| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Ravindran, J Chudzik, R J Bialik, Y D Lapierre, P D Hrdin. Platelet serotonin measures in primary dysthymia. The American journal of psychiatry. vol 151. issue 9. 1994-09-16. PMID:8067494. |
serotonergic function in 22 patients with primary dysthymia and 22 normal volunteers was evaluated by measuring [3h]serotonin uptake and [3h]paroxetine binding in platelets. |
1994-09-16 |
2023-08-12 |
human |
| U Scheffel, S Kim, E J Cline, M J Kuha. Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125I]RTI-55. Synapse (New York, N.Y.). vol 16. issue 4. 1994-09-15. PMID:8059336. |
occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125i]rti-55. |
1994-09-15 |
2023-08-12 |
mouse |
| U Scheffel, S Kim, E J Cline, M J Kuha. Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125I]RTI-55. Synapse (New York, N.Y.). vol 16. issue 4. 1994-09-15. PMID:8059336. |
fluoxetine, paroxetine, and sertraline, potent antidepressants and selective inhibitors of serotonin transporter sites, were administered in various doses and at various times. |
1994-09-15 |
2023-08-12 |
mouse |
| U Scheffel, S Kim, E J Cline, M J Kuha. Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125I]RTI-55. Synapse (New York, N.Y.). vol 16. issue 4. 1994-09-15. PMID:8059336. |
the rate of occupancy of the 5-ht transporter site was fastest for sertraline, intermediate for paroxetine and slowest for fluoxetine. |
1994-09-15 |
2023-08-12 |
mouse |
| T A Lovic. Influence of the dorsal and median raphe nuclei on neurons in the periaqueductal gray matter: role of 5-hydroxytryptamine. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058131. |
the duration of the inhibitory response evoked from the dorsal raphe nucleus was increased by 66-75% during iontophoretic application (3-10 na) of the 5-hydroxytryptamine (serotonin) reuptake blocker paroxetine (five of six cells). |
1994-09-12 |
2023-08-12 |
rat |
| T A Lovic. Influence of the dorsal and median raphe nuclei on neurons in the periaqueductal gray matter: role of 5-hydroxytryptamine. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058131. |
paroxetine also produced a reduction in baseline firing and potentiated the responses of neurons to iontophoretically applied 5-hydroxytryptamine. |
1994-09-12 |
2023-08-12 |
rat |
| R Mongeau, C De Montigny, P Blie. Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures. European journal of pharmacology. vol 256. issue 3. 1994-09-01. PMID:8045271. |
elevated levels of endogenous 5-ht, achieved through selective reuptake blockade with paroxetine, as well as the addition of exogenous 5-ht in the medium, also enhanced [3h]noradrenaline release. |
1994-09-01 |
2023-08-12 |
rat |
| M Pee. Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants. The British journal of psychiatry : the journal of mental science. vol 164. issue 4. 1994-08-25. PMID:8038948. |
the rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (ssris) fluoxetine, fluvoxamine, paroxetine, and sertraline, relative to comparative groups treated with tricyclic antidepressants (tcas) or placebo. |
1994-08-25 |
2023-08-12 |
Not clear |
| D L Dunne. An overview of paroxetine in the elderly. Gerontology. vol 40 Suppl 1. 1994-08-04. PMID:8020767. |
this paper reviews controlled studies of the treatment of depression in elderly patients using paroxetine, a selective serotonin reuptake inhibitor. |
1994-08-04 |
2023-08-12 |
Not clear |
| H H Berendsen, C L Broekkam. Comparison of stimulus properties of fluoxetine and 5-HT receptor agonists in a conditioned taste aversion procedure. European journal of pharmacology. vol 253. issue 1-2. 1994-07-26. PMID:8013551. |
pre-exposure to mk 212 also prevented the conditioned taste aversion induced by another serotonin uptake inhibitor, paroxetine. |
1994-07-26 |
2023-08-12 |
mouse |
| J Lundmark, J Wålinder, C Alling, P M Manniche, L Dalgaar. The effect of paroxetine on cerebrospinal fluid concentrations of neurotransmitter metabolites in depressed patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 4. issue 1. 1994-07-11. PMID:7515737. |
this paper describes the effect of the selective serotonin reuptake inhibiting drug (ssri), paroxetine, on cerebrospinal fluid concentrations of neurotransmitter metabolites in depressed patients. |
