| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Ballenge. Comorbidity of panic and depression: implications for clinical management. International clinical psychopharmacology. vol 13 Suppl 4. 1998-10-28. PMID:9690960. |
since treatment of panic attacks with an appropriate selective serotonin reuptake inhibitor such as paroxetine not only significantly reduces panic symptoms, but also alleviates comorbid anxiety and depression, a simple, yet effective, approach in the primary care setting may be to look for panic attacks and to treat sufferers with this class of antidepressants. |
1998-10-28 |
2023-08-12 |
Not clear |
| U Hegerl, R Bottlender, J Gallinat, H J Kuss, M Ackenheil, H J Mölle. The serotonin syndrome scale: first results on validity. European archives of psychiatry and clinical neuroscience. vol 248. issue 2. 1998-10-22. PMID:9684919. |
in a first study on the validity of this scale, the relationships between the serotonin syndrome score (sss) and both the paroxetine plasma levels (n = 42) and the loudness dependence of the auditory evoked potentials (ldaep; n = 24) were investigated in depressed patients treated with paroxetine. |
1998-10-22 |
2023-08-12 |
Not clear |
| Z Zylicz, C Smits, M Krajni. Paroxetine for pruritus in advanced cancer. Journal of pain and symptom management. vol 16. issue 2. 1998-10-22. PMID:9737103. |
we describe five patients suffering from pruritus of different etiologies who responded rapidly to administration of paroxetine, a serotonin reuptake inhibitor, in a dose-dependent manner. |
1998-10-22 |
2023-08-12 |
Not clear |
| W D Hirst, G W Price, M Rattray, G P Wilki. Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles. Neurochemistry international. vol 33. issue 1. 1998-10-09. PMID:9694037. |
cultured astrocytes derived from neonatal rat brain exhibited high affinity, na+-dependent, paroxetine and fluoxetine sensitive [3h]5-ht uptake. |
1998-10-09 |
2023-08-12 |
rat |
| C J McDougle, C N Epperson, L H Price, J Gelernte. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672904. |
for treatment of ocd, potent serotonin reuptake inhibitor (sri) drugs (clomipramine (anafranil), fluvoxamine (luvox), fluoxetine (prozac), sertraline (zoloft), and paroxetine (paxil)), which act on the serotonin transporter protein, are uniquely efficacious. |
1998-10-08 |
2023-08-12 |
Not clear |
| M S Lantz, E N Buchalter, V Giambanc. Serotonin syndrome following the administration of tramadol with paroxetine. International journal of geriatric psychiatry. vol 13. issue 5. 1998-10-06. PMID:9658268. |
serotonin syndrome following the administration of tramadol with paroxetine. |
1998-10-06 |
2023-08-12 |
Not clear |
| A Graudins, A Stearman, B Cha. Treatment of the serotonin syndrome with cyproheptadine. The Journal of emergency medicine. vol 16. issue 4. 1998-10-06. PMID:9696181. |
all patients gave a history of recent exposure to one or more serotonergic medications, including moclobemide, paroxetine, sertraline, and venlafaxine, with clinical evidence of serotonin syndrome. |
1998-10-06 |
2023-08-12 |
Not clear |
| D Dunner, R Kuma. Paroxetine: a review of clinical experience. Pharmacopsychiatry. vol 31. issue 3. 1998-09-17. PMID:9657236. |
the selective serotonin reuptake inhibitor paroxetine has been extensively studied and is now an established therapy for the treatment of depressive disorders. |
1998-09-17 |
2023-08-12 |
Not clear |
| Y Figueroa, D R Rosenberg, B Birmaher, M S Keshava. Combination treatment with clomipramine and selective serotonin reuptake inhibitors for obsessive-compulsive disorder in children and adolescents. Journal of child and adolescent psychopharmacology. vol 8. issue 1. 1998-09-16. PMID:9639080. |
medication management of obsessive-compulsive disorder (ocd) has consisted of monotherapy with either clomipramine (cmi) or selective serotonin reuptake inhibitors (ssris) such as fluvoxamine, paroxetine, or sertraline. |
1998-09-16 |
2023-08-12 |
Not clear |
| C Roberts, A Belenguer, D N Middlemiss, C Routledg. Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe innervated brain regions. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652357. |
paroxetine produced a small but non-significant increase in extracellular 5-ht in the frontal cortex, and a small decrease in the dentate gyrus. |
1998-09-16 |
2023-08-12 |
Not clear |
| C Roberts, A Belenguer, D N Middlemiss, C Routledg. Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe innervated brain regions. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652357. |
the lack of effect of paroxetine in terminal areas may be due to the limiting effects of cell body 5-ht autoreceptors. |
1998-09-16 |
2023-08-12 |
Not clear |
