| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Eichhammer, Monika Johann, Alexander Kharraz, Harald Binder, David Pittrow, Norbert Wodarz, Göran Haja. High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking. The Journal of clinical psychiatry. vol 64. issue 8. 2003-09-25. PMID:12927012. |
the mesolimbic dopaminergic reward system seems to play a crucial role in reinforcing effects of nicotine. |
2003-09-25 |
2023-08-12 |
Not clear |
| Nicolas Champtiaux, Cecilia Gotti, Matilde Cordero-Erausquin, Denis J David, Cédric Przybylski, Clément Léna, Francesco Clementi, Milena Moretti, Francesco M Rossi, Nicolas Le Novère, J Michael McIntosh, Alain M Gardier, Jean-Pierre Changeu. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944511. |
nicotinic acetylcholine receptors (nachrs) expressed by dopaminergic (da) neurons have long been considered as potential therapeutic targets for the treatment of several neuropsychiatric diseases, including nicotine and cocaine addiction or parkinson's disease. |
2003-09-16 |
2023-08-12 |
mouse |
| Hideyuki Iizumi, Yurinosuke Kitabayashi, Kenji Fuku. [Changes of serotonergic neurons induced by low dose nicotine in rat forebrain]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 38. issue 2. 2003-08-08. PMID:12784661. |
there are many studies on the relationship between dopaminergic neurons and nicotine dependence. |
2003-08-08 |
2023-08-12 |
rat |
| L M Marubio, A M Gardier, S Durier, D David, R Klink, M M Arroyo-Jimenez, J M McIntosh, F Rossi, N Champtiaux, M Zoli, J-P Changeu. Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. The European journal of neuroscience. vol 17. issue 7. 2003-06-20. PMID:12713636. |
effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. |
2003-06-20 |
2023-08-12 |
mouse |
| L M Marubio, A M Gardier, S Durier, D David, R Klink, M M Arroyo-Jimenez, J M McIntosh, F Rossi, N Champtiaux, M Zoli, J-P Changeu. Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. The European journal of neuroscience. vol 17. issue 7. 2003-06-20. PMID:12713636. |
the mesostriatal dopaminergic system influences locomotor activity and the reinforcing properties of many drugs of abuse including nicotine. |
2003-06-20 |
2023-08-12 |
mouse |
| L M Marubio, A M Gardier, S Durier, D David, R Klink, M M Arroyo-Jimenez, J M McIntosh, F Rossi, N Champtiaux, M Zoli, J-P Changeu. Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. The European journal of neuroscience. vol 17. issue 7. 2003-06-20. PMID:12713636. |
non-alpha4 subunit-containing nachrs are located on dopaminergic neurons, are functional and respond to nicotine as demonstrated by patch clamp recordings. |
2003-06-20 |
2023-08-12 |
mouse |
| Julian R A Wooltorton, Volodymyr I Pidoplichko, Ron S Broide, John A Dan. Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716925. |
although many psychopharmacological factors contribute to nicotine addiction, midbrain dopaminergic systems have received much attention because of their roles in reinforcement and associative learning. |
2003-05-30 |
2023-08-12 |
mouse |
| Tony P George, Jennifer C Vessicchio, Angelo Termine, Peter I Jatlow, Thomas R Kosten, Stephanie S O'Malle. A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation. Biological psychiatry. vol 53. issue 2. 2003-04-30. PMID:12547469. |
since dopaminergic mechanisms appear to be involved in nicotine dependence, we studied the safety and efficacy of the monoamine oxidase b inhibitor selegiline hydrochloride compared with placebo for smoking cessation in nicotine-dependent cigarette smokers. |
2003-04-30 |
2023-08-12 |
Not clear |
| Lidia Serova, Esther L Sabba. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438507. |
brain dopaminergic systems are critical in mediating the physiological responses to nicotine. |
2002-12-24 |
2023-08-12 |
rat |
| Lidia Serova, Esther L Sabba. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438507. |
nicotine also elevated mrna levels of gtp cyclohydrolase i (gtpch), rate limiting in biosynthesis of th's essential cofactor tetrahydrobiopterin in both dopaminergic locations. |
2002-12-24 |
2023-08-12 |
rat |
| Lidia Serova, Esther L Sabba. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438507. |
thus, agonists of alpha7 nachrs have therapeutic potential for increasing th gene expression in dopaminergic regions without some of nicotine's disadvantages, such as its harmful effects on the cardiovascular system. |
