| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Curra. Effect of paroxetine on seizure length during electroconvulsive therapy. Acta psychiatrica Scandinavica. vol 92. issue 3. 1995-12-22. PMID:7484206. |
this study reports the effect of paroxetine, a selective serotonin reuptake inhibitor, on seizure length during electroconvulsive therapy. |
1995-12-22 |
2023-08-12 |
Not clear |
| J Schmider, D J Greenblatt, L L von Moltke, J S Harmatz, R I Shade. N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors. The Journal of pharmacology and experimental therapeutics. vol 275. issue 2. 1995-12-19. PMID:7473143. |
all selective serotonin reuptake inhibitors (ssris) tested had an inhibitory effect on the formation of nt, with mean ki values of 4.37 (+/- 3.38) microm for sertraline, 5.46 (+/- 1.95) microm for desmethylsertraline, 9.22 (+/- 3.69) microm for fluvoxamine, 12.26 (+/- 5.67) microm for norfluoxetine, 15.76 (+/- 5.05) microm for paroxetine, and 43.55 (+/- 18.28) microm for fluoxetine. |
1995-12-19 |
2023-08-12 |
human |
| S E Gartside, V Umbers, M Hajós, T Shar. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. British journal of pharmacology. vol 115. issue 6. 1995-12-15. PMID:7582504. |
here, we determined the effects of the ssri, paroxetine, and a novel selective 5-ht1a receptor antagonist, way 100635, on 5-ht cell firing in the dorsal raphé nucleus (drn), and on extracellular 5-ht in both the drn and the frontal cortex (fcx). |
1995-12-15 |
2023-08-12 |
rat |
| S E Gartside, V Umbers, M Hajós, T Shar. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. British journal of pharmacology. vol 115. issue 6. 1995-12-15. PMID:7582504. |
paroxetine dose-dependently inhibited the firing of 5-ht neurones in the drn, with a maximally effective dose of approximately 0.8 mg kg-1, i.v. |
1995-12-15 |
2023-08-12 |
rat |
| S E Gartside, V Umbers, M Hajós, T Shar. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. British journal of pharmacology. vol 115. issue 6. 1995-12-15. PMID:7582504. |
paroxetine alone had no effect on extracellular 5-ht in the fcx, in rats pretreated with way 100635 (0.1 mg kg-1), paroxetine (0.8 mg kg-1, i.v.) |
1995-12-15 |
2023-08-12 |
rat |
| S E Gartside, V Umbers, M Hajós, T Shar. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. British journal of pharmacology. vol 115. issue 6. 1995-12-15. PMID:7582504. |
in conclusion, pretreatment with the selective 5-ht1a receptor antagonist, way 100635, blocked the inhibitory effect of paroxetine on 5-ht neuronal activity in the drn and, at the same time, markedly enhanced the effect of paroxetine on extracellular 5-ht in the fcx. |
1995-12-15 |
2023-08-12 |
rat |
| M P Kung, W D Essman, D Frederick, S Meegalla, M Goodman, M Mu, I Lucki, H F Kun. IPT: a novel iodinated ligand for the CNS dopamine transporter. Synapse (New York, N.Y.). vol 20. issue 4. 1995-12-14. PMID:7482291. |
the rank order of potency of several monoamine uptake inhibitors (paroxetine > fluoxetine > mazindol > r-nisoxetine > gbr12909) suggests that [125i] ipt labels 5-ht transporters in rat cortical homogenates. |
1995-12-14 |
2023-08-12 |
rat |
| J Chudzik, D McCarthy, D Bakish, A Ravindran, P D Hrdin. Synthesis and characterization of an aryl-azidoparoxetine. A novel photo-affinity probe for serotonin-transporter. Biochemical pharmacology. vol 50. issue 8. 1995-12-14. PMID:7488236. |
paroxetine is an effective antidepressant drug and potent serotonin (5-ht) uptake inhibitor. |
1995-12-14 |
2023-08-12 |
Not clear |
| J Chudzik, D McCarthy, D Bakish, A Ravindran, P D Hrdin. Synthesis and characterization of an aryl-azidoparoxetine. A novel photo-affinity probe for serotonin-transporter. Biochemical pharmacology. vol 50. issue 8. 1995-12-14. PMID:7488236. |
we report here the synthesis of an aryl-azido derivative of paroxetine, which is a novel photoactive and irreversible ligand for the [3h]paroxetine binding site on the platelet 5-ht transporter. |
1995-12-14 |
2023-08-12 |
Not clear |
| J Chudzik, D McCarthy, D Bakish, A Ravindran, P D Hrdin. Synthesis and characterization of an aryl-azidoparoxetine. A novel photo-affinity probe for serotonin-transporter. Biochemical pharmacology. vol 50. issue 8. 1995-12-14. PMID:7488236. |
the compound inhibited [3h]paroxetine binding (ic50, 55 nm) and 5-ht uptake (ic50, 12 nm) at equilibrium conditions and inactivated 10-20% of [3h]paroxetine binding sites upon irradiation at 320 nm. |
1995-12-14 |
2023-08-12 |
Not clear |
| I Erreboe, P Plenge, E T Melleru. Differences in brain 5-HT transporter dissociation rates among animal species. Pharmacology & toxicology. vol 76. issue 6. 1995-12-07. PMID:7479579. |
