| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Maurel, R Schreiber, J De Vr. Substitution of the selective serotonin reuptake inhibitors fluoxetine and paroxetine for the discriminative stimulus effects of ethanol in rats. Psychopharmacology. vol 130. issue 4. 1997-08-12. PMID:9160858. |
rats trained to discriminate ethanol (etoh, 1 g/kg ip) from saline in a two-lever procedure completely generalized to the selective serotonin reuptake inhibitors (ssris) fluoxetine and paroxetine. |
1997-08-12 |
2023-08-12 |
rat |
| K M Lawrence, F De Paermentier, S Lowther, M R Crompton, C L Katona, R W Horto. Brain 5-hydroxytryptamine uptake sites labeled with [3H]paroxetine in antidepressant drug-treated depressed suicide victims and controls. Journal of psychiatry & neuroscience : JPN. vol 22. issue 3. 1997-08-07. PMID:9183117. |
brain 5-hydroxytryptamine uptake sites labeled with [3h]paroxetine in antidepressant drug-treated depressed suicide victims and controls. |
1997-08-07 |
2023-08-12 |
Not clear |
| L Garreau, P Emond, C Belzung, D Guilloteau, Y Frangin, J C Besnard, S Chalo. N-(3-lodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(3',4'-dichloro phenyl)nortropane (beta-CDIT), a tropane derivative: pharmacological characterization as a specific ligand for the dopamine transporter in the rodent brain. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223589. |
in addition, competition studies in cerebral cortex regions with [3h]paroxetine and [3h]nisoxetine showed a very low affinity of beta-cdit for the 5-hydroxytryptamine (ki = 50 nm) and norepinephrine (ki = 500 nm) transporters compared with beta-cit (corresponding ki values were 3 and 80 nm). |
1997-08-07 |
2023-08-12 |
mouse |
| S Schreiber, C G Pic. Paroxetine for secondary stuttering: further interaction of serotonin and dopamine. The Journal of nervous and mental disease. vol 185. issue 7. 1997-08-06. PMID:9240367. |
paroxetine for secondary stuttering: further interaction of serotonin and dopamine. |
1997-08-06 |
2023-08-12 |
Not clear |
| C Roberts, G W Price, B J Jone. The role of 5-HT(1B/1D) receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European journal of pharmacology. vol 326. issue 1. 1997-08-05. PMID:9178651. |
in addition, extracellular 5-ht levels were lowered by the 5-ht(1b/1d) receptor agonist, sumatriptan, and the 5-ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, while perfusion of the selective serotonin re-uptake inhibitor, paroxetine, increased 5-ht in a concentration-dependent manner. |
1997-08-05 |
2023-08-12 |
Not clear |
| G Huether, D Zhou, S Schmidt, J Wiltfang, E Rüthe. Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex. Biological psychiatry. vol 41. issue 12. 1997-07-31. PMID:9171908. |
the influence of feeding rats only half the amount of their normal daily intake of a complete rat chow on the affinity and the density of serotonin (5-ht) transporters was measured in membrane preparations of the frontal cortex and the midbrain by a [3h]paroxetine binding assay. |
1997-07-31 |
2023-08-12 |
rat |
| G Huether, D Zhou, S Schmidt, J Wiltfang, E Rüthe. Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex. Biological psychiatry. vol 41. issue 12. 1997-07-31. PMID:9171908. |
the affinity of the 5-ht transporters, as indicated by the unchanged kd values of [3h]paroxetine binding, was not affected by semistarvation in both regions and at both ages. |
1997-07-31 |
2023-08-12 |
rat |
| G Huether, D Zhou, S Schmidt, J Wiltfang, E Rüthe. Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex. Biological psychiatry. vol 41. issue 12. 1997-07-31. PMID:9171908. |
the observed decline of [3h]paroxetine binding sites in the frontal cortex of young adult rats is the first demonstration of long-term regulatory phenomena of brain 5-ht transporters triggered by a physiologic stimulus. |
1997-07-31 |
2023-08-12 |
rat |
| O Benkert, A Szegedi, H Wetzel, H J Staab, W Meister, M Philip. Dose escalation vs. continued doses of paroxetine and maprotiline: a prospective study in depressed out-patients with inadequate treatment response. Acta psychiatrica Scandinavica. vol 95. issue 4. 1997-07-29. PMID:9150822. |
in view of the fact that controlled prospective studies on the benefits of dose escalation of the selective serotonin re-uptake inhibitor (ssri) paroxetine are lacking, we conducted a double-blind, randomized, parallel-group multicentre study designed to compare the possible benefits of dose escalation of paroxetine and maprotiline in patients suffering from major or minor depression according to modified research diagnostic criteria (rdc) with inadequate treatment response. |
1997-07-29 |
2023-08-12 |
Not clear |
