| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Bauman. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clinical pharmacokinetics. vol 31. issue 6. 1997-03-20. PMID:8968657. |
the recently introduced antidepressants, the selective serotonin reuptake inhibitors (ssris) [citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline], are known for their clinical efficacy, good tolerability and relative safety. |
1997-03-20 |
2023-08-12 |
human |
| P Robert, J M Senard, M Fabre, C Cabot, B Cathal. [Serotonin syndrome in acute poisoning with antidepressive agents]. Annales francaises d'anesthesie et de reanimation. vol 15. issue 5. 1997-03-19. PMID:9033760. |
we report a case of severe serotonin syndrome after self-poisoning with two antidepressant drugs, paroxetine (a selective inhibitor of serotonin reuptake) and moclobemide (a reversible inhibitor of mao-a). |
1997-03-19 |
2023-08-12 |
Not clear |
| C B Eap, P Bauman. Analytical methods for the quantitative determination of selective serotonin reuptake inhibitors for therapeutic drug monitoring purposes in patients. Journal of chromatography. B, Biomedical applications. vol 686. issue 1. 1997-03-18. PMID:8953192. |
five selective serotonin reuptake inhibitors (ssris) have been introduced recently: citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline. |
1997-03-18 |
2023-08-12 |
Not clear |
| N J Coupland, C J Bell, J P Potoka. Serotonin reuptake inhibitor withdrawal. Journal of clinical psychopharmacology. vol 16. issue 5. 1997-03-11. PMID:8889907. |
we studied reported withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective serotonin reuptake inhibitors (ssris), fluoxetine, fluvoxamine, paroxetine, or sertraline. |
1997-03-11 |
2023-08-12 |
Not clear |
| H S Lee, D H Song, C H Kim, H K Cho. An open clinical trial of fluoxetine in the treatment of premature ejaculation. Journal of clinical psychopharmacology. vol 16. issue 5. 1997-03-11. PMID:8889910. |
low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake blockers, have been found to retard ejaculation time. |
1997-03-11 |
2023-08-12 |
Not clear |
| M B Assié, W Koe. Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. British journal of pharmacology. vol 119. issue 5. 1997-03-10. PMID:8922730. |
to study the functional consequences of this property, the effects of 8-oh-dpat were compared with those of the 5-ht reuptake inhibitors, paroxetine and clomipramine, and of the 5-ht1a receptor agonist flesinoxan, in vitro on 5-ht reuptake, and in vivo on the extracellular concentration of 5-ht by use of microdialysis, in rat hippocampus. |
1997-03-10 |
2023-08-12 |
rat |
| M B Assié, W Koe. Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. British journal of pharmacology. vol 119. issue 5. 1997-03-10. PMID:8922730. |
because 5-ht reuptake inhibitors reportedly attenuate the ability of (+)-fenfluramine to increase the extracellular concentration of 5-ht, the possible reversal of these effects of 8-oh-dpat and by paroxetine were examined. |
1997-03-10 |
2023-08-12 |
rat |
| M B Assié, W Koe. Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. British journal of pharmacology. vol 119. issue 5. 1997-03-10. PMID:8922730. |
8-oh-dpat (10 and 100 microm), paroxetine (0.1 microm) and clomipramine (1 microm), administered through the dialysis probe, significantly increased the hippocampal extracellular concentration of 5-ht. |
1997-03-10 |
2023-08-12 |
rat |
| M B Assié, W Koe. Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. British journal of pharmacology. vol 119. issue 5. 1997-03-10. PMID:8922730. |
the increase in extracellular 5-ht induced by 10 mg kg-1, i.p., (+)-fenfluramine was prevented not only by 0.1 microm paroxetine, but also by 100 microm 8-oh-dpat. |
1997-03-10 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
consistent with its 5-ht reuptake blocking properties, single doses of the ssri paroxetine (1 and 3 mg/kg ip) and citalopram (1 mg/kg ip) significantly elevated extracellular 5-ht in the dorsal striatum. |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
pretreatment with (-)pindolol (15 mg/kg ip) potentiated the effect of 3 mg/kg paroxetine and 1 mg/kg citalopram on striatal extracellular 5-ht. |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
a 2-day treatment with 10 mg/kg/day (sc) of paroxetine reduced by 60% the spontaneous activity of 5-ht neurons of the drn. |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
however, 5-ht neurons displayed normal activity in rats treated with paroxetine and (-)pindolol for 2 days. |
1997-03-06 |
2023-08-12 |
rat |
| L John, M M Perreault, T Tao, P G Ble. Serotonin syndrome associated with nefazodone and paroxetine. Annals of emergency medicine. vol 29. issue 2. 1997-02-27. PMID:9018197. |
serotonin syndrome associated with nefazodone and paroxetine. |
1997-02-27 |
2023-08-12 |
Not clear |
| L John, M M Perreault, T Tao, P G Ble. Serotonin syndrome associated with nefazodone and paroxetine. Annals of emergency medicine. vol 29. issue 2. 1997-02-27. PMID:9018197. |
we believe this to be the first report of serotonin syndrome associated with nefazodone and paroxetine. |
1997-02-27 |
2023-08-12 |
Not clear |
| T A Slotkin, E C McCook, J C Ritchie, F J Seidle. Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological psychiatry. vol 40. issue 7. 1997-02-21. PMID:8886290. |
at the end of the infusion, we examined [3h]paroxetine binding to platelet, hippocampal, and cerebrocortical membranes, and [3h]serotonin uptake into platelets and synaptosomes. |
1997-02-21 |
2023-08-12 |
rat |
| M el Mansari, P Blie. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762094. |
following a 3-week treatment with the selective 5-ht reuptake inhibitor, paroxetine (10 mg kg-1 day-1) and a 48 h washout period, the electrically evoked release of [3h]-5-ht was enhanced in mesencephalic raphe, hippocampus and frontal cortex slices. |
1997-02-14 |
2023-08-12 |
Not clear |
| M el Mansari, P Blie. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762094. |
the enhancement of [3h]-5-ht release by long-term paroxetine treatment is possibly due to a desensitization of 5-ht1d autoreceptors activated by sumatriptan in mesencephalic raphe and by terminal 5-ht autoreceptors activated by 5-meot in hippocampus. |
1997-02-14 |
2023-08-12 |
Not clear |
| C A Glo. Recent advances in the pharmacotherapy of major depression. Archives of psychiatric nursing. vol 10. issue 6. 1997-02-12. PMID:8987206. |
this review highlights key features of several newer antidepressants: three selective serotonin reuptake inhibitors approved for major depression (fluoxetine [prozac, dista, indianapolis, in], sertraline [zoloft, roerig, new york, ny], and paroxetine [paxil, smithkline beecham, philadelphia, pa]), a serotonin-norepinephrine reuptake inhibitor venlafaxine (effexor, wyeth-ayerst, philadelphia, pa), and nefazodone (serzone, bristol-myers squibb, princeton, nj). |
1997-02-12 |
2023-08-12 |
Not clear |
| L K Lair. Issues in the monopharmacotherapy and polypharmacotherapy of obsessive-compulsive disorder. Psychopharmacology bulletin. vol 32. issue 4. 1997-02-12. PMID:8993077. |
presently, the highly potent serotonin reuptake inhibitors clomipramine, fluoxetine, fluvoxamine, and paroxetine are the only agents approved by the food and drug administration (fda) for ocd, but there is evidence that other sris, such as sertraline, are also effective. |
1997-02-12 |
2023-08-12 |
Not clear |