| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L L von Moltke, D J Greenblatt, M H Court, S X Duan, J S Harmatz, R I Shade. Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. Journal of clinical psychopharmacology. vol 15. issue 2. 1995-07-19. PMID:7782485. |
inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. |
1995-07-19 |
2023-08-12 |
human |
| L L von Moltke, D J Greenblatt, M H Court, S X Duan, J S Harmatz, R I Shade. Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. Journal of clinical psychopharmacology. vol 15. issue 2. 1995-07-19. PMID:7782485. |
in vitro preparations of human liver microsomes were used to study the inhibiting effects of two selective serotonin reuptake inhibitor (ssri) antidepressants, paroxetine and fluvoxamine, on metabolism via hydroxylation of alprazolam and of desipramine. |
1995-07-19 |
2023-08-12 |
human |
| D M Helmeste, S W Tang, C Reist, R V. Serotonin uptake inhibitors modulate intracellular Ca2+ mobilization in platelets. European journal of pharmacology. vol 288. issue 3. 1995-07-11. PMID:7774682. |
the serotonin uptake inhibitors sertraline, paroxetine and fluoxetine were compared with imipramine and the calmodulin antagonists n-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (w-7) and calmidazolium, for their effects on intracellular ca2+ mobilization in human platelets. |
1995-07-11 |
2023-08-12 |
human |
| G Piñeyro, L Deveault, P Blier, T Dennis, C de Montign. Effect of acute and prolonged tianeptine administration on the 5-HT transporter: electrophysiological, biochemical and radioligand binding studies in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770093. |
in keeping with this observation, the acute administration of tianeptine did not change the effectiveness of the 5-ht reuptake blocker paroxetine (1 mg/kg, i.v.) |
1995-07-06 |
2023-08-12 |
rat |
| G Piñeyro, L Deveault, P Blier, T Dennis, C de Montign. Effect of acute and prolonged tianeptine administration on the 5-HT transporter: electrophysiological, biochemical and radioligand binding studies in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770093. |
however, in rats that had received tianeptine for 14 days (20 mg/kg/day, s.c.), the recovery time from the suppressant effect of microiontophoretic applications of 5-ht was reduced by 40% and the effectiveness of paroxetine (1 mg/kg, i.v.) |
1995-07-06 |
2023-08-12 |
rat |
| K E Hewitt, A R Gree. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7539115. |
an investigation has been made into the effect of 3,4-methylenedioxymethamphetamine (mdma or 'ecstasy') administration on the concentration of 5-hydroxytryptamine (5-ht), uptake of [3h]5-ht and [3h]paroxetine binding in rat cerebral cortex tissue. |
1995-06-26 |
2023-08-12 |
rat |
| K E Hewitt, A R Gree. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7539115. |
the binding of [3h]paroxetine to the presynaptic 5-ht transporter was decreased and high affinity uptake of [3h]5-ht was reduced by a similar amount, indicating neurodegeneration of 5-ht terminals. |
1995-06-26 |
2023-08-12 |
rat |
| K E Hewitt, A R Gree. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7539115. |
also prevented the mdma-induced loss of [3h]paroxetine binding and attenuated the loss of 5-ht and 5-hiaa content. |
1995-06-26 |
2023-08-12 |
rat |
| J E Sprague, D E Nichol. The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. The Journal of pharmacology and experimental therapeutics. vol 273. issue 2. 1995-06-19. PMID:7538579. |
3,4-methylenedioxymethamphetamine (mdma)-induced serotonergic neurotoxicity was assessed in the striatum, hippocampus and frontal cortex of rats by using [3h]paroxetine binding to label serotonin (5-ht) uptake sites and 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) levels as markers of serotonergic function. |
1995-06-19 |
2023-08-12 |
rat |
| J E Sprague, D E Nichol. The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. The Journal of pharmacology and experimental therapeutics. vol 273. issue 2. 1995-06-19. PMID:7538579. |
nmda (40 mg/kg) induced a significant decrease in both [3h]paroxetine binding bmax and 5-ht and 5-hiaa levels 7 days after treatment. |
1995-06-19 |
2023-08-12 |
rat |
| A Stoudemir. Expanding psychopharmacologic treatment options for the depressed medical patient. Psychosomatics. vol 36. issue 2. 1995-05-25. PMID:7724709. |
