| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Chen, J Tonkiss, J R Galler, L Volice. Prenatal protein malnutrition in rats enhances serotonin release from hippocampus. The Journal of nutrition. vol 122. issue 11. 1992-12-04. PMID:1279142. |
hippocampal [3h]paroxetine binding indicated that there was no alteration of apparent maximal binding and affinity of the serotonin transporter in the 6,25 rats. |
1992-12-04 |
2023-08-11 |
rat |
| E Skjelbo, K Brøse. Inhibitors of imipramine metabolism by human liver microsomes. British journal of clinical pharmacology. vol 34. issue 3. 1992-11-20. PMID:1389950. |
the selective serotonin reuptake inhibitors (ssri), paroxetine, fluoxetine and norfluoxetine were potent inhibitors of the high affinity site having apparent ki-values of 0.36, 0.92 and 0.33 microm, respectively. |
1992-11-20 |
2023-08-11 |
human |
| C D Mann, P D Hrdin. Sodium dependence of [3H]paroxetine binding and 5-[3H]hydroxytryptamine uptake in rat diencephalon. Journal of neurochemistry. vol 59. issue 5. 1992-11-20. PMID:1402927. |
the kinetic analysis of results indicates that one sodium ion is required for the binding of [3h]paroxetine as well as for the binding and translocation of each [3h]5-ht molecule. |
1992-11-20 |
2023-08-11 |
rat |
| W A Wolf, D M Kuh. Role of essential sulfhydryl groups in drug interactions at the neuronal 5-HT transporter. Differences between amphetamines and 5-HT uptake inhibitors. The Journal of biological chemistry. vol 267. issue 29. 1992-11-18. PMID:1400397. |
[3h]paroxetine, a potent and selective 5-ht uptake inhibitor, was used to label the 5-ht transporter. |
1992-11-18 |
2023-08-11 |
rat |
| J O Marcusson, U Norinder, T Högberg, S B Ros. Inhibition of [3H]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships. European journal of pharmacology. vol 215. issue 2-3. 1992-11-13. PMID:1396986. |
inhibition of [3h]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships. |
1992-11-13 |
2023-08-11 |
mouse |
| J O Marcusson, U Norinder, T Högberg, S B Ros. Inhibition of [3H]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships. European journal of pharmacology. vol 215. issue 2-3. 1992-11-13. PMID:1396986. |
fifty-four compounds structurally related to zimeldine or alaproclate and eight reference substances were examined as inhibitors of the high affinity binding of [3h]paroxetine to rat cerebral cortical membranes as a measure of the affinity of the 5-hydroxytryptamine (5-ht) transporter. |
1992-11-13 |
2023-08-11 |
mouse |
| J O Marcusson, U Norinder, T Högberg, S B Ros. Inhibition of [3H]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships. European journal of pharmacology. vol 215. issue 2-3. 1992-11-13. PMID:1396986. |
the structure activity relationship for the compounds to inhibit [3h]paroxetine binding was highly significantly correlated to the inhibition of 5-ht uptake in mouse brain slices (p less than 0.01) and to the inhibition of noradrenaline uptake in the same slices (p less than 0.05). |
1992-11-13 |
2023-08-11 |
mouse |
| D Graham, H Esnaud, S Z Lange. Partial purification and characterization of the sodium-ion-coupled 5-hydroxytryptamine transporter of rat cerebral cortex. The Biochemical journal. vol 286 ( Pt 3). 1992-10-29. PMID:1417739. |
5-hydroxytryptamine transporters in the affinity-purified preparation were identified by using the selective 5-hydroxytryptamine-uptake inhibitor [3h]paroxetine, and were shown to display a similar pharmacological profile to those present in particulate preparations. |
1992-10-29 |
2023-08-11 |
rat |
| M Suehiro, U Scheffel, R F Dannals, A A Wilson, H T Ravert, H N Wagne. Synthesis and biodistribution of a new radiotracer for in vivo labeling of serotonin uptake sites by PET, cis-N,N-[11C]dimethyl-3-(2',4'-dichlorophenyl)-indanamine (cis-[11C]DDPI). International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 19. issue 5. 1992-10-26. PMID:1399685. |
following pre-injection of 1 mg/kg of paroxetine, a high affinity 5-ht uptake blocker, the binding of cis-[11c]ddpi in the olfactory tubercles, hypothalamus and frontal cortex was decreased by 23, 25 and 16%; this corresponds to 73, 82 and 59% of the specific binding in these regions. |
1992-10-26 |
2023-08-11 |
mouse |
| G Perrault, E Morel, B Zivkovic, D J Sange. Activity of litoxetine and other serotonin uptake inhibitors in the tail suspension test in mice. Pharmacology, biochemistry, and behavior. vol 42. issue 1. 1992-10-22. PMID:1528946. |
