| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R Nelson, G D Pratt, K J Palmer, A M Johnson, N G Bower. Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies. Neuropharmacology. vol 30. issue 6. 1991-10-31. PMID:1681445. |
effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies. |
1991-10-31 |
2023-08-11 |
rat |
| D R Nelson, G D Pratt, K J Palmer, A M Johnson, N G Bower. Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies. Neuropharmacology. vol 30. issue 6. 1991-10-31. PMID:1681445. |
in particular, the more potent and selective inhibitors of the uptake of 5-ht, such as paroxetine, appear to be devoid of effects on this receptor system. |
1991-10-31 |
2023-08-11 |
rat |
| N Koshikawa, E Mocaër, J D Stephenso. The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake. European journal of pharmacology. vol 198. issue 1. 1991-10-31. PMID:1915578. |
this effect of tianeptine was opposite to that of paroxetine, a selective 5-ht uptake inhibitor, which greatly increased the 5-htp-induced behavioural syndrome. |
1991-10-31 |
2023-08-11 |
rat |
| M E Newman, A Ben-Zeev, B Lere. Chloroamphetamine did not prevent the effects of chronic antidepressants on 5-hydroxytryptamine inhibition of forskolin-stimulated adenylate cyclase in rat hippocampus. European journal of pharmacology. vol 207. issue 3. 1991-10-22. PMID:1654266. |
on two occasions) to rats resulted in a severe depletion of [3h]paroxetine binding sites, a measure of presynaptic serotonergic terminals, in both cortex and hippocampus, but did not affect [3h]8-hydroxy-2-(di-n-propylamino)tetralin [( 3h]8-oh-dpat) binding or 5-hydroxytryptamine (5-ht)-induced inhibition of forskolin-stimulated adenylate cyclase in hippocampal membranes. |
1991-10-22 |
2023-08-11 |
rat |
| B O Bengtsson, J Lundmark, J Wålinde. No crossover reactions to citalopram or paroxetine among patients hypersensitive to zimeldine. The British journal of psychiatry : the journal of mental science. vol 158. 1991-09-26. PMID:1831396. |
five patients who reacted with the hypersensitive syndrome to zimeldine showed no reaction to one of two other selective 5-ht reuptake inhibitors, citalopram or paroxetine. |
1991-09-26 |
2023-08-11 |
Not clear |
| D F Smith, P N Jensen, S H Poulsen, E O Mikkelsen, E Elbaz, R Glase. Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats. European journal of pharmacology. vol 196. issue 1. 1991-09-26. PMID:1831423. |
the enantiomers of mcn-5652-z differed also in their ability to inhibit ex vivo binding of paroxetine in rat frontal cortex and hypothalamus, in vitro uptake of 5-ht in rat blood platelets, and 5-ht-induced contraction of rat vascular smooth muscle, with (+)-mcn-5652-z being most active. |
1991-09-26 |
2023-08-11 |
rat |
| H Akunne, B R deCosta, K C Rice, A E Jacobson, R B Rothma. Evidence for high and low affinity [3H]cocaine binding sites associated with the serotonin reuptake complex in guinea pig brain: allosteric modulation by paroxetine. NIDA research monograph. vol 105. 1991-09-20. PMID:1831543. |
evidence for high and low affinity [3h]cocaine binding sites associated with the serotonin reuptake complex in guinea pig brain: allosteric modulation by paroxetine. |
1991-09-20 |
2023-08-11 |
Not clear |
| N A Sharif, E H Wong, D N Loury, E Stefanich, A D Michel, R M Eglen, R L Whitin. Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1830236. |
in rat cortical homogenates, [3h]-quipazine bound to two populations of binding sites in the absence of the 5-hydroxytryptamine (5-ht) uptake inhibitor, paroxetine (kd1 = 1.6 +/- 0.5 nm, bmax1 = 75 +/- 14 fmol mg-1 protein; kd2 = 500 +/- 300 nm, bmax2 = 1840 +/- 1040 fmol mg-1 protein, n = 3), and to a single class of high affinity binding sites (kd = 2.0 +/- 0.5 nm, n = 3; bmax = 73 +/- 6 fmol mg-1 protein) in the presence of paroxetine. |
1991-08-28 |
2023-08-11 |
rat |
| N A Sharif, E H Wong, D N Loury, E Stefanich, A D Michel, R M Eglen, R L Whitin. Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1830236. |
binding to this site was potently inhibited by 5-ht uptake blockers such as paroxetine and fluoxetine (pki s = 8.6-9.9), while 5-ht3 receptor ligands exhibited only low affinity (pk; < 7). |
1991-08-28 |
2023-08-11 |
rat |
| N A Sharif, E H Wong, D N Loury, E Stefanich, A D Michel, R M Eglen, R L Whitin. Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1830236. |
in rat cortical homogenates, [3h]-quipazine also bound to 5-ht uptake sites, which could be blocked by 0.1 microm paroxetine. |
