| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Polsky, Peter Onesirosan, Mark S Bauer, Henry A Glic. Duration of therapy and health care costs of fluoxetine, paroxetine, and sertraline in 6 health plans. The Journal of clinical psychiatry. vol 63. issue 2. 2002-03-08. PMID:11874218. |
previous studies comparing fluoxetine, paroxetine, and sertraline, the 3 most common selective serotonin reuptake inhibitors (ssris), in naturalistic settings have produced conflicting results. |
2002-03-08 |
2023-08-12 |
Not clear |
| G Tournel, N Houdret, V Hédouin, M Deveau, D Gosset, M Lhermitt. High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum. Journal of chromatography. B, Biomedical sciences and applications. vol 761. issue 2. 2002-02-28. PMID:11587344. |
a high-performance liquid chromatographic screening method (hplc) is described for the determination of seven selective serotonin reuptake inhibitors (ssris) (fluvoxamine, milnacipran, paroxetine, sertraline, fluoxetine, citalopram, venlafaxine) and for three pharmacologically active n-demethylated metabolites (desmethylcitalopram, didesmethylcitalopram and norfluoxetine). |
2002-02-28 |
2023-08-12 |
human |
| A Serretti, R Zanardi, C Cusin, D Rossini, R Lilli, C Lorenzi, E Lattuada, E Smerald. No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors. Psychiatry research. vol 104. issue 3. 2002-02-26. PMID:11728608. |
the possible association of the dopamine receptor d(2) (ser 311cys) and d(4) exon 3 (48 base pair repeat) gene variants with the antidepressant activity of selective serotonin reuptake inhibitors (ssris) was investigated in a sample of 364 inpatients affected by a major depressive episode treated with fluvoxamine, 300 mg/day (n=266), or paroxetine, 20-40 mg/day (n=98). |
2002-02-26 |
2023-08-12 |
human |
| Giuseppe Maina, Alberto Vitalucci, Sergio Gandolfo, Filippo Bogett. Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. The Journal of clinical psychiatry. vol 63. issue 1. 2002-02-19. PMID:11838624. |
the purpose of this 8-week, single-blind study was to provide preliminary data on the efficacy and tolerability of amisulpride and the selective serotonin reuptake inhibitors (ssris) paroxetine and sertraline for patients with bms. |
2002-02-19 |
2023-08-12 |
Not clear |
| D J Stein, M B Stein, W Goodwin, R Kumar, B Hunte. The selective serotonin reuptake inhibitor paroxetine is effective in more generalized and in less generalized social anxiety disorder. Psychopharmacology. vol 158. issue 3. 2002-02-12. PMID:11713616. |
the selective serotonin reuptake inhibitor paroxetine is effective in more generalized and in less generalized social anxiety disorder. |
2002-02-12 |
2023-08-12 |
Not clear |
| I A Pullar, J R Boot, S L Carney, M L Cohen, E M Colvin, R G Conway, C H Hardy, V L Lucaites, D L Nelson, K W Schenck, R Tomlinson, S Wedle. In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine transporter with 5-HT(1B/1D/2) receptor antagonist properties. European journal of pharmacology. vol 432. issue 1. 2002-02-11. PMID:11734182. |
presynaptic autoreceptor antagonist activity was demonstrated by its ability to potentiate the k(+)-induced outflow of [3h]5-ht from guinea pig cortical slices (pec(50)=7.74+/-0.05 nm) in which the 5-ht transporter had been inhibited by a maximally effective concentration of paroxetine. |
2002-02-11 |
2023-08-12 |
human |
| A A Izzo, E Erns. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs. vol 61. issue 15. 2002-02-05. PMID:11772128. |
the results indicate that st john's wort (hypericum perforatum) lowers blood concentrations of cyclosporin, amitriptyline, digoxin, indinavir, warfarin, phenprocoumon and theophylline; furthermore it causes intermenstrual bleeding, delirium or mild serotonin syndrome, respectively, when used concomitantly with oral contraceptives (ethinylestradiol/desogestrel), loperamide or selective serotonin-reuptake inhibitors (sertaline, paroxetine, nefazodone). |
2002-02-05 |
2023-08-12 |
Not clear |
| A Fagiolini, D J Buysse, E Frank, P R Houck, J F Luther, D J Kupfe. Tolerability of combined treatment with lithium and paroxetine in patients with bipolar disorder and depression. Journal of clinical psychopharmacology. vol 21. issue 5. 2002-01-24. PMID:11593071. |
clinicians should be aware of the possible development of a serotonin syndrome among patients in whom paroxetine is added to ongoing lithium treatment. |
2002-01-24 |
2023-08-12 |
human |
