| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
rats were treated by osmotic minipump for 21 d with the selective serotonin reuptake inhibitors (ssris) paroxetine or sertraline, the selective norepinephrine reuptake inhibitor desipramine (dmi), or the monoamine oxidase inhibitor phenelzine. |
1999-12-17 |
2023-08-12 |
rat |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
the serotonin content of the hippocampus was unaffected by paroxetine or sertraline treatment, ruling out neurotoxicity as a possible explanation for the ssri-induced decrease in sert binding and alteration in 5-ht clearance. |
1999-12-17 |
2023-08-12 |
rat |
| S Javanmard, H M Deutsch, D M Collard, M J Kuhar, M M Schwer. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes. Journal of medicinal chemistry. vol 42. issue 23. 1999-12-17. PMID:10579846. |
to demonstrate transporter selectivity for the compounds, inhibitor potency was also tested using [(3)h]nisoxetine and [(3)h]paroxetine binding assays for the norepinephrine (ne) and serotonin (5-ht) transporters, respectively. |
1999-12-17 |
2023-08-12 |
Not clear |
| S M Southwick, S Paige, C A Morgan, J D Bremner, J H Krystal, D S Charne. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars in clinical neuropsychiatry. vol 4. issue 4. 1999-12-13. PMID:10553029. |
evidence of serotonergic dysregulation in ptsd includes frequent symptoms of aggression, impulsivity, depression and suicidality, decreased platelet paroxetine binding, blunted prolactin response to fenfluramine, exaggerated reactivity to m-chloro-phenyl-piperazine, and clinical efficacy of serotonin reuptake inhibitors. |
1999-12-13 |
2023-08-12 |
Not clear |
| Z Zylicz, M Krajni. [Pruritus in cancer: uncommon, but sometimes worse than the pain]. Nederlands tijdschrift voor geneeskunde. vol 143. issue 39. 1999-12-02. PMID:10526610. |
this was only alleviated after treatment with paroxetine, a serotonin re-uptake inhibitor, or with tropisetron, a serotonin antagonist. |
1999-12-02 |
2023-08-12 |
Not clear |
| F H Coleman, H D Christensen, C L Gonzalez, W F Raybur. Behavioral changes in developing mice after prenatal exposure to paroxetine (Paxil) American journal of obstetrics and gynecology. vol 181. issue 5 Pt 1. 1999-12-02. PMID:10561639. |
behavioral changes in developing mice after prenatal exposure to paroxetine (paxil) the aim of this study was to conduct in a randomized, placebo-controlled manner behavioral testing on mice offspring exposed prenatally to the selective serotonin reuptake inhibitor paroxetine. |
1999-12-02 |
2023-08-12 |
mouse |
| S M Husbands, S Izenwasser, T Kopajtic, W D Bowen, B J Vilner, J L Katz, A H Newma. Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. Journal of medicinal chemistry. vol 42. issue 21. 1999-11-22. PMID:10543888. |
several of the analogues displaced [(3)h]paroxetine from serotonin transporters with moderate to high affinity, with the n-phenylpropyl derivative (11) having the highest affinity (k(i) = 44.5 nm). |
1999-11-22 |
2023-08-12 |
mouse |
| B J Stanford, S C Stanfor. Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine? Journal of psychopharmacology (Oxford, England). vol 13. issue 3. 1999-11-19. PMID:10512094. |
postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine? |
1999-11-19 |
2023-08-12 |
Not clear |
| B J Stanford, S C Stanfor. Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine? Journal of psychopharmacology (Oxford, England). vol 13. issue 3. 1999-11-19. PMID:10512094. |
the patient had not been prescribed neuroleptics but, before surgery, she had been taking the selective serotonin reuptake inhibitor, paroxetine, to relieve her depression. |
1999-11-19 |
2023-08-12 |
Not clear |
| B J Stanford, S C Stanfor. Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine? Journal of psychopharmacology (Oxford, England). vol 13. issue 3. 1999-11-19. PMID:10512094. |
although there is no clear explanation for the delirium, it had many features in common with problems associated with paroxetine withdrawal, the serotonin syndrome and the malignant neuroleptic syndrome. |
1999-11-19 |
2023-08-12 |
Not clear |
| A H Abdelmawla, R W Langley, E Szabadi, C M Bradsha. Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. British journal of clinical pharmacology. vol 48. issue 3. 1999-11-16. PMID:10510145. |