| A Ramaiya, H T Karne. Simultaneous measurement of serotonin and paroxetine in rat brain microdialysate by a single-pump column-switching technique. Journal of chromatography. B, Biomedical sciences and applications. vol 691. issue 1. 1997-07-18. PMID:9140765. |
simultaneous measurement of serotonin and paroxetine in rat brain microdialysate by a single-pump column-switching technique. |
1997-07-18 |
2023-08-12 |
rat |
| A Ramaiya, H T Karne. Simultaneous measurement of serotonin and paroxetine in rat brain microdialysate by a single-pump column-switching technique. Journal of chromatography. B, Biomedical sciences and applications. vol 691. issue 1. 1997-07-18. PMID:9140765. |
simultaneous quantitation of paroxetine and serotonin in rat brain microdialysate is presented as a means to study the neuropharmacokinetics and neuropharmacodynamics of paroxetine, a selective serotonin reuptake inhibitor. |
1997-07-18 |
2023-08-12 |
rat |
| A Ramaiya, H T Karne. Simultaneous measurement of serotonin and paroxetine in rat brain microdialysate by a single-pump column-switching technique. Journal of chromatography. B, Biomedical sciences and applications. vol 691. issue 1. 1997-07-18. PMID:9140765. |
the limits of detection for serotonin and paroxetine were 6 fmol and 300 fmol, respectively. |
1997-07-18 |
2023-08-12 |
rat |
| J L Elmore, J T Quattlebau. Female sexual stimulation during antidepressant treatment. Pharmacotherapy. vol 17. issue 3. 1997-07-15. PMID:9165567. |
three women with several diagnoses, including depression and psychosis, personality disorder, attention deficit hyperactivity disorder, alcohol abuse, and physical disease, were treated with selective serotonin reuptake inhibitors (fluoxetine, paroxetine, fluvoxamine). |
1997-07-15 |
2023-08-12 |
Not clear |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
antidepressants which block 5-ht uptake (paroxetine, clomipramine, amitriptyline, venlafaxine), all caused dose-dependent and complete inhibition of 5-ht cell firing. |
1997-07-07 |
2023-08-12 |
Not clear |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
the selective 5-ht1a receptor antagonist, way 100635, reversed the inhibition of 5-ht cell firing induced by clomipramine, amitriptyline, venlafaxine, and paroxetine, but not that induced by the alpha 1 adrenoceptor antagonist, prazosin. |
1997-07-07 |
2023-08-12 |
Not clear |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
desipramine, at a dose which increased extracellular na in the drn, reversed the effect of prazosin but did not alter the ability of paroxetine to inhibit 5-ht cell firing. |
1997-07-07 |
2023-08-12 |
Not clear |
| R Davis, R Whittington, H M Bryso. Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs. vol 53. issue 4. 1997-06-30. PMID:9098663. |
in short term clinical trials of 6 or 8 weeks' duration, nefazodone produced clinical improvements that were significantly greater than those with placebo and similar to those achieved with imipramine, and the selective serotonin reuptake inhibitors (ssris) fluoxetine, paroxetine and sertraline. |
1997-06-30 |
2023-08-12 |
Not clear |
| P Emond, S Chalon, L Garreau, A M Dognon, S Bodard, Y Frangin, J L Baulieu, J C Besnard, D Guillotea. A new iodinated tropane derivative (beta-CDIT) for in vivo dopamine transporter exploration: comparison with beta-CIT. Synapse (New York, N.Y.). vol 26. issue 1. 1997-06-27. PMID:9097407. |
in contrast, competition studies with [3h]paroxetine and [3h]nisoxetine showed that beta-cdit had a lower affinity for the serotonin transporter than beta-cit (ki = 50 and 3 nm, respectively) and also a lower affinity for the noradrenaline transporter than beta-cit (ki = 500 and 80 nm, respectively). |
1997-06-27 |
2023-08-12 |
rat |
| P Blier, R Bergeron, C de Montign. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 5. 1997-06-27. PMID:9109104. |
it has been reported that the 5-ht1a autoreceptor antagonist pindolol can accelerate the antidepressant response to the selective serotonin (5-ht) reuptake inhibitor (ssri) paroxetine, presumably by preventing the initial decrease in firing activity of 5-ht neurons produced by the ssri. |
1997-06-27 |
2023-08-12 |
Not clear |
| K Tokarski, M Bija. Antidepressant-induced adaptive changes in the effects of 5-HT, 5-HT1A and 5-HT4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission. Polish journal of pharmacology. vol 48. issue 6. 1997-06-26. PMID:9112695. |
repeated treatment (14 days, twice daily, 10 mg/kg po) with imipramine and paroxetine augmented the inhibitory action of 5-ht on the population spike (by 50%), whereas treatment with citalopram and fluvoxamine had no effect. |
1997-06-26 |
2023-08-12 |
rat |