| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Pranzatelli, J Ballett. Characterization of 5-hydroxytryptamine 1A-like binding sites in human ganglioneuroblastoma. Neuroscience letters. vol 132. issue 1. 1992-03-26. PMID:1838579. |
no specific binding was found using [3h]paroxetine, [3h]dob, [3h]ketanserin, or [3h]mesulergine to label other types of 5-ht recognition sites. |
1992-03-26 |
2023-08-11 |
human |
| M Suehiro, A A Wilson, U Scheffel, R F Dannals, H T Ravert, H N Wagne. Radiosynthesis and evaluation of N-(3-[18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 18. issue 7. 1992-03-23. PMID:1787089. |
radiosynthesis and evaluation of n-(3-[18f]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by pet. |
1992-03-23 |
2023-08-11 |
Not clear |
| M Suehiro, A A Wilson, U Scheffel, R F Dannals, H T Ravert, H N Wagne. Radiosynthesis and evaluation of N-(3-[18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 18. issue 7. 1992-03-23. PMID:1787089. |
to visualize serotonin uptake sites by positron emission tomography (pet), n-(3-[18f]fluoropropyl)-paroxetine ([18f]fpp), a derivative of the selective serotonin uptake blocker paroxetine, was synthesized from 3-[18f]fluoropropyltosylate and paroxetine via a one-pot procedure. |
1992-03-23 |
2023-08-11 |
Not clear |
| M Suehiro, A A Wilson, U Scheffel, R F Dannals, H T Ravert, H N Wagne. Radiosynthesis and evaluation of N-(3-[18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 18. issue 7. 1992-03-23. PMID:1787089. |
in vitro binding assays revealed that n-fluoropropylation of paroxetine reduced the affinity for the serotonin uptake site by three orders of magnitude. |
1992-03-23 |
2023-08-11 |
Not clear |
| P Plenge, E T Mellerup, O S Jørgense. Lithium treatment regimens induce different changes in [3H]paroxetine binding protein and other rat brain proteins. Psychopharmacology. vol 106. issue 1. 1992-03-18. PMID:1310811. |
the 5ht transport protein, labelled with [3h]paroxetine, was found to be decreased in the lithium-injected rats (bmax = 347 fmol/mg protein) but was unchanged in the lithium-fed rats (bmax = 389 fmol/mg protein), as compared with control rats (bmax = 396 fmol/mg protein), and therefore probably is a specific effect only seen with varying lithium concentration. |
1992-03-18 |
2023-08-11 |
rat |
| X M Huang, M P Johnson, D E Nichol. Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase). European journal of pharmacology. vol 200. issue 1. 1992-02-25. PMID:1722753. |
serotonin and 5-hydroxyindole acetic acid (5-hiaa) levels and the number of 5-ht uptake sites (determined from [3h]paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. |
1992-02-25 |
2023-08-11 |
rat |
| A Andersson, R Adolfsson, K Eriksson, J Marcusso. Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1837595. |
platelet [3h]paroxetine binding to 5-ht uptake sites in alzheimer's disease. |
1992-02-21 |
2023-08-11 |
Not clear |
| A Andersson, R Adolfsson, K Eriksson, J Marcusso. Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1837595. |
platelet serotonin (5-hydroxytryptamine, 5-ht) uptake sites were studied in a control group (n = 30) and an alzheimer group (n = 40) using [3h]paroxetine as radioligand. |
1992-02-21 |
2023-08-11 |
Not clear |
| B Saletu, R Frey, M Krupka, P Anderer, J Grünberger, W R Se. Sleep laboratory studies on the single-dose effects of serotonin reuptake inhibitors paroxetine and fluoxetine on human sleep and awakening qualities. Sleep. vol 14. issue 5. 1992-02-05. PMID:1836894. |
sleep laboratory studies on the single-dose effects of serotonin reuptake inhibitors paroxetine and fluoxetine on human sleep and awakening qualities. |
1992-02-05 |
2023-08-11 |
human |
| B Saletu, R Frey, M Krupka, P Anderer, J Grünberger, W R Se. Sleep laboratory studies on the single-dose effects of serotonin reuptake inhibitors paroxetine and fluoxetine on human sleep and awakening qualities. Sleep. vol 14. issue 5. 1992-02-05. PMID:1836894. |
paroxetine is a novel antidepressant drug with selective serotonin (5-ht) reuptake inhibitory properties. |
1992-02-05 |
2023-08-11 |
human |
