| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Dean, W Hayes, K Opeskin, L Naylor, G Pavey, C Hill, N Keks, D L Copolo. Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788497. |
by contrast, [3h]paroxetine binds to the serotonin transporter and therefore our data suggest that the serotonin transporter is altered in the hippocampus of subjects with schizophrenia. |
1996-12-04 |
2023-08-12 |
human |
| S Hjorth, S B Auerbac. 5-HT1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI). Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788519. |
with 5-ht reuptake first blocked by local 'reverse-dialysis' infusion of citalopram (1 microm) into the hippocampus, acute systemic administration of citalopram or paroxetine resulted in a marked decrease in hippocampal 5-ht overflow. |
1996-12-04 |
2023-08-12 |
rat |
| T A Slotkin, G A Barnes, E C McCook, F J Seidle. Programming of brainstem serotonin transporter development by prenatal glucocorticoids. Brain research. Developmental brain research. vol 93. issue 1-2. 1996-11-29. PMID:8804702. |
pregnant rats were given 0.05, 0.2 or 0.8 mg/kg of dexamethasone on gestational days 17, 18 and 19, and the effects on development of the serotonin presynaptic transporter were assessed from birth to young adulthood by measurement of [3h]paroxetine binding to membrane preparations. |
1996-11-29 |
2023-08-12 |
rat |
| K R Bonson, J W Buckholtz, D L Murph. Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 6. 1996-11-27. PMID:8726753. |
twenty-eight out of 32 subjects (88%) who had taken an antidepressant with inhibitory effects on serotonin (5-ht) reuptake (fluoxetine, paroxetine, sertraline, trazodone) for over 3 weeks had a subjective decrease or virtual elimination of their responses to lsd. |
1996-11-27 |
2023-08-12 |
human |
| K A Yonkers, C Gullion, A Williams, K Novak, A J Rus. Paroxetine as a treatment for premenstrual dysphoric disorder. Journal of clinical psychopharmacology. vol 16. issue 1. 1996-11-27. PMID:8834412. |
in this open trial, patients were treated for one cycle with placebo and then for three consecutive cycles with the serotonin reuptake inhibitor paroxetine. |
1996-11-27 |
2023-08-12 |
human |
| Y K Wing, E M Clifford, B D Sheehan, G M Campling, R A Hockney, P J Cowe. Paroxetine treatment and the prolactin response to sumatriptan. Psychopharmacology. vol 124. issue 4. 1996-11-25. PMID:8739554. |
we studied the effect of the selective serotonin re-uptake inhibitor (ssri), paroxetine (20 mg daily for 16 days) on the neuroendocrine, cardiovascular, thermic and subjective responses to the 5-ht1d receptor agonist, sumatriptan (6 mg, sc). |
1996-11-25 |
2023-08-12 |
Not clear |
| E L Barker, R D Blakel. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Molecular pharmacology. vol 50. issue 4. 1996-11-25. PMID:8863842. |
interactions with other sert antagonists, including paroxetine and cocaine, as well as the sert substrates 5-hydroxytryptamine and d-amphetamine were unaffected by interconversion of this residue. |
1996-11-25 |
2023-08-12 |
human |
| T Hori, T Suzuki, A Baba, S Abe, T Yamamoto, T Moroji, H Shiraish. Effects of phencyclidine metabolites on serotonin uptake in rat brain. Neuroscience letters. vol 209. issue 3. 1996-11-08. PMID:8736633. |
pcp and its metabolites inhibited the uptake of [3h]5-ht and the binding of [3h]paroxetine in rat brain, while they failed to inhibit either [3h]5-ht binding to 5-ht1 receptors or [3h]ketanserin binding to 5-ht2 receptors. |
1996-11-08 |
2023-08-12 |
rat |
| H J Chiu, C J Hong, C H Cha. Paroxetine in the treatment of Chinese patients with depressive episode: a double-blind randomized comparison with imipramine. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. vol 57. issue 6. 1996-10-24. PMID:8803304. |
paroxetine is a potent inhibitor of serotonin re-uptake. |
1996-10-24 |
2023-08-12 |
Not clear |
| L Ereshefsky, C Riesenman, Y W La. Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6. Clinical pharmacokinetics. vol 29 Suppl 1. 1996-10-24. PMID:8846618. |