2002-12-24 |
2023-08-12 |
rat |
| Theodore A Slotki. Nicotine and the adolescent brain: insights from an animal model. Neurotoxicology and teratology. vol 24. issue 3. 2002-12-19. PMID:12009492. |
these changes were accompanied by alterations in synaptic activity of cholinergic, noradrenergic, dopaminergic and serotonergic systems during nicotine administration and persisting for extended periods after the termination of exposure; behavioral alterations were commensurate with the neurochemical changes. |
2002-12-19 |
2023-08-12 |
rat |
| Maria A Sullivan, Lirio S Cove. Nicotine dependence: the role for antidepressants and anxiolytics. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 2. 2002-12-17. PMID:12020058. |
through its effects on the dopaminergic, or 'reward', system, nicotine exerts psychoactive effects such as an increased sense of enjoyment. |
2002-12-17 |
2023-08-12 |
Not clear |
| Andrea Sbarbati, Bernd Bunnemann, Patrizia Cristofori, Andrea Terron, Christian Chiamulera, Flavia Merigo, Donatella Benati, Paolo Bernardi, Francesco Osculat. Chronic nicotine treatment changes the axonal distribution of 68 kDa neurofilaments in the rat ventral tegmental area. The European journal of neuroscience. vol 16. issue 5. 2002-12-09. PMID:12372024. |
ultrastructural analysis was applied to evaluate changes in nf-68, nf-160 and nf-200 immunoreactivity in regions of the vta that contain dopaminergic neurons following chronic nicotine treatment. |
2002-12-09 |
2023-08-12 |
rat |
| Michele Zoli, Milena Moretti, Alessio Zanardi, J Michael McIntosh, Francesco Clementi, Cecilia Gott. Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 20. 2002-11-25. PMID:12388584. |
neuronal nicotinic acetylcholine receptors (nachrs) expressed on mesostriatal dopaminergic neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. |
2002-11-25 |
2023-08-12 |
rat |
| Nicholas H Caskey, Murray E Jarvik, William C Wirshing, Damian C Madsen, Paula N Iwamoto-Schaap, Naomi I Eisenberger, Lorena Huerta, Scott M Terrace, Richard E Olmstea. Modulating tobacco smoking rates by dopaminergic stimulation and blockade. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 4. issue 3. 2002-11-07. PMID:12215234. |
this study was designed to demonstrate that dopaminergic stimulation would result in decreased smoking behavior and nicotine intake, whereas dopaminergic blockade would result in increased smoking behavior and nicotine intake, in the same subjects. |
2002-11-07 |
2023-08-12 |
human |
| Nicholas H Caskey, Murray E Jarvik, William C Wirshing, Damian C Madsen, Paula N Iwamoto-Schaap, Naomi I Eisenberger, Lorena Huerta, Scott M Terrace, Richard E Olmstea. Modulating tobacco smoking rates by dopaminergic stimulation and blockade. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 4. issue 3. 2002-11-07. PMID:12215234. |
in prior human studies, a dopaminergic antagonist, haloperidol, increased smoking and/or nicotine intake, and a dopamine agonist, bromocriptine, decreased smoking. |
2002-11-07 |
2023-08-12 |
human |
| Wim Vleeming, Bisoen Rambali, Antoon Opperhuize. The role of nitric oxide in cigarette smoking and nicotine addiction. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 4. issue 3. 2002-11-07. PMID:12215243. |
this second form of exposure to no also inhibits the re-uptake of dopamine, which may contribute to dopaminergic receptor stimulation and thus to the acute rewarding effects of nicotine. |
2002-11-07 |
2023-08-12 |
Not clear |
| Laura Cardenas, Lescia K Tremblay, Claudio A Naranjo, Nathan Herrmann, Martin Zack, Usoa E Bust. Brain reward system activity in major depression and comorbid nicotine dependence. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183688. |
we hypothesized that a dysfunctional dopaminergic brain reward system (brs) might be a neurobiological link between mdd and nicotine dependence and that smoking modulates the activity of the brs by enhancing dopaminergic activity and relieving some depressive symptoms. |
2002-09-18 |
2023-08-12 |
human |
| Sean P David, Elaine Johnstone, Siân-Elin Griffiths, Michael Murphy, Patricia Yudkin, David Mant, Robert Walto. No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation. Pharmacogenetics. vol 12. issue 3. 2002-09-03. PMID:11927842. |
nicotine stimulates dopamine release and activates dopaminergic reward neurones in central pathways giving rise to dependence. |
2002-09-03 |
2023-08-12 |
Not clear |