| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Maguire, T Norman, G Burrows, M Hopwood, P Morri. Platelet paroxetine binding in post-traumatic stress disorder. Psychiatry research. vol 77. issue 1. 2000-03-31. PMID:10710169. |
this study finds no relationship between ptsd, major depressive disorder and peripheral serotonin function measured by [3h]paroxetine binding to blood platelets. |
2000-03-31 |
2023-08-12 |
human |
| G C Uhler, P T Huminski, F T Les, P P Fon. Cilia-driven rotational behavior in gastropod (Physa elliptica) embryos induced by serotonin and putative serotonin reuptake inhibitors (SSRIs). The Journal of experimental zoology. vol 286. issue 4. 2000-03-29. PMID:10684564. |
the ssris paroxetine and fluoxetine both caused an increase in rotation at 10(-6) and 10(-5) m but reduced rotation rate below that of baseline at 10(-4) m. these results agree with other studies on aquatic molluscs, suggest a 5-ht receptor with a mixed 5-ht(1)/5-ht(2) pharmacological profile and add to a now growing body of literature on the pharmacology of molluscan 5-ht receptors. |
2000-03-29 |
2023-08-12 |
Not clear |
| E Di Girolamo, C Di Iorio, L Leonzio, P Sabatini, G Ranalli, A Barsott. [Effectiveness of paroxetine in the treatment of refractory vasovagal syncope in young patients]. Giornale italiano di cardiologia. vol 29. issue 12. 2000-03-28. PMID:10687110. |
the aim of the study was to assess whether the well-tolerated serotonin re-uptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in young patients resistant to or intolerant of previous traditional therapies. |
2000-03-28 |
2023-08-12 |
Not clear |
| C Hiemke, S Härtte. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & therapeutics. vol 85. issue 1. 2000-03-23. PMID:10674711. |
the five selective serotonin reuptake inhibitors (ssris), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect profile. |
2000-03-23 |
2023-08-12 |
Not clear |
| D K Kim, S W Lim, S Lee, S E Sohn, S Kim, C G Hahn, B J Carrol. Serotonin transporter gene polymorphism and antidepressant response. Neuroreport. vol 11. issue 1. 2000-03-16. PMID:10683861. |
we examined allelic polymorphisms of the serotonin transporter (5-htt) gene and antidepressant response to 6 weeks' treatment with the selective serotonin reuptake inhibitor (ssri) drugs fluoxetine or paroxetine. |
2000-03-16 |
2023-08-12 |
Not clear |
| S Hamilton, K Malon. Serotonin syndrome during treatment with paroxetine and risperidone. Journal of clinical psychopharmacology. vol 20. issue 1. 2000-03-15. PMID:10653219. |
serotonin syndrome during treatment with paroxetine and risperidone. |
2000-03-15 |
2023-08-12 |
Not clear |
| R Zanardi, F Benedetti, D Di Bella, M Catalano, E Smerald. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Journal of clinical psychopharmacology. vol 20. issue 1. 2000-03-15. PMID:10653220. |
efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. |
2000-03-15 |
2023-08-12 |
Not clear |
| T Hori, S Abe, A Baba, T Suzuki, H Shiraish. Effects of repeated phencyclidine treatment on serotonin transporter in rat brain. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696810. |
furthermore, repeated pcp treatment decreased the equilibrium dissociation constant (kd) of [3h]paroxetine binding to 5-ht transporters in whole brain excluding the cerebellum without any change of maximum number of binding sites (bmax). |
2000-03-13 |
2023-08-12 |
rat |
| T Hori, S Abe, A Baba, T Suzuki, H Shiraish. Effects of repeated phencyclidine treatment on serotonin transporter in rat brain. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696810. |
these results indicate that repeated pcp treatment causes tolerance in serotonergic stereotyped behavior and increases affinity of 5-ht transporters for [3h]paroxetine binding. |
2000-03-13 |
2023-08-12 |
rat |
| P Brust, A Friedrich, I A Krizbai, R Bergmann, F Roux, V Ganapathy, B Johannse. Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells. Journal of neurochemistry. vol 74. issue 3. 2000-03-09. PMID:10693957. |
the 5-ht uptake was sensitive to specific 5-ht transport inhibitors such as paroxetine, clomipramine, fluoxetine, and citalopram but not to inhibitors of the vesicular amine transporter such as reserpine or tetrabenazine. |
2000-03-09 |
2023-08-12 |
rat |
| Y Akagawa, Y Masuda, A Maruyama, T Shimizu, Y Hishikaw. Effects of repeated selective serotonin reuptake inhibitor paroxetine treatments on mouse forced swimming. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669904. |
