| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
inhibition of hippocampal 5-ht synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-ht1a and 5-ht1b/d autoreceptors. |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
), an antagonist with high affinity for 5-ht1b/d receptors, blocked the reduction of hippocampal 5-ht synthesis following the 5-ht receptor agonist tfmpp (3 mg/kg s.c.) without affecting the reduction of hippocampal 5-ht synthesis by either fluoxetine or paroxetine. |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
significantly attenuated the decrease of hippocampal 5-ht synthesis by both fluoxetine and paroxetine. |
1999-05-04 |
2023-08-12 |
rat |
| S Y Ye. N-tert-butyl-alpha-phenylnitrone protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029234. |
density of the 5-ht transporters was assayed by [3h]paroxetine binding. |
1999-05-04 |
2023-08-12 |
rat |
| B D Greenberg, T J Tolliver, S J Huang, Q Li, D Bengel, D L Murph. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American journal of medical genetics. vol 88. issue 1. 1999-05-03. PMID:10050973. |
the 5-httlpr genotype had no effect on platelet [3h]paroxetine binding (bmax), affinity for [3h]5-ht or [3h]paroxetine, or 5-ht content. |
1999-05-03 |
2023-08-12 |
human |
| A C Trillat, I Malagié, M Bourin, C Jacquot, R Hen, A M Gardie. [Homozygote mice deficient in serotonin 5-HT1B receptor and antidepressant effect of selective serotonin reuptake inhibitors]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101609. |
using microdialysis in awake 129/sv mice, we show that the absence of the 5-ht1b receptor in mutant mice (ko 1b -/-) potentiated the effect of paroxetine on extracellular 5-ht levels in the ventral hippocampus, but not in the frontal cortex compared to wild-type mice (wt). |
1999-05-03 |
2023-08-12 |
mouse |
| J P Redrobe, M Bourin, M C Colombel, G B Bake. Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms. Journal of psychopharmacology (Oxford, England). vol 12. issue 4. 1999-04-23. PMID:10065908. |
psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms. |
1999-04-23 |
2023-08-12 |
mouse |
| J P Redrobe, M Bourin, M C Colombel, G B Bake. Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms. Journal of psychopharmacology (Oxford, England). vol 12. issue 4. 1999-04-23. PMID:10065908. |
the present study was designed to evaluate the psychopharmacological profile of the selective serotonin reuptake inhibitor paroxetine, and thus assess potential noradrenergic and/or serotonergic activity. |
1999-04-23 |
2023-08-12 |
mouse |
| F Mentré, J L Golmard, J M Launay, V Aubin-Brunet, M Bouhassira, R Jouven. Relationships between low red blood cell count and clinical response to fluoxetine in depressed elderly patients. Psychiatry research. vol 81. issue 3. 1999-04-19. PMID:9925192. |
biological variables measured on days 1 and 42 included whole blood and plasma serotonin, plasma total and free tryptophan, and platelet paroxetine and ketanserin binding. |
1999-04-19 |
2023-08-12 |
Not clear |
| E Di Girolamo, C Di Iorio, P Sabatini, L Leonzio, C Barbone, A Barsott. Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study. Journal of the American College of Cardiology. vol 33. issue 5. 1999-04-19. PMID:10193720. |
effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study. |
1999-04-19 |
2023-08-12 |
Not clear |
| E Di Girolamo, C Di Iorio, P Sabatini, L Leonzio, C Barbone, A Barsott. Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study. Journal of the American College of Cardiology. vol 33. issue 5. 1999-04-19. PMID:10193720. |
the purpose of the study was to determine whether the well tolerated serotonin reuptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in patients resistant to or intolerant of previous traditional therapies. |
1999-04-19 |
2023-08-12 |
Not clear |
| S Abe, T Hori, T Suzuki, A Baba, H Shiraishi, T Yamamot. Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain. Neurochemical research. vol 24. issue 3. 1999-04-16. PMID:10215509. |
ifn did not alter either [3h]ketanserin binding to 5-ht2a receptors or [3h]paroxetine binding to 5-ht transporters. |
1999-04-16 |
2023-08-12 |
human |
| R Schlösser, J Röschke, W Rossbach, O Benker. Conventional and spectral power analysis of all-night sleep EEG after subchronic treatment with paroxetine in healthy male volunteers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 8. issue 4. 1999-04-13. PMID:9928916. |
paroxetine is a selective and potent serotonin reuptake inhibitor with reported antidepressant properties. |
1999-04-13 |
2023-08-12 |
human |
| M Stamenkovic, L Pezawas, M de Zwaan, H N Aschauer, S Kaspe. Mirtazapine in recurrent brief depression. International clinical psychopharmacology. vol 13. issue 1. 1999-04-02. PMID:9988366. |
results of treatment studies with selective serotonin reuptake inhibitors (fluoxetine, paroxetine) did not demonstrate superiority of the active drug over placebo in rbd. |
1999-04-02 |
2023-08-12 |
Not clear |
| M J Millan, A Gobert, S Girardon, A Dekeyn. Citalopram elicits a discriminative stimulus in rats at a dose selectively increasing extracellular levels of serotonin vs. dopamine and noradrenaline. European journal of pharmacology. vol 364. issue 2-3. 1999-03-24. PMID:9932717. |
at this dose, employing a two-lever, food-reinforced, drug discrimination procedure, citalopram generated reliable recognition and fully (> 80%) generalized to itself with an effective dose50 (ed50) of 0.1 mg/kg, s.c. two further selective 5-ht reuptake inhibitors, sertraline and paroxetine, fully generalized with ed50s of 0.01 and 0.04 mg/kg, s.c., respectively. |
1999-03-24 |
2023-08-12 |
rat |
| S Eddahibi, V Fabre, C Boni, M P Martres, B Raffestin, M Hamon, S Adno. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circulation research. vol 84. issue 3. 1999-03-12. PMID:10024307. |
this effect was dependent on the 5-ht transporter (5-htt), since it was prevented by the 5-htt inhibitors fluoxetine (10(-6) mol/l) and paroxetine (10(-7) mol/l), but it was unaltered by ketanserin (10(-6) mol/l), a 5-ht2a receptor antagonist. |
1999-03-12 |
2023-08-12 |
human |
| J C Béïque, C de Montigny, P Blier, G Debonne. Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806336. |
blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. |
1999-03-04 |
2023-08-12 |
rat |
| J C Béïque, C de Montigny, P Blier, G Debonne. Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806336. |
the present in vivo electrophysiological studies were undertaken, in the rat, to compare the effects of venlafaxine on 5-ht and na reuptake to those of the selective 5-ht reuptake inhibitor paroxetine and the selective na reuptake inhibitor desipramine. |
1999-03-04 |
2023-08-12 |
rat |
| J C Béïque, C de Montigny, P Blier, G Debonne. Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806336. |
venlafaxine and paroxetine increased with a similar potency the rt50 values for 5-ht, while desipramine was more potent than venlafaxine at increasing the rt50 values for na. |
1999-03-04 |
2023-08-12 |
rat |
| E C Dimitriou, C E Dimitrio. Buspirone augmentation of antidepressant therapy. Journal of clinical psychopharmacology. vol 18. issue 6. 1999-02-18. PMID:9864079. |
of the 22 patients who had buspirone added to their selective serotonin reuptake inhibitor antidepressant regimen (fluoxetine, paroxetine, or citalopram), 59% (13/22) showed complete or partial remission of their depressive symptomatology. |
1999-02-18 |
2023-08-12 |
Not clear |