| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Kleinlogel, H R Burk. Effects of the selective 5-hydroxytryptamine uptake inhibitors paroxetine and zimeldine on EEG sleep and waking stages in the rat. Neuropsychobiology. vol 17. issue 4. 1988-04-13. PMID:2964564. |
to ascertain that at the doses used for the eeg studies paroxetine and zimeldine selectively affect the serotoninergic system, their effects on brain 5-hydroxytryptamine (5-ht), dopamine and noradrenaline were determined. |
1988-04-13 |
2023-08-11 |
rat |
| S Aoki, N Koshikawa, M Kobayashi, J D Stephenso. In vivo voltammetric study of cortical 5-HT after administration of 5-HTP or paroxetine to phenelzine-treated rats. The Journal of Nihon University School of Dentistry. vol 29. issue 3. 1988-03-02. PMID:2963096. |
in vivo voltammetric study of cortical 5-ht after administration of 5-htp or paroxetine to phenelzine-treated rats. |
1988-03-02 |
2023-08-11 |
rat |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
structure-activity relationships for 25 structural variants around the 5-hydroxytryptamine (5-ht) uptake inhibitors paroxetine and femoxetine have been investigated. |
1988-02-26 |
2023-08-11 |
human |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
three parameters related to the 5-ht system were investigated: (i) the inhibition of [3h]5-ht uptake into rat brain synaptosomes, (ii) the inhibition of [3h]paroxetine binding to rat neuronal membranes and (iii) the effect of the compounds on the affinity of [3h]imipramine for the human platelet membrane binding site, measured as the dissociation rate of the [3h]imipramine human platelet membrane binding site complex. |
1988-02-26 |
2023-08-11 |
human |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
a highly significant correlation was found for 5-ht uptake inhibition and inhibition of [3h]paroxetine binding for the different substances, indicating that the two parameters are closely connected. |
1988-02-26 |
2023-08-11 |
human |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
however the slope of the regression line was only 0.6 and not 1.0; this may indicate that [3h]paroxetine binding is necessary, but not sufficient for 5-ht uptake inhibition. |
1988-02-26 |
2023-08-11 |
human |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
the two binding sites are therefore probably situated on different parts of the 5-ht transport system, the [3h]paroxetine binding site being part of the 5-ht transport mechanism whereas the [3h]imipramine binding site may represent a site modulating the activity of, and affinity for, 5-ht in the 5-ht transport mechanism. |
1988-02-26 |
2023-08-11 |
human |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
structure-activity relationships among the substances showed that stereochemical changes from (-)- to (+)-trans changed the activity towards both 5-ht uptake inhibition and [3h]paroxetine displacement for most of the (-)-/(+)-pairs. |
1988-02-26 |
2023-08-11 |
human |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
for example, 8-oh-dpat 5ht1a had an ic50 of 117 nm; tfmpp 5ht1b (2.3 microm0 and papp 1a + 5ht2 (9 microm); ipsapirone 5ht1a (21.1 microm) and buspirone 5ht1a (greater than 100 microm); ketanserin 5ht2 (greater than 100 microm); 5-ht uptake inhibitors: paroxetine (13 nm); chlorimipramine (73 nm) and fluoxetine (653 nm). |
1988-02-23 |
2023-08-11 |
human |
| G Nistico, G B De Sarro, S Z Lange. Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats. European journal of pharmacology. vol 142. issue 1. 1988-02-20. PMID:3691630. |
the high potency of 5-methoxytryptoline following injection into the third cerebral ventricle and the relative order of potencies with 5-hydroxytryptoline and tryptoline is compared to the affinity of these compounds for the modulatory site of the serotonin transporter which was labelled with [3h]imipramine or [3h]paroxetine. |
1988-02-20 |
2023-08-11 |
rat |
| D R Thomas, D R Nelson, A M Johnso. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:2962217. |
biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. |
1988-02-03 |
2023-08-11 |
rat |
| D R Thomas, D R Nelson, A M Johnso. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:2962217. |
paroxetine was shown to be a potent (ki = 1.1 nm) and specific inhibitor of [3h]-5-hydroxytryptamine (5-ht) uptake into rat cortical and hypothalamic synaptosomes in vitro. |
1988-02-03 |
2023-08-11 |
rat |
| D R Thomas, D R Nelson, A M Johnso. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:2962217. |
paroxetine (ed50 1-3 mg/kg po) prevented the 5-ht depleting effect of p-chloroamphetamine (pca) in rat brain, demonstrating 5-ht uptake blockade in vivo. |
1988-02-03 |
2023-08-11 |
rat |
| D R Thomas, D R Nelson, A M Johnso. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:2962217. |
paroxetine, therefore, provides a useful pharmacological tool for investigating 5-ht systems and furthermore should be an antidepressant with reduced tricyclic-like side-effects. |
1988-02-03 |
2023-08-11 |
rat |
| D Graham, L Tahraoui, S Z Lange. Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat. Neuropharmacology. vol 26. issue 8. 1987-11-18. PMID:2958720. |
effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3h]paroxetine binding to cerebral cortical membranes of the rat. |
1987-11-18 |
2023-08-11 |
rat |
| D Graham, L Tahraoui, S Z Lange. Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat. Neuropharmacology. vol 26. issue 8. 1987-11-18. PMID:2958720. |
[3h]paroxetine is a highly selective ligand for the 5-hydroxytryptamine transporter complex and the specific binding of this ligand to membrane fractions from cerebral cortex or hippocampus was studied in rats treated with specific inhibitors of the uptake of 5-hydroxytryptamine and monoamine oxidase inhibitors. |
1987-11-18 |
2023-08-11 |
rat |
| N Tanigaki, K Manno, K Sugihara, N Miki, S Ichida, H Yoshid. [Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 89. issue 4. 1987-08-28. PMID:3038714. |
[specific inhibitory action of a novel antidepressant paroxetine on 5-ht uptake]. |
1987-08-28 |
2023-08-11 |
Not clear |
| N Tanigaki, K Manno, K Sugihara, N Miki, S Ichida, H Yoshid. [Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 89. issue 4. 1987-08-28. PMID:3038714. |
effect of a novel antidepressant, paroxetine, on the uptake of serotonin (5-ht), noradrenaline (na) and dopamine (da) as well as on various neuro-receptors were investigated in comparison with those of the tricyclic antidepressants amitriptyline, chlorimipramine and imipramine. |
1987-08-28 |
2023-08-11 |
Not clear |
| N Tanigaki, K Manno, K Sugihara, N Miki, S Ichida, H Yoshid. [Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 89. issue 4. 1987-08-28. PMID:3038714. |
paroxetine showed a potent 5-ht uptake inhibitory action, giving the na/5-ht ratio of 886 in comparison with the ratios of 1.7, 15 and 1.5 for amitriptyline, chlorimipramine and imipramine, respectively. |
1987-08-28 |
2023-08-11 |
Not clear |
| N Tanigaki, K Manno, K Sugihara, N Miki, S Ichida, H Yoshid. [Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 89. issue 4. 1987-08-28. PMID:3038714. |
on the other hand, paroxetine showed almost no inhibitory action on the binding of the [3h]-labeled ligands examined in this study [( 3h]quinuclidinyl benzilate, [3h]5-ht, [3h]ketanserine, [3h]pyrilamine, [3h]dihydroalprenolol, [3h]prazosin, [3h]clonidine and [3h]spiroperidol). |
1987-08-28 |
2023-08-11 |
Not clear |