effects of repeated selective serotonin reuptake inhibitor paroxetine treatments on mouse forced swimming. |
2000-02-28 |
2023-08-12 |
mouse |
| C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international. vol 36. issue 2. 2000-02-25. PMID:10676872. |
this study reports the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on 5-ht1b and 5-ht1d autoreceptors controlling stimulated 5-ht efflux in slices of rat dorsal raphe nucleus. |
2000-02-25 |
2023-08-12 |
rat |
| Y Smicun, S D Campbell, M A Chen, H Gu, G Rudnic. The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593887. |
chimeric transporters did not gain affinity for dopamine, a net substrate, or desipramine, an inhibitor, at the expense of affinity for serotonin or paroxetine, a selective sert inhibitor. |
2000-01-27 |
2023-08-12 |
Not clear |
| S Park, J A Harrold, P S Widdowson, G William. Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats. Brain research. vol 847. issue 1. 2000-01-19. PMID:10564740. |
binding to 5-ht transporters ([3h]paroxetine) was significantly increased (p<0.05) in both dorsal and median raphe, paraventricular nuclei (pvn), ventromedial nuclei (vmh), anterior hypothalamic area (aha) and lha of dio rats, by 47%-165%. |
2000-01-19 |
2023-08-12 |
rat |
| J Sigurdh, O Spigset, P Allard, T Mjörndal, B Hägglö. Binding of [(3)H]lysergic acid diethylamide to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites in platelets from healthy children, adolescents and adults. Neuropsychobiology. vol 40. issue 4. 2000-01-11. PMID:10559700. |
binding of [(3)h]lysergic acid diethylamide to serotonin 5-ht(2a) receptors and of [(3)h]paroxetine to serotonin uptake sites in platelets from healthy children, adolescents and adults. |
2000-01-11 |
2023-08-12 |
Not clear |
| J Sigurdh, O Spigset, P Allard, T Mjörndal, B Hägglö. Binding of [(3)H]lysergic acid diethylamide to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites in platelets from healthy children, adolescents and adults. Neuropsychobiology. vol 40. issue 4. 2000-01-11. PMID:10559700. |
possible age effects on binding of [(3)h]lysergic acid diethylamide ([(3)h]lsd) to serotonin 5-ht(2a) receptors and of [(3)h]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11-12 years of age), adolescents (16-17 years of age) and adults. |
2000-01-11 |
2023-08-12 |
Not clear |
| F Monaco, A Cicoli. Interactions between anticonvulsant and psychoactive drugs. Epilepsia. vol 40 Suppl 10. 2000-01-05. PMID:10609607. |
the newer antidepressants that selectively inhibit the reuptake of serotonin (ssris), although in different fashions for the different substances (fluoxetine, fluvoxamine, paroxetine) may cause an increase of plasma aed levels through inhibition of the isoenzyme p450 2d6. |
2000-01-05 |
2023-08-12 |
Not clear |
| L Kristoffersen, A Bugge, E Lundanes, L Slørda. Simultaneous determination of citalopram, fluoxetine, paroxetine and their metabolites in plasma and whole blood by high-performance liquid chromatography with ultraviolet and fluorescence detection. Journal of chromatography. B, Biomedical sciences and applications. vol 734. issue 2. 2000-01-04. PMID:10595721. |
a method for the simultaneous determination of the three selective serotonin reuptake inhibitors (ssris) citalopram, fluoxetine, paroxetine and their metabolites in whole blood and plasma was developed. |
2000-01-04 |
2023-08-12 |
Not clear |
| H G Nurnberg, P L Hensley, P M Thompson, S S Pain. Modeling the pharmacoeconomic cost of three selective serotonin reuptake inhibitors. Psychiatric services (Washington, D.C.). vol 50. issue 10. 1999-12-30. PMID:10506306. |
the authors present a method for modeling cost data on three selective serotonin reuptake inhibitors (ssris)-fluoxetine, paroxetine, and sertraline-from a large clinical outcomes study in a university-affiliated mental health center. |
1999-12-30 |
2023-08-12 |
Not clear |
| J H Atkinson, M A Slater, D R Wahlgren, R A Williams, S Zisook, S D Pruitt, J E Epping-Jordan, T L Patterson, I Grant, I Abramson, S R Garfi. Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity. Pain. vol 83. issue 2. 1999-12-17. PMID:10534584. |
to understand the relative efficacy of noradrenergic and serotonergic antidepressants as analgesics in chronic back pain without depression, we conducted a randomized, double-blind, placebo-control head-to-head comparison of maprotiline (a norepinephrine reuptake blocker) and paroxetine (a serotonin reuptake blocker) in 103 patients with chronic low back pain. |
1999-12-17 |
2023-08-12 |
Not clear |