| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Andersson, J Marcusso. [3H]paroxetine binding in human platelets in relation to age and sex. Neurobiology of aging. vol 11. issue 6. 1991-03-14. PMID:2149169. |
the binding of [3h]paroxetine to serotonin uptake sites in human platelets from 47 individuals between 15 and 95 years of age was investigated. |
1991-03-14 |
2023-08-11 |
human |
| J O Marcusson, S B Ros. Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets. Psychopharmacology. vol 102. issue 2. 1991-02-26. PMID:2274599. |
[3h]imipramine, [3h]paroxetine and [3h]citalopram label specific binding sites related to the 5-ht transporter. |
1991-02-26 |
2023-08-11 |
rat |
| P Plenge, E T Melleru. [3H]citalopram binding to brain and platelet membranes of human and rat. Journal of neurochemistry. vol 56. issue 1. 1991-02-15. PMID:1824783. |
the bmax value for the binding of [3h]citalopram to platelet membranes was close to that found using the 5-ht uptake inhibitors [3h]imipramine and [3h]paroxetine, suggesting that all three 5-ht uptake inhibitors bind to the 5-ht transporter. |
1991-02-15 |
2023-08-11 |
human |
| J F Nash, R C Arora, M A Schreiber, H Y Meltze. Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats. Biochemical pharmacology. vol 41. issue 1. 1991-02-08. PMID:1702633. |
the effects of single or repeated administration of the racemic mixture of 3,4-methylenedioxymethamphetamine (mdma; 20 mg/kg, s.c.) on the number (bmax) of serotonin (5-ht) uptake sites as determined by [3h]paroxetine binding and the concentration of 5-ht and its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa), were measured in the frontal cortex and blood platelets of rats 1 and 7 days following its administration. |
1991-02-08 |
2023-08-11 |
rat |
| J F Nash, R C Arora, M A Schreiber, H Y Meltze. Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats. Biochemical pharmacology. vol 41. issue 1. 1991-02-08. PMID:1702633. |
a single injection of mdma significantly (p less than 0.05) decreased the number of [3h]paroxetine binding sites as well as the concentrations of 5-ht and 5-hiaa in the frontal cortex but not in platelets 7 days following administration. |
1991-02-08 |
2023-08-11 |
rat |
| J F Nash, R C Arora, M A Schreiber, H Y Meltze. Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats. Biochemical pharmacology. vol 41. issue 1. 1991-02-08. PMID:1702633. |
pretreatment with the 5-ht2/5-ht1c antagonist, ketanserin, inhibited the mdma-induced decrease in 5-ht and 5-hiaa concentrations and the number of [3h]paroxetine binding sites in the frontal cortex 7 days following a single administration. |
1991-02-08 |
2023-08-11 |
rat |
| K Rickels, E Schweize. Clinical overview of serotonin reuptake inhibitors. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:2147922. |
serotonin reuptake inhibitors discussed are sertraline, zimelidine, fluoxetine, fluvoxamine, and paroxetine. |
1991-01-30 |
2023-08-11 |
Not clear |
| D E McBean, J Sharkey, I M Ritchie, P A Kell. Chronic effects of the selective serotoninergic neurotoxin, methylenedioxyamphetamine, upon cerebral function. Neuroscience. vol 38. issue 1. 1991-01-24. PMID:2255397. |
samples of frontal cortex taken from these animals for in vitro [3h]paroxetine binding showed a 64% reduction in 5-hydroxytryptamine uptake sites. |
1991-01-24 |
2023-08-11 |
rat |
| P Plenge, E T Mellerup, M Nielse. Inhibitory and regulatory binding sites on the rat brain serotonin transporter: molecular weight of the [3H]paroxetine and [3H]citalopram binding proteins. European journal of pharmacology. vol 189. issue 2-3. 1991-01-22. PMID:2147655. |
inhibitory and regulatory binding sites on the rat brain serotonin transporter: molecular weight of the [3h]paroxetine and [3h]citalopram binding proteins. |
1991-01-22 |
2023-08-11 |
rat |
| D R Nelson, K J Palmer, A M Johnso. Effect of prolonged 5-hydroxytryptamine uptake inhibition by paroxetine on cortical beta 1 and beta 2-adrenoceptors in rat brain. Life sciences. vol 47. issue 18. 1991-01-15. PMID:1979137. |
