| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisatsugu Miyata, Kiyoshi Ando, Tomoji Yanagit. Brain regions mediating the discriminative stimulus effects of nicotine in rats. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105111. |
substitution tests with nicotine administered into the medial prefrontal cortex, nucleus accumbens, and ventral tegmental area, all of which are located on the mesolimbocortical dopaminergic neurons, and into the dorsal hippocampus and medial habenular nucleus, which possess high densities of nicotinic cholinergic receptors, were conducted in rats trained to discriminate nicotine (0.5 mg/kg s.c.) from saline solution in a two-lever, food-reinforced, operant task. |
2002-08-02 |
2023-08-12 |
rat |
| Yousef Tizabi, Robert L Copeland, Vely A Louis, Robert E Taylo. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcoholism, clinical and experimental research. vol 26. issue 3. 2002-07-25. PMID:11923594. |
the mesolimbic dopaminergic pathway is believed to play an important role in the reinforcing effects of both ethanol and nicotine. |
2002-07-25 |
2023-08-12 |
Not clear |
| D H Overstreet, V Djuri. A genetic rat model of cholinergic hypersensitivity: implications for chemical intolerance, chronic fatigue, and asthma. Annals of the New York Academy of Sciences. vol 933. 2002-05-24. PMID:12000038. |
hypothermia, a centrally mediated response, is more pronounced in the fsl rats after nicotine and alcohol, as well as agents that are selective for the dopaminergic and serotonergic systems. |
2002-05-24 |
2023-08-12 |
human |
| Marina R Picciotto, William A Corrigal. Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 9. 2002-05-20. PMID:11978809. |
recent studies have expanded initial observations that the actions of nicotine on dopaminergic systems increase dopaminergic activity and release, leading to nicotine-induced reinforcement. |
2002-05-20 |
2023-08-12 |
mouse |
| G Jeyarasasingam, L Tompkins, M Qui. Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. Neuroscience. vol 109. issue 2. 2002-04-12. PMID:11801364. |
in the present studies, we investigated the effect of nicotine against 1-methyl-4-phenylpyridinium-induced toxicity in dopaminergic ventral mesencephalic cultures to identify the nicotinic receptor population that may be involved. |
2002-04-12 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, L Tompkins, M Qui. Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. Neuroscience. vol 109. issue 2. 2002-04-12. PMID:11801364. |
we next examined the effect of nicotine on cultures treated with 1-methyl-4-phenylpyridinium, a neurotoxin that selectively damages nigrostriatal dopaminergic neurons. |
2002-04-12 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, L Tompkins, M Qui. Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. Neuroscience. vol 109. issue 2. 2002-04-12. PMID:11801364. |
pre-treatment with nicotine, at 10(-7)-10(-4) m, partially prevented the toxin-induced decline in dopaminergic cells. |
2002-04-12 |
2023-08-12 |
Not clear |
| John G Partridge, Subbu Apparsundaram, Greg A Gerhardt, Jennifer Ronesi, David M Lovinge. Nicotinic acetylcholine receptors interact with dopamine in induction of striatal long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923419. |
dopamine release is modulated by activation of nicotinic receptors in the dorsal striatum, and activation of nicotinic receptors during high-frequency synaptic activation appears to be capable of interacting with dopaminergic actions that lead to striatal ltd. our results suggest that stimulation of mechanisms involved in striatal synaptic plasticity is an important role for striatal nicotinic acetylcholine receptors and that these mechanisms may contribute to the enhancement of learning and habit formation produced by nicotine intake. |
2002-04-08 |
2023-08-12 |
Not clear |
| J A Dani, M De Bias. Cellular mechanisms of nicotine addiction. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796143. |
although the impact of nicotine obtained from tobacco is not completely understood, a portion of nicotine's addictive power is attributable to actions upon the dopaminergic systems, which normally help to reinforce rewarding behaviors. |
2002-03-12 |
2023-08-12 |
Not clear |
| Layla Azam, Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. The Journal of comparative neurology. vol 444. issue 3. 2002-03-05. PMID:11840479. |
