| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P E Hansen, A G Wang, P Kragh-Sørense. [Mortality--suicide and natural death--among depressed patients. Relation to type of depression]. Ugeskrift for laeger. vol 156. issue 48. 1995-02-06. PMID:7817434. |
the patients were previous participants in psychopharmacological multicentre trials, which were carried out for the purpose of comparing the antidepressant effect of newer selective serotonin reuptake inhibitors (ssri), citalopram and paroxetine, with that of the tricyclic antidepressant drug, clomipramine. |
1995-02-06 |
2023-08-12 |
human |
| M Gobbi, M C Regondi, M Pompeiano, J M Palacios, T Mennin. Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802971. |
reserpine had no significant effect on [3h]paroxetine binding, indicating that the depletion of serotonin is not sufficient per se to alter the serotonin uptake sites in any region. |
1995-01-31 |
2023-08-12 |
rat |
| M Gobbi, M C Regondi, M Pompeiano, J M Palacios, T Mennin. Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802971. |
results were similar using [3h]citalopram as ligand for the serotonin uptake sites, in the brains of rats lesioned 5 days before death; an exception was the ventral portion of the dorsal raphe, where there was a significant increase with [3h]paroxetine and a decrease with [3h]citalopram binding. |
1995-01-31 |
2023-08-12 |
rat |
| M Gobbi, M C Regondi, M Pompeiano, J M Palacios, T Mennin. Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802971. |
thus, considering the extent of serotonin cell body degeneration, there appears to be a paradoxical mismatch between the excessive loss of [3h]8-oh-dpat binding and the resistance of [3h]citalopram or [3h]paroxetine binding in the dorsal raphe, suggesting that the two binding sites may undergo adaptive regulation in surviving neurons. |
1995-01-31 |
2023-08-12 |
rat |
| P D'Hondt, M Maes, J E Leysen, W Gommeren, S Scharpé, P Cosyn. Binding of [3H]paroxetine to platelets of depressed patients: seasonal differences and effects of diagnostic classification. Journal of affective disorders. vol 32. issue 1. 1995-01-20. PMID:7798464. |
[3h]paroxetine is a more reliable ligand for studying the serotonin (5-ht) transporter complex than [3h]imipramine. |
1995-01-20 |
2023-08-12 |
human |
| C L DeVan. Pharmacokinetics of the newer antidepressants: clinical relevance. The American journal of medicine. vol 97. issue 6A. 1995-01-11. PMID:7992822. |
the selective serotonin reuptake inhibitors (ssris)--paroxetine, sertraline, and fluvoxamine--have elimination half-lives of 15-26 hours. |
1995-01-11 |
2023-08-12 |
Not clear |
| C F Reynold. Treatment of depression in late life. The American journal of medicine. vol 97. issue 6A. 1995-01-11. PMID:7992826. |
nortriptyline, desipramine, and the newer selective serotonin reuptake inhibitors (ssris), paroxetine and sertraline, are preferred pharmacotherapy for short-term and long-term treatment. |
1995-01-11 |
2023-08-12 |
Not clear |
| S Hjorth, S B Auerbac. Further evidence for the importance of 5-HT1A autoreceptors in the action of selective serotonin reuptake inhibitors. European journal of pharmacology. vol 260. issue 2-3. 1995-01-09. PMID:7988652. |
in vivo microdialysis in rat hippocampus was used to assess the release-inhibitory properties of the 5-ht reuptake inhibitors citalopram and paroxetine. |
1995-01-09 |
2023-08-12 |
rat |
| S Hjorth, S B Auerbac. Further evidence for the importance of 5-HT1A autoreceptors in the action of selective serotonin reuptake inhibitors. European journal of pharmacology. vol 260. issue 2-3. 1995-01-09. PMID:7988652. |
when reuptake was first blocked by infusing citalopram into the hippocampus, systemic administration of citalopram or paroxetine resulted in a 50-70% decrease in hippocampal 5-ht overflow. |
1995-01-09 |
2023-08-12 |
rat |
| E L Barker, H L Kimmel, R D Blakel. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molecular pharmacology. vol 46. issue 5. 1994-12-29. PMID:7969065. |
several other ligand such as fluoxetine, paroxetine, (+)-methylenedioxymethamphetamine, cocaine, and the substrate 5-hydroxytryptamine, shows no significant species selectivity. |
