| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Shirayama, K Hashimoto, M Iyo, K Watanabe, T Higuchi, Y Minab. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced egr-1 mRNA in rat brain: pharmacological manipulation. European journal of pharmacology. vol 402. issue 3. 2000-11-28. PMID:10958887. |
furthermore, the expression of egr-1 mrna in the prefrontal cortex, striatum and hippocampal dentate gyrus after administration of mdma (10 mg/kg) was blocked significantly by pretreatment with nmda receptor antagonist (5r, 10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,b]-cyclohepten-5, 10-imine ((+)-mk801; 1 mg/kg), dopamine d(1) receptor antagonist sch 23390 (1 mg/kg) or 5-ht uptake inhibitor paroxetine (5 mg/kg), but not by 5-ht(2a) receptor antagonist sr46349b (5 mg/kg). |
2000-11-28 |
2023-08-12 |
rat |
| B G Pollock, R E Ferrell, B H Mulsant, S Mazumdar, M Miller, R A Sweet, S Davis, M A Kirshner, P R Houck, J A Stack, C F Reynolds, D J Kupfe. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027924. |
allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. |
2000-11-21 |
2023-08-12 |
human |
| B G Pollock, R E Ferrell, B H Mulsant, S Mazumdar, M Miller, R A Sweet, S Davis, M A Kirshner, P R Houck, J A Stack, C F Reynolds, D J Kupfe. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027924. |
the relationship of the serotonin transporter gene promoter region polymorphism (5-httlpr) to antidepressant response was examined in 95 elderly patients receiving a protocolized treatment for depression with paroxetine or nortriptyline. |
2000-11-21 |
2023-08-12 |
human |
| N Hergovich, M Aigner, H G Eichler, J Entlicher, C Drucker, B Jilm. Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clinical pharmacology and therapeutics. vol 68. issue 4. 2000-11-21. PMID:11061584. |
paroxetine decreases platelet serotonin storage and platelet function in human beings. |
2000-11-21 |
2023-08-12 |
human |
| E Healy, P McKeo. Dopaminergic sensitivity and prediction of antidepressant response. Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890309. |
this study was designed to examine neuroendocrine predictors of antidepressant response to the selective serotonin reuptake inhibitor (ssri) paroxetine. |
2000-11-16 |
2023-08-12 |
human |
| J L Palme. Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine? Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890314. |
postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine? |
2000-11-16 |
2023-08-12 |
Not clear |
| L Ferraro, K Fuxe, S Tanganelli, M Fernandez, F A Rambert, T Antonell. Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil. Neuropharmacology. vol 39. issue 11. 2000-11-03. PMID:10963741. |
the effects of modafinil were more pronounced when the 5-ht reuptake was blocked by paroxetine. |
2000-11-03 |
2023-08-12 |
rat |
| L Ferraro, K Fuxe, S Tanganelli, M Fernandez, F A Rambert, T Antonell. Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil. Neuropharmacology. vol 39. issue 11. 2000-11-03. PMID:10963741. |
contrary to paroxetine (0.3-3 microm) and dl-fenfluramine (1-5 microm), modafinil failed to influence the [(3)h]5-ht uptake. |
2000-11-03 |
2023-08-12 |
rat |
| L Ferraro, K Fuxe, S Tanganelli, M Fernandez, F A Rambert, T Antonell. Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil. Neuropharmacology. vol 39. issue 11. 2000-11-03. PMID:10963741. |
in the presence of paroxetine (3 microm), the effect of modafinil at 30 mg/kg was higher than that observed in the absence of 5-ht reuptake inhibition. |
2000-11-03 |
2023-08-12 |
rat |
| S C Cheetham, J A Viggers, N A Slater, D J Hea. Sibutramine does not decrease the number of 5-HT re-uptake sites in rat brain and, like fluoxetine, protects against the deficits produced by dexfenfluramine. Neuropharmacology. vol 39. issue 11. 2000-11-03. PMID:10963746. |
the effect of sibutramine and dexfenfluramine on 5-ht re-uptake sites, labelled with [(3)h]paroxetine, have been determined in various rat brain regions. |
2000-11-03 |
2023-08-12 |
rat |
| I Malagié, A Deslandes, A M Gardie. Effects of acute and chronic tianeptine administration on serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis. European journal of pharmacology. vol 403. issue 1-2. 2000-10-31. PMID:10969144. |
effects of acute and chronic tianeptine administration on serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis. |
2000-10-31 |