this article discusses the important pharmacodynamic and pharmacokinetic properties of the selective serotonin reuptake inhibitors (fluoxetine, paroxetine, and sertraline), bupropion, venlafaxine, and nefazodone--with an emphasis on their side effects relevant to medical patients as well as important drug interactions. |
1995-05-25 |
2023-08-12 |
Not clear |
| R R Reeves, J A Bulle. Serotonin syndrome produced by paroxetine and low-dose trazodone. Psychosomatics. vol 36. issue 2. 1995-05-25. PMID:7724720. |
serotonin syndrome produced by paroxetine and low-dose trazodone. |
1995-05-25 |
2023-08-12 |
Not clear |
| K P Lesch, J Gross, E Franzek, B L Wolozin, P Riederer, D L Murph. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biological psychiatry. vol 37. issue 4. 1995-05-18. PMID:7711157. |
decreased platelet serotonin (5-ht) transport and reduced binding of imipramine or paroxetine to brain and platelet 5-ht uptake sites/transporters in patients with depression and suicide victims define the 5-ht transporter (5-htt) as a candidate gene. |
1995-05-18 |
2023-08-12 |
Not clear |
| M L Silverthorn, C M Dersch, M H Baumann, J L Cadet, J S Partilla, K C Rice, F I Carroll, K M Becketts, A Brockington, R B Rothma. Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714769. |
the first series of experiments established that [125i]rti-55 labels both da and 5-ht transporters and that 50 nm paroxetine and either 1000 nm 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)homopiperazine (lr1111) or 500 nm (rti-120) could be used to block [125i]rti-55 binding to the 5-ht and da transporters, thereby generating selective assay conditions for the da and 5-ht transporters, respectively. |
1995-05-17 |
2023-08-12 |
rat |
| M L Silverthorn, C M Dersch, M H Baumann, J L Cadet, J S Partilla, K C Rice, F I Carroll, K M Becketts, A Brockington, R B Rothma. Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714769. |
in summary, the major findings of the present study are that [125i]rti-55 labels both da and 5-ht transporters in membranes prepared from whole brain minus caudate, that 50 nm paroxetine and either 1000 nm lr1111 or 500 nm rti-120 can be used as a blocking agent to generate selective assay conditions for the da and 5-ht transporters, respectively, and that [125i]rti-55 binding to the 5-ht transporter can be resolved into two similar components. |
1995-05-17 |
2023-08-12 |
rat |
| P Barone, C Moret, M Briley, G Fillio. Autoradiographic characterization of binding sites for [3H]milnacipran, a new antidepressant drug, and their relationship to the serotonin transporter in rat brain. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704599. |
the binding was na(+)-dependent, potently displaced by serotonin uptake inhibitors in all structures and moderately or weakly displaced by catecholamine uptake inhibitors (order of potency: paroxetine > fluoxetine > mazindol > desipramine > nomifensine > maprotiline). |
1995-05-10 |
2023-08-12 |
rat |
| H Hayakawa, Y Okamoto, M Shimizu, A Nishida, N Motohashi, S Yamawak. Single or repeated treatment with electroconvulsive shock increases number of serotonin uptake binding sites in the frontal cortex. Neuropsychobiology. vol 31. issue 1. 1995-05-10. PMID:7708175. |
the selective 5-ht uptake inhibitor citalopram and clomipramine potently inhibited the binding for [3h]paroxetine (5-ht uptake binding sites) in the frontal cortex. |
1995-05-10 |
2023-08-12 |
rat |
| C Sánchez, J Hytte. Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors. European journal of pharmacology. vol 264. issue 3. 1995-04-28. PMID:7698161. |
the selective 5-ht uptake inhibitors, sertraline, floxetine, femoxetine and fluvoxamine, showed weak antiaggressive effects, and citalopram and paroxetine were ineffective. |
1995-04-28 |
2023-08-12 |
mouse |
| A Rotondo, G Giannaccini, C Quattrone, D Marazziti, C Martini, G B Cassano, A Lucacchin. Solubilization and characterization of [3H]imipramine and [3H]paroxetine binding sites from calf striatum. Neurochemical research. vol 19. issue 10. 1995-04-20. PMID:7891847. |
our results suggest that both 3h-imipramine and [3h]paroxetine bind to a common site on the 5-ht transporter. |
1995-04-20 |
2023-08-12 |
Not clear |
| B Arranz, J Marcusso. [3H]paroxetine and [3H]citalopram as markers of the human brain 5-HT uptake site: a comparison study. Journal of neural transmission. General section. vol 97. issue 1. 1995-04-17. PMID:7888147. |
[3h]paroxetine and [3h]citalopram as markers of the human brain 5-ht uptake site: a comparison study. |
1995-04-17 |
2023-08-12 |
human |