| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F P Peeters, J Zandberge. [Severe withdrawal symptoms with fever during paroxetine tapering off]. Nederlands tijdschrift voor geneeskunde. vol 143. issue 27. 1999-08-26. PMID:10422558. |
such withdrawal symptoms are most prevalent after discontinuation of paroxetine but can occur after use of all selective serotonin reuptake inhibitors. |
1999-08-26 |
2023-08-12 |
Not clear |
| C Sánchez, J Hytte. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cellular and molecular neurobiology. vol 19. issue 4. 1999-08-24. PMID:10379421. |
the following antide-pressants were included in the study: the tricyclic antidepressants amitriptyline, dothiepin, and lofepramine and the atypical antidepressant bupropion, which all have considerable market shares in the uk and/or us markets; the selective serotonin reuptake inhibitors (ssris) citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline; and the recently approved antidepressants venlafaxine and nefazodone. |
1999-08-24 |
2023-08-12 |
Not clear |
| C Sánchez, J Hytte. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cellular and molecular neurobiology. vol 19. issue 4. 1999-08-24. PMID:10379421. |
the five approved ssris, citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, are potent 5-ht reuptake inhibitors, and the demethyl metabolites, norfluoxetine, demethylsertraline, and demethylcitalopram, also show selectivity. |
1999-08-24 |
2023-08-12 |
Not clear |
| C Sánchez, J Hytte. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cellular and molecular neurobiology. vol 19. issue 4. 1999-08-24. PMID:10379421. |
paroxetine and sertraline are the most potent inhibitors of 5-ht reuptake, whereas citalopram is the most selective. |
1999-08-24 |
2023-08-12 |
Not clear |
| C L DeVan. Metabolism and pharmacokinetics of selective serotonin reuptake inhibitors. Cellular and molecular neurobiology. vol 19. issue 4. 1999-08-24. PMID:10379420. |
this class of psychoactive drugs, known as selective serotonin reuptake inhibitors (ssris), is comprised of fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram. |
1999-08-24 |
2023-08-12 |
Not clear |
| J F Cryan, C McGrath, B E Leonard, T R Norma. Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. Pharmacology, biochemistry, and behavior. vol 63. issue 2. 1999-08-20. PMID:10371664. |
in this study we investigate the effects of combining a full antagonist at the 5-ht1a receptor, way 100635 (0.2 mg/kg, sc) with the selective serotonin reuptake inhibitor (ssri) paroxetine (5 mg/kg. |
1999-08-20 |
2023-08-12 |
rat |
| C Thompso. Mirtazapine versus selective serotonin reuptake inhibitors. The Journal of clinical psychiatry. vol 60 Suppl 17. 1999-08-17. PMID:10446737. |
the results of 3 completed comparative studies of mirtazapine versus selective serotonin reuptake inhibitors (ssris; fluoxetine, paroxetine, and citalopram) are reviewed. |
1999-08-17 |
2023-08-12 |
Not clear |
| M Hajós, E Hajós-Korcsok, T Shar. Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. British journal of pharmacology. vol 126. issue 8. 1999-07-29. PMID:10372816. |
similarly, cortical transection did not alter the sensitivity of 5-ht neurones to systemic administration of the selective 5-ht reuptake inhibitor, paroxetine (0.1-0.8 mg kg(-1) , i.v.). |
1999-07-29 |
2023-08-12 |
rat |
| T J Sayer, S D Hannon, P H Redfern, K F Marti. Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. British journal of pharmacology. vol 126. issue 8. 1999-07-29. PMID:10372820. |
the data show that, as defined by the response to ru24969, the function of the 5-ht1b receptors that control 5-ht output in the anterior hypothalamus is attenuated following chronic desipramine or paroxetine treatment in a time-of-day-dependent manner. |
1999-07-29 |
2023-08-12 |
rat |
| J C Béïque, C de Montigny, P Blier, G Debonne. Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites. Synapse (New York, N.Y.). vol 32. issue 3. 1999-07-15. PMID:10340630. |
using an in vivo electrophysiological paradigm, venlafaxine and paroxetine displayed similar potency for suppressing the firing activity of dorsal raphe 5-ht neurons (ed50: 233 and 211 microg/kg i.v., respectively), while venlafaxine was three times less potent than desipramine (ed50: 727 and 241 microg/kg i.v., respectively) to suppress the firing activity of locus coeruleus ne neurons. |
