| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H M Haughey, A E Fleckenstein, R R Metzger, G R Hanso. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987842. |
multiple high-dose meth injections rapidly decreased 5ht uptake without altering binding of the 5ht transporter ligand paroxetine. |
2000-10-05 |
2023-08-12 |
rat |
| J Béïque, C de Montigny, P Blier, G Debonne. Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: II. In vitro studies in the rat. Neuropharmacology. vol 39. issue 10. 2000-09-28. PMID:10884562. |
finally, the enhancing effect of 1 microm of paroxetine in the perfusion medium on the electrical release of [(3)h]5-ht was unaltered in hippocampal slices prepared from rats that had been treated for 21 days with 40 mg/kg/day of venlafaxine. |
2000-09-28 |
2023-08-12 |
rat |
| S Oya, S R Choi, C Hou, M Mu, M P Kung, P D Acton, M Siciliano, H F Kun. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nuclear medicine and biology. vol 27. issue 3. 2000-09-26. PMID:10832081. |
serotonin transporters (sert) are target-sites for commonly used antidepressants, such as fluoxetine, paroxetine, sertraline, and so on. |
2000-09-26 |
2023-08-12 |
human |
| A Bertani, G Perna, C Arancio, D Caldirola, L Bellod. Pharmacologic effect of imipramine, paroxetine, and sertraline on 35% carbon dioxide hypersensitivity in panic patients: a double-blind, random, placebo-controlled study. Journal of clinical psychopharmacology. vol 17. issue 2. 2000-09-05. PMID:10950471. |
the effects of short treatment (7 days) with the tricyclic antidepressant imipramine and the two selective serotonin reuptake inhibitors paroxetine and sertraline on the reactivity to inhalation of 35% co2/65% o2 were compared in 70 panic patients who had positive responses to 35% co2 inhalations. |
2000-09-05 |
2023-08-12 |
Not clear |
| F I Tarazi, K Zhang, R J Baldessarin. Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain. Neuroscience letters. vol 287. issue 2. 2000-08-17. PMID:10854717. |
we compared labeling of dopamine (dat) and serotonin (sert) transporter proteins in subregions of rat corpus striatum by quantitative autoradiography with [(3)h]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane ([(3)h]beta-cit) and [(3)h]paroxetine after 28 days of continuous subcutaneous infusion of olanzapine, quetiapine, risperidone, or vehicle controls. |
2000-08-17 |
2023-08-12 |
rat |
| J P Anthony, T J Sexton, J F Neumaie. Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation. Journal of neuroscience research. vol 61. issue 1. 2000-08-14. PMID:10861803. |
paroxetine and fluoxetine reduced drn 5-ht(1b) mrna by 36% and 27%, respectively whereas sertraline had a no significant effect. |
2000-08-14 |
2023-08-12 |
rat |
| S J Partridge, D H MacIver, T Solank. A depressed myocardium. Journal of toxicology. Clinical toxicology. vol 38. issue 4. 2000-08-11. PMID:10930064. |
paroxetine is a potent selective inhibitor of serotonin reuptake. |
2000-08-11 |
2023-08-12 |
Not clear |
| I Modai, A Gibel, B Rauchverger, M Ritsner, E Klein, D Ben-Shacha. Paroxetine binding in aggressive schizophrenic patients. Psychiatry research. vol 94. issue 1. 2000-08-07. PMID:10788680. |
[3h]paroxetine binding in blood platelets represents the activity of serotonin peripheral binding sites. |
2000-08-07 |
2023-08-12 |
human |
| A Besson, N Haddjeri, P Blier, C de Montign. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 3. 2000-08-01. PMID:10793320. |
the alpha(2)-adrenoreceptor antagonist mirtazapine, which is also a 5-ht(2), 5-ht(3) and h(1) receptors antagonist and the selective serotonin (5-ht) reuptake inhibitor paroxetine are effective antidepressant drugs which enhance 5-ht neurotransmission via different mechanisms. |
2000-08-01 |
2023-08-12 |
rat |
| A Besson, N Haddjeri, P Blier, C de Montign. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 3. 2000-08-01. PMID:10793320. |
using in vivo electrophysiological paradigms, the firing activity of dorsal raphe 5-ht neurons was decreased by 70% in rats treated with paroxetine (10 mg/kg/day, s.c.) for 2 days and was back to normal after 21 days. |