1994-12-29 |
2023-08-12 |
human |
| C Hiemk. [Paroxetine: pharmacokinetics and pharmacodynamics]. Fortschritte der Neurologie-Psychiatrie. vol 62 Suppl 1. 1994-12-21. PMID:7959522. |
paroxetine is a trans-isomeric phenylpiperidine with antidepressant properties induced by selective inhibition of the neuronal high affinity uptake of serotonin. |
1994-12-21 |
2023-08-12 |
Not clear |
| C Hiemk. [Paroxetine: pharmacokinetics and pharmacodynamics]. Fortschritte der Neurologie-Psychiatrie. vol 62 Suppl 1. 1994-12-21. PMID:7959522. |
in comparison with other selective serotonin uptake inhibitors paroxetine is 2 to 23 times more potent. |
1994-12-21 |
2023-08-12 |
Not clear |
| C Hiemk. [Paroxetine: pharmacokinetics and pharmacodynamics]. Fortschritte der Neurologie-Psychiatrie. vol 62 Suppl 1. 1994-12-21. PMID:7959522. |
the pharmacokinetic and pharmacodynamic properties of paroxetine taken together indicate that this selective serotonin uptake inhibitor seems advantageous to other antidepressant agents because of its high selectivity and poor toxicity. |
1994-12-21 |
2023-08-12 |
Not clear |
| B P Skop, J A Finkelstein, T R Mareth, M R Magoon, T M Brow. The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. The American journal of emergency medicine. vol 12. issue 6. 1994-12-20. PMID:7945606. |
the serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. |
1994-12-20 |
2023-08-12 |
Not clear |
| B P Skop, J A Finkelstein, T R Mareth, M R Magoon, T M Brow. The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. The American journal of emergency medicine. vol 12. issue 6. 1994-12-20. PMID:7945606. |
fluoxetine (prozac, dista products co, division of eli lilly co, indianapolis, in), sertraline (zoloft, roerig division, pfizer inc, new york, ny), and paroxetine (paxil, smithkline beecham pharmaceuticals, philadelphia, pa) belong to a new class of antidepressant medication: the serotonin reuptake-inhibitors (sris). |
1994-12-20 |
2023-08-12 |
Not clear |
| C H Stuppaeck, C Geretsegger, A B Whitworth, H Schubert, T Platz, P König, H Hinterhuber, W W Fleischhacke. A multicenter double-blind trial of paroxetine versus amitriptyline in depressed inpatients. Journal of clinical psychopharmacology. vol 14. issue 4. 1994-12-12. PMID:7962679. |
the phenylpiperidine derivative paroxetine is a selective serotonin reuptake inhibitor. |
1994-12-12 |
2023-08-12 |
Not clear |
| C B Nemeroff, D L Knight, J Franks, W E Craighead, K R Krishna. Further studies on platelet serotonin transporter binding in depression. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943450. |
in addition, the binding of both [3h]imipramine and the more specific ligand [3h]paroxetine to the platelet 5-ht transporter was compared in drug-free depressed patients and age- and sex-matched normal comparison subjects. |
1994-11-15 |
2023-08-12 |
human |
| Y Kuroda, Y Watanabe, B S McEwe. Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain. European journal of pharmacology. vol 268. issue 1. 1994-11-10. PMID:7925606. |
tianeptine (10 mg/kg twice daily, for 14 days) significantly reduced both the expression of serotonin transporter mrna and serotonin transporter binding sites labeled by [3h]paroxetine in rat dorsal raphe nucleus. |
1994-11-10 |
2023-08-12 |
rat |
| D Marona-Lewicka, D E Nichol. Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan. European journal of pharmacology. vol 258. issue 1-2. 1994-10-21. PMID:7925587. |
fluoxetine (10 mg/kg) or paroxetine (2.5 mg/kg), both selective 5-ht uptake inhibitors, reduced the discriminability of mmai to 40% and 50%, respectively. |
1994-10-21 |
2023-08-12 |
rat |
| P D Prasad, F H Leibach, V B Mahesh, V Ganapath. Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter. Placenta. vol 15. issue 3. 1994-09-22. PMID:8066050. |
the function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush border membrane vesicles, paroxetine binding in placental brush border membrane vesicles, and serotonin uptake in cultured human placental choriocarcinoma cells. |
1994-09-22 |
2023-08-12 |
human |