the potential of using receptor-ligand dissociation rates as a model for investigating molecular changes in receptors was tested using the dissociation of [3h]citalopram, [3h]paroxetine and [3h]imipramine from the brain 5-ht transporter of four different species (mouse, rat, pig and man). |
1995-12-07 |
2023-08-12 |
mouse |
| J H Hsu, W W She. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. International journal of psychiatry in medicine. vol 25. issue 2. 1995-12-06. PMID:7591493. |
from the chart review, thirty-four out of eighty male patients were identified to have reported loss of libido, erectile difficulty, anorgasmia, and delayed ejaculation while receiving pharmacotherapy of selective serotonin reuptake blockers (fluoxetine, paroxetine, and sertraline); tricyclic antidepressants (nortriptyline, imipramine, amitriptyline, desipramine, and clomipramine); and a monoamine oxidase inhibitor (phenelzine). |
1995-12-06 |
2023-08-12 |
Not clear |
| L Staner, M Kerkhofs, D Detroux, S Leyman, P Linkowski, J Mendlewic. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep. vol 18. issue 6. 1995-11-30. PMID:7481419. |
paroxetine (30 mg), a selective serotonin (5-ht) reuptake inhibitor, was compared in a double-blind trial to amitriptyline (150 mg) in a sample of 40 inpatients aged 18-65 years who fulfilled research diagnostic criteria for major depression. |
1995-11-30 |
2023-08-12 |
Not clear |
| L Staner, M Kerkhofs, D Detroux, S Leyman, P Linkowski, J Mendlewic. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep. vol 18. issue 6. 1995-11-30. PMID:7481419. |
paroxetine shows an antidepressant effect similar to amitriptyline with a different side-effect profile typical of 5-ht reuptake inhibition. |
1995-11-30 |
2023-08-12 |
Not clear |
| L Staner, M Kerkhofs, D Detroux, S Leyman, P Linkowski, J Mendlewic. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep. vol 18. issue 6. 1995-11-30. PMID:7481419. |
paroxetine also shared with other 5-ht reuptake inhibitors an alerting effect on sleep that was not shown to be detrimental on subjective sleep quality. |
1995-11-30 |
2023-08-12 |
Not clear |
| M Popoli, C Vocaturo, J Perez, E Smeraldi, G Racagn. Presynaptic Ca2+/calmodulin-dependent protein kinase II: autophosphorylation and activity increase in the hippocampus after long-term blockade of serotonin reuptake. Molecular pharmacology. vol 48. issue 4. 1995-11-29. PMID:7476887. |
long-term treatment with two selective serotonin reuptake inhibitors (paroxetine and fluvoxamine) and with a nonselective reuptake inhibitor (venlafaxine) induces a large increase of kinase autophosphorylation in synaptic vesicles and synaptic cytosol in the hippocampus but not in synaptosomal membranes. |
1995-11-29 |
2023-08-12 |
Not clear |
| M I Wilde, R Whittingto. Paroxetine. A pharmacoeconomic evaluation of its use in depression. PharmacoEconomics. vol 8. issue 1. 1995-11-29. PMID:10155603. |
there has been intense debate about whether the use of paroxetine or other selective serotonin reuptake inhibitors (ssris) as alternatives to tricyclic antidepressants for first-line treatment of depression can be justified, considering their higher acquisition costs. |
1995-11-29 |
2023-08-12 |
Not clear |
| J D Bentkover, J P Feighne. Cost analysis of paroxetine versus imipramine in major depression. PharmacoEconomics. vol 8. issue 3. 1995-11-29. PMID:10155618. |
a simulation decision analytical model was used to compare the annual direct medical costs of treating patients with major depression using the selective serotonin reuptake inhibitor (ssri) paroxetine or the tricyclic antidepressant (tca) imipramine. |
1995-11-29 |
2023-08-12 |
Not clear |
| P Brust, R Bergmann, B Johannse. Specific binding of [3H]imipramine indicates the presence of a specific serotonin transport system on endothelial cells of porcine brain. Neuroscience letters. vol 194. issue 1-2. 1995-11-28. PMID:7478203. |
imipramine binding could be inhibited by potent non-tricyclic inhibitors of the serotonin transporter such as paroxetine and fluoxetine but also by the tricyclic antidepressant drugs clomipramine and desipramine. |
1995-11-28 |
2023-08-12 |
Not clear |
| J J Rutter, C Gundlah, S B Auerbac. Systemic uptake inhibition decreases serotonin release via somatodendritic autoreceptor activation. Synapse (New York, N.Y.). vol 20. issue 3. 1995-10-25. PMID:7570354. |
subsequent systemic fluoxetine, sertraline, or paroxetine, produced a 50% decrease in extracellular 5-ht in the diencephalon, presumably due to activation of the 5-ht1a somatodendritic autoreceptors. |
1995-10-25 |
2023-08-12 |
rat |