| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Arranz, J Marcusso. [3H]paroxetine and [3H]citalopram as markers of the human brain 5-HT uptake site: a comparison study. Journal of neural transmission. General section. vol 97. issue 1. 1995-04-17. PMID:7888147. |
the binding of [3h]paroxetine and [3h]citalopram to the human brain serotonin (5-ht) uptake site has been characterized and compared. |
1995-04-17 |
2023-08-12 |
human |
| B Arranz, J Marcusso. [3H]paroxetine and [3H]citalopram as markers of the human brain 5-HT uptake site: a comparison study. Journal of neural transmission. General section. vol 97. issue 1. 1995-04-17. PMID:7888147. |
together these findings suggest that both [3h]paroxetine and [3h]citalopram are good markers of the 5-ht transporter as both bind selectively and with high affinity to the serotonin uptake sites. |
1995-04-17 |
2023-08-12 |
human |
| B Arranz, J Marcusso. [3H]paroxetine and [3H]citalopram as markers of the human brain 5-HT uptake site: a comparison study. Journal of neural transmission. General section. vol 97. issue 1. 1995-04-17. PMID:7888147. |
however, the higher affinity of [3h]paroxetine confirms that this compound is the best radioligand for the 5-ht uptake site available today. |
1995-04-17 |
2023-08-12 |
human |
| K M Lawrence, J Falkowski, R R Jacobson, R W Horto. Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870891. |
platelet 5-ht uptake sites in depression: three concurrent measures using [3h] imipramine and [3h] paroxetine. |
1995-03-29 |
2023-08-12 |
human |
| K M Lawrence, J Falkowski, R R Jacobson, R W Horto. Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870891. |
platelet 5-ht uptake sites were measured in 40 depressed patients and 40 controls using [3h] imipramine binding, defined with desmethylimipramine (dmi) and na+ dependence, and [3h] paroxetine binding. |
1995-03-29 |
2023-08-12 |
human |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
the uptake of [3h]5-ht and the density (bmax) as well as affinity (kd) of 5-ht uptake sites labelled with [3h]paroxetine and of 5-ht2 receptors labelled by [3h]lsd were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. |
1995-03-27 |
2023-08-12 |
human |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
no changes were found in the affinity (kd) of 5-ht2 receptors and in 5-ht uptake or [3h]paroxetine binding parameters. |
1995-03-27 |
2023-08-12 |
human |
| K M Lawrence, C L Katona, M T Abou-Saleh, M M Robertson, B L Nairac, D R Edwards, T Lock, R A Burns, D A Harrison, R W Horto. Platelet 5-HT uptake sites, labelled with [3H] paroxetine, in controls and depressed patients before and after treatment with fluoxetine or lofepramine. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862905. |
platelet 5-ht uptake sites, labelled with [3h] paroxetine, in controls and depressed patients before and after treatment with fluoxetine or lofepramine. |
1995-03-20 |
2023-08-12 |
human |
| B Dean, K Opeskin, G Pavey, L Naylor, C Hill, N Keks, D L Copolo. [3H]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861151. |
as [3h]paroxetine binds to the serotonin transporter, these data suggest that the serotonin transporter is altered in the hippocampus in subjects with schizophrenia. |
1995-03-17 |
2023-08-12 |
human |
| D Pan, S J Gatley, S L Dewey, R Chen, D A Alexoff, Y S Ding, J S Fowle. Binding of bromine-substituted analogs of methylphenidate to monoamine transporters. European journal of pharmacology. vol 264. issue 2. 1995-03-16. PMID:7851480. |
they also bound more strongly than methylphenidate to norepinephrine reuptake sites labeled with [3h]nisoxetine (ic50 = 32, 20, 31 and 440 nm, respectively), but were weak ligands (ic50 > or = 1 microm) at the serotonin transporter labeled with [3h]paroxetine. |
1995-03-16 |
2023-08-12 |
Not clear |
| M C Ritz, C R Mantione, E D Londo. Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846207. |
spermine significantly inhibited the binding of both [3h] cft and [3h] mazindol to dopamine transporters, while it had no apparent effects on the binding of the potent serotonin uptake inhibitor [3h] paroxetine. |
1995-03-08 |
2023-08-12 |
Not clear |
| P Blier, C Bouchar. Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs. British journal of pharmacology. vol 113. issue 2. 1995-03-01. PMID:7834200. |
