| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Alderman, S H Preskorn, D J Greenblatt, W Harrison, D Penenberg, J Allison, M Chun. Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers. Journal of clinical psychopharmacology. vol 17. issue 4. 1997-09-22. PMID:9241008. |
the pharmacokinetics of desipramine when coadministered with the selective serotonin reuptake inhibitors (ssris) paroxetine and sertraline were studied in 24 healthy male volunteers (cyp2d6 extensive metabolizers). |
1997-09-22 |
2023-08-12 |
human |
| A C Egberts, J ter Borgh, C C Brodie-Meije. Serotonin syndrome attributed to tramadol addition to paroxetine therapy. International clinical psychopharmacology. vol 12. issue 3. 1997-09-22. PMID:9248876. |
serotonin syndrome attributed to tramadol addition to paroxetine therapy. |
1997-09-22 |
2023-08-12 |
Not clear |
| S E Ball, D Ahern, J Scatina, J Ka. Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2. British journal of clinical pharmacology. vol 43. issue 6. 1997-09-19. PMID:9205822. |
the data obtained were compared with the selective serotonin re-uptake inhibitors, fluoxetine, sertraline, fluvoxamine and paroxetine. |
1997-09-19 |
2023-08-12 |
human |
| M Suehiro, U A Scheffel, H T Ravert, G A Ricaurte, G Hatzidimitriou, R F Dannals, K P Bøgesø, H N Wagne. Highly potent indanamine serotonin uptake blockers as radiotracers for imaging serotonin uptake sites. Nuclear medicine and biology. vol 21. issue 8. 1997-09-18. PMID:9234366. |
in vitro, the iodo analog, trans-dipi, showed an ic50 value of 0.26 nm in inhibition of [3h]paroxetine binding to 5-ht uptake sites in rat cortex. |
1997-09-18 |
2023-08-12 |
mouse |
| T Singletary, D S North, M Weiss, G Marma. A cost-effective approach to the use of selective serotonin reuptake inhibitors in a Veterans Affairs Medical Center. The American journal of managed care. vol 3. issue 1. 1997-09-16. PMID:10169244. |
in light of the tremendous expansion in the number of selective serotonin reuptake inhibitors available to the clinician, the pharmacy and therapeutics committee of the denver veterans affairs medical center considered the advantages and disadvantages of fluoxethine, paroxetine, and sertraline, to determine which agent or agents would be carried on the formulary. |
1997-09-16 |
2023-08-12 |
Not clear |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
the selective 5-ht reuptake inhibitor, paroxetine (0.8 mg kg-1, i.v. |
1997-09-15 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
without paroxetine, had no effect on extracellular 5-ht in the frontal cortex. |
1997-09-15 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
despite the lack of effect of gr127935 on 5-ht under basal conditions, when 5-ht output was elevated about 3 fold (by adding 1 microm paroxetine to the perfusion medium), the drug caused a dose-related (1 and 5 mg kg-1, i.v.) |
1997-09-15 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
), but did not prevent the inhibition of 5-ht cell firing induced by paroxetine. |
1997-09-15 |
2023-08-12 |
rat |
| K Tokarski, A Czyrak, M Maćkowiak, K Wedzony, M Bija. Prolonged treatment with antidepressants increases the 5-HT1A-mediated inhibition of hippocampal neurons without changing the 5-HT1A receptor binding. Acta physiologica Hungarica. vol 84. issue 3. 1997-09-05. PMID:9219632. |
the effect of repeated treatment with antidepressant drugs imipramine, (+)oxaprotiline and paroxetine on neuronal responsiveness to 5-ht and the 5-ht1a receptor agonist 8-oh-dpat was examined in the hippocampal slice preparation from the rat. |
1997-09-05 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Brain research bulletin. vol 43. issue 4. 1997-09-05. PMID:9241443. |
synergism of 5-ht 1b/d antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. |
1997-09-05 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Brain research bulletin. vol 43. issue 4. 1997-09-05. PMID:9241443. |
paroxetine (100 nm), a selective serotonin reuptake inhibitor (ssri), increased stimulated 5-ht efflux to 194 +/- 25% of pre-drug values at maximum (mean +/- sem, n = 5) and the half-life of uptake to 684 +/- 135%. |
1997-09-05 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Brain research bulletin. vol 43. issue 4. 1997-09-05. PMID:9241443. |
when added in combination with paroxetine, both isamoltane and gr 127935 significantly potentiated the effect of paroxetine on stimulated 5-ht efflux: isamoltane to 302 +/- 48% at maximum (p < 0.05 vs. paroxetine alone), gr 127935 to 318 +/- 95% (p < 0.05 vs. paroxetine alone) of pre-drug values. |
1997-09-05 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Brain research bulletin. vol 43. issue 4. 1997-09-05. PMID:9241443. |
the selective 5-ht 1a antagonist way 100635 (10 nm) had no effect on 5-ht efflux or uptake, alone or in combination with paroxetine. |
1997-09-05 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Brain research bulletin. vol 43. issue 4. 1997-09-05. PMID:9241443. |
these data suggest that, under these experimental conditions, paroxetine gives rise to tonic activation of the vlgn terminal 5-ht autoreceptors. |
1997-09-05 |
2023-08-12 |
rat |
| D F Smith, P N Jensen, A D Gee, S B Hansen, E Danielsen, F Andersen, P A Saiz, A Gjedd. PET neuroimaging with [11C]venlafaxine: serotonin uptake inhibition, biodistribution and binding in living pig brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7. issue 3. 1997-09-02. PMID:9213078. |
venlafaxine resembled imipramine, paroxetine and citalopram in causing a dose-dependent inhibition of 5-ht uptake in blood platelets from pigs and humans. |
1997-09-02 |
2023-08-12 |
Not clear |
| T Sobanski, M Bagli, G Laux, M L Ra. Serotonin syndrome after lithium add-on medication to paroxetine. Pharmacopsychiatry. vol 30. issue 3. 1997-08-27. PMID:9211572. |
serotonin syndrome after lithium add-on medication to paroxetine. |
1997-08-27 |
2023-08-12 |
Not clear |
| T Sobanski, M Bagli, G Laux, M L Ra. Serotonin syndrome after lithium add-on medication to paroxetine. Pharmacopsychiatry. vol 30. issue 3. 1997-08-27. PMID:9211572. |
on a combination of lithium (400 mg/day) and paroxetine (30 mg/day) she developed symptoms of shivering, high-frequency tremor of the upper and lower limbs, skin flush in the face, agitation, and slight impairment of mental focusing, suggestive of a serotonin syndrome. |
1997-08-27 |
2023-08-12 |
Not clear |
| I A Meynaar, A J Peeters, A H Mulder, J P Ottervange. Syndrome of inappropriate ADH secretion attributed to the serotonin re-uptake inhibitors, venlafaxine and paroxetine. The Netherlands journal of medicine. vol 50. issue 6. 1997-08-19. PMID:9232089. |
syndrome of inappropriate adh secretion attributed to the serotonin re-uptake inhibitors, venlafaxine and paroxetine. |
1997-08-19 |
2023-08-12 |
Not clear |
| S Maurel, R Schreiber, J De Vr. Substitution of the selective serotonin reuptake inhibitors fluoxetine and paroxetine for the discriminative stimulus effects of ethanol in rats. Psychopharmacology. vol 130. issue 4. 1997-08-12. PMID:9160858. |
substitution of the selective serotonin reuptake inhibitors fluoxetine and paroxetine for the discriminative stimulus effects of ethanol in rats. |
1997-08-12 |
2023-08-12 |
rat |