| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Galzin, C Moret, B Verzier, S Z Lange. Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:2864432. |
their order of potency to enhance 5-ht overflow after pretreatment with parachlorophenylalanine paralleled their potency at inhibiting neuronal uptake of 5-ht (paroxetine = citalopram greater than imipramine greater than amitriptyline). |
1985-11-08 |
2023-08-11 |
rat |
| M H Richard. Efflux of 3H-5-hydroxytryptamine from rat hypothalamic slices by continuous electrical stimulation: frequency-dependent responses to serotonergic antagonists and 5-hydroxytryptamine. Naunyn-Schmiedeberg's archives of pharmacology. vol 329. issue 4. 1985-10-15. PMID:4033805. |
rat hypothalamic slices were incubated with 3h-5-hydroxytryptamine and superfused in the presence of paroxetine to inhibit 5-hydroxytryptamine (5-ht) reuptake. |
1985-10-15 |
2023-08-11 |
rat |
| N Koshikawa, R W Smokcum, J D Stephenso. Is waning of a 5-hydroxytryptamine (5-HT)-mediated syndrome due to 5-HT2 receptor down-regulation? Neuroscience letters. vol 55. issue 3. 1985-08-12. PMID:3159977. |
the 5-hydroxytryptamine (5-ht) uptake inhibitor, paroxetine (11.6 mg/kg i.p. |
1985-08-12 |
2023-08-11 |
rat |
| E Schlicker, F Brandt, K Classen, M Göther. Serotonin release in human cerebral cortex and its modulation via serotonin receptors. Brain research. vol 331. issue 2. 1985-06-17. PMID:2580598. |
subsequent to incubation with [3h]serotonin, the slices were superfused with physiological salt solution containing paroxetine, and 3h overflow was evoked by electrical field stimulation. |
1985-06-17 |
2023-08-11 |
human |
| I Magnusse. p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission. Acta pharmacologica et toxicologica. vol 56. issue 2. 1985-05-30. PMID:2986413. |
the extracerebral decarboxylase inhibitor carbidopa and the selective 5-ht reuptake inhibitor paroxetine both enhanced the antimyoclonic action of 5-htp. |
1985-05-30 |
2023-08-11 |
mouse |
| b' A L Laursen, P L Mikkelsen, S Rasmussen, P le F\\xc3\\xa8vre Honor\\xc3\\xa. Paroxetine in the treatment of depression--a randomized comparison with amitriptyline. Acta psychiatrica Scandinavica. vol 71. issue 3. 1985-05-03. PMID:3157296.' |
paroxetine is a new antidepressant drug with potent serotonin (5ht) uptake inhibitory properties. |
1985-05-03 |
2023-08-11 |
Not clear |
| E T Mellerup, P Plenge, M Nielse. Size determination of binding polymers for [3H]imipramine and [3H]paroxetine in human platelet membranes. European journal of pharmacology. vol 106. issue 2. 1985-04-26. PMID:6099278. |
imipramine and paroxetine both inhibit the transport of serotonin in serotonergic neurons and in platelets; furthermore specific high affinity binding sites for [3h]imipramine and [3h]paroxetine are located in these two cell types, probably on the serotonin transport mechanism. |
1985-04-26 |
2023-08-12 |
human |
| G R McClelland, P Raptopoulo. EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers. Psychopharmacology. vol 83. issue 4. 1984-12-12. PMID:6238338. |
the eeg profile obtained with 70 mg paroxetine is similar to that reported for other antidepressant 5-ht uptake inhibitors, but dissimilar to the classical, sedative antidepressants. |
1984-12-12 |
2023-08-12 |
human |
| D N Middlemis. 8-Hydroxy-2-(di-n-propylamino) tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H] 5-HT recognition site. Naunyn-Schmiedeberg's archives of pharmacology. vol 327. issue 1. 1984-12-05. PMID:6238235. |
rat brain frontal cortex slices were preincubated with [3h] 5-hydroxytryptamine and continuously stimulated with krebs solution containing paroxetine and elevated k+ ions (25 mmol/l). |
1984-12-05 |
2023-08-12 |
rat |
| E Marley, K M Woznia. Interactions of a non-selective monoamine oxidase inhibitor, phenelzine, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake. Journal of psychiatric research. vol 18. issue 2. 1984-09-12. PMID:6747915. |
combinations of antidepressants included phenelzine with 5-ht re-uptake inhibitors (paroxetine, fluoxetine, clomipramine); with "mixed" re-uptake inhibitors affecting 5-ht and noradrenaline (imipramine, amitriptyline); with noradrenaline re-uptake inhibitors (desipramine, maprotiline, nisoxetine) and with dopamine re-uptake inhibitors (benztropine, nomifensine). |
1984-09-12 |
2023-08-12 |
rat |
| E T Mellerup, P Plenge, M Engelstof. High affinity binding of [3H]paroxetine and [3H]imipramine to human platelet membranes. European journal of pharmacology. vol 96. issue 3-4. 1984-07-09. PMID:6233162. |