| J C Béïque, N Lavoie, C de Montigny, G Debonne. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. European journal of pharmacology. vol 349. issue 1. 1998-09-14. PMID:9669506. |
the selective 5-ht reuptake inhibitors paroxetine, indalpine and fluvoxamine displayed a high affinity for the 5-ht transporter, whereas the norepinephrine reuptake inhibitor desipramine had a high affinity for the norepinephrine transporter. |
1998-09-14 |
2023-08-12 |
rat |
| E Richelso. Pharmacokinetic interactions of antidepressants. The Journal of clinical psychiatry. vol 59 Suppl 10. 1998-08-28. PMID:9720479. |
seven of the newest antidepressants are the serotonin selective reuptake inhibitors (fluoxetine, sertraline, paroxetine, and fluvoxamine [currently approved in the united states for obsessive-compulsive disorder only]), a serotonin norepinephrine reuptake inhibitor (venlafaxine), a postsynaptic serotonin antagonist/presynaptic serotonin reuptake inhibitor (nefazodone), and presynaptic/postsynaptic noradrenergic/serotonergic receptor antagonist (mirtazapine). |
1998-08-28 |
2023-08-12 |
Not clear |
| J A den Boe. Pharmacotherapy of panic disorder: differential efficacy from a clinical viewpoint. The Journal of clinical psychiatry. vol 59 Suppl 8. 1998-08-24. PMID:9707160. |
an extensive database is available for the tricyclic antidepressants imipramine and clomipramine, the serotonin selective reuptake inhibitor paroxetine, and the benzodiazepine alprazolam. |
1998-08-24 |
2023-08-12 |
Not clear |
| D Marazziti, A Rossi, G Giannaccini, S Baroni, A Lucacchini, G B Cassan. Presence and characterization of the serotonin transporter in human resting lymphocytes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 2. 1998-08-21. PMID:9629569. |
the most potent drugs inhibiting [3h]par binding were ssris (paroxetine, fluoxetine, citalopram) followed by clomipramine, imipramine, and 5-ht, whereas haloperidol, mazindol, and nomifensine had a negligible effect. |
1998-08-21 |
2023-08-12 |
human |
| M Bourin, M C Colombel, J P Redrobe, J Nizard, M Hascoët, G B Bake. Evaluation of efficacies of different classes of antidepressants in the forced swimming test in mice at different ages. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 2. 1998-08-11. PMID:9608606. |
the selective serotonin reuptake inhibitors (ssris) citalopram (16 and 32 mg) and paroxetine (4 and 8 mg) were inactive in the oldest (40 weeks) group of mice, despite showing activity at the same doses in mice ranging in age from 4-24 weeks old. |
1998-08-11 |
2023-08-12 |
mouse |
| C B Eap, G Bouchoux, M Amey, N Cochard, L Savary, P Bauman. Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography-mass spectrometry. Journal of chromatographic science. vol 36. issue 7. 1998-08-10. PMID:9679303. |
a gas chromatography-mass spectrometry method is presented which allows the simultaneous determination of the plasma concentrations of the selective serotonin reuptake inhibitors citalopram, paroxetine, sertraline, and their pharmacologically active n-demethylated metabolites (desmethylcitalopram, didesmethylcitalopram, and desmethylsertraline) after derivatization with the reagent n-methyl-bis(trifluoroacetamide). |
1998-08-10 |
2023-08-12 |
human |
| R J Verkes, R C Van der Mast, A J Kerkhof, D Fekkes, M W Hengeveld, J P Tuyl, G M Van Kempe. Platelet serotonin, monoamine oxidase activity, and [3H]paroxetine binding related to impulsive suicide attempts and borderline personality disorder. Biological psychiatry. vol 43. issue 10. 1998-08-04. PMID:9606528. |
platelet serotonin, monoamine oxidase activity, and [3h]paroxetine binding related to impulsive suicide attempts and borderline personality disorder. |
1998-08-04 |
2023-08-12 |
Not clear |
| O Spigset, P Allard, T Mjörnda. Circannual variations in the binding of [3H]lysergic acid diethylamide to serotonin2A receptors and of [3H]paroxetine to serotonin uptake sites in platelets from healthy volunteers. Biological psychiatry. vol 43. issue 10. 1998-08-04. PMID:9606533. |
circannual variations in the binding of [3h]lysergic acid diethylamide to serotonin2a receptors and of [3h]paroxetine to serotonin uptake sites in platelets from healthy volunteers. |
1998-08-04 |
2023-08-12 |
human |
| P A Kelly, D E McBean, I M Ritchi. Intracerebral fetal raphé implants normalize hippocampal function but not cerebrovascular control in serotonin-depleted adult rat brain. Neuroscience. vol 85. issue 1. 1998-07-27. PMID:9607703. |
following the experiments, transplants were visualized by acetylcholinesterase histochemistry, and serotonergic reinnervation assessed using [3h]paroxetine binding to serotonin reuptake sites. |
1998-07-27 |
2023-08-12 |
rat |