| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Meoni, F C Tortella, N G Bower. An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: sodium-dependency and colocalization with paroxetine. British journal of pharmacology. vol 120. issue 7. 1997-06-24. PMID:9105700. |
the distribution of the sodium-dependent binding identified in this study correlated significantly with the distribution of the selective 5-ht uptake inhibitor [3h]-paroxetine, and paroxetine and dextromethorphan mutually displaced their binding at concentrations in the low nanomolar range. |
1997-06-24 |
2023-08-12 |
rat |
| P Meoni, F C Tortella, N G Bower. An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: sodium-dependency and colocalization with paroxetine. British journal of pharmacology. vol 120. issue 7. 1997-06-24. PMID:9105700. |
these data show that dextromethorphan and paroxetine share a sodium-dependent high affinity binding site in rat brain, and suggest that dextromethorphan might interact, in the presence of sodium, with the 5-ht uptake mechanism in rat brain. |
1997-06-24 |
2023-08-12 |
rat |
| C J Faherty, B Earley, B E Leonar. Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat. Journal of psychopharmacology (Oxford, England). vol 11. issue 1. 1997-06-19. PMID:9097894. |
the behavioural effects of selective serotonin reuptake inhibitors (paroxetine, sertraline, citalopram, fluvoxamine, fluoxetine) and reference compounds (n,n'-di(o-tolyl)guanidine, haloperidol, 3-(3-hydroxyphenyl)-n-(l-propyl)piperidine and chlorpromazine) were studied for their ability to produce dystonia and torticollis following direct micro injection into the left red nucleus of the rat, an area of the brain containing a high density of sigma2 receptors but relatively devoid of biogenic amine receptors. |
1997-06-19 |
2023-08-12 |
rat |
| R P Kraus, P Diaz, A McEachra. Managing rapid metabolizers of antidepressants. Depression and anxiety. vol 4. issue 6. 1997-06-18. PMID:9166660. |
fluoxetine or paroxetine, selective serotonin re-uptake inhibitors (ssris) known to potently inhibit cytochrome p450 2d6 (the isoenzyme responsible for desipramine metabolism), was then added to continuing desipramine. |
1997-06-18 |
2023-08-12 |
Not clear |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
the maximal elevations of extracellular concentration of 5-ht (5-ht(ext)) induced by the 5-ht uptake inhibitor paroxetine in forebrain were potentiated by the 5-ht1a antagonist way-100635 (1 mg/kg s.c.) in a regionally dependent manner (striatum > frontal cortex > dorsal hippocampus). |
1997-06-17 |
2023-08-12 |
Not clear |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
paroxetine (3 mg/kg s.c.) decreased forebrain 5-ht(ext) during local blockade of uptake. |
1997-06-17 |
2023-08-12 |
Not clear |
| P D Hrdina, D Bakish, A Ravindran, J Chudzik, P Cavazzoni, Y D Lapierr. Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research. vol 66. issue 2-3. 1997-06-12. PMID:9075272. |
this study examined, in the largest sample of major depressives reported so far, platelet serotonergic parameters (5-ht uptake, [3h]paroxetine binding and 5-ht2a receptors measured by [3h]lsd binding) in 60 antidepressant-free depressed patients and 40 age- and gender-matched control subjects before treatment, and in 45 major depression patients during treatment with antidepressants. |
1997-06-12 |
2023-08-12 |
human |
| P D Hrdina, D Bakish, A Ravindran, J Chudzik, P Cavazzoni, Y D Lapierr. Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research. vol 66. issue 2-3. 1997-06-12. PMID:9075272. |
the affinity of serotonin uptake site for 5-ht and [3h]paroxetine significantly decreased during treatment with antidepressants, particularly ssris. |
1997-06-12 |
2023-08-12 |
human |
| P Emond, L Garreau, S Chalon, M Boazi, M Caillet, J Bricard, Y Frangin, L Mauclaire, J C Besnard, D Guillotea. Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter. Journal of medicinal chemistry. vol 40. issue 9. 1997-06-05. PMID:9135033. |
they were evaluated for their inhibitory properties on dopamine (da(t)), serotonin (5-ht(t)), and norepinephrine (ne(t)) transporters in rat brain homogenates using [3h]gbr-12935, [3h]paroxetine, and [3h]nisoxetine as specific ligands. |
