| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Bourin, P Chue, Y Guillo. Paroxetine: a review. CNS drug reviews. vol 7. issue 1. 2001-07-26. PMID:11420571. |
paroxetine, a phenylpiperidine derivative, is the most potent inhibitor of the reuptake of serotonin (5-hydroxytryptamine, 5-ht) of all the currently available antidepressants including the class of ssris. |
2001-07-26 |
2023-08-12 |
Not clear |
| M Bourin, P Chue, Y Guillo. Paroxetine: a review. CNS drug reviews. vol 7. issue 1. 2001-07-26. PMID:11420571. |
the selectivity of paroxetine, i.e., the ratio of inhibition of uptake of norepinephrine to serotonin (ne/5-ht) is amongst the highest of the ssris. |
2001-07-26 |
2023-08-12 |
Not clear |
| M Bourin, P Chue, Y Guillo. Paroxetine: a review. CNS drug reviews. vol 7. issue 1. 2001-07-26. PMID:11420571. |
in addition, the adaptive changes of somatodendritic (5-ht(1a)) and terminal (5-ht(1b/1d)) autoreceptors observed with paroxetine are different to those observed with tcas; it also inhibits nitric oxide synthase. |
2001-07-26 |
2023-08-12 |
Not clear |
| F Borsini, A Brambilla, R Cesana, N Gripp. Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats. The international journal of neuropsychopharmacology. vol 4. issue 1. 2001-07-19. PMID:11343624. |
this study was aimed at evaluating the ability of flibanserin, a 5-ht1a receptor full agonist with antidepressant potential, to induce the 5-ht syndrome (flat body posture, hindlimb abduction and forepaw treading) in rats previously administered with clinically active antidepressants imipramine, fluoxetine or paroxetine. |
2001-07-19 |
2023-08-12 |
rat |
| F Clenet, A De Vos, M Bouri. Involvement of 5-HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 2. 2001-07-05. PMID:11313160. |
spontaneous locomotor activity was measured as an index of intact sensorimotor functions and the dose-effect of ro 60-0175 alone, as well as interactions with several antidepressants, such as tricyclic antidepressants (imipramine, desipramine and maprotiline) and selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, fluvoxamine and sertraline), were studied in the mouse forced swimming test. |
2001-07-05 |
2023-08-12 |
mouse |
| W E Webe. [Pharmacotherapy for neuropathic pain caused by injury to the afferent nerve fibers]. Nederlands tijdschrift voor geneeskunde. vol 145. issue 17. 2001-07-05. PMID:11370425. |
the activity of new drugs, such as the selective serotonin reuptake inhibitor paroxetine as well as venlafaxine, has yet to be clearly shown. |
2001-07-05 |
2023-08-12 |
Not clear |
| A Harkin, T J Connor, J Mulrooney, J P Kelly, B E Leonar. Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats. Life sciences. vol 68. issue 12. 2001-06-21. PMID:11388689. |
in addition, [3h] paroxetine binding was reduced by (40%) in the cortex of mda treated rats indicating that the decrease in 5-ht concentrations were accompanied by a reduction in intact presynaptic 5-ht nerve terminals. |
2001-06-21 |
2023-08-12 |
rat |
| C Mannoury la Cour, C Boni, N Hanoun, K P Lesch, M Hamon, L Lanfume. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245702. |
extracellular recordings showed that application of selective 5-ht reuptake inhibitors such as paroxetine and citalopram onto brainstem slices resulted in a concentration-dependent inhibition of 5-ht neuron firing in the dorsal raphe nucleus of wild-type 5-htt+/+ mice, but not 5-htt-/- mutants. |
2001-06-07 |
2023-08-12 |
mouse |
| L Ferraro, S Tanganelli, K Fuxe, B W Bebe, M C Tomasini, F A Rambert, T Antonell. Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs. Brain research. vol 894. issue 2. 2001-06-07. PMID:11251206. |
modafinil did not affect spontaneous and k(+)-evoked [3h]5-ht efflux from cortical synaptosomes while it increased k(+)-evoked tritium efflux from cortical slices, an action that became stronger in the presence of paroxetine. |
2001-06-07 |
2023-08-12 |
rat |
| J Daléry, V Aubi. [Comparative study of paroxetine and mianserin in depression in elderly patients: efficacy, tolerance, serotonin dependence]. L'Encephale. vol 27. issue 1. 2001-06-07. PMID:11294041. |
[comparative study of paroxetine and mianserin in depression in elderly patients: efficacy, tolerance, serotonin dependence]. |
2001-06-07 |
2023-08-12 |
Not clear |
