| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S C Cheetham, J A Viggers, N A Slater, D J Heal, W R Bucket. [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology. vol 32. issue 8. 1993-11-09. PMID:8413837. |
in addition, a very good correlation was demonstrated between the ability of twenty-three compounds to inhibit [3h]paroxetine binding to rat frontal cortical membranes and [3h]5-ht uptake into rat frontal cortical synaptosomes. |
1993-11-09 |
2023-08-12 |
rat |
| S C Cheetham, J A Viggers, N A Slater, D J Heal, W R Bucket. [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology. vol 32. issue 8. 1993-11-09. PMID:8413837. |
these data support the view that [3h]paroxetine binds to a single site which corresponds to the 5-ht uptake site. |
1993-11-09 |
2023-08-12 |
rat |
| C A Mathis, S E Taylor, A Biegon, J D Ena. [125I]5-iodo-6-nitroquipazine: a potent and selective ligand for the 5-hydroxytryptamine uptake complex. I. In vitro studies. Brain research. vol 619. issue 1-2. 1993-10-20. PMID:8374781. |
non-radiolabeled 5-iodo-6-nitroquipazine potently inhibited the binding of [3h]paroxetine to serotonin reuptake sites in rat cortical membranes with a ki of 0.17 +/- 0.06 nm. |
1993-10-20 |
2023-08-12 |
rat |
| J S Sprouse, D R McCarty, M W Dudle. Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites. Brain research. vol 617. issue 1. 1993-10-15. PMID:8374738. |
the binding of [3h]8-oh-dpat and [3h]paroxetine to 5-ht1a and 5-ht uptake sites (respectively) was examined in membranes prepared from bovine dorsal raphe and hippocampus. |
1993-10-15 |
2023-08-12 |
cattle |
| J S Sprouse, D R McCarty, M W Dudle. Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites. Brain research. vol 617. issue 1. 1993-10-15. PMID:8374738. |
the low affinity component in the dorsal raphe was reduced in the presence of fluoxetine; saturation isotherms with [3h]paroxetine indicated a 5-fold greater concentration of 5-ht uptake sites in this region. |
1993-10-15 |
2023-08-12 |
cattle |
| R I Westphalen, P R Dod. New evidence for a loss of serotonergic nerve terminals in rats treated with d,l-fenfluramine. Pharmacology & toxicology. vol 72. issue 4-5. 1993-10-12. PMID:8372042. |
synaptosomes prepared from such animals showed the predicted reduction in the bmax of [3h]paroxetine binding to the 5-ht uptake site, and a reduction in the vmax of [14c]5-ht uptake. |
1993-10-12 |
2023-08-12 |
rat |
| R I Westphalen, P R Dod. New evidence for a loss of serotonergic nerve terminals in rats treated with d,l-fenfluramine. Pharmacology & toxicology. vol 72. issue 4-5. 1993-10-12. PMID:8372042. |
in contrast, fenfluramine-treated animals showed reduced [3h]paroxetine binding, reduced maximal [14c]5-ht uptake and significantly (p < 0.02) reduced synaptosomal [14c]5-ht loading. |
1993-10-12 |
2023-08-12 |
rat |
| Y Watanabe, R R Sakai, B S McEwen, S Mendelso. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin. Brain research. vol 615. issue 1. 1993-10-05. PMID:8364729. |
the interactions between 14 days of repeated restraint stress and daily administration of imipramine or tianeptine (2 h before the beginning of stress) were investigated in rats to assess responses of 5-ht2 and 5-ht1a receptors and serotonin transporter sites labelled by [3h]paroxetine in the cerebral cortex and hippocampus, two brain regions in which adrenal steroid effects on serotonin receptor-binding have been reported. |
1993-10-05 |
2023-08-12 |
rat |
| Y Watanabe, R R Sakai, B S McEwen, S Mendelso. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin. Brain research. vol 615. issue 1. 1993-10-05. PMID:8364729. |
whereas the actions of imipramine and tianeptine on 5-ht2 and 5-ht1a receptors are specific to each drug, the surprising finding of a similar effect of both drugs to reduce serotonin transporter sites labelled by [3h]paroxetine suggest the possibility of a common action for these two drugs in spite of their opposite effects on serotonin re-uptake. |
1993-10-05 |
2023-08-12 |
rat |
| M Suehiro, U Scheffel, H T Ravert, R F Dannals, H N Wagne. [11C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET. Life sciences. vol 53. issue 11. 1993-10-01. PMID:8366755. |
the binding of [11c](+)mcn5652 was inhibited by 45-73% by pre-injection of 5 mg/kg of paroxetine, a selective 5-ht uptake blocker, in all regions examined except cerebellum where no significant effect of the drug was observed. |