paroxetine, one of the most potent and specific serotonin uptake inhibitors, was tritiated and used for binding studies with human platelet membranes. |
1984-07-09 |
2023-08-12 |
human |
| E Schlicker, M Göther. Effects of bretylium and guanethidine on 3H-noradrenaline and 3H-serotonin release in rat brain cortex slices. Archives internationales de pharmacodynamie et de therapie. vol 261. issue 2. 1983-05-27. PMID:6220681. |
bretylium inhibited the evoked tritium overflow both from slices labelled with 3h-noradrenaline and from those labelled with 3h-serotonin (by 49 and 74%, respectively, at 10(-4)m bretylium); the inhibitory effect on slices preincubated with 3h-serotonin was only slightly attenuated by paroxetine, an inhibitor of the neuronal serotonin uptake. |
1983-05-27 |
2023-08-12 |
rat |
| M Göthert, E Schlicke. Autoreceptor-mediated inhibition of 3H-5-hydroxytryptamine release from rat brain cortex slices by analogues of 5-hydroxytryptamine. Life sciences. vol 32. issue 11. 1983-05-05. PMID:6572776. |
rat brain cortex slices preincubated with 3h-5-hydroxytryptamine (3h-5-ht) were superfused with physiological salt solution containing paroxetine, an inhibitor of 5-hydroxytryptamine (5-ht) uptake. |
1983-05-05 |
2023-08-12 |
rat |
| M Sette, M S Briley, S Z Lange. Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers. Journal of neurochemistry. vol 40. issue 3. 1983-04-07. PMID:6827265. |
nontricyclic inhibitors of serotonin uptake such as fluoxetine, paroxetine, norzimelidine, and citalopram inhibit [3h]imipramine binding in the same complex manner as serotonin. |
1983-04-07 |
2023-08-12 |
rat |
| b' C B\\xc3\\xb8rup, B Meidahl, I M Petersen, A Vangtorp, P le F\\xc3\\xa8vre Honor\\xc3\\xa. An early clinical phase II evaluation of paroxetine, a new potent and selective 5HT-uptake inhibitor in patients with depressive illness. Pharmacopsychiatria. vol 15. issue 6. 1983-03-17. PMID:6218507.' |
paroxetine, a new, potent and selective serotonin (5-ht) uptake inhibitor has been evaluated in an open study for its clinical effect as well as its effect on the 5-ht concentration in whole blood in 19 patients with depressive illness. |
1983-03-17 |
2023-08-12 |
Not clear |
| J B Lassen, J Lund, I Søndergaar. Central and peripheral 5-HT uptake in rats treated chronically with femoxetine, paroxetine, and chlorimipramine. Psychopharmacology. vol 68. issue 3. 1980-09-28. PMID:6446724. |
central and peripheral 5-ht uptake in rats treated chronically with femoxetine, paroxetine, and chlorimipramine. |
1980-09-28 |
2023-08-12 |
rat |
| M Göthert, G Weinheime. Extracellular 5-hydroxytryptamine inhibits 5-hydroxytryptamine release from rat brain cortex slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 310. issue 1. 1980-04-26. PMID:530316. |
after blockade of neuronal 5-hydroxy-tryptamine (5-ht) uptake with clomipramine or paroxetine, the 3h overflow evoked by both methods of stimulation was decreased by unlabelled 5-ht and increased by methiothepin. |
1980-04-26 |
2023-08-11 |
rat |
| E N Petersen, L Edvinsson, J E Hardeb. 5-HT antagonism on cerebral and common carotid arteries by the 5-HT uptake inhibitors femoxetine and paroxetine. Acta pharmacologica et toxicologica. vol 45. issue 4. 1980-03-24. PMID:525361. |
5-ht antagonism on cerebral and common carotid arteries by the 5-ht uptake inhibitors femoxetine and paroxetine. |
1980-03-24 |
2023-08-11 |
rat |
| E N Petersen, L Edvinsson, J E Hardeb. 5-HT antagonism on cerebral and common carotid arteries by the 5-HT uptake inhibitors femoxetine and paroxetine. Acta pharmacologica et toxicologica. vol 45. issue 4. 1980-03-24. PMID:525361. |
the 5-hydroxytryptamine (5-ht) antagonism of methysergide was compared with that of the phenylpiperidine 5-ht uptake inhibitors, paroxetine and femoxetine, using two different models; the isolated cat middle cerebral artery and the common carotid artery of pithed rat perfused with the rat's own blood (autoperfusion). |
1980-03-24 |
2023-08-11 |
rat |
| E N Peterse. The interaction of desipramine and the 5-HT uptake inhibitors femoxetine and paroxetine with the acute hypotensive effect of guanethidine in conscious spontaneously hypertensive rats. The Journal of pharmacy and pharmacology. vol 31. issue 9. 1980-01-24. PMID:41071. |
the interaction of desipramine and the 5-ht uptake inhibitors femoxetine and paroxetine with the acute hypotensive effect of guanethidine in conscious spontaneously hypertensive rats. |
1980-01-24 |
2023-08-11 |
rat |