2023-08-12 |
rat |
| I Malagié, A Deslandes, A M Gardie. Effects of acute and chronic tianeptine administration on serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis. European journal of pharmacology. vol 403. issue 1-2. 2000-10-31. PMID:10969144. |
using in vivo microdialysis, we compared the effects of tianeptine (an antidepressant drug which, in marked contrast with other antidepressants, is thought to increase the uptake of serotonin (5-hydroxytryptamine, 5-ht) on extracellular 5-ht concentrations ([5-ht](ext)) in the frontal cortex and raphe nuclei of freely moving rats with those of paroxetine, a potent selective serotonin reuptake inhibitor. |
2000-10-31 |
2023-08-12 |
rat |
| U W Preuss, M Soyka, M Bahlmann, K Wenzel, S Behrens, S de Jonge, M Krüger, B Bond. Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry research. vol 96. issue 1. 2000-10-31. PMID:10980326. |
serotonin transporter gene regulatory region polymorphism (5-httlpr), [3h]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. |
2000-10-31 |
2023-08-12 |
human |
| U W Preuss, M Soyka, M Bahlmann, K Wenzel, S Behrens, S de Jonge, M Krüger, B Bond. Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry research. vol 96. issue 1. 2000-10-31. PMID:10980326. |
the aim of this study was to investigate [3h]paroxetine binding and impulsivity in alcohol-dependent and age-matched control subjects in relation to a 5'-promoter region serotonin transporter (5-htt) polymorphism (5-httlpr). |
2000-10-31 |
2023-08-12 |
human |
| Sertraline and obsessive compulsive disorder: new indication. Limited assessment. Prescrire international. vol 9. issue 48. 2000-10-26. PMID:11067720. |
(2) in this indication the clinical file is of acceptable methodological quality, but it is incomplete: sertraline has not been compared with the other two serotonin reuptake inhibitors approved in obsessive-compulsive disorder, namely fluoxetine and paroxetine. |
2000-10-26 |
2023-08-12 |
Not clear |
| K R Krishna. Depression as a contributing factor in cerebrovascular disease. American heart journal. vol 140. issue 4 Suppl. 2000-10-25. PMID:11011351. |
emerging evidence suggests that nortriptyline and fluoxetine may be effective; paroxetine, sertraline, and other selective serotonin reuptake inhibitors have shown efficacy in treating a related phenomenon known as pathologic crying. |
2000-10-25 |
2023-08-12 |
Not clear |
| J M Gorman, R P Sloa. Heart rate variability in depressive and anxiety disorders. American heart journal. vol 140. issue 4 Suppl. 2000-10-25. PMID:11011352. |
although tricyclic antidepressants reduce heart rate variability, at least one study has suggested that, in patients with panic disorder, treatment with the selective serotonin reuptake inhibitor paroxetine normalizes heart rate variability. |
2000-10-25 |
2023-08-12 |
Not clear |
| S Kalsne. The question of feedback at the somadendritic region and antidepressant drug action. Brain research bulletin. vol 52. issue 6. 2000-10-16. PMID:10974485. |
one conspicuous example is the attribution of the clinical efficacy of 5-ht uptake inhibitors, such as fluoxetine and paroxetine, to desensitization of somadendritic 5-ht autoreceptors. |
2000-10-16 |
2023-08-12 |
Not clear |
| J Sunderram, R A Parisi, R J Strobe. Serotonergic stimulation of the genioglossus and the response to nasal continuous positive airway pressure. American journal of respiratory and critical care medicine. vol 162. issue 3 Pt 1. 2000-10-12. PMID:10988107. |
direct activation of upper airway (ua) motor neurons in the hypoglossal nucleus by a selective serotonin reuptake inhibitor (ssri), paroxetine hydrochloride, may increase genioglossal electromyographic (emg) activity (emggg) in a manner resistant to mechanoreflex inhibition. |
2000-10-12 |
2023-08-12 |
human |
| R L Elkins, T E Orr, J Q Li, P A Walters, J L Whitford, G F Carl, J L Rausc. Serotonin reuptake is less efficient in taste aversion resistant than in taste aversion-prone rats. Pharmacology, biochemistry, and behavior. vol 66. issue 3. 2000-10-05. PMID:10899378. |
in the present study, tar rats demonstrated significantly less efficient brain serotonin transport compared to tap rats, but the rat lines demonstrated similar levels of serotonin transporter or v(max) and similar whole brain paroxetine (a specific serotonin reuptake inhibitor) binding (b(max)). |
2000-10-05 |
2023-08-12 |
rat |