1993-10-01 |
2023-08-12 |
mouse |
| b' K Tikal, M Hrab\\xc3\\xa1nkov\\xc3\\xa. [Indications for antidepressive agents in relation to diseases of the cardiovascular system]. Ceskoslovenska psychiatrie. vol 89. issue 3. 1993-09-23. PMID:8353831.' |
with regard to cardiovascular toxicity, antidepressants from the series of selective inhibitors of serotonin reabsorption are very promising: fluvoxamine, fluoxetine, citalopram, paroxetine and sertraline. |
1993-09-23 |
2023-08-12 |
Not clear |
| J P Feighner, J B Cohn, L F Fabre, R R Fieve, J Mendels, R K Shrivastava, G C Dunba. A study comparing paroxetine placebo and imipramine in depressed patients. Journal of affective disorders. vol 28. issue 2. 1993-09-22. PMID:8354771. |
side effects for paroxetine were typical of other serotonin (5-ht) uptake inhibitors but different from those of imipramine. |
1993-09-22 |
2023-08-12 |
Not clear |
| J Chudzik, A Strijewski, S W Tan. Further evidence for the existence of endogenous serotonin uptake inhibitors and their purification by calmodulin affinity chromatography. Psychiatry research. vol 47. issue 2. 1993-08-31. PMID:8341765. |
these fractions effectively inhibited serotonin uptake, imipramine, and/or paroxetine binding, and they apparently contained some compounds that were recognized by the anti-imipramine or anti-paroxetine antibodies. |
1993-08-31 |
2023-08-12 |
Not clear |
| S M Holliday, G L Ploske. Paroxetine. A review of its pharmacology, therapeutic use in depression and therapeutic potential in diabetic neuropathy. Drugs & aging. vol 3. issue 3. 1993-08-12. PMID:8324301. |
paroxetine is a selective serotonin reuptake inhibitor effective in a once-daily administration regimen in the treatment of depression. |
1993-08-12 |
2023-08-12 |
Not clear |
| S M Holliday, G L Ploske. Paroxetine. A review of its pharmacology, therapeutic use in depression and therapeutic potential in diabetic neuropathy. Drugs & aging. vol 3. issue 3. 1993-08-12. PMID:8324301. |
future research should attempt to define more fully the efficacy of paroxetine as long term prophylactic therapy for recurrent depression and to assess how its overall therapeutic profile compares with other selective serotonin reuptake inhibitors in the elderly. |
1993-08-12 |
2023-08-12 |
Not clear |
| K M Dewar, L Grondin, E K Nénonéné, M Ohayon, T A Reade. [3H]paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments. European journal of pharmacology. vol 235. issue 1. 1993-07-29. PMID:8519275. |
[3h]paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments. |
1993-07-29 |
2023-08-12 |
rat |
| J G Carver, D G Grahame-Smith, E S Johnson, Z Madgwic. The effects of 5-HT and m-chlorophenylpiperazine (m-CPP) on the efflux of [3H]-5-HT from human perfused platelets. British journal of clinical pharmacology. vol 35. issue 5. 1993-07-21. PMID:8512759. |
the results were identical whether or not the 5-ht reuptake blocker paroxetine (1 microm) was present. |
1993-07-21 |
2023-08-12 |
human |
| D T Wong, F P Bymaster, L R Reid, D A Mayle, J H Krushinski, D W Robertso. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8512621. |
s-norfluoxetine inhibited serotonin (5-ht) uptake and [3h]paroxetine binding to 5-ht uptake sites with a pki of 7.86 and 8.88 or 14 and 1.3 nm, respectively, whereas r-norfluoxetine was 22 and 20 times, respectively, less potent. |
1993-07-20 |
2023-08-12 |
rat |
| G C Dunbar, J L Claghorn, A Kiev, K Rickels, W T Smit. A comparison of paroxetine and placebo in depressed outpatients. Acta psychiatrica Scandinavica. vol 87. issue 5. 1993-07-16. PMID:8517168. |
side effects were more common on paroxetine and were similar to other serotonin reuptake inhibitors. |
1993-07-16 |
2023-08-12 |
Not clear |
| S H Preskor. Recent pharmacologic advances in antidepressant therapy for the elderly. The American journal of medicine. vol 94. issue 5A. 1993-06-30. PMID:8503477. |
the practicing clinician now has five distinct classes of antidepressant medications that may be used for treating depression in the elderly: tricyclic antidepressants (tcas; e.g., desipramine, nortriptyline), monoamine oxidase inhibitors (maois; e.g., isocarboxazid, tranylcypromine), selective serotonin reuptake inhibitors (ssris; i.e., fluoxetine, sertraline, and paroxetine), aminoketones (i.e., bupropion), and triazolopyridines (i.e., trazodone). |
1993-06-30 |
2023-08-12 |
Not clear |