the selective serotonin reuptake inhibitors (ssris) and venlafaxine display the following rank order of in vitro potency against the cytochrome p450 (cyp) isoenzyme cyp2d6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. |
1996-10-24 |
2023-08-12 |
Not clear |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
the ability of renzapride (100 microm, administered via the microdialysis probe) to elevate extracellular levels of 5-ht remained in the presence of the selective 5-ht reuptake blocker, paroxetine (1.0 microm, administered via the microdialysis probe). |
1996-10-10 |
2023-08-12 |
rat |
| P Bauman. Pharmacology and pharmacokinetics of citalopram and other SSRIs. International clinical psychopharmacology. vol 11 Suppl 1. 1996-10-09. PMID:8732438. |
citalopram together with fluoxetine, fluvoxamine, paroxetine and sertraline belong to the group of ssris, so named because of their pharmacological action as selective serotonin reuptake inhibitors in rat brain synaptosomes-their potency of inhibiting noradrenaline uptake is low and, from a clinical point of view, irrelevant. |
1996-10-09 |
2023-08-12 |
rat |
| S J Gatley, D Pan, R Chen, G Chaturvedi, Y S Din. Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters. Life sciences. vol 58. issue 12. 1996-09-20. PMID:8786705. |
ic50 values for binding these compounds to rat brain monoamine transporters were assessed using [3h]win 35,428 (striatal membranes, dopamine transporters, dat), [3h]nisoxetine (frontal cortex membranes, norepinephrine transporters, net) and [3h]paroxetine (brain stem membranes, 5ht transporters, 5htt). |
1996-09-20 |
2023-08-12 |
rat |
| D Zhou, G Huether, J Wiltfang, G Hajak, E Rüthe. Serotonin transporters in the rat frontal cortex: lack of circadian rhythmicity but down-regulation by food restriction. Journal of neurochemistry. vol 67. issue 2. 1996-09-19. PMID:8764592. |
by means of [3h]paroxetine binding to rat cortical membranes, we studied the influence of two physiological variables that are clearly associated with altered serotonergic activity--circadian rhythm and semistarvation--on k(d)and bmax values of the serotonin transporter of the rat frontal cortex. |
1996-09-19 |
2023-08-12 |
human |
| E V Gurevich, J N Joyc. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703300. |
comparison of [3h]paroxetine and [3h]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. |
1996-09-12 |
2023-08-12 |
human |
| E V Gurevich, J N Joyc. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703300. |
previous studies have demonstrated that [3h]paroxetine and [3h]cyanoimipramine ([3h]cn-imi) are highly selective ligands for the serotonin (5-ht) transporter. |
1996-09-12 |
2023-08-12 |
human |
| E V Gurevich, J N Joyc. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703300. |
using membrane preparation from the putamen, we confirmed that in human brain [3h]paroxetine labeled with high affinity one class of site associated with the 5-ht transporter. |
1996-09-12 |
2023-08-12 |
human |
| E V Gurevich, J N Joyc. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703300. |
however, [3h]paroxetine underestimated high concentrations of the 5-ht transporter comparing to [3h]cn-imi. |
1996-09-12 |
2023-08-12 |
human |
| E V Gurevich, J N Joyc. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703300. |
there is a good correlation between the regional distribution of 5-ht transporter sites labeled with either [3h]paroxetine or [3h]cn-imi and the density of serotonergic innervation. |
1996-09-12 |
2023-08-12 |
human |
| K Kobayashi, T Yamamoto, K Chiba, M Tani, T Ishizaki, Y Kuroiw. The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4'-hydroxylase activity in human liver microsomes. British journal of clinical pharmacology. vol 40. issue 5. 1996-09-12. PMID:8703653. |
the inhibitory effects of four selective serotonin reuptake inhibitors (ssris), fluoxetine, sertraline, paroxetine and citalopram, and three metabolites (norfluoxetine, demethylcitalopram and didemethylcitalopram), on s-mephenytoin 4'-hydroxylation activities in human liver microsomes were studied. |
1996-09-12 |
2023-08-12 |
human |