effect of prolonged 5-hydroxytryptamine uptake inhibition by paroxetine on cortical beta 1 and beta 2-adrenoceptors in rat brain. |
1991-01-15 |
2023-08-11 |
rat |
| Søren H Sindrup, Lars F Gram, Kim Brøsen, Ole Eshøj, Erik F Mogense. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain. vol 42. issue 2. 1991-01-09. PMID:2147235. |
the selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. |
1991-01-09 |
2023-08-11 |
Not clear |
| Søren H Sindrup, Lars F Gram, Kim Brøsen, Ole Eshøj, Erik F Mogense. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain. vol 42. issue 2. 1991-01-09. PMID:2147235. |
the effect of the selective serotonin reuptake inhibitor paroxetine on diabetic neuropathy symptoms was examined in comparison to imipramine and placebo in a randomised, double-blind, cross-over study. |
1991-01-09 |
2023-08-11 |
Not clear |
| D R Cool, F H Liebach, V Ganapath. Interaction of fluoxetine with the human placental serotonin transporter. Biochemical pharmacology. vol 40. issue 9. 1990-12-10. PMID:2146964. |
the interaction of fluoxetine, a non-tricyclic antidepressant, with the human placental serotonin transporter was investigated by studying its influence on [3h]paroxetine binding to the transporter and on [3h]serotonin uptake via the transporter. |
1990-12-10 |
2023-08-11 |
human |
| A Andersson, J Marcusso. Inhibition and dissociation of [3H]-paroxetine binding to human platelets. Neuropsychobiology. vol 22. issue 3. 1990-12-04. PMID:2535005. |
the 5-ht uptake inhibitors tested (citalopram, clomipramine, imipramine, norzimeldine and paroxetine) and 5-ht itself produced competitive inhibition patterns in saturation experiments, suggesting that these agents bind to the same site. |
1990-12-04 |
2023-08-11 |
human |
| B A Vogt, M D Plager, P B Crino, E D Bir. Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex. Neuroscience. vol 36. issue 1. 1990-11-19. PMID:1977100. |
of the ligands for serotonin uptake and receptor binding paroxetine binding was evenly distributed in layers i-iii and had a low index of heterogeneity of 9.8. |
1990-11-19 |
2023-08-11 |
human |
| B A Vogt, M D Plager, P B Crino, E D Bir. Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex. Neuroscience. vol 36. issue 1. 1990-11-19. PMID:1977100. |
in contrast, serotonin and 8-hydroxy-2-(di-n-propylamino)tetralin binding peaked in layer ii and had very high indices of 20.8 and 50.3, respectively, suggesting only a limited association with that of the paroxetine distribution. |
1990-11-19 |
2023-08-11 |
human |
| D C Martin, R P Introna, R S Aronsta. Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter. Neuroscience letters. vol 112. issue 1. 1990-09-20. PMID:2143567. |
the effects of halothane and ketamine on (1) serotonin (5-hydroxytryptamine; 5-ht) uptake and (2) paroxetine binding to the 5-ht transporter in neuronal membranes were determined in rat brain. |
1990-09-20 |
2023-08-11 |
rat |
| D C Martin, R P Introna, R S Aronsta. Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter. Neuroscience letters. vol 112. issue 1. 1990-09-20. PMID:2143567. |
both anesthetics inhibited the uptake of [3h]5-ht by synaptosomes, but only ketamine affected binding of [3h]paroxetine to the 5-ht transporter. |
1990-09-20 |
2023-08-11 |
rat |
| K Hashimoto, T Goromar. Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine. Neuropharmacology. vol 29. issue 7. 1990-09-18. PMID:1696701. |
the effects of 3,4-methylenedioxymethamphetamine (mdma) on the in vivo binding of [3h]paroxetine, a potent and selective 5-hydroxytryptamine (5-ht; serotonin) uptake inhibitor, in the brain of the mouse were studied. |
1990-09-18 |
2023-08-11 |
mouse |
| K Hashimoto, T Goromar. Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine. Neuropharmacology. vol 29. issue 7. 1990-09-18. PMID:1696701. |
the hypothalamus/cerebellum and cerebral cortex/cerebellum ratios, as a function of time, were significantly decreased after the pretreatment with mdma, indicating that the in vivo binding of [3h]paroxetine to uptake sites for 5-ht in the brain of the mouse was significantly decreased by mdma. |
1990-09-18 |
2023-08-11 |
mouse |