| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Hashimoto, H Maeda, K Hirai, T Goromar. Drug effects on distribution of [3H]3,4-methylenedioxymethamphetamine in mice. European journal of pharmacology. vol 228. issue 5-6. 1993-05-28. PMID:8097718. |
furthermore, the radioactivity in the brain 60 min after injection of [3h]mdma was increased significantly by pretreatment with paroxetine, but not by pretreatment with 6-nitroquipazine, fluoxetine, clomipramine, gbr 12909 or desipramine, indicating that paroxetine-induced alteration of the brain radioactivity was not due to the inhibitory effect of 5-hydroxytryptamine (5-ht) uptake of paroxetine. |
1993-05-28 |
2023-08-12 |
mouse |
| A K Cadogan, C A Marsden, I Tulloch, D A Kendal. Evidence that chronic administration of paroxetine or fluoxetine enhances 5-HT2 receptor function in the brain of the guinea pig. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8386340. |
chronic (but not acute) treatment with the selective 5-ht uptake inhibitors, paroxetine and fluoxetine (10 mg/kg, p.o., for 21 days), resulted in a significant increase in the maximum response to 5-ht without altering the ec50. |
1993-05-17 |
2023-08-12 |
Not clear |
| T A Lovic. Serotonergic influence from nucleus raphe obscurus on neurones in the periaqueductal grey matter in the rat. Brain research. vol 606. issue 1. 1993-05-03. PMID:8462008. |
selective activation of neuronal perikarya in nucleus raphe obscurus (nro) by microinjection of 50-100 nl d,l-homocysteic acid (dlh) inhibited ongoing activity of 25/31 neurones tested in the pag for periods of 30-580 s, mean 183.5 s. the duration of the inhibition was potentiated by between 36 and 300% during iontophoresis of the 5-ht re-uptake blocker paroxetine (1-25 na, 6/6 cells). |
1993-05-03 |
2023-08-12 |
rat |
| S Ramamoorthy, A L Bauman, K R Moore, H Han, T Yang-Feng, A S Chang, V Ganapathy, R D Blakel. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 6. 1993-04-23. PMID:7681602. |
transfection of one of these cdnas into hela cells yields a high-affinity (km = 463 nm), na(+)- and cl(-)-dependent 5ht transport activity which can be blocked by selective 5ht transport inhibitors, including paroxetine, fluoxetine, and imipramine, and which is antagonized by cocaine and amphetamine. |
1993-04-23 |
2023-08-12 |
human |
| A Gulati, R C Arora, J Crayto. Central serotonergic uptake mechanisms in hypertensive rats: effects of clonidine and centhaquin. European journal of pharmacology. vol 231. issue 2. 1993-04-20. PMID:8453971. |
the binding of a highly specific ligand for serotonin (5-ht) uptake sites, [3h]paroxetine, was studied in brain regions of normotensive wistar-kyoto rats (wky) and spontaneous hypertensive rats (shr). |
1993-04-20 |
2023-08-12 |
rat |
| A Gulati, R C Arora, J Crayto. Central serotonergic uptake mechanisms in hypertensive rats: effects of clonidine and centhaquin. European journal of pharmacology. vol 231. issue 2. 1993-04-20. PMID:8453971. |
the effect of centrally acting hypotensive agents, clonidine and centhaquin, on [3h]paroxetine binding was also determined and compared with imipramine, a known 5-ht uptake inhibitor. |
1993-04-20 |
2023-08-12 |
rat |
| A Gulati, R C Arora, J Crayto. Central serotonergic uptake mechanisms in hypertensive rats: effects of clonidine and centhaquin. European journal of pharmacology. vol 231. issue 2. 1993-04-20. PMID:8453971. |
the ic50 of centhaquin in displacing paroxetine from 5-ht uptake sites, was 10 times lower in the cerebral cortex and 4 times lower in the brainstem membranes when compared to imipramine. |
1993-04-20 |
2023-08-12 |
rat |
| T Kitatani, Y Watanabe, T Shibuy. Different effects of methylxanthines on central serotonergic postsynaptic neurons in a mouse behavioral model. Pharmacology, biochemistry, and behavior. vol 44. issue 2. 1993-04-07. PMID:8446679. |
the potentiating effect of pentoxifylline was increased by paroxetine, the selective inhibitor of uptake of 5-hydroxytryptamine (5-ht), but those of the other drugs were not. |
1993-04-07 |
2023-08-12 |
mouse |
| F Chaouloff, C Layeillon, V Baudri. 5-HT1C/5-HT2 receptor blockade prevents 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane-, but not stress-induced increases in brain tryptophan. European journal of pharmacology. vol 231. issue 1. 1993-04-05. PMID:8095238. |
on the other hand, pretreatment with either the peripherally acting 5-ht1c/5-ht2 receptor blocker, bw 501c67, the 5-ht uptake enhancer, tianeptine, the 5-ht uptake blocker, paroxetine, or the beta 2-adrenoceptor antagonist, ici 118.551, proved ineffective. |
1993-04-05 |