| D Marazziti, L Dell'Osso, A Rossi, I Masala, S Baroni, A Armani, G Giannaccini, E Di Nasso, A Lucacchini, G B Cassan. Decreased platelet [3H]paroxetine binding sites in suicide attempters. Psychiatry research. vol 103. issue 2-3. 2002-01-03. PMID:11549401. |
with this study, we aimed to investigate the platelet 5-ht transporter, by means of the specific binding of tritiated paroxetine ([3h]par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. |
2002-01-03 |
2023-08-12 |
human |
| F Yamane, H Okazawa, P Blier, M Diksi. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728384. |
reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14c]methyl-l-tryptophan(2). |
2002-01-02 |
2023-08-12 |
rat |
| F Yamane, H Okazawa, P Blier, M Diksi. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728384. |
in the first series of experiments, an acute intraperitoneal injection of paroxetine (10 mg/kg) produced a significant reduction in 5-ht synthesis in brain structures containing serotonergic cell bodies (the dorsal, median, and pallidum raphe nuclei), as well as in most projection areas: the ventral tegmental area, median forebrain bundle, hippocampus ca3 region, and nigrostriatal structures (substantia nigra, lateral and medial caudate nuclei). |
2002-01-02 |
2023-08-12 |
rat |
| F Yamane, H Okazawa, P Blier, M Diksi. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728384. |
in the cerebral cortex, 5-ht synthesis rates were not modified by acute paroxetine treatment. |
2002-01-02 |
2023-08-12 |
rat |
| F Yamane, H Okazawa, P Blier, M Diksi. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728384. |
in conclusion, the present data suggest that the effects of paroxetine on 5-ht synthesis in the cerebral cortex are different from its effects in the cell body area of the brainstem. |
2002-01-02 |
2023-08-12 |
rat |
| J H Meyer, A A Wilson, N Ginovart, V Goulding, D Hussey, K Hood, S Houl. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. The American journal of psychiatry. vol 158. issue 11. 2001-12-13. PMID:11691690. |
occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)c]dasb pet imaging study. |
2001-12-13 |
2023-08-12 |
Not clear |
| Z Xu, F J Seidler, S F Ali, W Slikker, T A Slotki. Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. Brain research. vol 914. issue 1-2. 2001-12-07. PMID:11578609. |
fetal nicotine exposure (gestational days 4-21) decreased the cerebrocortical binding of paroxetine (pxt), a marker for the serotonin (5ht) transporter, likely indicative of a decrease in nerve terminals in that region; the effect lasted into adulthood. |
2001-12-07 |
2023-08-12 |
rat |
| P J Goodnic. Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 13. issue 1. 2001-12-04. PMID:11465683. |
yet, there are positive reports concerning the ssris (paroxetine, citalopram, sertraline), as well as nefazodone, that focus on serotonin selectivity. |
2001-12-04 |
2023-08-12 |
human |
| K W Raines, F J Seidler, T A Slotki. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain research. Developmental brain research. vol 130. issue 1. 2001-12-04. PMID:11557094. |
at the end of the treatment period (pn5 and 15, respectively) and 5-7 days later, we then examined the effects on paroxetine (pxt) binding to the presynaptic 5ht high-affinity transporter, a marker for serotonin (5ht) projections. |
2001-12-04 |
2023-08-12 |
rat |
| P Venault, D Rudrauf, E M Lepicard, A Berthoz, R Jouvent, G Chapouthie. Balance control and posture in anxious mice improved by SSRI treatment. Neuroreport. vol 12. issue 14. 2001-12-04. PMID:11568643. |
the model, already validated with acutely administered diazepam, was used to assess the action of two chronically administered selective serotonin reuptake inhibitors (ssris), fluoxetine and paroxetine. |
2001-12-04 |
2023-08-12 |
mouse |
| M D Waldinger, A H Zwinderman, B Olivie. Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. Journal of clinical psychopharmacology. vol 21. issue 3. 2001-11-01. PMID:11386492. |
a double-blind, placebo-controlled study in men with lifelong rapid ejaculation was performed to assess the effects of two selective serotonin (5-ht) reuptake inhibitors--paroxetine and sertraline--and the 5-ht2 antagonist and 5-ht/noradrenaline reuptake inhibitor nefazodone on the latency to ejaculate. |
2001-11-01 |
2023-08-12 |
Not clear |
| P K Gillma. Comments on "Serotonin syndrome during treatment with paroxetine and risperidone". Journal of clinical psychopharmacology. vol 21. issue 3. 2001-11-01. PMID:11386501. |
comments on "serotonin syndrome during treatment with paroxetine and risperidone". |
2001-11-01 |
2023-08-12 |
Not clear |