paroxetine to the serotonin uptake system was marginally increased in the caudate nucleus and unchanged in the putamen. |
1986-08-15 |
2023-08-11 |
human |
| E Habert, D Graham, S Z Lange. Solubilization and characterization of the 5-hydroxytryptamine transporter complex from rat cerebral cortical membranes. European journal of pharmacology. vol 122. issue 2. 1986-07-03. PMID:2940096. |
the affinity of the solubilized transporter complex for [3h]paroxetine, a very selective and potent inhibitor of 5-hydroxytryptamine uptake, was not affected and remained unchanged when compared with the parent membrane preparation. |
1986-07-03 |
2023-08-11 |
rat |
| T C Hamilton, J Norton, R H Poyser, D Thormähle. Comparison of some effects of paroxetine with amitriptyline on the cardiovascular system in animals. Arzneimittel-Forschung. vol 36. issue 3. 1986-06-09. PMID:2939838. |
the effects of intravenous infusions of paroxetine, a novel inhibitor of 5-hydroxytryptamine (5ht) uptake, and of the tricyclic antidepressant, amitriptyline, on the cardiovascular system have been compared in the conscious rabbit and in the anaesthetised cat. |
1986-06-09 |
2023-08-11 |
rabbit |
| P Plenge, E T Melleru. Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes. European journal of pharmacology. vol 119. issue 1-2. 1986-03-07. PMID:2935414. |
we now report that antidepressive drugs can influence the serotonin transport complex in platelets and brain in other ways: [3h]imipramine and [3h]paroxetine, which bind with high affinity to the serotonin transport complex, can be dissociated from the complex with velocity constants strongly influenced by the different antidepressants. |
1986-03-07 |
2023-08-11 |
Not clear |
| E Habert, D Graham, L Tahraoui, Y Claustre, S Z Lange. Characterization of [3H]paroxetine binding to rat cortical membranes. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935409. |
paroxetine is a selective and potent inhibitor of 5-hydroxytryptamine uptake into serotonergic neurons. |
1986-03-05 |
2023-08-11 |
rat |
| E Habert, D Graham, L Tahraoui, Y Claustre, S Z Lange. Characterization of [3H]paroxetine binding to rat cortical membranes. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935409. |
[3h]paroxetine binding was inhibited selectively by 5-ht uptake blockers, and a good correlation was demonstrated between the potency of various drugs to inhibit [3h]paroxetine binding and [3h]5-hydroxytryptamine uptake. |
1986-03-05 |
2023-08-11 |
rat |
| E Habert, D Graham, L Tahraoui, Y Claustre, S Z Lange. Characterization of [3H]paroxetine binding to rat cortical membranes. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935409. |
also, lesions performed with the neurotoxin, 5,7-dihydroxytryptamine resulted in a 94% decrease in endogenous 5-hydroxytryptamine levels and concomitantly, a 90% reduction in [3h]paroxetine binding when compared to sham controls. |
1986-03-05 |
2023-08-11 |
rat |
| E Habert, D Graham, L Tahraoui, Y Claustre, S Z Lange. Characterization of [3H]paroxetine binding to rat cortical membranes. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935409. |
these results indicate that the binding site labelled by [3h]paroxetine is associated with the neuronal 5-hydroxytryptamine transporter complex. |
1986-03-05 |
2023-08-11 |
rat |
| F Koshikawa, N Koshikawa, J D Stephenso. Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats. European journal of pharmacology. vol 118. issue 3. 1986-03-05. PMID:2935412. |
rats pretreated with the monoamine oxidase inhibitor, phenelzine 18 h (46.8 mg/kg) and 90 min (11.7 mg/kg) previously or only 90 min (46.8 mg/kg) previously developed a 5-ht dependent syndrome (including wet-dog shakes, wds) when given the 5-ht uptake inhibitor, paroxetine (11.6 mg/kg). |
1986-03-05 |
2023-08-11 |
rat |
| S Korsgaard, J Gerlach, E Christensso. Behavioral aspects of serotonin-dopamine interaction in the monkey. European journal of pharmacology. vol 118. issue 3. 1986-03-05. PMID:4085556. |
conversely the 5-ht uptake inhibitors paroxetine and cgp 6085 a decreased amphetamine-induced repetitive movements and aggravated haloperidol-induced dystonia and parkinsonism. |
1986-03-05 |
2023-08-11 |
human |
| A M Galzin, C Moret, B Verzier, S Z Lange. Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:2864432. |
exposure to tricyclic antidepressants, like imipramine and amitriptyline, and to nontricyclic 5-ht uptake inhibitors, like paroxetine and citalopram, did not modify by themselves the electrically evoked overflow of [3h]-5-ht. |
1985-11-08 |
2023-08-11 |
rat |