2023-08-12 |
Not clear |
| M R Liebowit. Depression with anxiety and atypical depression. The Journal of clinical psychiatry. vol 54 Suppl. 1993-04-02. PMID:8444829. |
the serotonin selective reuptake inhibitor paroxetine seems to have a beneficial effect on symptoms of anxiety and agitation in depressed patients. |
1993-04-02 |
2023-08-12 |
Not clear |
| C Bolden-Watson, E Richelso. Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life sciences. vol 52. issue 12. 1993-04-02. PMID:8445992. |
among the newer compounds, tomoxetine (ki = 0.7 nm) and lofepramine (ki = 1.9 nm) were potent and selective [3h]norepinephrine uptake blockers; paroxetine (ki = 0.73 nm), sertraline (ki = 3.4 nm), and femoxetine (ki = 22 nm) potently and selectively inhibited [3h]5-hydroxytryptamine uptake. |
1993-04-02 |
2023-08-12 |
rat |
| J De Wilde, R Spiers, C Mertens, F Bartholomé, G Schotte, S Leyma. A double-blind, comparative, multicentre study comparing paroxetine with fluoxetine in depressed patients. Acta psychiatrica Scandinavica. vol 87. issue 2. 1993-04-02. PMID:8447241. |
a randomized, double-blind, parallel-group, 6-week study was undertaken to compare the efficacy and tolerability of once or twice daily administration of the selective serotonin reuptake inhibitors paroxetine and fluoxetine. |
1993-04-02 |
2023-08-12 |
Not clear |
| S Goto, T Egashira, Y Yamanak. Further studies on the endogenous serotonin-uptake-inhibitor-like substances in the human cerebrospinal fluid. Japanese journal of pharmacology. vol 61. issue 1. 1993-03-23. PMID:7679764. |
about 2000) displaced [3h]paroxetine binding noncompetitively (decreased bmax and did not change kd) and inhibited [3h]5ht uptake noncompetitively (decreased vmax and did not change km), but had no effect on either [3h]norepinephrine uptake or [3h]dopamine uptake. |
1993-03-23 |
2023-08-12 |
human |
| J M Launa. [Platelet plasma membrane: characterization of the serotonin transporter]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 186. issue 3. 1993-03-10. PMID:1493576. |
the purified 68-kda glycoprotein is therefore likely to correspond at least to the paroxetine and imipramine binding domains of the 5-ht transporter located at the human platelet plasma membrane. |
1993-03-10 |
2023-08-11 |
human |
| P Blier, C Bouchar. Functional characterization of a 5-HT3 receptor which modulates the release of 5-HT in the guinea-pig brain. British journal of pharmacology. vol 108. issue 1. 1993-03-09. PMID:8428202. |
the 5-ht reuptake blocker, paroxetine, enhanced the electrically evoked release of tritium when introduced 8 min before stimulation; this effect of paroxetine was blocked by ics 205-930, thus indicating that these 5-ht3 receptors can be activated by endogenous 5-ht. |
1993-03-09 |
2023-08-12 |
Not clear |
| A Biegon, C Mathi. Evaluation of [3H]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain. Synapse (New York, N.Y.). vol 13. issue 1. 1993-03-02. PMID:8427010. |
evaluation of [3h]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain. |
1993-03-02 |
2023-08-12 |
human |
| A Biegon, C Mathi. Evaluation of [3H]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain. Synapse (New York, N.Y.). vol 13. issue 1. 1993-03-02. PMID:8427010. |
paroxetine, a selective inhibitor of serotonin uptake and an antidepressant, was used in conjunction with quantitative ex vivo autoradiography to study the feasibility of imaging serotonin terminals in the living brain. |
1993-03-02 |
2023-08-12 |
human |
| A Biegon, C Mathi. Evaluation of [3H]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain. Synapse (New York, N.Y.). vol 13. issue 1. 1993-03-02. PMID:8427010. |
only a relatively small proportion of cortical and hippocampal binding (20-40%) could be blocked by excess unlabeled paroxetine, indicating that most of the radioactivity in these regions is not associated with serotonin terminals or uptake sites. |
1993-03-02 |
2023-08-12 |
human |
| A Biegon, C Mathi. Evaluation of [3H]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain. Synapse (New York, N.Y.). vol 13. issue 1. 1993-03-02. PMID:8427010. |
the usefulness of [3h]paroxetine as an in vivo ligand for imaging serotonin terminals in the human brain is limited by these nonserotonergic binding sites. |
1993-03-02 |
2023-08-12 |
human |
| W M Wilson, R J Maugha. Evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise. Experimental physiology. vol 77. issue 6. 1993-02-26. PMID:1489548. |
evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-ht re-uptake inhibitor, reduces the capacity to perform prolonged exercise. |
1993-02-26 |
2023-08-11 |
human |