| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ishigooka, T Kasahara, E Nagata, M Murasaki, S Miur. Effects of washing procedure on platelets pretreated with serotonin uptake inhibitors in vitro: low Ki values predict long-lasting inhibition of serotonin uptake in vivo. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 18. issue 1. 1998-07-22. PMID:9592808. |
among the drugs tested, those with low ki values, such as clomipramine, duloxetine and paroxetine, inhibited 5-ht uptake even after removal from the medium, while those with high ki values such as amitriptyline, desipramine, imipramine, mianserin, trazodone, and zimelidine were easily removed by washing. |
1998-07-22 |
2023-08-12 |
human |
| J G Rella, R S Hoffma. Possible serotonin syndrome from paroxetine and clonazepam. Journal of toxicology. Clinical toxicology. vol 36. issue 3. 1998-07-22. PMID:9656985. |
possible serotonin syndrome from paroxetine and clonazepam. |
1998-07-22 |
2023-08-12 |
Not clear |
| G J Moore, F P MacMaster, C Stewart, D R Rosenber. Case study: caudate glutamatergic changes with paroxetine therapy for pediatric obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 37. issue 6. 1998-07-09. PMID:9628087. |
ocd symptoms improved markedly in a 9-year-old boy treated with paroxetine, a selective serotonin reuptake inhibitor, for whom pre/posttreatment proton magnetic resonance spectroscopic examinations were acquired to assess the relationship between neurochemical profile in the caudate nucleus, symptom severity, and treatment with paroxetine. |
1998-07-09 |
2023-08-12 |
Not clear |
| P A Davanzo, T R Belin, M H Widawski, B H Kin. Paroxetine treatment of aggression and self-injury in persons with mental retardation. American journal of mental retardation : AJMR. vol 102. issue 5. 1998-06-15. PMID:9544340. |
an open, prospective assessment of the treatment of severe aggression and self-injurious behavior (sib) with paroxetine, a serotonin re-uptake inhibitor, in 15 institutionalized persons with mental retardation was undertaken. |
1998-06-15 |
2023-08-12 |
Not clear |
| C Gundlah, L D Simon, S B Auerbac. Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study. Brain research. vol 785. issue 1. 1998-05-29. PMID:9526054. |
the aim of the present study was to assess whether there are gender differences in (1) levels of extracellular serotonin (5-ht) in the forebrain, and (2) the effect on 5-ht of a reuptake inhibitor, paroxetine, or a releasing drug, fenfluramine. |
1998-05-29 |
2023-08-12 |
rat |
| C Gundlah, L D Simon, S B Auerbac. Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study. Brain research. vol 785. issue 1. 1998-05-29. PMID:9526054. |
paroxetine (1 mg/kg) increased hypothalamic 5-ht in males, and diestrous and estrous females to approximately 2 pg/sample. |
1998-05-29 |
2023-08-12 |
rat |
| C Gundlah, L D Simon, S B Auerbac. Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study. Brain research. vol 785. issue 1. 1998-05-29. PMID:9526054. |
however, the increase in hypothalamic 5-ht produced by a maximally effective dose of paroxetine (10 mg/kg) was significantly greater in male rats and during diestrous than during estrous. |
1998-05-29 |
2023-08-12 |
rat |
| L Lima, M Urbin. Serotonergic projections to the retina of rat and goldfish. Neurochemistry international. vol 32. issue 2. 1998-05-19. PMID:9542725. |
the binding of [3h]paroxetine, a marker of serotonin transporter, was reduced in the retina of both species after the central treatment with the neurotoxic substance. |
1998-05-19 |
2023-08-12 |
mouse |
| J H Thakore, C Barnes, J Joyce, S Medbak, T G Dina. Effects of antidepressant treatment on corticotropin-induced cortisol responses in patients with melancholic depression. Psychiatry research. vol 73. issue 1-2. 1998-05-11. PMID:9463836. |
patients were then randomised to receive either 50 mg of sertraline or 20 mg of paroxetine (both of which are selective serotonin re-uptake inhibitors) and were re-tested while medication-free. |
1998-05-11 |
2023-08-12 |
human |
| B Dean, A Pereira, G Pavey, B Sing. Repeated antidepressant drug treatment, time of death and frequency of handling do not affect [3H]paroxetine binding in rat cortex. Psychiatry research. vol 73. issue 3. 1998-04-30. PMID:9481808. |
[3h]paroxetine binding to the serotonin transporter has been shown to be altered in brain tissue from schizophrenic subjects. |