| J Daléry, V Aubi. [Comparative study of paroxetine and mianserin in depression in elderly patients: efficacy, tolerance, serotonin dependence]. L'Encephale. vol 27. issue 1. 2001-06-07. PMID:11294041. |
in the perspective of this assessment, paroxetine was chosen due to its potential to inhibit serotonin re-uptake, as compared to mianserin which blocks presynaptic alpha-adrenergic receptors with negligible action on serotonin. |
2001-06-07 |
2023-08-12 |
Not clear |
| R Kopp, O Kunitz, J H Baumert, R Rossain. [A patient with nodal tachycardia after general anesthesia during medication with a selective serotonin reuptake inhibitor]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. vol 36. issue 3. 2001-05-24. PMID:11324355. |
we report on a 62 year old female patient treated with paroxetine, a selective serotonin reuptake inhibitor, because of an anxiety neurosis undergoing a vaginal hysterectomy in general anesthesia. |
2001-05-24 |
2023-08-12 |
Not clear |
| R Stain-Malmgren, A E Khoury, A Aberg-Wistedt, A Tha. Serotonergic function in major depression and effect of sertraline and paroxetine treatment. International clinical psychopharmacology. vol 16. issue 2. 2001-05-17. PMID:11236074. |
we investigated platelet [14c]serotonin (5-ht) uptake and lysergic acid diethylamide [n-methyl-3h] ([3h]lsd)- and phenyl-6'-paroxetine ([3h]paroxetine) binding in 30 patients with major depression at baseline and after 6 months of treatment with either paroxetine or sertraline. |
2001-05-17 |
2023-08-12 |
human |
| S Kõks, S Beljajev, I Koovit, U Abramov, M Bourin, E Vasa. 8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze. Psychopharmacology. vol 153. issue 3. 2001-05-17. PMID:11271409. |
to investigate whether a 5-hydroxytryptamine (5-ht) reuptake inhibitor (paroxetine) has an anxiogenic-like effect and what possible pharmacological mechanism underlies that action. |
2001-05-17 |
2023-08-12 |
Not clear |
| T K Murphy, M A Bengtson, J Y Tan, E Carbonell, G M Levi. Selective serotonin reuptake inhibitors in the treatment of paediatric anxiety disorders: a review. International clinical psychopharmacology. vol 15 Suppl 2. 2001-04-26. PMID:11110019. |
the selective serotonin reuptake inhibitors (ssris)--citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline--have demonstrated efficacy in treating anxiety disorders in adults. |
2001-04-26 |
2023-08-12 |
Not clear |
| P M Ryan, J P Kelly, P L Chambers, B E Leonar. The toxicity profile of a single dose of paroxetine: an alternative approach to acute toxicity testing in the rat. Pharmacology & toxicology. vol 88. issue 2. 2001-04-12. PMID:11169163. |
in this study we have examined the effect of a single administration of the selective serotonin reuptake inhibitor, paroxetine (120-300 mg kg(-1), orally) in a recently developed rodent model of acute toxicity testing. |
2001-04-12 |
2023-08-12 |
rat |
| P J Goodnick, M Hernande. Treatment of depression in comorbid medical illness. Expert opinion on pharmacotherapy. vol 1. issue 7. 2001-04-05. PMID:11249471. |
evidence for safe administration of bupropion, as well as the selective serotonin re-uptake inhibitors (ssris) fluoxetine and paroxetine, is also available. |
2001-04-05 |
2023-08-12 |
Not clear |
| I Malagié, A C Trillat, M Bourin, C Jacquot, R Hen, A M Gardie. 5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158258. |
however, in the ventral hippocampus, paroxetine at the two doses studied induced a larger increase in [5-ht]ext in knockout than in wild-type mice. |
2001-03-15 |
2023-08-12 |
mouse |
| I Malagié, A C Trillat, M Bourin, C Jacquot, R Hen, A M Gardie. 5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158258. |
in addition, either the absence of the 5-ht1b receptor or its blockade with the mixed 5-ht1b/1d receptor antagonist, gr 127935, potentiated the effect of a single administration of paroxetine on extracellular 5-ht levels more in the ventral hippocampus than in the frontal cortex. |
2001-03-15 |
2023-08-12 |
mouse |
| G Gobbi, D L Murphy, K Lesch, P Blie. Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181933. |
the selective 5-ht reuptake inhibitor paroxetine significantly prolonged the rt(50) in 5-htt +/+ and 5-htt +/- mice, without altering the maximal inhibitory effect of 5-ht. |
2001-03-15 |
2023-08-12 |
mouse |