| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Yamamoto, S Shibata, T Shimazoe, K Iwasaki, M Ohno, Y Minamoto, Y Furuya, K Miyamoto, S Watanabe, S Uek. [Behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake inhibitor]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 94. issue 3. 1989-12-21. PMID:2530142. |
[behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-ht uptake inhibitor]. |
1989-12-21 |
2023-08-11 |
mouse |
| C R Hekmatpanah, D J McKenna, S J Peroutk. Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat. Neuroscience letters. vol 104. issue 1-2. 1989-12-20. PMID:2573011. |
rats given mdma (30 mg/kg) displayed significant decreases in the density of 5-ht nerve terminals labeled by [3h]paroxetine both with (51 +/- 8%) and without (43 +/- 20%) reserpine pre-treatment. |
1989-12-20 |
2023-08-11 |
rat |
| The antidepressant paroxetine: a specific 5-HT uptake inhibitor. Proceedings of an international symposium. September, 1988. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530758. |
the antidepressant paroxetine: a specific 5-ht uptake inhibitor. |
1989-12-18 |
2023-08-11 |
Not clear |
| S A Montgomer. New antidepressants and 5-HT uptake inhibitors. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530760. |
the efficacy of 5-ht uptake inhibitors, including paroxetine, as antidepressants is compared with that of the reference tricyclic antidepressants. |
1989-12-18 |
2023-08-11 |
Not clear |
| J P Feighner, W F Boye. Paroxetine in the treatment of depression: a comparison with imipramine and placebo. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530763. |
paroxetine is a selective serotonin uptake inhibitor, which is being investigated as an antidepressant. |
1989-12-18 |
2023-08-11 |
Not clear |
| A M Johnso. An overview of the animal pharmacology of paroxetine. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530769. |
animal studies show that paroxetine is a potent and selective inhibitor of 5-hydroxytryptamine (5-ht) neuronal uptake. |
1989-12-18 |
2023-08-11 |
rat |
| A M Johnso. An overview of the animal pharmacology of paroxetine. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530769. |
the weak affinity of paroxetine for muscarinic cholinergic receptors in vitro is associated with mydriasis in vivo, but only at doses well in excess of those required to potentiate the effects of 5-ht in the cns. |
1989-12-18 |
2023-08-11 |
rat |
| H P Schlake, H Kuhs, L H Rolf, T Bosse, E Schuhknecht, G A Rudolf, G G Brun. Platelet 5-HT transport in depressed patients under double-blind treatment with paroxetine versus amitriptyline. Acta psychiatrica Scandinavica. Supplementum. vol 350. 1989-12-18. PMID:2530775. |
platelet 5-ht transport in depressed patients under double-blind treatment with paroxetine versus amitriptyline. |
1989-12-18 |
2023-08-11 |
Not clear |
| M A Audet, L Descarries, G Douce. Quantified regional and laminar distribution of the serotonin innervation in the anterior half of adult rat cerebral cortex. Journal of chemical neuroanatomy. vol 2. issue 1. 1989-11-17. PMID:2789731. |
in par1, for example, there was a second band of predilection amounting to 5.3 million varicosities per mm3 at the height of layer va. on the basis of these figures, it was possible to extrapolate the average number of cortical 5-ht varicosities per midbrain raphe nerve cell body of origin (500,000 at least), their average number per cortical target neuron (145-230), their incidence among all axon terminals in cortex (1/200), their mean endogenous amine content (0.045 fg), and their mean number per varicosity of recognition sites for reuptake blockers such as paroxetine, citalopram or cyanoimipramine (5000-6200). |
1989-11-17 |
2023-08-11 |
rat |
| J O Marcusson, A Andersson, I Bäckströ. Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain. Psychopharmacology. vol 99. issue 1. 1989-10-25. PMID:2528778. |
