| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K D Hunter, W S Wilso. The effects of antidepressant drugs on salivary flow and content of sodium and potassium ions in human parotid saliva. Archives of oral biology. vol 40. issue 11. 1996-08-05. PMID:8670028. |
the saliva from patients using amitriptyline, dothiepin (tricyclics), fluoxetine and paroxetine (selective serotonin re-uptake inhibitors; ssri) was analysed for flow rate, [na+] and [k+], and was compared with that from unmedicated, non-depressed volunteers for all variables. |
1996-08-05 |
2023-08-12 |
human |
| T Kasahara, J Ishigooka, E Nagata, M Murasaki, S Miur. Long-lasting inhibition of 5-HT uptake of platelets in subjects treated by duloxetine, a potential antidepressant. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 16. issue 1. 1996-07-18. PMID:8640460. |
furthermore, a comparison was made by measuring parameters for serotonin uptake in vitro and [3h]paroxetine binding before and after administration. |
1996-07-18 |
2023-08-12 |
human |
| M Agnel, H Esnaud, S Z Langer, D Graha. Pharmacological characterization of the cloned human 5-hydroxytryptamine transporter. Biochemical pharmacology. vol 51. issue 9. 1996-07-15. PMID:8645336. |
the pharmacological profile of [3h]citalopram binding to these transfected cells showed a good correlation with that of [3h]paroxetine binding to the rat cerebral cortical 5-ht transporter (r = 0.79). |
1996-07-15 |
2023-08-12 |
human |
| G Piñeyro, P Blie. Regulation of 5-hydroxytryptamine release from rat midbrain raphe nuclei by 5-hydroxytryptamine1D receptors: effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration. The Journal of pharmacology and experimental therapeutics. vol 276. issue 2. 1996-07-03. PMID:8632339. |
in a third series of experiments, rats were treated for 21 days either with the selective 5-ht reuptake inhibitor paroxetine (10 mg/kg/day, s.c.) or the reversible type a monoamine oxidase inhibitor befloxatone (0.75 mg/kg/day, s.c.) and superfusion experiments were performed after a 48-hr washout period. |
1996-07-03 |
2023-08-12 |
rat |
| S A Montgomer. Efficacy in long-term treatment of depression. The Journal of clinical psychiatry. vol 57 Suppl 2. 1996-06-25. PMID:8626360. |
the serotonin selective reuptake inhibitors paroxetine, fluoxetine, sertraline, and citalopram, as well as nefazodone, a new antidepressant with a dual mechanism of action that is classified as a serotonin receptor modulator, are effective compared with placebo. |
1996-06-25 |
2023-08-12 |
Not clear |
| R A Dominguez, P J Goodnic. Adverse events after the abrupt discontinuation of paroxetine. Pharmacotherapy. vol 15. issue 6. 1996-05-09. PMID:8602387. |
paroxetine is an antidepressant of the selective serotonin reuptake inhibitor (ssri) class. |
1996-05-09 |
2023-08-12 |
Not clear |
| M el Mansari, C Bouchard, P Blie. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 2. 1996-04-25. PMID:8597523. |
since the delay of the maximal therapeutic effect of selective 5-ht reuptake inhibitors (ssri) is longer in ocd than in major depression and the terminal 5-ht autoreceptor is not desensitized in the guinea pig frontal cortex after 3 weeks of ssri administration, the effects of the ssri paroxetine (10 mg/kg/day) and fluoxetine (5 mg/kg/day) on 5-ht release and on the sensitivity of the terminal 5-ht autoreceptor were investigated in the guinea pig frontal cortex, the orbito-frontal cortex, and the head of caudate nucleus following a washout period after 3 and 8 weeks of treatment. |
1996-04-25 |
2023-08-12 |
Not clear |
| M el Mansari, C Bouchard, P Blie. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 2. 1996-04-25. PMID:8597523. |
in preloaded slices prepared from guinea pigs treated with paroxetine for 3 weeks, the electrically evoked release of [3h]5-ht release was enhanced in the frontal cortex (21%) but not in the orbito-frontal cortex or in the head of caudate nucleus. |
1996-04-25 |
2023-08-12 |
Not clear |
| M el Mansari, C Bouchard, P Blie. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 2. 1996-04-25. PMID:8597523. |