the effects of venlafaxine were compared with those of desipramine, a tricyclic antidepressant with noradrenaline uptake inhibiting properties, and paroxetine, a selective serotonin re-uptake inhibitor (ssri), on noradrenaline-and methoxamine-evoked venoconstriction using the dorsal hand vein compliance technique. |
1999-11-16 |
2023-08-12 |
Not clear |
| D A Sclar, T L Skaer, L M Robison, R S Gali. Economic appraisal of citalopram in the management of single-episode depression. Journal of clinical psychopharmacology. vol 19. issue 5 Suppl 1. 1999-11-10. PMID:10507508. |
a retrospective intent-to-treat analysis (n = 1,339) was conducted to discern the natural course of antidepressant use and direct health service expenditures for the treatment of single-episode depression (dsm-iv code 296.20) among patients initiating antidepressant pharmacotherapy with either a tricyclic antidepressant (tca) (amitriptyline, n = 237) or a selective serotonin reuptake inhibitor (ssri) (citalopram, n = 71; fluoxetine, n = 411; paroxetine, n = 334; or sertraline, n = 286). |
1999-11-10 |
2023-08-12 |
Not clear |
| B Arranz, P Rosel, S Sarró, E Zaldivar, R Cano, M A Navarro, L Sa. Platelet serotonergic binding sites in alcohol-dependent patients. Alcohol and alcoholism (Oxford, Oxfordshire). vol 34. issue 5. 1999-11-09. PMID:10528815. |
the serotonin (5-hydroxytryptamine, 5-ht) uptake sites assessed with both [3h]imipramine and [3h]paroxetine, and the 5-ht2a receptors were simultaneously measured in platelets from 24 male subjects meeting the american psychiatric association's dsm-iv criteria for alcohol dependence and admitted for inpatient detoxification. |
1999-11-09 |
2023-08-12 |
human |
| B Arranz, P Rosel, S Sarró, E Zaldivar, R Cano, M A Navarro, L Sa. Platelet serotonergic binding sites in alcohol-dependent patients. Alcohol and alcoholism (Oxford, Oxfordshire). vol 34. issue 5. 1999-11-09. PMID:10528815. |
abstinence from alcohol for 2 weeks (day 14) resulted in a decrease in the number of 5-ht uptake sites labelled with [3h]paroxetine compared to normal values, together with a significant decrease in the number of 5-ht2a binding sites. |
1999-11-09 |
2023-08-12 |
human |
| A M Gray, D M Pache, R D Sewel. Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds? European journal of pharmacology. vol 378. issue 2. 1999-11-01. PMID:10478628. |
the antidepressants or monoamine reuptake inhibitors included the serotonin selective reuptake inhibitor paroxetine, the serotonin-noradrenaline reuptake inhibitor sibutramine, the resolved (+)- and (-)-enantiomers of the noradrenaline reuptake inhibitor oxaprotiline, plus the tricyclics amitriptyline and dothiepin. |
1999-11-01 |
2023-08-12 |
mouse |
| G Chouinard, B Saxena, M C Bélanger, A Ravindran, D Bakish, L Beauclair, P Morris, N P Vasavan Nair, R Manchanda, R Reesal, R Remick, M C O'Neil. A Canadian multicenter, double-blind study of paroxetine and fluoxetine in major depressive disorder. Journal of affective disorders. vol 54. issue 1-2. 1999-10-26. PMID:10403145. |
in a 12-week randomized, multicenter, double-blind trial, the antidepressant and anxiolytic efficacy of the selective serotonin reuptake inhibitors paroxetine and fluoxetine was compared in patients with moderate to severe depression. |
1999-10-26 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
the effects of selective serotonin re-uptake inhibitor (ssri), paroxetine, and 5-ht1a, 5-ht1b and 5-ht1b/1d receptor antagonists on in vivo extracellular 5-ht levels in the guinea-pig frontal cortex and dorsal hippocampus were investigated using the technique of microdialysis. |
1999-10-25 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
paroxetine (10 microm) significantly increased extracellular 5-ht levels when perfused locally into the cortex. |
1999-10-25 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
in contrast, sequential administration of either way 100635 and gr 127935, or sb-224289 and paroxetine significantly increased extracellular 5-ht levels. |
1999-10-25 |
2023-08-12 |
Not clear |
| R M Bagby, R D Levitan, S H Kennedy, A J Levitt, R T Joff. Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificity. Psychiatry research. vol 86. issue 3. 1999-10-21. PMID:10482340. |
in this study, 76 depressed outpatients were treated with either the noradrenergic antidepressant desipramine (n = 38) or a selective serotonin re-uptake inhibitor (paroxetine or sertraline) (n = 38) over a period of 8-14 weeks. |
1999-10-21 |
2023-08-12 |
Not clear |