| K M Dewar, L Grondin, M Carli, L Lima, T A Reade. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Journal of neurochemistry. vol 58. issue 1. 1992-01-22. PMID:1370077. |
[3h]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. |
1992-01-22 |
2023-08-11 |
rat |
| K M Dewar, L Grondin, M Carli, L Lima, T A Reade. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Journal of neurochemistry. vol 58. issue 1. 1992-01-22. PMID:1370077. |
after pcpa treatment, neither the maximum binding capacity (bmax) nor the dissociation constant (kd) of [3h]paroxetine for the 5-ht uptake recognition site differed from controls despite a substantial reduction in the concentration of 5-ht and 5-hiaa. |
1992-01-22 |
2023-08-11 |
rat |
| K M Dewar, L Grondin, M Carli, L Lima, T A Reade. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Journal of neurochemistry. vol 58. issue 1. 1992-01-22. PMID:1370077. |
furthermore, [3h]paroxetine binding and tissue concentrations of 5-ht and 5-hiaa were measured in the following different regions of the rat brain: cingulate, parietal, and visual cortical areas; dorsal and ventral hippocampus; rostral and caudal halves of neostriatum; ventral mesencephalic tegmentum; and midbrain raphe nuclei region after administration of pcpa, pca, or saline vehicle. |
1992-01-22 |
2023-08-11 |
rat |
| K M Dewar, L Grondin, M Carli, L Lima, T A Reade. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Journal of neurochemistry. vol 58. issue 1. 1992-01-22. PMID:1370077. |
there was an excellent correlation between regional 5-ht levels and specific [3h]paroxetine binding in control and pca-treated rats although this correlation was lost after pcpa treatment. |
1992-01-22 |
2023-08-11 |
rat |
| K M Dewar, L Grondin, M Carli, L Lima, T A Reade. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Journal of neurochemistry. vol 58. issue 1. 1992-01-22. PMID:1370077. |
thus, [3h]paroxetine binding appears to provide a reliable marker of 5-ht innervation density within the mammalian cns. |
1992-01-22 |
2023-08-11 |
rat |
| S H Sindrup, E Grodum, L F Gram, H Beck-Nielse. Concentration-response relationship in paroxetine treatment of diabetic neuropathy symptoms: a patient-blinded dose-escalation study. Therapeutic drug monitoring. vol 13. issue 5. 1992-01-02. PMID:1835549. |
a single-blind dose-escalation study with the selective serotonin reuptake inhibitor paroxetine was conducted in 19 diabetic patients with neuropathy symptoms. |
1992-01-02 |
2023-08-11 |
Not clear |
| D T Wong, P G Threlkeld, D W Robertso. Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 5. issue 1. 1991-12-26. PMID:1930610. |
the new antidepressant drugs, fluoxetine (and its enantiomers), citalopram, indalpine, paroxetine, and femoxetine show relatively weak affinities for 5-ht receptors as measured by radioligand binding to 5-ht-1(a,b,c and d), 5-ht-2, and 5-ht-3 subtypes. |
1991-12-26 |
2023-08-11 |
cattle |
| R D Blakely, H E Berson, R T Fremeau, M G Caron, M M Peek, H K Prince, C C Bradle. Cloning and expression of a functional serotonin transporter from rat brain. Nature. vol 354. issue 6348. 1991-12-11. PMID:1944572. |
transfection with a single 2.3-kilobase brainstem complementary dna clone is sufficient to confer expression of a na(+)-dependent 5ht transporter upon nonneural cells, with transport selectively and potently antagonized by 5ht uptake-specific antidepressants, including paroxetine, citalopram and fluoxetine. |
1991-12-11 |
2023-08-11 |
rat |
| P Blie. Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins. Naunyn-Schmiedeberg's archives of pharmacology. vol 344. issue 2. 1991-12-02. PMID:1944610. |
the enhancing effect of the 5-ht reuptake blocker paroxetine (1 mumol/l) on the evoked [3h]5-ht overflow was also unaltered by these toxins. |
1991-12-02 |
2023-08-11 |
rat |
| J Ortiz, E Mocaër, F Artiga. Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat. European journal of pharmacology. vol 199. issue 3. 1991-11-15. PMID:1717295. |
tianeptine attenuated the large increase in 5-ht concentrations in platelet-free plasma elicited by the specific 5-ht uptake inhibitors citalopram and paroxetine. |
1991-11-15 |
2023-08-11 |
rat |