| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashwin A Patkar, Wade H Berrettini, Allan Lundy, Heather W Murray, Kevin P Hill, Michael J Vergare, Stephen P Weinstei. Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers. Human psychopharmacology. vol 18. issue 2. 2003-07-22. PMID:12590403. |
seasonal variations in the binding of [3h]paroxetine to the platelet serotonin transporter sites in african-american cocaine-dependent patients and healthy volunteers. |
2003-07-22 |
2023-08-12 |
human |
| Ashwin A Patkar, Wade H Berrettini, Allan Lundy, Heather W Murray, Kevin P Hill, Michael J Vergare, Stephen P Weinstei. Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers. Human psychopharmacology. vol 18. issue 2. 2003-07-22. PMID:12590403. |
platelet [(3)h]paroxetine binding, a measure of serotonin transporter sites, was assayed in 141 african-american cocaine-dependent subjects and in 60 race matched healthy volunteers who served as the control group. |
2003-07-22 |
2023-08-12 |
human |
| Ashwin A Patkar, Wade H Berrettini, Allan Lundy, Heather W Murray, Kevin P Hill, Michael J Vergare, Stephen P Weinstei. Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers. Human psychopharmacology. vol 18. issue 2. 2003-07-22. PMID:12590403. |
b(max) (density of serotonin transporter) and k(d) (affinity constant) values of [(3)h]paroxetine binding were compared during spring, summer, fall and winter. |
2003-07-22 |
2023-08-12 |
human |
| Elena Castro, Rosa M Tordera, Zoe A Hughes, Qi Pei, Trevor Shar. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787067. |
here, arc expression was used to test whether, in rats, co-administration of a 5-ht re-uptake inhibitor (paroxetine) and a 5-ht1a receptor antagonist (way 100635) increases postsynaptic 5-ht function. |
2003-07-10 |
2023-08-12 |
rat |
| Elena Castro, Rosa M Tordera, Zoe A Hughes, Qi Pei, Trevor Shar. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787067. |
after pre-treatment with way 100635 (0.3 mg/kg s.c.), paroxetine (5 mg/kg s.c.) caused a threefold increase in 5-ht in prefrontal cortex microdialysates. |
2003-07-10 |
2023-08-12 |
rat |
| E J Bull, P H Hutson, K C F Fon. Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity. Neuropharmacology. vol 44. issue 4. 2003-07-03. PMID:12646281. |
hippocampal and frontal cortical 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) were significantly reduced in mdma pre-treated rats, without any change in [(3)h]paroxetine binding or plasma corticosterone levels. |
2003-07-03 |
2023-08-12 |
rat |
| Alan Wade, Gordon M Crawford, Margaret Angus, Richard Wilson, Lorna Hamilto. A randomized, double-blind, 24-week study comparing the efficacy and tolerability of mirtazapine and paroxetine in depressed patients in primary care. International clinical psychopharmacology. vol 18. issue 3. 2003-06-17. PMID:12702891. |
an observed difference in efficacy favouring mirtazapine between weeks 1 and 4 indicates that mirtazapine patients had improved earlier compared to those on paroxetine, and corroborates similar findings in other comparisons of mirtazapine versus selective serotonin reuptake inhibitors. |
2003-06-17 |
2023-08-12 |
Not clear |
| Ashwin A Patkar, Edward Gottheil, Wade H Berrettini, Charles C Thornton, Kevin P Hill, Stephen P Weinstei. Relationship between platelet serotonin uptake sites and treatment outcome among African-American cocaine dependent individuals. Journal of addictive diseases. vol 22. issue 1. 2003-06-06. PMID:12661981. |
we investigated whether platelet tritiated paroxetine binding, a measure of serotonin uptake sites differed between cocaine-dependent subjects and controls, and whether paroxetine binding was related to treatment-outcome for cocaine patients. |
2003-06-06 |
2023-08-12 |
human |
| Göksel Altiokka, Kevser Kircal. Simple method of paroxetine determination using a single channel FIA with no in-line reaction process. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 19. issue 4. 2003-05-23. PMID:12725406. |
a flow-injection analysis (fia) of paroxetine hydrochloride (prx), a selective serotonin reuptake inhibitor (ssri) currently used as an antidepressant drug, is described. |
2003-05-23 |
2023-08-12 |
Not clear |
| Chad E Beyer, Steve Boikess, Bin Luo, Lee A Dawso. Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. Journal of psychopharmacology (Oxford, England). vol 16. issue 4. 2003-05-19. PMID:12503828. |
