| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Netta Roz, Yehuda Mazur, Amiram Hirshfeld, Moshe Rehav. Inhibition of vesicular uptake of monoamines by hyperforin. Life sciences. vol 71. issue 19. 2002-10-25. PMID:12215370. |
hyperforin had no inhibitory effect on the binding of [3h]paroxetine, [3h]gbr12935 and [3h]nisoxetine to membrane presynaptic transporters for 5-ht, da and ne, respectively. |
2002-10-25 |
2023-08-12 |
rat |
| Michelle L Gilmor, Michael J Owens, Charles B Nemerof. Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine. The American journal of psychiatry. vol 159. issue 10. 2002-10-23. PMID:12359676. |
the study examined whether paroxetine inhibits the human norepinephrine transporter in addition to the human serotonin (5-ht) transporter in patients with major depressive disorder. |
2002-10-23 |
2023-08-12 |
human |
| Caroline Bell, Sam Forshall, Mariona Adrover, Jon Nash, Sean Hood, Spilios Argyropoulos, Ann Rich, David J Nut. Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine. Journal of psychopharmacology (Oxford, England). vol 16. issue 1. 2002-10-08. PMID:11949771. |
fourteen patients with panic disorder who had responded to treatment with the selective serotonin reuptake inhibitor (ssri) paroxetine received a tryptophan-free amino acid drink on one occasion and a control drink on the other in a double-blind crossover design. |
2002-10-08 |
2023-08-12 |
Not clear |
| Theodore S Takata, Stephen L Wasmund, Michael L Smith, Jian-Ming Li, Jose A Joglar, Kim Banks, Robert C Kowal, Richard L Page, Mohamed H Hamda. Serotonin reuptake inhibitor (Paxil) does not prevent the vasovagal reaction associated with carotid sinus massage and/or lower body negative pressure in healthy volunteers. Circulation. vol 106. issue 12. 2002-10-03. PMID:12234955. |
the purpose of this study was to assess the effect of the serotonin reuptake inhibitor paroxetine hydrochloride (paxil, smithkline beecham) on cardiovascular reflexes. |
2002-10-03 |
2023-08-12 |
human |
| Isabelle Loubinoux, Jérémie Pariente, Olivier Rascol, Pierre Celsis, François Cholle. Selective serotonin reuptake inhibitor paroxetine modulates motor behavior through practice. A double-blind, placebo-controlled, multi-dose study in healthy subjects. Neuropsychologia. vol 40. issue 11. 2002-09-24. PMID:12062893. |
selective serotonin reuptake inhibitor paroxetine modulates motor behavior through practice. |
2002-09-24 |
2023-08-12 |
human |
| Lankupalle D Jayanthi, Gricelly Vargas, Louis J DeFelic. Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts. British journal of pharmacology. vol 135. issue 8. 2002-09-17. PMID:11959795. |
ne transport in rat trophoblasts is sensitive to net-specific antagonists, desipramine (ds) and nisoxetine (nx), but not to the dopamine-transporter (dat) specific antagonist, gbr12909 or to the serotonin (5ht) transporter (sert) specific antagonist paroxetine (px). |
2002-09-17 |
2023-08-12 |
human |
| M I Smith, D C Piper, M S Duxon, N Upto. Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888551. |
effect of sb-243213, a selective 5-ht(2c) receptor antagonist, on the rat sleep profile: a comparison to paroxetine. |
2002-09-11 |
2023-08-12 |
rat |
| M I Smith, D C Piper, M S Duxon, N Upto. Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888551. |
here, we examine the acute effect of the selective 5-ht(2c) receptor antagonist 5-methyl-1-[[-2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-triflouromethylindoline hydrochloride (sb-243213-a) on rat sleep in comparison to the selective serotonin reuptake inhibitor (ssri) paroxetine. |
2002-09-11 |
2023-08-12 |
rat |
| M I Smith, D C Piper, M S Duxon, N Upto. Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888551. |
the similar effect of sb-243213-a to paroxetine with regard to ps quantity provides further evidence that 5-ht(2c) receptor antagonists maybe beneficial in the treatment of depression/anxiety. |
2002-09-11 |
2023-08-12 |
rat |
| Mauricette Brocco, Anne Dekeyne, Sylvie Veiga, Sylvie Girardon, Mark J Milla. Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888558. |