many behavioral effects of nicotine result from activation of nigrostriatal and mesolimbic dopaminergic systems. |
2002-03-05 |
2023-08-12 |
Not clear |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
previous in vivo experiments using rats anesthetized with chloral hydrate have revealed that nicotine applied iontophoretically increased firing of striatal neurons receiving excitatory dopaminergic input from the substantia nigra, and nicotine-induced firing was inhibited by domperidone, a dopamine d2 antagonist. |
2002-02-22 |
2023-08-12 |
rat |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
the results suggest that nicotine increases release of dopamine from the terminals of dopaminergic neurons. |
2002-02-22 |
2023-08-12 |
rat |
| C Labarca, J Schwarz, P Deshpande, S Schwarz, M W Nowak, C Fonck, R Nashmi, P Kofuji, H Dang, W Shi, M Fidan, B S Khakh, Z Chen, B J Bowers, J Boulter, J M Wehner, H A Leste. Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 5. 2001-09-13. PMID:11226318. |
the viable mice display increased anxiety, poor motor learning, excessive ambulation that is eliminated by very low levels of nicotine, and a reduction of nigrostriatal dopaminergic function upon aging. |
2001-09-13 |
2023-08-12 |
mouse |
| M J Neal, J R Cunningham, K L Matthew. Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release. Visual neuroscience. vol 18. issue 1. 2001-09-13. PMID:11347816. |
these results suggested that nicotine might increase dopamine release indirectly by stimulating the release of gaba, which in turn inhibited the release of an inhibitory transmitter acting tonically on the dopaminergic amacrines. |
2001-09-13 |
2023-08-12 |
rabbit |
| J Carlson, K Noguchi, G Elliso. Nicotine produces selective degeneration in the medial habenula and fasciculus retroflexus. Brain research. vol 906. issue 1-2. 2001-09-13. PMID:11430869. |
past research has shown the medial habenula to be highly sensitive to the effects of nicotine, and these findings, in conjunction with related research using dopaminergic stimulants, indicate that the habenula may be a weak link in the neurotoxicity seen following stimulant drugs of abuse. |
2001-09-13 |
2023-08-12 |
rat |
| M Reuter, P Nette. The influence of personality on nicotine craving: a hierarchical multivariate statistical prediction model. Neuropsychobiology. vol 44. issue 1. 2001-08-30. PMID:11408793. |
the present study proposes a hierarchical multivariate statistical prediction model which enables to determine the most prominent variables (physiological, biochemical and personality factors) related to nicotine craving and dopaminergic activation. |
2001-08-30 |
2023-08-12 |
Not clear |
| S M Boye, R J Grant, P B Clark. Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and D-amphetamine in rats. Neuropharmacology. vol 40. issue 6. 2001-08-09. PMID:11369033. |
disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and d-amphetamine in rats. |
2001-08-09 |
2023-08-12 |
rat |
| S M Boye, R J Grant, P B Clark. Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and D-amphetamine in rats. Neuropharmacology. vol 40. issue 6. 2001-08-09. PMID:11369033. |
in the first experiment, rats received bilateral intra-accumbens infusion of the dopaminergic antagonist eticlopride (or saline) prior to saline or nicotine (0.2 mg/kg s.c.) challenge. |
2001-08-09 |
2023-08-12 |
rat |
| R E Ryan, S A Ross, J Drago, R E Loiacon. Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309235. |
the present study examined the effect of a range of doses of chronic nicotine (0.75, 1.5, 3.0 and 30.0 mg kg(-1) day(-1), s.c., 14 days) upon striatal dopaminergic nerve terminal survival following 6-hydroxydopamine (6-ohda; 10 microg intrastriatal unilaterally) in rats; and the effects of acute nicotine (1 mg kg(-1), s.c.) pretreatment upon striatal neurodegeneration induced by methamphetamine (5 mg kg(-1), i.p., three doses at 2 h intervals) in wild-type and alpha4 nicotinic receptor (nachr) subunit knockout mice. |
2001-07-19 |
2023-08-12 |
mouse |
| R E Ryan, S A Ross, J Drago, R E Loiacon. Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309235. |
nicotine is capable of protecting dopaminergic neurons against parkinsonian-like neurodegeneration in vivo. |
2001-07-19 |
2023-08-12 |
mouse |