conversely, acute injection of the selective serotonin reuptake inhibitors, fluoxetine (30 mg/kg, s.c.) and paroxetine (1-10 mg/kg, s.c.), did not alter forebrain ne concentrations. |
2003-05-19 |
2023-08-12 |
rat |
| Chad E Beyer, Steve Boikess, Bin Luo, Lee A Dawso. Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. Journal of psychopharmacology (Oxford, England). vol 16. issue 4. 2003-05-19. PMID:12503828. |
these changes in ne were not paralleled by 5-ht, which showed no increase following administration of desipramine, venlafaxine, paroxetine or fluoxetine. |
2003-05-19 |
2023-08-12 |
rat |
| Chad E Beyer, Steve Boikess, Bin Luo, Lee A Dawso. Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. Journal of psychopharmacology (Oxford, England). vol 16. issue 4. 2003-05-19. PMID:12503828. |
combination treatment with the 5-ht1a receptor antagonist, way-100635 (0.3 mg/kg, s.c.), significantly enhanced extracellular 5-ht concentrations following venlafaxine (10 and 30 mg/kg), fluoxetine (30 mg/kg) and paroxetine (3-30 mg/kg). |
2003-05-19 |
2023-08-12 |
rat |
| Chad E Beyer, Steve Boikess, Bin Luo, Lee A Dawso. Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. Journal of psychopharmacology (Oxford, England). vol 16. issue 4. 2003-05-19. PMID:12503828. |
collectively, these studies show that paroxetine, at low to intermediate doses, and fluoxetine are selective for 5-ht versus ne systems, whereas venlafaxine produces similar effects on both 5-ht and ne levels at the effective doses tested. |
2003-05-19 |
2023-08-12 |
rat |
| J Melke, L Westberg, M Landén, C Sundblad, O Eriksson, F Baghei, R Rosmond, E Eriksson, A Ekma. Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria. Psychoneuroendocrinology. vol 28. issue 3. 2003-05-13. PMID:12573307. |
serotonin transporter gene polymorphisms and platelet [3h] paroxetine binding in premenstrual dysphoria. |
2003-05-13 |
2023-08-12 |
human |
| J Melke, L Westberg, M Landén, C Sundblad, O Eriksson, F Baghei, R Rosmond, E Eriksson, A Ekma. Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria. Psychoneuroendocrinology. vol 28. issue 3. 2003-05-13. PMID:12573307. |
the results support the assumption that serotonin-related psychiatric disorders-such as premenstrual dysphoria-may be associated with a reduction in platelet [(3)h]paroxetine binding, but argue against the notion that this reduction is due to certain variants of the serotonin transporter gene being more common in patients than in controls. |
2003-05-13 |
2023-08-12 |
human |
| Jun Fujishiro, Taiichiro Imanishi, Kaname Onozawa, Masaki Tsushim. Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. European journal of pharmacology. vol 454. issue 2-3. 2003-05-06. PMID:12421645. |
paroxetine, a selective serotonin reuptake inhibitor, shows relatively high affinity for muscarinic acetylcholine receptors compared to other selective serotonin reuptake inhibitors. |
2003-05-06 |
2023-08-12 |
mouse |
| Jun Fujishiro, Taiichiro Imanishi, Kaname Onozawa, Masaki Tsushim. Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. European journal of pharmacology. vol 454. issue 2-3. 2003-05-06. PMID:12421645. |
to determine whether paroxetine has anticholinergic effects in vivo, we examined the effects of paroxetine on oxotremorine-induced tremor, spontaneous defecation and passive avoidance performance using mice and compared the results with those using fluvoxamine, another selective serotonin reuptake inhibitor, and clomipramine, a tricyclic antidepressant with serotonin selectivity. |
2003-05-06 |
2023-08-12 |
mouse |
| J Tack, D Broekaert, B Coulie, B Fischler, J Janssen. Influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans. Alimentary pharmacology & therapeutics. vol 17. issue 4. 2003-04-28. PMID:12622770. |
influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans. |
2003-04-28 |
2023-08-12 |
Not clear |
| Justine M Kent, Jeremy D Coplan, Ilise Lombardo, Dah-Ren Hwang, Yiyun Huang, Osama Mawlawi, Ronald L Van Heertum, Mark Slifstein, Anissa Abi-Dargham, Jack M Gorman, Marc Laruell. Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457263. |
occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11c mcn 5652. |
2003-04-23 |
2023-08-12 |
Not clear |
| H Murck, T Nickel, H Künzel, I A Antonijevic, J Schill, A Zobel, A Steiger, A Sonntag, F Holsboe. State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589388. |
tianeptine enhances while paroxetine inhibits serotonin reuptake into neurons; however, both show an antidepressive action. |
2003-04-21 |
2023-08-12 |
Not clear |