| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Andersson, I Sundman, J Marcusso. Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding. Gerontology. vol 38. issue 3. 1992-08-13. PMID:1385585. |
age stability of human brain 5-ht terminals studied with [3h]paroxetine binding. |
1992-08-13 |
2023-08-11 |
human |
| A Andersson, I Sundman, J Marcusso. Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding. Gerontology. vol 38. issue 3. 1992-08-13. PMID:1385585. |
the effect of age on serotonin uptake sites labeled with [3h]paroxetine was studied in two sets of brains. |
1992-08-13 |
2023-08-11 |
human |
| A Andersson, I Sundman, J Marcusso. Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding. Gerontology. vol 38. issue 3. 1992-08-13. PMID:1385585. |
regarding the [3h]paroxetine binding as an indirect marker for 5-ht terminals, the data suggest a stability of 5-ht terminals with increasing age in the human brain. |
1992-08-13 |
2023-08-11 |
human |
| U Scheffel, R F Dannals, E J Cline, G A Ricaurte, F I Carroll, P Abraham, A H Lewin, M J Kuha. [123/125I]RTI-55, an in vivo label for the serotonin transporter. Synapse (New York, N.Y.). vol 11. issue 2. 1992-08-10. PMID:1385663. |
specific [123i]rti-55 binding to serotonin uptake sites was inhibited by paroxetine but not by gbr 12,909. |
1992-08-10 |
2023-08-11 |
rat |
| M P Kung, S Chumpradit, J Billings, H Kun. 4-Iodotomoxetine: a novel ligand for serotonin uptake sites. Life sciences. vol 51. issue 2. 1992-07-28. PMID:1614281. |
the tomoxetine analog, r-4-iodotomoxetine, binds in vitro to a single site of rat cortical membranes with high affinity (kd = 0.03 +/- 0.01 nm, n = 4) and can be blocked by a selective serotonin reuptake site inhibitor, paroxetine. |
1992-07-28 |
2023-08-11 |
rat |
| H M Akbari, H K Kramer, P M Whitaker-Azmitia, L P Spear, E C Azmiti. Prenatal cocaine exposure disrupts the development of the serotonergic system. Brain research. vol 572. issue 1-2. 1992-07-24. PMID:1535274. |
[3h]paroxetine, a selective ligand for the serotonin uptake carrier, was used to quantify serotonin terminal fiber density at one day, one week, and four weeks postnatal. |
1992-07-24 |
2023-08-11 |
rat |
| K A Stauderman, V C Gandhi, D J Jone. Fluoxetine-induced inhibition of synaptosomal [3H]5-HT release: possible Ca(2+)-channel inhibition. Life sciences. vol 50. issue 26. 1992-07-17. PMID:1608295. |
this effect reflected a property shared by another selective 5-ht uptake inhibitor paroxetine but not by less selective uptake inhibitors such as amitriptyline, desipramine, imipramine or nortriptyline. |
1992-07-17 |
2023-08-11 |
rat |
| H Kuhs, H P Schlake, L H Rolf, G A Rudol. Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline. Acta psychiatrica Scandinavica. vol 85. issue 5. 1992-07-15. PMID:1534961. |
relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline. |
1992-07-15 |
2023-08-11 |
Not clear |
| H Kuhs, H P Schlake, L H Rolf, G A Rudol. Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline. Acta psychiatrica Scandinavica. vol 85. issue 5. 1992-07-15. PMID:1534961. |
in a double-blind clinical study, antidepressant plasma levels, parameters of platelet serotonin (5-ht) transport (km, vmax and basal platelet 5-ht content) and therapeutic response were measured in depressive patients treated with either paroxetine (30 mg/day) or amitriptyline (150 mg/day) for 6 weeks. |
1992-07-15 |
2023-08-11 |
Not clear |
| B B Andersen, M Mikkelsen, A Vesterager, M Dam, H B Kristensen, B Pedersen, J Lund, H Menge. No influence of the antidepressant paroxetine on carbamazepine, valproate and phenytoin. Epilepsy research. vol 10. issue 2-3. 1992-07-15. PMID:1840138. |
a single-blind, placebo-controlled, cross-over trial investigating possible interactions between paroxetine, a serotonin re-uptake inhibitor, and carbamazepine (cbz), valproate (vpa) and phenytoin (pht) was carried out in 20 outpatients with epilepsy. |
1992-07-15 |
2023-08-11 |
Not clear |