1994-07-11 |
2023-08-12 |
Not clear |
| C B Nemerof. The clinical pharmacology and use of paroxetine, a new selective serotonin reuptake inhibitor. Pharmacotherapy. vol 14. issue 2. 1994-06-30. PMID:8197030. |
the clinical pharmacology and use of paroxetine, a new selective serotonin reuptake inhibitor. |
1994-06-30 |
2023-08-12 |
Not clear |
| C B Nemerof. The clinical pharmacology and use of paroxetine, a new selective serotonin reuptake inhibitor. Pharmacotherapy. vol 14. issue 2. 1994-06-30. PMID:8197030. |
the selective serotonin reuptake inhibitors (ssris) fluoxetine, sertraline, and, more recently, paroxetine are viewed as welcome additions to existing therapy. |
1994-06-30 |
2023-08-12 |
Not clear |
| R Mongeau, C de Montigny, P Blie. Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 10. issue 1. 1994-06-15. PMID:8179793. |
rats were treated for 3 weeks with 0.75 mg/kg per day of befloxatone (a reversible inhibitor of monoamine oxidase a), 10 mg/kg per day of nisoxetine (a selective ne reuptake inhibitor), 10 mg/kg per day of paroxetine (a selective 5-ht reuptake inhibitor) or saline using subcutaneous osmotic minipumps (removed 48 hours before the experiment). |
1994-06-15 |
2023-08-12 |
rat |
| G Piñeyro, P Blier, T Dennis, C de Montign. Desensitization of the neuronal 5-HT carrier following its long-term blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182457. |
in vivo extracellular unitary recordings, in vitro 3h-5-hydroxy-tryptamine (5-ht) uptake, and 3h-paroxetine binding assays were used to assess the effect of acute and long-term administration of the 5-ht reuptake inhibitor paroxetine on the neuronal 5-ht transporter in the rat dorsal hippocampus. |
1994-06-14 |
2023-08-12 |
rat |
| G Piñeyro, P Blier, T Dennis, C de Montign. Desensitization of the neuronal 5-HT carrier following its long-term blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182457. |
in a first series of experiments, the acute intravenous administration of paroxetine and 5-ht denervation with the neurotoxin 5,7-dihydroxytryptamine produced a marked prolongation of the suppressant effect of 5-ht, indicating that reuptake into 5-ht terminals plays a significant role in terminating the action of microiontophoretically applied 5-ht. |
1994-06-14 |
2023-08-12 |
rat |
| G Piñeyro, P Blier, T Dennis, C de Montign. Desensitization of the neuronal 5-HT carrier following its long-term blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182457. |
in a second series of experiments, rats were treated with paroxetine (10 mg/kg/d, s.c.) for 2 or 21 d. in both treatment groups, there was a marked prolongation of the effect of microiontophoretically applied 5-ht; however, in rats treated for 2 d, the prolongation was significantly greater than that observed in rats treated for 21 d. after the 21 d treatment with paroxetine and a 48 hr washout, the prolongation of the effect of microiontophoretically applied 5-ht by acute intravenous paroxetine was significantly reduced, suggesting a decrease in the number of 5-ht carriers. |
1994-06-14 |
2023-08-12 |
rat |
| M B Ma. Treatment of post-herpetic neuralgia: antidepressants. Annals of neurology. vol 35 Suppl. 1994-06-14. PMID:8185299. |
the selective serotonin reuptake inhibitors, zimelidine and paroxetine, have shown little effectiveness in neuropathic pain, but small studies in diabetic neuropathy have shown that paroxetine and citalopram have modest effects. |
1994-06-14 |
2023-08-12 |
Not clear |
| D A Gorard, G W Libby, M J Farthin. 5-Hydroxytryptamine and human small intestinal motility: effect of inhibiting 5-hydroxytryptamine reuptake. Gut. vol 35. issue 4. 1994-06-07. PMID:8174987. |
using a selective 5-hydroxytryptamine reuptake inhibitor, paroxetine, this study investigated the effect of indirect 5-hydroxytryptamine agonism on fasting small intestinal motility and transit. |
1994-06-07 |
2023-08-12 |
human |
| I Lucki, A Singh, D S Kreis. Antidepressant-like behavioral effects of serotonin receptor agonists. Neuroscience and biobehavioral reviews. vol 18. issue 1. 1994-06-01. PMID:8170624. |
other 5-ht uptake inhibitors, such as fluoxetine, fluvoxamine and paroxetine, substituted for the sertraline stimulus. |
1994-06-01 |
2023-08-12 |
rat |