concentration-effect curves, constructed with the 5-ht autoreceptor agonist 5-methoxytryptamine, showed that the terminal 5-ht autoreceptor was desensitized only in the orbito-frontal cortex after 8 weeks of treatment with paroxetine. |
1996-04-25 |
2023-08-12 |
Not clear |
| M I Colado, A R Gree. The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. European journal of pharmacology. vol 280. issue 3. 1996-03-07. PMID:8566105. |
binding of [3h]paroxetine to the presynaptic 5-ht nerve terminals in cortex was decreased by approximately 30%. |
1996-03-07 |
2023-08-12 |
rat |
| M I Colado, A R Gree. The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. European journal of pharmacology. vol 280. issue 3. 1996-03-07. PMID:8566105. |
10 min prior and 120 min post mdma administration totally prevented the loss in [3h]paroxetine binding in the cortex and attenuated the loss of 5-ht and 5-hiaa in both brain regions. |
1996-03-07 |
2023-08-12 |
rat |
| M I Colado, A R Gree. The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. European journal of pharmacology. vol 280. issue 3. 1996-03-07. PMID:8566105. |
pbn alone had no effect on [3h]paroxetine binding or brain 5-ht content. |
1996-03-07 |
2023-08-12 |
rat |
| N Aguirre, J L Galbete, B Lasheras, J Del Rí. Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats. European journal of pharmacology. vol 281. issue 1. 1996-03-06. PMID:8566108. |
as expected, both schedules of treatment reduced the serotonin (5-hydroxytryptamine, 5-ht) content and [3h]paroxetine binding in the frontal cortex but not in the brain stem. |
1996-03-06 |
2023-08-12 |
rat |
| L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570030. |
serotonin turnover rate, [3h]paroxetine binding sites, and 5-ht1a receptors in the hippocampus of rats subchronically treated with clonazepam. |
1996-03-04 |
2023-08-12 |
rat |
| L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570030. |
the binding of [3h]paroxetine to 5-ht reuptake sites was increased by the treatment with clonazepam. |
1996-03-04 |
2023-08-12 |
rat |
| L H Brauer, M R Rukstalis, H de Wi. Acute subjective responses to paroxetine in normal volunteers. Drug and alcohol dependence. vol 39. issue 3. 1996-02-27. PMID:8556971. |
the purpose of this study was to compare the subjective effects of the selective serotonin reuptake inhibitor, paroxetine, to those of the prototypic stimulant, d-amphetamine. |
1996-02-27 |
2023-08-12 |
human |
| W Y Guo, K G Todd, M Bourin, M Hascoe. The additive effects of quinine on antidepressant drugs in the forced swimming test in mice. Psychopharmacology. vol 121. issue 2. 1996-02-14. PMID:8545522. |
when combined with quin, all drugs that act via inhibition of 5-ht uptake (imipramine, amitriptyline, citalopram, paroxetine, fluoxetine and fluvoxamine) significantly increased the swimming time of mice. |
1996-02-14 |
2023-08-12 |
mouse |
| R W Fulle. Serotonin uptake inhibitors: uses in clinical therapy and in laboratory research. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 45. 1996-02-13. PMID:8545537. |
fluoxetine, zimelidine, sertraline, paroxetine, fluvoxamine, indalpine and citalopram are the selective inhibitors of serotonin uptake that have been most widely studied. |
1996-02-13 |
2023-08-12 |
Not clear |
| M J Detke, M Rickels, I Luck. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology. vol 121. issue 1. 1996-02-07. PMID:8539342. |
the selective ne uptake inhibitors desipramine and maprotiline selectively increased climbing, whereas the selective serotonin reuptake inhibitors (ssris) fluoxetine, sertraline and paroxetine selectively increased swimming. |
1996-02-07 |
2023-08-12 |
rat |
| E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477436. |
electrophysiological and autoradiographic approaches were used to assess possible changes in 5-hydroxytryptamine (serotonin) 5-ht1a receptors in the rat dorsal raphe nucleus after a subchronic treatment with fluoxetine or paroxetine, two specific serotonin reuptake inhibitors with antidepressant properties. |
1995-12-27 |
2023-08-12 |
rat |