| J M Launay, C Geoffroy, V Mutel, M Buckle, A Cesura, J E Alouf, M Da Prad. One-step purification of the serotonin transporter located at the human platelet plasma membrane. The Journal of biological chemistry. vol 267. issue 16. 1992-07-06. PMID:1534559. |
the purified glycoprotein bound the 5-ht uptake blocker [3h]paroxetine with a kd (0.25 nm) similar to the one observed for intact human platelets. |
1992-07-06 |
2023-08-11 |
human |
| J M Launay, C Geoffroy, V Mutel, M Buckle, A Cesura, J E Alouf, M Da Prad. One-step purification of the serotonin transporter located at the human platelet plasma membrane. The Journal of biological chemistry. vol 267. issue 16. 1992-07-06. PMID:1534559. |
5-ht derivatives and 5-ht uptake inhibitors exhibited similar ki values for 5-ht uptake and paroxetine binding in intact human platelets and in the purified glycoprotein. |
1992-07-06 |
2023-08-11 |
human |
| J McGuirk, R Muscat, P Willne. Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1534413. |
effects of the 5-ht uptake inhibitors, femoxetine and paroxetine, and a 5-ht1a/b agonist, eltoprazine, on the behavioural satiety sequence. |
1992-06-30 |
2023-08-11 |
rat |
| J McGuirk, R Muscat, P Willne. Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1534413. |
this "behavioural satiety sequence" was advanced in time by the 5-ht uptake inhibitors femoxetine and paroxetine and by the 5-ht1a/b agonist eltoprazine at anorectic and subanorectic doses. |
1992-06-30 |
2023-08-11 |
rat |
| M P Johnson, X M Huang, D E Nichol. Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1726189. |
monoamine and metabolite levels and the number of 5-ht uptake sites (using [3h]paroxetine binding) were determined 3 hours or 1 week after treatments. |
1992-06-30 |
2023-08-11 |
rat |
| A Molcho, M Stanle. Antidepressants and suicide risk: issues of chemical and behavioral toxicity. Journal of clinical psychopharmacology. vol 12. issue 2 Suppl. 1992-06-09. PMID:1577985. |
although this hypothesis rests on only a few reported cases, large-scale clinical trials of serotonin uptake inhibitors such as fluoxetine, paroxetine, and sertraline do not support it. |
1992-06-09 |
2023-08-11 |
Not clear |
| D Baldwin, T Bullock, D Montgomery, S Montgomer. 5-HT reuptake inhibitors, tricyclic antidepressants and suicidal behaviour. International clinical psychopharmacology. vol 6 Suppl 3. 1992-05-11. PMID:1839632. |
an analysis of the data from double-blind controlled trials of fluvoxamine, fluoxetine and paroxetine indicates that 5-ht uptake inhibitors exercise some protective effects on the emergence of suicidal thoughts, whereas the data from the studies with maprotiline show an increase in suicidal thoughts compared with placebo. |
1992-05-11 |
2023-08-11 |
Not clear |
| Y Chaput, C de Montigny, P Blie. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 5. issue 4. 1992-05-05. PMID:1839498. |
repeated electroconvulsive shocks (ecs; administered every other day for 14 days) as well as the sustained 21-day administration of the tricyclic antidepressant imipramine (10 mg/kg/day) and of the selective 5-hydroxytryptamine (5-ht) reuptake blocker paroxetine (5 mg/kg/day), increased the suppressant effect of the electrical stimulation of the afferent 5-ht pathway on the firing activity of ca3 hippocampus pyramidal neurons. |
1992-05-05 |
2023-08-11 |
rat |
| Y Chaput, C de Montigny, P Blie. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 5. issue 4. 1992-05-05. PMID:1839498. |
the long-term treatments with imipramine and ecs, but not with paroxetine, increased the responsiveness of postsynaptic ca3 hippocampus pyramidal neurons to the microiontophoretic application of 5-ht and to that of the selective 5-ht1a receptor ligand 8-oh-dpat. |
1992-05-05 |
2023-08-11 |
rat |
| Y Chaput, C de Montigny, P Blie. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 5. issue 4. 1992-05-05. PMID:1839498. |
in contrast, the long-term treatment with paroxetine, but not with imipramine or ecs, attenuated the negative feedback exerted by terminal 5-ht autoreceptors on 5-ht release. |
1992-05-05 |
2023-08-11 |
rat |