the selective serotonin (5-ht) reuptake inhibitors (ssris), citalopram, fluoxetine, paroxetine, fluvoxamine, litoxetine and zimelidine, dose-dependently enhanced la. |
2002-09-11 |
2023-08-12 |
mouse |
| John J Sramek, Victoria Zarotsky, Neal R Cutle. Generalised anxiety disorder: treatment options. Drugs. vol 62. issue 11. 2002-09-11. PMID:12109925. |
the antidepressants that offer both a good adverse effect profile and efficacy are the selective serotonin reuptake inhibitors including paroxetine, and the serotonin-norepinephrine reuptake inhibitors such as venlafaxine. |
2002-09-11 |
2023-08-12 |
Not clear |
| I Varia, F Rausche. Treatment of generalized anxiety disorder with citalopram. International clinical psychopharmacology. vol 17. issue 3. 2002-09-06. PMID:11981350. |
serotonin reuptake inhibitors (ssri), such as venalafaxine and paroxetine, are used in the treatment of generalized anxiety disorder (gad). |
2002-09-06 |
2023-08-12 |
Not clear |
| Feng C Zhou, Klaus-Peter Lesch, Dennis L Murph. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain research. vol 942. issue 1-2. 2002-09-04. PMID:12031859. |
normal rats treated with a 5-ht uptake blocker paroxetine also showed similar result. |
2002-09-04 |
2023-08-12 |
mouse |
| Feng C Zhou, Klaus-Peter Lesch, Dennis L Murph. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain research. vol 942. issue 1-2. 2002-09-04. PMID:12031859. |
these data indicate that: (a) 5-ht can be taken into da neurons in rats and mice when the 5-htt is not functionally adequate to remove extracellular 5-ht; (b) the 5-ht uptake into da neurons is not affected by the 5-ht uptake blocker paroxetine; and (c) the da transporter is responsible for the 5-ht uptake into da neurons. |
2002-09-04 |
2023-08-12 |
mouse |
| Lotte De Groote, Berend Olivier, Herman G M Westenber. The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT(1B) receptor knockout mice. European journal of pharmacology. vol 439. issue 1-3. 2002-08-08. PMID:11937097. |
systemic administration of the selective 5-ht reuptake inhibitor paroxetine (5 mg/kg, i.p.) |
2002-08-08 |
2023-08-12 |
mouse |
| P L Freijzer, J H E Brenninkmeije. [Hallucinations caused by paroxetine taken together with a levodopa-carbidopa preparation]. Nederlands tijdschrift voor geneeskunde. vol 146. issue 12. 2002-08-01. PMID:11938583. |
a 79-year-old woman suffering from parkinson's disease, for which she was taking a levodopa-carbidopa preparation, was prescribed the selective serotonin reuptake inhibitor paroxetine 20 mg once daily. |
2002-08-01 |
2023-08-12 |
Not clear |
| Antona J Wagstaff, Susan M Cheer, Anna J Matheson, Douglas Ormrod, Karen L Go. Spotlight on paroxetine in psychiatric disorders in adults. CNS drugs. vol 16. issue 6. 2002-07-19. PMID:12027788. |
paroxetine is a selective serotonin reuptake inhibitor (ssri), with antidepressant and anxiolytic activity. |
2002-07-19 |
2023-08-12 |
Not clear |
| Esther O'Shea, N Easton, J R Fry, A R Green, C A Marsde. Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia. Journal of neurochemistry. vol 81. issue 4. 2002-07-12. PMID:12065628. |
in the present study, depletion of peripheral (hepatic) glutathione by 43% with dl-buthionine-(s,r)-sulfoximine (an inhibitor of glutathione synthesis) did not attenuate mdma-induced neurotoxicity as indicated by the 34% loss of [(3) h]paroxetine binding to the serotonin uptake sites in dark agouti rats treated with the inhibitor. |
2002-07-12 |
2023-08-12 |
rat |
| Marcel D Waldinger, Afke van De Plas, Tommy Pattij, Ruud van Oorschot, Lique M Coolen, Jan G Veening, Berend Olivie. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology. vol 160. issue 3. 2002-07-08. PMID:11889497. |
the selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. |
2002-07-08 |
2023-08-12 |
Not clear |
| Saadia Eddahibi, Bernadette Raffestin, Michel Hamon, Serge Adno. Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension? The Journal of laboratory and clinical medicine. vol 139. issue 4. 2002-06-20. PMID:12024106. |
these mitogenic and comitogenic effects require 5-ht internalization by the high-affinity 5-htt, which can be competitively inhibited by specific drugs such as fluoxetine and paroxetine. |
2002-06-20 |
2023-08-12 |
mouse |