| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
effects of chronic paroxetine treatment on dialysate serotonin in 5-ht1b receptor knockout mice. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
the role of serotonin (5-ht)1b receptors in the mechanism of action of selective serotonin re-uptake inhibitors (ssri) was studied by using intracerebral in vivo microdialysis in conscious, freely moving wild-type and 5-ht1b receptor knockout (ko 5-ht1b) mice in order to compare the effects of chronic administration of paroxetine via osmotic minipumps (1 mg per kg per day for 14 days) on extracellular 5-ht levels ([5-ht]ext) in the medial prefrontal cortex and ventral hippocampus. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
basal [5-ht]ext values in the medial prefrontal cortex and ventral hippocampus, approximately 20 h after removing the minipump, were not altered by chronic paroxetine treatment in both genotypes. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
conversely, in the medial prefrontal cortex, the paroxetine challenge increased [5-ht]ext similarly in saline-pretreated mice of both genotypes. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
to avoid the interaction with raphe 5-ht1a autoreceptors, 1 micro m paroxetine was perfused locally through the dialysis probe implanted in the ventral hippocampus; similar increases in hippocampal [5-ht]ext were found in acutely or chronically treated wild-type mice. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
systemic administration of the mixed 5-ht1b/1d receptor antagonist gr 127935 (4 mg/kg) in chronically treated wild-type mice potentiated the effect of a paroxetine challenge dose on [5-ht]ext in the ventral hippocampus, whereas systemic administration of the selective 5-ht1a receptor antagonist way 100635 did not. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
as steady-state brain concentrations of paroxetine at day 14 were similar in both genotypes, it is unlikely that differences in the effects of a paroxetine challenge on hippocampal [5-ht]ext are due to alterations of the drug's pharmacokinetic properties in mutants. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
these presynaptic receptors retain their capacity to limit 5-ht release mainly in the ventral hippocampus following chronic paroxetine treatment in mice. |
2003-08-26 |
2023-08-12 |
mouse |
| H Kojima, T Terao, M Iwakawa, A Soya, N Inoue, Y Shiraishi, Y Son, S Soeda, N Ueda, R Yoshimura, J Nakamur. Paroxetine as a 5-HT neuroendocrine probe. Psychopharmacology. vol 167. issue 1. 2003-08-22. PMID:12601506. |
paroxetine as a 5-ht neuroendocrine probe. |
2003-08-22 |
2023-08-12 |
human |
| H Kojima, T Terao, M Iwakawa, A Soya, N Inoue, Y Shiraishi, Y Son, S Soeda, N Ueda, R Yoshimura, J Nakamur. Paroxetine as a 5-HT neuroendocrine probe. Psychopharmacology. vol 167. issue 1. 2003-08-22. PMID:12601506. |
acute administration of 40 mg paroxetine (a selective serotonin reuptake inhibitor) reportedly increases plasma cortisol in human subjects. |
2003-08-22 |
2023-08-12 |
human |
| H Kojima, T Terao, M Iwakawa, A Soya, N Inoue, Y Shiraishi, Y Son, S Soeda, N Ueda, R Yoshimura, J Nakamur. Paroxetine as a 5-HT neuroendocrine probe. Psychopharmacology. vol 167. issue 1. 2003-08-22. PMID:12601506. |
this suggests that paroxetine may be a useful tool to probe brain serotonin function. |
2003-08-22 |
2023-08-12 |
human |
| Cristina Messa, Cristina Colombo, Rosa Maria Moresco, Clara Gobbo, Laura Galli, Giovanni Lucignani, Maria Carla Gilardi, Giovanna Rizzo, Enrico Smeraldi, Raffaella Zanardi, Francesc Artigas, Ferruccio Fazi. 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study. Psychopharmacology. vol 167. issue 1. 2003-08-22. PMID:12632246. |
the aim of the study was to investigate differences in 5-ht(2a) receptor binding between healthy volunteers and patients with major depressive disorder (mdd), either never treated before with antidepressants (drug-naive: dn) or responding to paroxetine treatment (drug-treated: dt). |
2003-08-22 |
2023-08-12 |
human |
| Michel Bouri. Use of paroxetine for the treatment of depression and anxiety disorders in the elderly: a review. Human psychopharmacology. vol 18. issue 3. 2003-08-22. PMID:12672169. |
paroxetine is a potent selective serotonin reuptake inhibitor (ssri) with indications for the treatment of depression, obsessive- compulsive disorder, panic disorder and social phobia. |
2003-08-22 |
2023-08-12 |
Not clear |
| Adam Roman, Jerzy Vetulani, Irena Nalep. Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866718. |
in this study, we investigated how two modem antidepressant therapies, chronic treatment with transcranial magnetic stimulation (tms) and administration of an antidepressant belonging to selective serotonin reuptake inhibitors (ssri), paroxetine, affect the proliferative response of thymocytes and splenocytes stimulated in vitro with various mitogens. |
2003-08-15 |
2023-08-12 |
rat |
| Lucimey Lima, Mary Urbin. Serotonin transporter modulation in blood lymphocytes from patients with major depression. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585696. |
measurement [3h]paroxetine binding showed that human lymphocytes contain a high-affinity serotonin transporter. |
2003-08-13 |
2023-08-12 |
human |
| M Urbina, S Pineda, L Piñango, I Carreira, L Lim. [3H]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine. International journal of immunopharmacology. vol 21. issue 10. 2003-08-06. PMID:12609459. |
we determined the density of serotonin uptake sites by the binding of [3h]paroxetine to blood peripheral lymphocyte membrane preparations of controls and of patients with major depression before and after treatment with fluoxetine for six weeks. |
2003-08-06 |
2023-08-12 |
human |
| M Urbina, S Pineda, L Piñango, I Carreira, L Lim. [3H]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine. International journal of immunopharmacology. vol 21. issue 10. 2003-08-06. PMID:12609459. |
the significant correlation between specific binding of [3h]paroxetine and plasma serotonin levels in controls was not present in the patients. |
2003-08-06 |
2023-08-12 |
human |
| R Tordera, Q Pei, M Newson, K Gray, M Sprakes, T Shar. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726821. |
the present study tested the effect of different selective 5-ht(1a) receptor antagonists (way 100635, nad-299, p-mppi and ly 426965) in combination with a ssri (paroxetine), on postsynaptic 5-ht function measured by increased expression of the immediate early gene, arc. |
2003-08-04 |
2023-08-12 |
rat |
| R Tordera, Q Pei, M Newson, K Gray, M Sprakes, T Shar. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726821. |
whilst ly 426965 (3 or 10 mg/kg s.c.) had no effect alone, when combined with paroxetine (5 mg/kg s.c.), the drug increased arc mrna in caudate putamen but not cortical regions.in conclusion, this study demonstrates that four 5-ht(1a) receptor antagonists augment the effect of an ssri on arc mrna expression, which is suggestive of increased postsynaptic 5-ht function. |
2003-08-04 |
2023-08-12 |
rat |
| A L Coppell, Q Pei, T S C Zetterströ. Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726822. |
it was found that repeated administration of either the monoamine oxidase inhibitor tranylcypromine (tcp) or 5-hydroxytryptamine (5-ht) re-uptake inhibitors (fluoxetine, paroxetine and sertraline), evoke a bi-phasic and time-dependent effect on bdnf gene expression in the rat hippocampus (especially dentate gyrus). |
2003-08-04 |
2023-08-12 |
rat |