these data suggest that there is no heterogeneity of specific [3h]paroxetine binding, supporting a single site model of the 5-ht uptake site and antidepressant binding site. |
1989-10-25 |
2023-08-11 |
human |
| A M De Oliveira, H Schoemaker, A Segonzac, S Z Lange. Differences in the temperature dependence of drug interaction with the noradrenaline and serotonin transporters. Neuropharmacology. vol 28. issue 8. 1989-10-20. PMID:2528702. |
high affinity, sodium-dependent binding of [3h]mazindol is associated with the noradrenergic transporter while the binding of [3h]imipramine and [3h]paroxetine are associated with the serotonin transporter, e.g. |
1989-10-20 |
2023-08-11 |
human |
| I Bäckström, M Bergström, J Marcusso. High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain research. vol 486. issue 2. 1989-07-18. PMID:2525060. |
high affinity [3h]paroxetine binding to serotonin uptake sites in human brain tissue. |
1989-07-18 |
2023-08-11 |
human |
| I Bäckström, M Bergström, J Marcusso. High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain research. vol 486. issue 2. 1989-07-18. PMID:2525060. |
based on these findings, only the [3h]paroxetine binding representing the fraction sensitive to 30 microm 5-ht (or e.g. |
1989-07-18 |
2023-08-11 |
human |
| I Bäckström, M Bergström, J Marcusso. High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain research. vol 486. issue 2. 1989-07-18. PMID:2525060. |
the [3h]paroxetine binding was competitively inhibited by low concentrations of 5-ht, imipramine and norzimeldine, suggesting that the substrate recognition site for 5-ht uptake was labeled. |
1989-07-18 |
2023-08-11 |
human |
| I Bäckström, M Bergström, J Marcusso. High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain research. vol 486. issue 2. 1989-07-18. PMID:2525060. |
it is concluded that [3h]paroxetine is a marker for the 5-ht uptake site in the human brain, provided that an adequate pharmacological definition of specific binding is performed. |
1989-07-18 |
2023-08-11 |
human |
| P Blier, R Ramdine, A M Galzin, S Z Lange. Frequency-dependence of serotonin autoreceptor but not alpha 2-adrenoceptor inhibition of [3H]-serotonin release in rat hypothalamic slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 1-2. 1989-07-07. PMID:2566927. |
in the same paradigm, the 5-ht reuptake inhibitors citalopram and paroxetine did not alter the overflow of radioactivity elicited by stimulation at 3 hz but significantly decreased it at 1 hz. |
1989-07-07 |
2023-08-11 |
rat |
| P D Hrdin. Imipramine binding sites in brain and platelets: role in affective disorders. International journal of clinical pharmacology research. vol 9. issue 2. 1989-06-22. PMID:2541089. |
[3h]paroxetine) should be used in future studies of serotonin transporter function in depression. |
1989-06-22 |
2023-08-11 |
human |
| U Scheffel, P R Harti. In vivo labeling of serotonin uptake sites with [3H]paroxetine. Journal of neurochemistry. vol 52. issue 5. 1989-06-02. PMID:2523469. |
in vivo labeling of serotonin uptake sites with [3h]paroxetine. |
1989-06-02 |
2023-08-11 |
mouse |
| U Scheffel, P R Harti. In vivo labeling of serotonin uptake sites with [3H]paroxetine. Journal of neurochemistry. vol 52. issue 5. 1989-06-02. PMID:2523469. |
previous work has shown that [3h]paroxetine is a potent and selective in vitro label for serotonin uptake sites in the mammalian brain. |
1989-06-02 |
2023-08-11 |
mouse |
| U Scheffel, P R Harti. In vivo labeling of serotonin uptake sites with [3H]paroxetine. Journal of neurochemistry. vol 52. issue 5. 1989-06-02. PMID:2523469. |
in the present study, [3h]paroxetine was tested in mice as an in vivo label for serotonin uptake sites. |
1989-06-02 |
2023-08-11 |
mouse |