the electrically evoked release of tritium was significantly enhanced following a 21-day treatment with the 5-ht reuptake blocker, paroxetine and the reversible mao-a inhibitor, befloxatone, in preloaded slices of the hypothalamus, hippocampus and frontal cortex 48 h after removal of the osmotic minipumps used to deliver the drugs. |
1995-03-01 |
2023-08-12 |
Not clear |
| P Blier, C Bouchar. Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs. British journal of pharmacology. vol 113. issue 2. 1995-03-01. PMID:7834200. |
the inhibitory effect of the terminal 5-ht autoreceptor agonist, 5-methoxytryptamine, on the evoked release of tritium was attenuated in slices of the hypothalamus, hippocampus, but not frontal cortex, following the paroxetine treatment. |
1995-03-01 |
2023-08-12 |
Not clear |
| C A Mathis, S E Taylor, J D Enas, E Akgü. Binding potency of 6-nitroquipazine analogues for the 5-hydroxytryptamine reuptake complex. The Journal of pharmacy and pharmacology. vol 46. issue 9. 1995-02-27. PMID:7837045. |
using bromine as a steric probe, the rank order of potency of bromine-substituted 6-nitroquipazine analogues for inhibiting the binding of [3h]paroxetine to the 5-ht reuptake binding site was: 8- < 3- < 7- < 4- < 5-bromo. |
1995-02-27 |
2023-08-12 |
Not clear |
| S Lightowler, G A Kennett, I J Williamson, T P Blackburn, I F Tulloc. Anxiolytic-like effect of paroxetine in a rat social interaction test. Pharmacology, biochemistry, and behavior. vol 49. issue 2. 1995-02-15. PMID:7824539. |
the effects of short- and long-term administration of the selective serotonin reuptake inhibitor paroxetine were investigated in a rat social interaction test. |
1995-02-15 |
2023-08-12 |
rat |
| N E Rowlan. Long-term administration of dexfenfluramine to genetically obese (ob/ob) and lean mice: body weight and brain serotonin changes. Pharmacology, biochemistry, and behavior. vol 49. issue 2. 1995-02-15. PMID:7824540. |
the levels of brain 5-ht, or of paroxetine binding that correlates with 5-ht level, were reduced by 24 mg dfen/kg/day, a decline that persisted for at least 14 days after the end of treatment. |
1995-02-15 |
2023-08-12 |
mouse |
| N Ozaki, N E Rosenthal, P Mazzola, C C Chiueh, T Hardin, D Garcia-Borreguero, P J Schwartz, E Turner, D A Oren, D L Murph. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological psychiatry. vol 36. issue 7. 1995-02-09. PMID:7811842. |
platelet [3h]paroxetine binding, 5-ht-stimulated ca2+ response, and 5-ht content in winter seasonal affective disorder. |
1995-02-09 |
2023-08-12 |
Not clear |
| N Ozaki, N E Rosenthal, P Mazzola, C C Chiueh, T Hardin, D Garcia-Borreguero, P J Schwartz, E Turner, D A Oren, D L Murph. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological psychiatry. vol 36. issue 7. 1995-02-09. PMID:7811842. |
the present study was designed to evaluate cellular serotonergic functions in winter seasonal affective disorder (sad) using serotonin (5-ht)-stimulated ca2+ response as an integrated measure of 5-ht2 receptor function in platelets, [3h]paroxetine binding to characterize the platelet 5-ht transporter and 5-ht content as an index of the platelet storage capacity for this neurotransmitter amine. |
1995-02-09 |
2023-08-12 |
Not clear |
| N Ozaki, N E Rosenthal, P Mazzola, C C Chiueh, T Hardin, D Garcia-Borreguero, P J Schwartz, E Turner, D A Oren, D L Murph. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological psychiatry. vol 36. issue 7. 1995-02-09. PMID:7811842. |
we found no differences between sad patients and controls on any of the measures, nor between light therapy conditions in sad patients, although we found a higher bmax of [3h]paroxetine binding and 5-ht content in heavy platelets compared to light platelets. |
1995-02-09 |
2023-08-12 |
Not clear |
| C B Nemerof. Evolutionary trends in the pharmacotherapeutic management of depression. The Journal of clinical psychiatry. vol 55 Suppl. 1995-02-06. PMID:7814356. |
in addition to monoamine oxidase inhibitors and tricyclic and tetracyclic antidepressants, the serotonin reuptake inhibitors fluoxetine, sertraline, and paroxetine are now available, as well as a group of antidepressants with atypical mechanisms of action that includes bupropion, trazodone, venlafaxin, and nefazodone. |
1995-02-06 |
2023-08-12 |
Not clear |