2000-08-01 |
2023-08-12 |
rat |
| A Besson, N Haddjeri, P Blier, C de Montign. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 3. 2000-08-01. PMID:10793320. |
a low dose of mirtazapine (5 mg/kg/day, s.c.x2 days) failed to offset the decremental effect of paroxetine on the 5-ht neuron firing activity, but a higher dose (10 mg/kg/day, s.c.x2 days) did attenuate the decremental effect of paroxetine. |
2000-08-01 |
2023-08-12 |
rat |
| A Besson, N Haddjeri, P Blier, C de Montign. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 3. 2000-08-01. PMID:10793320. |
in the dorsal hippocampus, neither mirtazapine (5 mg/kg/day, s.c.) nor a paroxetine (10 mg/kg/day, s.c.) treatment altered the responsiveness of 5-ht(1a) receptors to microiontophoretically-applied 5-ht. |
2000-08-01 |
2023-08-12 |
rat |
| A Besson, N Haddjeri, P Blier, C de Montign. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 3. 2000-08-01. PMID:10793320. |
both in controls and in rats treated for 2 days with paroxetine alone, the administration of the 5-ht(1a) antagonist way 100635 (25-100 microg/kg, i.v.) |
2000-08-01 |
2023-08-12 |
rat |
| Z Zhuang, S Choi, C Hou, M Mu, M Kung, P D Acton, H F Kun. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol. Nuclear medicine and biology. vol 27. issue 2. 2000-07-27. PMID:10773546. |
the serotonin transporters (sert) are the primary binding sites for selective serotonin reuptake inhibitors, commonly used antidepressants such as fluoxetine, sertraline, and paroxetine. |
2000-07-27 |
2023-08-12 |
rat |
| U Rüth, J Mayer-Rosa, D Schlamp, F J Freislede. [Tourette's syndrome and antidepressant therapy: exacerbation of nervous tics with paroxetine]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie. vol 28. issue 2. 2000-07-27. PMID:10863766. |
one possible side effect of selective serotonin re-uptake inhibitors (ssri) is the exacerbation of nervous tics in a 12-year-old boy treated with tiapride following prescription of paroxetine for a depressive syndrome. |
2000-07-27 |
2023-08-12 |
Not clear |
| L Belloeuf, C Le Jeunne, F C Hugue. [Paroxetine withdrawal syndrome]. Annales de medecine interne. vol 151 Suppl A. 2000-07-19. PMID:10855379. |
withdrawal syndrome after discontinuing serotonin re-uptake inhibitors, especially paroxetine, is largely unknown to most physicians. |
2000-07-19 |
2023-08-12 |
Not clear |
| M J Owens, D L Knight, C B Nemerof. Paroxetine binding to the rat norepinephrine transporter in vivo. Biological psychiatry. vol 47. issue 9. 2000-07-18. PMID:10812044. |
the antidepressant paroxetine is believed to produce its therapeutic effects primarily by acting as a highly selective antagonist of the serotonin transporter (sert). |
2000-07-18 |
2023-08-12 |
rat |
| P J Goodnick, A M Kuma. Pretreatment platelet 5-HT concentration predicts the short-term response to paroxetine in major depression. Biological psychiatry. vol 47. issue 9. 2000-07-18. PMID:10819459. |
pretreatment platelet 5-ht concentration predicts the short-term response to paroxetine in major depression. |
2000-07-18 |
2023-08-12 |
Not clear |
| Y Kodama, R Nonaka, Y Hagino, M Watanab. The distribution of serotonergic nerves in microencephalic rats treated prenatally with methylazoxymethanol. Neurochemical research. vol 25. issue 4. 2000-07-18. PMID:10823582. |
in the present study of these microencephalic rats (mam rats) we used quantitative autoradiography to investigate [3h] paroxetine binding sites, which are a selective marker of serotonin (5-ht) transporters (5-htt). |
2000-07-18 |
2023-08-12 |
rat |
| P Scholze, J Zwach, A Kattinger, C Pifl, E A Singer, H H Sitt. Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter. The Journal of pharmacology and experimental therapeutics. vol 293. issue 3. 2000-07-14. PMID:10869387. |
5-ht reuptake blockers (e.g., imipramine, paroxetine) also raised [(3)h]5-ht efflux, reaching approximately one-third of the maximal effect of the hsert substrates. |
2000-07-14 |
2023-08-12 |
human |