the present study showed that five compounds previously shown to be selective serotonin uptake inhibitors--fluoxetine, zimeldine, paroxetine, indalpine, and litoxetine--produced dose-related decreases in immobility in the tail suspension test typical of the effects shown by other antidepressants. |
1992-10-22 |
2023-08-11 |
mouse |
| J C Bloomer, F R Woods, R E Haddock, M S Lennard, G T Tucke. The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes. British journal of clinical pharmacology. vol 33. issue 5. 1992-10-19. PMID:1388041. |
paroxetine is a selective serotonin reuptake inhibitor possessing anti-depressant activity. |
1992-10-19 |
2023-08-11 |
human |
| E Edwards, W Kornrich, P V Houtten, F A Hen. Presynaptic serotonin mechanisms in rats subjected to inescapable shock. Neuropharmacology. vol 31. issue 4. 1992-10-09. PMID:1387924. |
in the hippocampus, these included a statistically significant increase in three presynaptic 5-hydroxytryptamine (5-ht) mechanisms: k(+)-induced release of [3h]serotonin, high affinity uptake of [3h]serotonin and maximum density of binding sites for uptake of 5-ht, measured with [3h]paroxetine. |
1992-10-09 |
2023-08-11 |
rat |
| E Edwards, W Kornrich, P V Houtten, F A Hen. Presynaptic serotonin mechanisms in rats subjected to inescapable shock. Neuropharmacology. vol 31. issue 4. 1992-10-09. PMID:1387924. |
a significant decrease in: k(+)-induced release of [3h]serotonin, in high affinity uptake of [3h]serotonin and the maximum binding site density of [3h]paroxetine binding was observed. |
1992-10-09 |
2023-08-11 |
rat |
| S Ramamoorthy, D R Cool, F H Leibach, V B Mahesh, V Ganapath. Reconstitution of the human placental 5-hydroxytryptamine transporter in a catalytically active form after detergent solubilization. The Biochemical journal. vol 286 ( Pt 1). 1992-10-06. PMID:1520288. |
the system was specific for 5-ht and was inhibited by imipramine, paroxetine and fluoxetine. |
1992-10-06 |
2023-08-11 |
human |
| N E Rowland, R M Robertso. Administration of dexfenfluramine in pregnant rats: effect on brain serotonin parameters in offspring. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513868. |
brain serotonin (5-ht) concentration and/or paroxetine binding to the 5-ht uptake carrier was reduced by 20% on the day after birth in one study but not in two other studies. |
1992-09-25 |
2023-08-11 |
rat |
| J Ortiz, F Artiga. Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. British journal of pharmacology. vol 105. issue 4. 1992-09-22. PMID:1387022. |
injection (10 mg kg-1) of each of six inhibitors of the high-affinity 5-ht uptake (fluvoxamine, fluoxetine, alaproclate, paroxetine, sertraline and clomipramine). |
1992-09-22 |
2023-08-11 |
rat |
| H Johanning, P Plenge, E Melleru. Serotonin receptors in the brain of rats treated chronically with imipramine or RU24969: support for the 5-HT1B receptor being a 5-HT autoreceptor. Pharmacology & toxicology. vol 70. issue 2. 1992-09-18. PMID:1508839. |
the 5-ht transport protein (5-ht uptake site), labelled with [3h]paroxetine, was unaffected after treatment with either one of the drugs. |
1992-09-18 |
2023-08-11 |
rat |
| D Graham, S Z Lange. Advances in sodium-ion coupled biogenic amine transporters. Life sciences. vol 51. issue 9. 1992-09-11. PMID:1501510. |
over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5ht), nisoxetine, desipramine, maprotiline (for noradrenaline) and gbr-12935 (for dopamine). |
1992-09-11 |
2023-08-11 |
rat |
| S E Mølle. 5-HT uptake inhibitors and tricyclic antidepressants: relation between tryptophan availability and clinical response in depressed patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 1. issue 1. 1992-08-25. PMID:2136212. |
the amount of tryptophan (trp) available for transport from plasma into the brain was estimated in patients with major depression before treatment for 4 weeks with a 5-ht potentiating tricyclic antidepressant (tca), amitriptyline (n = 21) or clomipramine (n = 17), or a selective 5-ht uptake inhibitor, citalopram (n = 14) or paroxetine (n = 27). |
1992-08-25 |
2023-08-11 |
Not clear |
| J C Chen, P W Schnepper, A To, L Volice. Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione. Neuropharmacology. vol 31. issue 3. 1992-08-20. PMID:1378572. |
however, administration of 4,5-dkt did not alter the binding of [3h]paroxetine, a specific antagonist of the uptake of 5-ht, to nerve terminals. |
1992-08-20 |
2023-08-11 |
rat |