1991-08-28 |
2023-08-11 |
rat |
| P Plenge, E T Mellerup, H Laurse. Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets. European journal of pharmacology. vol 206. issue 3. 1991-08-28. PMID:1830276. |
affinity modulation of [3h]imipramine, [3h]paroxetine and [3h]citalopram binding to the 5-ht transporter from brain and platelets. |
1991-08-28 |
2023-08-11 |
human |
| P Plenge, E T Mellerup, H Laurse. Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets. European journal of pharmacology. vol 206. issue 3. 1991-08-28. PMID:1830276. |
the dissociations of [3h]imipramine, [3h]paroxetine and [3h]citalopram from the 5-ht (serotonin 5-hydroxytryptamine) transporter were found to be markedly influenced by several drugs, although concentrations in the microm range were needed. |
1991-08-28 |
2023-08-11 |
human |
| P Plenge, E T Mellerup, H Laurse. Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets. European journal of pharmacology. vol 206. issue 3. 1991-08-28. PMID:1830276. |
for example, 5-ht markedly attenuated the dissociation of [3h]imipramine, had a moderate effect on [3h]paroxetine and very little effect on [3h]citalopram dissociation. |
1991-08-28 |
2023-08-11 |
human |
| H H Berendsen, C L Broekkamp, A M van Delf. Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats. Behavioral and neural biology. vol 55. issue 2. 1991-08-01. PMID:1829353. |
the dose-response curve for penile erections, a 5ht1c receptor-mediated response after mcpp (0.1-1.0 mg/kg), a direct 5ht1c agonist, is shifted to the left after 5ht depletion, whereas the response to indirect activation of the 5ht1c receptor with the 5ht reuptake inhibitors citalopram (2.2-4.6 mg/kg) and paroxetine (0.22-2.2 mg/kg) was inhibited after 5ht depletion. |
1991-08-01 |
2023-08-11 |
human |
| M J Millan, F C Colpaer. Methylenedioxymethamphetamine induces spontaneous tail-flicks in the rat via 5-HT1A receptors. European journal of pharmacology. vol 193. issue 2. 1991-07-25. PMID:1675609. |
selective inhibitors of 5-hydroxytryptamine (5-ht) uptake and carrier-mediated 5-ht release, paroxetine and citalopram, did not induce spontaneous tail-flicks themselves and blocked those induced by mdma. |
1991-07-25 |
2023-08-11 |
rat |
| U Scheffel, S Pögün, M Stathis, J W Boja, M J Kuha. In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428. The Journal of pharmacology and experimental therapeutics. vol 257. issue 3. 1991-07-12. PMID:2046028. |
paroxetine, a drug that blocks serotonin transporters, had no effect. |
1991-07-12 |
2023-08-11 |
mouse |
| K L Dechant, S P Clissol. Paroxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. vol 41. issue 2. 1991-07-02. PMID:1709852. |
paroxetine is a potent and selective inhibitor of the neuronal reuptake of serotonin, thereby facilitating serotoninergic transmission; this action appears to account for the antidepressant activity observed with this drug. |
1991-07-02 |
2023-08-11 |
Not clear |
| D Graham, H Esnaud, S Z Lange. Characterization and purification of the neuronal sodium-ion-coupled 5-hydroxytryptamine transporter. Biochemical Society transactions. vol 19. issue 1. 1991-07-02. PMID:1828051. |
the selective 5-hydroxytryptamine (5-ht) uptake inhibitor, [3h]paroxetine, has been used as a specific probe in a series of experiments aimed at characterizing the substrate and 5-ht uptake inhibitor binding domains on the neuronal sodium-ion-coupled 5-ht transporter. |
1991-07-02 |
2023-08-11 |
Not clear |
| M P Johnson, S P Frescas, R Oberlender, D E Nichol. Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA). Journal of medicinal chemistry. vol 34. issue 5. 1991-06-26. PMID:1674539. |
in addition, radioligand-binding parameters in rat brain homogenate with the 5-ht uptake inhibitor [3h]paroxetine were unchanged after subacute dosing with either racemic 6 or 11. |
1991-06-26 |
2023-08-11 |
rat |
| K Hashimoto, T Goromar. High affinity binding of [3H]6-nitroquipazine to cortical membranes in the rat: inhibition by 5-hydroxytryptamine and 5-hydroxytryptamine uptake inhibitors. Neuropharmacology. vol 30. issue 2. 1991-06-20. PMID:2030818. |
the inhibition of 5-ht and several inhibitors of the uptake of 5-ht (paroxetine, clomipramine, citalopram, z-norzimelidine, fluoxetine, imipramine, desipramine and 5-methoxytryptoline) against the binding of [3h]6-nitroquipazine to membranes from the cortex of the rat were the same and competition curves indicated a single population of binding sites. |
1991-06-20 |
2023-08-11 |
rat |