1999-07-15 |
2023-08-12 |
rat |
| J C Béïque, C de Montigny, P Blier, G Debonne. Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites. Synapse (New York, N.Y.). vol 32. issue 3. 1999-07-15. PMID:10340630. |
reversed the suppressant effect of venlafaxine and paroxetine on the firing activity of 5-ht neurons and the alpha2-adrenoceptor antagonist piperoxane (1 mg/kg, i.v.) |
1999-07-15 |
2023-08-12 |
rat |
| S P Roose, E Spat. Treating depression in patients with ischaemic heart disease: which agents are best to use and to avoid? Drug safety. vol 20. issue 5. 1999-07-08. PMID:10348096. |
short term studies of the safety of other antidepressant agents, specifically amfebutamone (bupropion) and the selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitors (ssris) fluoxetine, paroxetine and sertraline, suggest that these medications have a benign cardiovascular profile in patients with depression and pre-existing cardiac disease. |
1999-07-08 |
2023-08-12 |
Not clear |
| E L Barker, K R Moore, F Rakhshan, R D Blakel. Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366604. |
mutation of a conserved asp (d98) in the rat serotonin (5ht) transporter (rsert) to glu (d98e) led to decreased 5ht transport capacity, diminished coupling to extracellular na+ and cl-, and a selective loss of antagonist potencies (cocaine, imipramine, and citalopram but not paroxetine or mazindol) with no change in 5ht km value. |
1999-06-28 |
2023-08-12 |
rat |
| J G Edwards, I Anderso. Systematic review and guide to selection of selective serotonin reuptake inhibitors. Drugs. vol 57. issue 4. 1999-06-15. PMID:10235690. |
a meta-analysis of 20 short term comparative studies of 5 selective serotonin reuptake inhibitors (ssris; citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) has shown no difference in efficacy between individual compounds but a slower onset of action of fluoxetine. |
1999-06-15 |
2023-08-12 |
Not clear |
| J L Yau, P A Kelly, T Olsson, J Noble, J R Seck. Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats. Neuroscience letters. vol 261. issue 3. 1999-06-07. PMID:10081979. |
the effects of ageing and of chronic antidepressant treatment upon 5-ht transporter sites ([3h]paroxetine binding) in the rat hippocampus was examined. |
1999-06-07 |
2023-08-12 |
rat |
| J Neuger, A El Khoury, B F Kjellman, B Wahlund, A Aberg-Wistedt, R Stain-Malmgre. Platelet serotonin functions in untreated major depression. Psychiatry research. vol 85. issue 2. 1999-06-07. PMID:10220009. |
the uptake of [14c]5-ht, [3h]paroxetine and [3h]lsd binding was determined in platelets from 30 untreated patients with major depression and compared with corresponding variables from 30 healthy age-, sex- and season-matched control subjects. |
1999-06-07 |
2023-08-12 |
human |
| S T Szabo, C de Montigny, P Blie. Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188964. |
using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) administration of the selective 5-ht reuptake inhibitor (ssri) paroxetine (10 mg kg(-1) day(-1), s.c. using osmotic minipumps) was examined on the spontaneous firing activity of locus coeruleus noradrenergic neurons. |
1999-05-27 |
2023-08-12 |
Not clear |
| J Mos, I Mollet, J T Tolboom, M D Waldinger, B Olivie. A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 1-2. 1999-05-26. PMID:10082238. |
the only differentiation that could be made is that paroxetine and sertraline had slightly stronger effects than the other 5-ht reuptake inhibitors. |
1999-05-26 |
2023-08-12 |
human |
| P B Bergqvist, C Bouchard, P Blie. Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder. Biological psychiatry. vol 45. issue 2. 1999-05-24. PMID:9951563. |
an 8-week, but not a 3-week treatment with the ssri paroxetine results in an increased electrically evoked [3h]5-ht release and a desensitization of 5-ht autoreceptors in the guinea pig orbitofrontal cortex, a brain region implicated in ocd. |
1999-05-24 |
2023-08-12 |
Not clear |
| A Guidotti, E Cost. Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability? Biological psychiatry. vol 44. issue 9. 1999-05-04. PMID:9807641. |
fluoxetine and paroxetine, two selective serotonin reuptake inhibitors (ssris), when administered to rats increase brain allo content without altering the brain content of other steroids, including allo's precursor 5 alpha dihydroprogesterone. |
1999-05-04 |
2023-08-12 |
rat |