1997-06-05 |
2023-08-12 |
rat |
| A Kiev, A Feige. A double-blind comparison of fluvoxamine and paroxetine in the treatment of depressed outpatients. The Journal of clinical psychiatry. vol 58. issue 4. 1997-06-03. PMID:9164424. |
fluvoxamine and paroxetine, both serotonin selective reuptake inhibitors (ssris), were compared at two centers in a 7-week double-blind study in outpatients with major depression, diagnosed by dsm-iii-r criteria. |
1997-06-03 |
2023-08-12 |
Not clear |
| A Galli, C I Petersen, M deBlaquiere, R D Blakely, L J DeFelic. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 10. 1997-06-02. PMID:9133366. |
rna-injected xenopus oocytes accumulate 5ht, and paroxetine or desipramine inhibit this uptake. |
1997-06-02 |
2023-08-12 |
xenopus_laevis |
| T K Murray, J L Williams, A Misra, M I Colado, A R Gree. The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025109. |
had substantial decreases (approximately 50%) in the concentration of 5-ht and 5-hiaa and binding of [3h]paroxetine in the cerebral cortex 7 days later. |
1997-05-28 |
2023-08-12 |
rat |
| T K Murray, J L Williams, A Misra, M I Colado, A R Gree. The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025109. |
130 min apart had no effect on cortical 5-ht content or [3h]paroxetine binding. |
1997-05-28 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025111. |
of paroxetine (0.1 microm), desipramine (50 nm) and vanoxerine (0.5 microm), selective blockers of 5-ht, noradrenaline and dopamine uptake respectively, only paroxetine increased monoamine efflux (to 194 +/- 25%, mean +/- sem) and prolonged the removal half-life (to 638 +/- 105%). |
1997-05-28 |
2023-08-12 |
rat |
| S Cragg, M E Rice, S A Greenfiel. Heterogeneity of electrically evoked dopamine release and reuptake in substantia nigra, ventral tegmental area, and striatum. Journal of neurophysiology. vol 77. issue 2. 1997-05-22. PMID:9065855. |
paroxetine, a selective 5-hydroxytryptamine uptake inhibitor had little effect in any region tested. |
1997-05-22 |
2023-08-12 |
Not clear |
| C Davidson, J A Stamfor. 5-HT1B/D antagonists potentiate paroxetine's effect on 5-HT efflux in the lateral geniculate nucleus: in vitro voltammetric data. Biochemical Society transactions. vol 25. issue 1. 1997-05-15. PMID:9056947. |
5-ht1b/d antagonists potentiate paroxetine's effect on 5-ht efflux in the lateral geniculate nucleus: in vitro voltammetric data. |
1997-05-15 |
2023-08-12 |
Not clear |
| J G Modell, C R Katholi, J D Modell, R L DePalm. Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clinical pharmacology and therapeutics. vol 61. issue 4. 1997-05-15. PMID:9129565. |
to investigate patient reported prosexual side effects of the aminoketone antidepressant bupropion (inn, amfebutamone) and to compare directly the sexual side effects of bupropion and the selective serotonin reuptake inhibitor (ssri) antidepressants fluoxetine, paroxetine, and sertraline. |
1997-05-15 |
2023-08-12 |
Not clear |
| D Bakish, P Cavazzoni, J Chudzik, A Ravindran, P D Hrdin. Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018388. |
the effects of treatment with serotonin (5-ht) reuptake inhibitors on platelet 5-ht2 receptors, 5-ht reuptake sites an 5-ht uptake were studied in a double-blind trial comparing two selective serotonin reuptake inhibitors (ssri), paroxetine, and fluoxetine, for the treatment of major depression. |
1997-04-02 |
2023-08-12 |
Not clear |
| D Bakish, P Cavazzoni, J Chudzik, A Ravindran, P D Hrdin. Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018388. |
antidepressant treatment did not significantly alter the density of 5-ht reuptake sites, labelled with [3h]paroxetine, or 5-ht2 receptors, labelled with [3h]lsd. |
1997-04-02 |
2023-08-12 |
Not clear |
| D Bakish, P Cavazzoni, J Chudzik, A Ravindran, P D Hrdin. Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018388. |
changes in [3h]paroxetine bmax and in [3h]5-ht uptake significantly correlated with change in ham-d score at 4 and 8 weeks respectively. |
1997-04-02 |
2023-08-12 |
Not clear |