1998-04-30 |
2023-08-12 |
human |
| R B Rothman, M L Silverthorn, J R Glowa, D Matecka, K C Rice, F I Carroll, J S Partilla, G R Uhl, D J Vandenbergh, C M Dersc. Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517841. |
quantitative ligand binding studies revealed a novel high affinity [125i]rti-55 binding site assayed under 5-ht transporter (sert) conditions which has low affinity for almost all classic biogenic amine transporter ligands, including high affinity 5-ht transporter inhibitors such as paroxetine, but which retains high affinity for cocaine analogs. |
1998-04-30 |
2023-08-12 |
human |
| P A Sargent, D J Williamson, P J Cowe. Brain 5-HT neurotransmission during paroxetine treatment. The British journal of psychiatry : the journal of mental science. vol 172. 1998-04-29. PMID:9534832. |
brain 5-ht neurotransmission during paroxetine treatment. |
1998-04-29 |
2023-08-12 |
Not clear |
| R J Verkes, R C Van der Mast, M W Hengeveld, J P Tuyl, A H Zwinderman, G M Van Kempe. Reduction by paroxetine of suicidal behavior in patients with repeated suicide attempts but not major depression. The American journal of psychiatry. vol 155. issue 4. 1998-04-22. PMID:9546002. |
because selective serotonin reuptake inhibitors (ssris) enhance serotonergic function, the authors studied the efficacy of an ssri, paroxetine, in the prevention of recurrent suicidal behavior. |
1998-04-22 |
2023-08-12 |
Not clear |
| V Uzunova, Y Sheline, J M Davis, A Rasmusson, D P Uzunov, E Costa, A Guidott. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 6. 1998-04-10. PMID:9501247. |
we recently reported that fluoxetine or paroxetine, two selective serotonin reuptake inhibitors (ssris), when administered to rats, increase the brain content of the neurosteroid 3alpha-hydroxy-5alpha-pregnane-20-one (3alpha5alpha-allo) without altering the brain content of other neurosteroids. |
1998-04-10 |
2023-08-12 |
human |
| H Wetzel, I Anghelescu, A Szegedi, J Wiesner, H Weigmann, S Härter, C Hiemk. Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472836. |
pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study. |
1998-04-02 |
2023-08-12 |
Not clear |
| H Wetzel, I Anghelescu, A Szegedi, J Wiesner, H Weigmann, S Härter, C Hiemk. Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472836. |
pharmacokinetic interactions of clozapine and its metabolites n-desmethylclozapine and clozapine n-oxide with the selective serotonin reuptake inhibitors (ssris) fluvoxamine and paroxetine were investigated in a prospective study in schizophrenic patients under steady-state conditions. |
1998-04-02 |
2023-08-12 |
Not clear |
| A J Elliott, K K Uldall, K Bergam, J Russo, K Claypoole, P P Roy-Byrn. Randomized, placebo-controlled trial of paroxetine versus imipramine in depressed HIV-positive outpatients. The American journal of psychiatry. vol 155. issue 3. 1998-03-27. PMID:9501747. |
this study examined whether a selective serotonin reuptake inhibitor (paroxetine) had comparable efficacy but greater tolerability than a tricyclic antidepressant (imipramine) in depressed patients with hiv infection. |
1998-03-27 |
2023-08-12 |
Not clear |
| K E McGrath, F J Seidler, T A Slotki. Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Brain research. Developmental brain research. vol 104. issue 1-2. 1998-03-20. PMID:9466725. |
in this study, expression of the serotonin presynaptic transporter protein, which regulates the extracellular serotonin concentration, was measured with [3h]paroxetine in rats exposed to dexamethasone or cocaine prenatally. |
1998-03-20 |
2023-08-12 |
rat |
| M A Bunin, C Prioleau, R B Mailman, R M Wightma. Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489728. |
autoradiography using [3h]paroxetine revealed highest 5-ht transporter binding densities in the regions in which voltammetric measurements were made. |
1998-03-12 |
2023-08-12 |
rat |
| K I Keverline-Frantz, J W Boja, M J Kuhar, P Abraham, J P Burgess, A H Lewin, F I Carrol. Synthesis and ligand binding of tropane ring analogues of paroxetine. Journal of medicinal chemistry. vol 41. issue 2. 1998-03-06. PMID:9457247. |
(3s,4r)-4-(4-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl] piperidine [(3s,9r)-3, paroxetine] is a selective serotonin reuptake inhibitor (ssri) used as an antidepressant in humans. |
1998-03-06 |
2023-08-12 |
Not clear |